公开(公告)号：US20110231411A1

公开(公告)日：2011-09-22

申请号：US13058062

申请日：2008-11-07

申请人： Fraser Shein ,  Tom Nantais ,  Dan Li

发明人： Fraser Shein ,  Tom Nantais ,  Dan Li

IPC分类号： G06F17/30

CPC分类号： G06F17/3071

摘要： A method of, and system for, extracting topic words from a collection of documents across multiple and potentially very large number of domains. Documents are selected and ranked based on similarity with at least one seed word, which defines a topic. Seed words may be entered directly by a user or provided by another application. Keywords are extracted from documents determined to be a sufficiently good match to the topic and may be displayed to the user or used as input into word prediction or word analysis and display software. Documents are determined to be a sufficiently good match to the topic using an iterative algorithm starting with the best match and selecting documents containing keywords sufficiently similar to the previously selected documents.

摘要翻译： 一种用于从跨越多个可能非常大数量的域的文档集合中提取主题词的方法和系统。 基于与定义主题的至少一个种子词的相似性来选择和排序文档。 种子字可以由用户直接输入或由另一应用提供。 从确定为与该主题足够好的匹配的文档中提取关键字，并且可以向用户显示或用作词预测或词分析和显示软件的输入。 文档被确定为与主题的足够好的匹配，使用从最佳匹配开始的迭代算法，并选择包含与先前选择的文档充分相似的关键字的文档。

公开(公告)号：US20110160551A1

公开(公告)日：2011-06-30

申请号：US13043346

申请日：2011-03-08

申请人： Dan Li ,  Shelley Cazares ,  Jaeho Kim ,  Kent Lee

发明人： Dan Li ,  Shelley Cazares ,  Jaeho Kim ,  Kent Lee

IPC分类号： A61B5/02

CPC分类号： A61B5/0464 ,  A61B5/7264 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/3925 ,  A61N1/3962

摘要： A tachyarrhythmia detection and classification system classifies tachyarrhythmias based on an analysis of morphological features of a cardiac signal enhanced by using one or more physiological parameters indicative of hemodynamic stability and/or activity level. The tachyarrhythmia detection and classification system computes a measure of similarity between an arrhythmic waveform of the cardiac signal, a template waveform for that cardiac signal, such as a correlation coefficient representative of the correlation between morphological features of the arrhythmic waveform and morphological features of the template waveform. A detected tachyarrhythmia episode is classified by comparing the measure of similarity to a threshold that is dynamically adjusted using the one or more physiological parameters.

摘要翻译： 快速心律失常检测和分类系统基于通过使用指示血液动力学稳定性和/或活动水平的一个或多个生理参数来增强的心脏信号的形态学特征的分析来分类快速性心律失常。 快速心律失常检测和分类系统计算心脏信号的心律失常波形与该心脏信号的模板波形之间的相似性的度量，例如表示心律失常波形的形态特征与模板的形态特征之间的相关性的相关系数 波形 通过将相似性测量值与使用一个或多个生理参数动态调整的阈值进行比较来分类检测到的快速性心律失常发作。

公开(公告)号：US20100305635A1

公开(公告)日：2010-12-02

申请号：US12786074

申请日：2010-05-24

申请人： Lili Liu ,  Dan Li ,  Allan C. Shuros ,  James O. Gilkerson

发明人： Lili Liu ,  Dan Li ,  Allan C. Shuros ,  James O. Gilkerson

IPC分类号： A61N1/365 ,  A61N1/39

CPC分类号： A61N1/36564 ,  A61B5/02028 ,  A61B5/0452 ,  A61N1/3622 ,  A61N1/36585 ,  A61N1/3962

摘要： A system and method for controlling cardiac ventricular tachyarrhythmias by acquiring a pressure signal representative of coronary venous pressure (CVP) from a pressure sensor implanted within a coronary vein of the patient. A CVP index is derived based on the pressure signal. The onset of a ventricular tachyarrhythmia episode is detected based on a cardiac rates signal. The CVP index and the rate signal are monitored and, responsive to the rate signal indicating a sustained tachycardia episode during the episode monitoring period, anti-tachycardia therapy selectively withheld and the episode monitoring period is extended based on the CVP index.

