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公开(公告)号：US20080145321A1
公开(公告)日：2008-06-19
申请号：US12036674
申请日：2008-02-25
CPC分类号： A61K8/8176 , A61K8/0208 , A61K8/22 , A61K8/24 , A61K8/49 , A61K8/817 , A61K8/891 , A61K8/90 , A61K2800/805 , A61Q11/00 , A61Q11/02
摘要： Oral care compositions comprising: (a) a peroxide complex comprising a peroxide component and an N-vinyl heterocyclic polymer (e.g., poly-N-vinyl polylactam, or poly-N-vinyl-polyimide); (b) a whitening agent (e.g., hydrogen peroxide); and (c) an orally acceptable carrier. In one embodiment, the carrier comprises a film forming material. Methods are also provided for making an oral care composition comprising: (a) mixing a whitening agent, silicone adhesive and carrier fluid to form a homogenous mixture; (b) adding a peroxide complex to said homogenous mixture, wherein said complex comprises hydrogen peroxide and an N-vinyl heterocyclic polymer; and (c) mixing under vacuum.
摘要翻译： 口腔护理组合物，其包含：（a）包含过氧化物组分和N-乙烯基杂环聚合物（例如聚-N-乙烯基聚内酰胺或聚-N-乙烯基 - 聚酰亚胺）的过氧化物络合物; （b）增白剂（例如过氧化氢）; 和（c）口头可接受的承运人。 在一个实施方案中，载体包括成膜材料。 还提供了用于制备口腔护理组合物的方法，其包括：（a）将增白剂，硅氧烷粘合剂和载体流体混合以形成均匀的混合物; （b）向所述均匀混合物中加入过氧化物络合物，其中所述络合物包含过氧化氢和N-乙烯基杂环聚合物; 和（c）在真空下混合。
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公开(公告)号：US20060029554A1
公开(公告)日：2006-02-09
申请号：US11191501
申请日：2005-07-28
IPC分类号： A61K8/66
CPC分类号： A61Q11/00 , A61K8/66 , A61K2800/88
摘要： A two component desensitizing dentifrice composition is disclosed which comprises a first dentifrice component containing an enzyme such as papain and a second dentifrice component containing an ionic surfactant such as sodium lauryl sulfate, the first and second dentifrice components being maintained separate from the other until dispensed for application to teeth whereby enzyme activity is maintained with improved dentifrice foaming characteristics.
摘要翻译： 公开了一种双组分脱敏洁牙剂组合物，其包含含有酶如木瓜蛋白酶的第一洁齿剂组分和含有离子表面活性剂如十二烷基硫酸钠的第二洁齿剂组分，第一和第二洁齿剂组分彼此分离直到分配 应用于牙齿，由此保持酶活性并提高洁牙剂发泡特性。
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公开(公告)号：US20050281757A1
公开(公告)日：2005-12-22
申请号：US10870848
申请日：2004-06-17
申请人： Sayed Ibrahim , Suman Chopra , Michael Prencipe
发明人： Sayed Ibrahim , Suman Chopra , Michael Prencipe
CPC分类号： A61K8/0208 , A61K8/8135 , A61K8/8176 , A61K8/8182 , A61Q11/00
摘要： A composition for delivery of an oral care substance to a dental surface upon application of the composition thereto is a flexible film comprising the oral care substance dispersed in a film-forming effective amount of a polymeric matrix having a hydrophilic component, e.g., vinylpyrrolidone (VP), and a hydrophobic component, e.g., vinyl acetate (VA), in a weight ratio selected such that the film is substantially dissolvable in saliva in a period of time effective for delivery of the oral care substance. The polymeric matrix illustratively comprises a poly(VP/VA) copolymer having a VP/VA weight ratio of about 90:10 to about 10:90.
摘要翻译： 用于将组合物施用于口腔护理物质到牙齿表面的组合物是包含分散在成膜有效量的具有亲水组分的聚合物基质例如乙烯基吡咯烷酮（VP）的柔性膜 ）和疏水组分，例如乙酸乙烯酯（VA），其选择的重量比使得该膜在有效递送口腔护理物质的时间段内基本上可溶于唾液中。 聚合物基体示例性地包含VP / VA重量比为约90:10至约10:90的聚（VP / VA）共聚物。
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94.发明授权公开(公告)号：US06447758B1
公开(公告)日：2002-09-10
申请号：US09847819
申请日：2001-05-02
IPC分类号： A61K716
CPC分类号： A61K31/4425 , A61K8/463 , A61K8/4926 , A61Q11/00
摘要： A dual component antiplaque oral composition having superior foaming properties in which a first component contains a cationic antibacterial agent and the second component contains a anionic surfactant normally incompatible with the cationic antibacterial agent, the first and second components are simultaneously combined for application to the teeth, the first and second components being physically segregated prior to use, the components when mixed upon application to teeth providing substantially unimpaired antiplaque effect with superior foaming properties.
