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    Compositions and Their Uses Directed to Ptpru
    91.
    发明申请
    Compositions and Their Uses Directed to Ptpru 失效
    组合及其用途导向Ptpru

    公开(公告)号：US20080280845A1

    公开(公告)日：2008-11-13

    申请号：US11915309

    申请日：2006-05-24

    申请人： Robert McKay ,  Ravi Jain ,  Kenneth W. Dobie ,  Sanjay K. Pandey ,  Sanjay Bhanot

    发明人： Robert McKay ,  Ravi Jain ,  Kenneth W. Dobie ,  Sanjay K. Pandey ,  Sanjay Bhanot

    IPC分类号： A61K31/7125 ,  C07H21/04 ,  A61P3/10 ,  A61P3/04 ,  A61P3/00

    CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y301/03048 ,  C12N2310/3525

    摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRU in a cell, tissue or animal. Also provided are methods of active target segment validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, obesity, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hyperfattyacidemia, liver steatosis, steatohepatitis, non-alcoholic steatohepatitis, metabolic syndrome, cardiovascular disease and coronary heart disease by administration of antisense compounds targeted to PTPRU.

    摘要翻译： 本文公开了用于调节细胞，组织或动物中PTPRU表达的化合物，组合物和方法。 还提供了主动目标段验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。 还提供了用于预防，改善和/或治疗糖尿病，肥胖症，胰岛素抵抗，胰岛素缺乏，高胆固醇血症，高血糖症，高脂血症，高甘油三酯血症，高脂肪肝，肝脂肪变性，脂肪性肝炎，非酒精性脂肪性肝炎，代谢综合征，心血管疾病和 通过给予针对PTPRU的反义化合物的冠心病。

    MODULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE-MITCHONDRIAL (PEPCK-M) EXPRESSION
    100.
    发明申请
    MODULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE-MITCHONDRIAL (PEPCK-M) EXPRESSION 审中-公开
    磷酸羟丙酯羧酸酶（PEPCK-M）表达的调节

    公开(公告)号：US20130217749A1

    公开(公告)日：2013-08-22

    申请号：US13702965

    申请日：2011-06-10

    申请人： Sanjay Bhanot ,  Gerald Shulman

    发明人： Sanjay Bhanot ,  Gerald Shulman

    IPC分类号： A61K31/7088

    CPC分类号： A61K31/7088 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y401/01032 ,  C12N2310/321 ,  C12N2310/3525

    摘要： Provided herein are methods, compounds, and compositions for reducing expression of phosphoenolpyruvate carboxykinase-mitochondrial (PEPCK-M) mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preventing or decreasing diabetes, obesity, metabolic syndrome, diabetic dyslipidemia, and/or hypertriglyceridemia in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of diabetes, obesity, metabolic syndrome, diabetic dyslipidemia, and/or hypertriglyceridemia, or a symptom thereof.

    摘要翻译： 本文提供了用于在动物中降低磷酸烯醇丙酮酸羧激酶 - 线粒体（PEPCK-M）mRNA和蛋白质的表达的方法，化合物和组合物。 本文还提供用于预防或减少动物体内的糖尿病，肥胖，代谢综合征，糖尿病性血脂异常和/或高甘油三酯血症的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善糖尿病，肥胖，代谢综合征，糖尿病性血脂异常和/或高甘油三酯血症或其症状中的任何一种或多种。