摘要翻译： 一种用于通过从植入在患者的冠状静脉内的压力传感器获取代表冠状静脉压（CVP）的压力信号来控制心室性心律失常的系统和方法。 基于压力信号导出CVP指数。 基于心率信号检测心室快速性心律失常事件的发作。 监测CVP指数和速率信号，并且响应于在发作监测期间指示持续性心动过速发作的速率信号，选择性地保留抗心动过速治疗，并且基于CVP指数扩大发作监测期。

公开(公告)号：US20100173076A1

公开(公告)日：2010-07-08

申请号：US12724252

申请日：2010-03-15

申请人： Richard B. Kaner ,  Dan Li ,  Jiaxing Huang

发明人： Richard B. Kaner ,  Dan Li ,  Jiaxing Huang

IPC分类号： B05D5/00 ,  B05D1/18 ,  B05D3/10 ,  C08L79/02

CPC分类号： C08G73/0266 ,  D01D5/38 ,  D01D5/40 ,  D01F6/76

摘要： A new method for forming stable polyaniline nanofiber colloids uses electrostatic repulsion to maintain dispersion of the nanofibers and prevent aggregation during synthesis of the nanofibers. The colloidal suspensions are formed directly from the reactants in solution maintained at a pH of about 1.0 to about 4.0 and a temperature of about 10° C. to about 100° C. with minimal or no stirring. Also set forth are new methods for forming ultrathin films of polyaniline nanofibers via self-assembly.

摘要翻译： 用于形成稳定的聚苯胺纳米纤维胶体的新方法使用静电排斥来保持纳米纤维的分散并防止在纳米纤维合成期间的聚集。 胶体悬浮液直接由溶液中的反应物形成，保持在约1.0至约4.0的pH和约10℃至约100℃的温度，同时最小或不搅拌。 还阐述了通过自组装形成聚苯胺纳米纤维超薄膜的新方法。

公开(公告)号：US20100036447A1

公开(公告)日：2010-02-11

申请号：US12535332

申请日：2009-08-04

申请人： Yunlong Zhang ,  Dan Li

发明人： Yunlong Zhang ,  Dan Li

IPC分类号： A61N1/365 ,  A61N1/39

CPC分类号： A61N1/36114 ,  A61N1/3622 ,  A61N1/37288 ,  A61N1/3787 ,  A61N1/3962

摘要： A system and method can sense a tachyarrhythmia, compare the sensed tachyarrhythmia with a ventricular tachyarrhythmia criterion, provide a ventricular tachyarrhythmia therapy when the sensed tachyarrhythmia satisfies the ventricular tachyarrhythmia criterion, provide a neural stimulation when the sensed tachyarrhythmia does not satisfy the ventricular tachyarrhythmia criterion, determine whether the tachyarrhythmia continues during or after the neural stimulation when the tachyarrhythmia is sustained, compare the tachyarrhythmia sensed during or after the neural stimulation with a supraventricular tachyarrhythmia (SVT) criterion, and provide a ventricular tachyarrhythmia therapy when the sensed tachyarrhythmia does not satisfy the SVT criterion.

摘要翻译： 系统和方法可以感觉到快速性心律失常，将感觉到的快速性心律失常与室性快速性心律失常标准进行比较，当感觉到的快速性心律失常满足心室快速性心律失常标准时，提供室性快速性心律失常治疗，当感觉到的快速性心律失常不满足心室快速性心律失常标准时提供神经刺激， 确定当紧张性心律失常持续时神经刺激期间或之后快速性心律失常是否持续，将神经刺激期间或之后感觉到的快速性心律失常与室上性快速性心律失常（SVT）标准进行比较，并且当感觉到的快速性心律不齐不满足时，提供室性快速性心律失常治疗 SVT标准。