摘要翻译： 一种具有优异发泡性能的双组分抗菌素口服组合物，其中第一组分含有阳离子抗菌剂，第二组分含有通常与阳离子抗菌剂不相容的阴离子表面活性剂，第一和第二组分同时组合施用于牙齿， 第一和第二组分在使用前被物理隔离，组分在施用于牙齿上混合时提供基本上未受损的抗牙斑效应和优异的发泡性能。
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公开(公告)号：US06290933B1
公开(公告)日：2001-09-18
申请号：US09567402
申请日：2000-05-09
申请人： Gary A. Durga , Michael Prencipe , Peter J. Priolo , Peter Ren
发明人： Gary A. Durga , Michael Prencipe , Peter J. Priolo , Peter Ren
IPC分类号： A61K716
CPC分类号： A61K8/042 , A61K8/25 , A61K2800/412 , A61Q11/00
摘要： A high cleaning low abrasion dentifrice containing a silica hydrogel having a mean particle size from about 5 to about 11 microns; an Einlehner hardness of from 1 to about 20; an oil absorption of about 40 to less about 100 cc/g, a BET surface area from 100 to 700 m2/g of silica, the particles having a morphology characterized by glass conchoidal fracture surfaces whereby, the dentifrice composition has a RDA of 110 to 200 and a PCR from about 150 to about 300.
摘要翻译： 含有平均粒度约5至约11微米的二氧化硅水凝胶的高清洁低磨损洁齿剂; Einlehner硬度为1至约20; 约40至少约100cc / g的吸油量，100-700m2 / g二氧化硅的BET表面积，所述颗粒具有以玻璃花岗岩骨折表面为特征的形态，因此洁齿剂组合物的RDA为110〜 200和约150至约300的PCR。
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公开(公告)号：US6106812A
公开(公告)日：2000-08-22
申请号：US231042
申请日：1999-01-13
申请人： Michael Prencipe , Mike Wong , Vincent O. Drago , Marcus Bentley , Mahmoud Hassan , Nagaraj S. Dixit
发明人： Michael Prencipe , Mike Wong , Vincent O. Drago , Marcus Bentley , Mahmoud Hassan , Nagaraj S. Dixit
CPC分类号： A61Q11/00 , A61K8/22 , A61K8/24 , A61K8/73 , A61K8/8147 , A61K2800/88
摘要： A dual component tooth whitening composition is disclosed, which composition contains a peroxide whitening and a second ingredient incompatible with the peroxide compound, the second ingredient and the peroxide compound each being incorporated in separate dentifrice components which are physically separated until dispensed for use, the components retaining their original physical state when in contact, the first component being a composition containing a peroxide whitening compound in a vehicle thickened with a combination of a particulated water insoluble inorganic compound and an organic thickener other than an alkylene oxide polymer, and the second component containing the ingredient incompatible with the peroxide.
摘要翻译： 公开了双组分牙齿增白组合物，该组合物含有过氧化物增白剂和与过氧化物化合物不相容的第二成分，第二成分和过氧化合物各自被并入分离的洁齿剂组分中，这些成分物理分离直到分配使用，组分 在接触时保持其原始的物理状态，第一组分是在混合有不溶于水的不溶性无机化合物和除了烯化氧聚合物之外的有机增稠剂的混合物中加入过氧化物增白化合物的组合物，和含有 该成分与过氧化物不相容。
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公开(公告)号：US5976507A
公开(公告)日：1999-11-02
申请号：US90293
申请日：1998-06-04
申请人： Mike Wong , Michael Prencipe
发明人： Mike Wong , Michael Prencipe
IPC分类号： A61K8/21 , A61K20060101 , A61K8/11 , A61K8/20 , A61K8/73 , A61K9/48 , A61Q11/00 , A61K7/16 , A61K7/18
CPC分类号： A61Q11/00 , A61K8/11 , A61K2800/412 , A61K2800/88
摘要： An aqueous dentifrice composition comprising an aqueous vehicle containing at least two active ingredients reactive with each other, at least one of the active ingredients being encapsulated in a substantially water immiscible, pressure rupturable shell which is rupturable during use of the dentifrice, causing the same to be released for interaction with the other active ingredient, the shell being formed from a plasticized alkyl cellulose polymer. The dentifrice exhibits increased efficacy for fluoridation of teeth when the active ingredients are soluble fluoride salt and a calcium salt encapsulated in the plasticized alkyl cellulose polymer.