公开(公告)号：US20100028469A1

公开(公告)日：2010-02-04

申请号：US12478431

申请日：2009-06-04

申请人： Randall S. Alberte ,  William P. Roschek, JR. ,  Dan Li

发明人： Randall S. Alberte ,  William P. Roschek, JR. ,  Dan Li

IPC分类号： A61K36/45 ,  A61K31/195 ,  A61K31/70 ,  A61K31/415 ,  A61P13/00

CPC分类号： A61K9/0034 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/7023 ,  Y02A50/473 ,  A23V2250/21

摘要： The present disclosure relates in part to extracts of cranberry (Vaccinium macrocarpon) comprising an enriched amount of certain compounds having anti-infective activity, e.g. antibacterial and/or antifungal activity, e.g. activity against C. albicans. Another aspect of the disclosure relates to combined cranberry and cinnamon extracts. In certain embodiments, these combined extracts have been optimized to control urinary tract infections caused by E. coli, S. aureus and C. albicans. Certain embodiments of the extract are enriched in bioactive compounds that have been shown to inhibit C. albicans adhesion and/or biofilm formation and its growth in vitro. In another aspect of the disclosure, the extracts are enriched in bioactives derived from cranberry and cinnamon that have been shown to inhibit the attachment and the growth of common urinary tract pathogens like E. coli, S. aureus and C. albicans.

摘要翻译： 本公开部分涉及包含富集量的某些具有抗感染活性的化合物的蔓越莓（牛痘macrocarpon）的提取物。 抗菌和/或抗真菌活性，例如 针对白色念珠菌的活性。 本公开的另一方面涉及组合的蔓越莓和肉桂提取物。 在某些实施方案中，这些组合的提取物已被优化以控制由大肠杆菌，金黄色葡萄球菌和白色念珠菌引起的尿路感染。 提取物的某些实施方案富含生物活性化合物，其已被证明能抑制白色念珠菌粘附和/或生物膜形成及其体外生长。 在本公开的另一方面，提取物富含衍生自蔓越莓和肉桂的生物活性物质，其已被证明可抑制普通尿道病原体如大肠杆菌，金黄色葡萄球菌和白色念珠菌的附着和生长。

公开(公告)号：US20100009927A1

公开(公告)日：2010-01-14

申请号：US12502543

申请日：2009-07-14

申请人： Randall S. Alberte ,  William P. Roschek, JR. ,  Dan Li

发明人： Randall S. Alberte ,  William P. Roschek, JR. ,  Dan Li

IPC分类号： A61K31/70 ,  C07D239/20 ,  A61K31/505 ,  C07C59/185 ,  A61K31/19 ,  C07C229/06 ,  A61K31/195 ,  C07C229/28 ,  A61K31/192 ,  C07D311/02 ,  A61K31/352 ,  C07F9/02 ,  A61K31/685 ,  C07D221/28 ,  A61K31/439 ,  C07H15/00 ,  A61P29/00 ,  A61P37/08 ,  A61P19/02 ,  A61P17/00 ,  A61P11/06

CPC分类号： C07F9/106 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/352 ,  A61K31/439 ,  A61K31/505 ,  A61K31/685 ,  A61K31/70 ,  A61K36/185 ,  A61K45/06 ,  C07C229/36 ,  C07D239/20 ,  C07D311/04 ,  C07F9/091 ,  C07F9/4006 ,  C07H15/00

摘要： The present invention relates in part to nettle extracts that are useful for treating or preventing seasonal allergies, allergic rhinitis, and other inflammatory conditions.

摘要翻译： 本发明部分涉及可用于治疗或预防季节性过敏，过敏性鼻炎和其它炎性病症的荨麻提取物。

公开(公告)号：US20090318985A1

公开(公告)日：2009-12-24

申请号：US12487251

申请日：2009-06-18

申请人： Allan C. Shuros ,  Dan Li

发明人： Allan C. Shuros ,  Dan Li

IPC分类号： A61N1/365 ,  A61N1/39

CPC分类号： A61N1/36521 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/053 ,  A61B5/4884 ,  A61B5/7264 ,  A61N1/3655 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/37247 ,  A61N1/385

摘要： A cardiac rhythm management system identifies a relationship between one or more hemodynamic parameters sensed from a patient and levels of hemodynamic tolerability of the patient. The identified relationship allows an implantable medical device to control delivery of anti-tachyarrhythmia therapy using the patient's hemodynamic tolerability during a detected tachyarrhythmia episode, in addition to classifying the detected tachyarrhythmia episode by its type and origin.