摘要翻译： 一种含水洁牙剂组合物，其包含含有至少两种彼此反应的活性成分的水性载体，所述活性成分中的至少一种被包封在基本上不与水混溶的压力破裂的壳体中，所述壳体在使用洁齿剂期间是可破裂的， 被释放以与其它活性成分相互作用，壳由增塑的烷基纤维素聚合物形成。 当活性成分是可溶性氟化物盐和包封在增塑的烷基纤维素聚合物中的钙盐时，洁牙剂表现出增加的牙齿氟化功效。
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公开(公告)号：US5939051A
公开(公告)日：1999-08-17
申请号：US31727
申请日：1998-02-27
申请人： John Santalucia , Peter Ren , Nagaraj Dixit , Gary Durga , Michael Prencipe , Mahmoud Hassan , Marcus Bentley , Barry Self
发明人： John Santalucia , Peter Ren , Nagaraj Dixit , Gary Durga , Michael Prencipe , Mahmoud Hassan , Marcus Bentley , Barry Self
摘要： Oral compositions, such as oral gels and toothpastes, containing a novel high cleaning, low abrasion silica hydrogel abrasive.
摘要翻译： 口服组合物，例如口服凝胶和牙膏，含有新型高清洁，低磨损的二氧化硅水凝胶研磨剂。
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公开(公告)号：US5851514A
公开(公告)日：1998-12-22
申请号：US692841
申请日：1996-08-02
摘要： An aqueous abrasive whitening composition containing a peroxide whitening compound which is chemically and physically stable and exhibits heightened and rapid whitening of teeth and stain removal which comprises a combination of water, abrasive and peroxide compounds, a humectant containing a polyethylene glycol, a polyoxyethylene-polyoxypropylene block copolymer, a metal ion complexing agent and an antioxidant, the pH of the composition being in the range of about 5.8 to about 7.2.
摘要翻译： 一种水性磨料增白组合物，其含有化学和物理稳定的过氧化物增白化合物，其表现出增加和快速增白的牙齿和污渍去除，其包括水，磨料和过氧化物的组合，含有聚乙二醇的湿润剂，聚氧乙烯 - 聚氧丙烯 嵌段共聚物，金属离子络合剂和抗氧化剂，组合物的pH在约5.8至约7.2的范围内。
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100.发明授权
公开(公告)号：US5843409A
公开(公告)日：1998-12-01
申请号：US287371
申请日：1994-08-08
申请人： Shannon K. Campbell , Edward Albert Tavss , Steven W. Fisher , Marilou Joziak , Richard F. Theiler , Michael Prencipe
发明人： Shannon K. Campbell , Edward Albert Tavss , Steven W. Fisher , Marilou Joziak , Richard F. Theiler , Michael Prencipe
CPC分类号： A61K8/19 , A61K8/21 , A61K8/347 , A61Q11/00 , A61K2800/88
摘要： A two component desensitizing dentifrice composition is disclosed which comprises a first dentifrice component containing a desensitizing potassium salt such as potassium nitrate and a second dentifrice component containing a second desensitizing agent other than a potassium salt the such as SnF.sub.2, the second desensitizing agent being incompatible with the potassium salt, the first and second dentifrice components being maintained separate from the other until dispensed for application to teeth requiring relief from dentine hypersensitivity.
摘要翻译： 公开了一种双组分脱敏洁牙剂组合物，其包含含有脱敏钾盐如硝酸钾的第一洁牙剂组分和含有除SnF 2以外的钾盐的第二脱敏剂的第二洁齿剂组分，所述第二脱敏剂与 钾盐，第一和第二洁齿剂组分彼此分开，直到分配用于施用于需要缓解牙质超敏反应的牙齿。
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