摘要翻译： 心律管理系统识别从患者感测的一个或多个血液动力学参数与患者的血液动力学耐受性水平之间的关系。 所识别的关系允许可植入医疗装置在检测到的快速性心律失常发作期间使用患者的血液动力学耐受性来控制抗快速性心律失常治疗的递送，以及根据其类型和来源对检测到的快速性心律失常发作进行分类。

公开(公告)号：US20090234211A1

公开(公告)日：2009-09-17

申请号：US12402224

申请日：2009-03-11

申请人： Dan Li ,  Haresh G. Sachanandani ,  Michael John Kane ,  Yi Zhang

发明人： Dan Li ,  Haresh G. Sachanandani ,  Michael John Kane ,  Yi Zhang

IPC分类号： A61B5/1468 ,  A61B5/04

CPC分类号： A61B5/0402 ,  A61B5/0468 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1459 ,  A61N1/3627 ,  A61N1/36585

摘要： Embodiments of the invention are related to devices and methods for myocardial ischemia detection, amongst other things. In an embodiment, the invention includes an implantable medical device including control circuitry, an electrical field sensor in communication with the control circuitry, the electrical field sensor configured to generate a signal corresponding to cardiac electrical fields. The implantable medical device can also include a chemical sensor in communication with the control circuitry, the chemical sensor configured to generate a signal corresponding to the concentration of a physiological analyte that affects cardiac electrical field waveform morphology. The control circuitry can be configured to monitor for the presence of myocardial ischemia by evaluating both the signal generated by the electrical field sensor and the signal generated by the chemical sensor. Other embodiments are also included herein.

摘要翻译： 本发明的实施方案涉及用于心肌缺血检测的装置和方法等。 在一个实施例中，本发明包括可植入医疗装置，其包括控制电路，与控制电路通信的电场传感器，电场传感器被配置为产生对应于心​​脏电场的信号。 可植入医疗装置还可以包括与控制电路通信的化学传感器，化学传感器被配置为产生对应于影响心电场波形形态的生理分析物的浓度的信号。 控制电路可以被配置为通过评估由电场传感器产生的信号和由化学传感器产生的信号来监测是否存在心肌缺血。 本文还包括其它实施例。

公开(公告)号：US20090131999A1

公开(公告)日：2009-05-21

申请号：US12283234

申请日：2008-09-10

申请人： Dan Li ,  Krzysztof Siejko ,  Abhilash Patangay

发明人： Dan Li ,  Krzysztof Siejko ,  Abhilash Patangay

IPC分类号： A61N1/00

CPC分类号： A61N1/36585 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578

摘要： Systems and methods provide for sensing, during an event of tachycardia, hemodynamic signals concurrently from at least two spatially separated locations within a patient, and quantifying a spatial relationship between the hemodynamic signals. Hemodynamic stability or state of the patient during the tachycardia event is determine based at least in part on the quantified spatial relationship. One or more anti-tachycardia therapies to treat the tachycardia may be selected based at least in part on the determined stability or state of patient hemodynamics, and the selected one or more anti-tachycardia therapies may be delivered to treat the tachycardia. The hemodynamic signals may comprise at least two, or a mixed combination, of cardiac impedance signals, cardiac chamber pressure signals, arterial pressure signals, heart sounds; and acceleration signals.

摘要翻译： 系统和方法提供在心动过速事件期间从患者内的至少两个空间上分离的位置同时感测血液动力学信号，并且量化血液动力学信号之间的空间关系。 至少部分地基于定量的空间关系确定在心动过速事件期间患者的血流动力学稳定性或状态。 可以至少部分地基于所确定的患者血液动力学的稳定性或状态来选择治疗心动过速的一种或多种抗心动过速疗法，并且可以递送所选择的一种或多种抗心动过速疗法以治疗心动过速。 血液动力学信号可以包括心脏阻抗信号，心室压力信号，动脉压信号，心音的至少两个或混合组合; 和加速度信号。