公开(公告)号：US20090234211A1

公开(公告)日：2009-09-17

申请号：US12402224

申请日：2009-03-11

申请人： Dan Li ,  Haresh G. Sachanandani ,  Michael John Kane ,  Yi Zhang

发明人： Dan Li ,  Haresh G. Sachanandani ,  Michael John Kane ,  Yi Zhang

IPC分类号： A61B5/1468 ,  A61B5/04

CPC分类号： A61B5/0402 ,  A61B5/0468 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1459 ,  A61N1/3627 ,  A61N1/36585

摘要： Embodiments of the invention are related to devices and methods for myocardial ischemia detection, amongst other things. In an embodiment, the invention includes an implantable medical device including control circuitry, an electrical field sensor in communication with the control circuitry, the electrical field sensor configured to generate a signal corresponding to cardiac electrical fields. The implantable medical device can also include a chemical sensor in communication with the control circuitry, the chemical sensor configured to generate a signal corresponding to the concentration of a physiological analyte that affects cardiac electrical field waveform morphology. The control circuitry can be configured to monitor for the presence of myocardial ischemia by evaluating both the signal generated by the electrical field sensor and the signal generated by the chemical sensor. Other embodiments are also included herein.

摘要翻译： 本发明的实施方案涉及用于心肌缺血检测的装置和方法等。 在一个实施例中，本发明包括可植入医疗装置，其包括控制电路，与控制电路通信的电场传感器，电场传感器被配置为产生对应于心​​脏电场的信号。 可植入医疗装置还可以包括与控制电路通信的化学传感器，化学传感器被配置为产生对应于影响心电场波形形态的生理分析物的浓度的信号。 控制电路可以被配置为通过评估由电场传感器产生的信号和由化学传感器产生的信号来监测是否存在心肌缺血。 本文还包括其它实施例。

公开(公告)号：US08864677B2

公开(公告)日：2014-10-21

申请号：US12402224

申请日：2009-03-11

申请人： Dan Li ,  Haresh G. Sachanandani ,  Michael John Kane ,  Yi Zhang

发明人： Dan Li ,  Haresh G. Sachanandani ,  Michael John Kane ,  Yi Zhang

IPC分类号： A61B5/02 ,  A61B5/04 ,  A61B5/145 ,  A61N1/362 ,  A61B5/0468 ,  A61N1/365 ,  A61B5/1459 ,  A61B5/0402

CPC分类号： A61B5/0402 ,  A61B5/0468 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1459 ,  A61N1/3627 ,  A61N1/36585

摘要： Embodiments of the invention are related to devices and methods for myocardial ischemia detection, amongst other things. In an embodiment, the invention includes an implantable medical device including control circuitry, an electrical field sensor in communication with the control circuitry, the electrical field sensor configured to generate a signal corresponding to cardiac electrical fields. The implantable medical device can also include a chemical sensor in communication with the control circuitry, the chemical sensor configured to generate a signal corresponding to the concentration of a physiological analyte that affects cardiac electrical field waveform morphology. The control circuitry can be configured to monitor for the presence of myocardial ischemia by evaluating both the signal generated by the electrical field sensor and the signal generated by the chemical sensor. Other embodiments are also included herein.

摘要翻译： 本发明的实施方案涉及用于心肌缺血检测的装置和方法等。 在一个实施例中，本发明包括可植入医疗装置，其包括控制电路，与控制电路通信的电场传感器，电场传感器被配置为产生对应于心​​脏电场的信号。 可植入医疗装置还可以包括与控制电路通信的化学传感器，化学传感器被配置为产生对应于影响心电场波形形态的生理分析物的浓度的信号。 控制电路可以被配置为通过评估由电场传感器产生的信号和由化学传感器产生的信号来监测是否存在心肌缺血。 本文还包括其它实施例。

公开(公告)号：US08527064B2

公开(公告)日：2013-09-03

申请号：US12327601

申请日：2008-12-03

申请人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

发明人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

IPC分类号： A61N1/36

CPC分类号： A61N1/0587 ,  A61B5/4035 ,  A61B5/6862 ,  A61B5/6876 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37288

摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

摘要翻译： 各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。 神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。 锚结构被配置为长期且牢固地植入神经刺激器，电源和至少一个电极在肺动脉内。 锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。 在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

公开(公告)号：US20090228078A1

公开(公告)日：2009-09-10

申请号：US12327601

申请日：2008-12-03

申请人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

发明人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

IPC分类号： A61N1/36

CPC分类号： A61N1/0587 ,  A61B5/4035 ,  A61B5/6862 ,  A61B5/6876 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37288

摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

摘要翻译： 各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。 神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。 锚结构被配置为长期且牢固地植入神经刺激器，电源和至少一个电极在肺动脉内。 锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。 在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

公开(公告)号：US20090043355A1

公开(公告)日：2009-02-12

申请号：US11835812

申请日：2007-08-08

申请人： Shelley M. Cazares ,  Haresh G. Sachanandani ,  Benjamin Ettori ,  Dan Li ,  Yanting Dong

发明人： Shelley M. Cazares ,  Haresh G. Sachanandani ,  Benjamin Ettori ,  Dan Li ,  Yanting Dong

IPC分类号： A61N1/02

CPC分类号： A61N1/37282 ,  A61B5/0031 ,  A61N1/3627 ,  A61N1/36585 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/63

摘要： A system evaluates the performance of an implantable medical device, such as by using a remote external server and a user interface and stored historical physiological data of a population of congestive heart failure (CHF) patients. A processor is coupled to a patient data storage device to apply multiple algorithm variations against the same implantable physiological data from the patient to produce corresponding resulting CHF indicators. The user interface includes a display that is configured to display to a user information allowing comparison between the resulting CHF indicators from the multiple algorithm variations. The display also includes a population data selector to permit the user to select physiological data from a population that includes a different set of one or more patients or physiological data collected over a period of time from the patient. This permits optimization of an algorithm parameter or selection of a best performing algorithm.

摘要翻译： 系统评估可植入医疗装置的性能，例如通过使用远程外部服务器和用户界面以及存储充血性心力衰竭（CHF）患者群体的历史生理数据。 处理器耦合到患者数据存储装置，以对来自患者的相同的可植入生理数据应用多个算法变化，以产生相应的所得CHF指示符。 用户界面包括被配置为向用户显示信息的显示器，允许根据多个算法变化比较所得到的CHF指示符。 显示器还包括种群数据选择器，以允许用户从包括不同组的一个或多个患者或在患者的一段时间内收集的生理数据的群体中选择生理数据。 这允许优化算法参数或选择最佳执行算法。

公开(公告)号：US08036735B2

公开(公告)日：2011-10-11

申请号：US11835812

申请日：2007-08-08

申请人： Shelley M. Cazares ,  Haresh G. Sachanandani ,  Benjamin Ettori ,  Dan Li ,  Yanting Dong

发明人： Shelley M. Cazares ,  Haresh G. Sachanandani ,  Benjamin Ettori ,  Dan Li ,  Yanting Dong

IPC分类号： A61B5/044 ,  A61B5/0452

CPC分类号： A61N1/37282 ,  A61B5/0031 ,  A61N1/3627 ,  A61N1/36585 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/63

摘要： A system evaluates the performance of an implantable medical device, such as by using a remote external server and a user interface and stored historical physiological data of a population of congestive heart failure (CHF) patients. A processor is coupled to a patient data storage device to apply multiple algorithm variations against the same implantable physiological data from the patient to produce corresponding resulting CHF indicators. The user interface includes a display that is configured to display to a user information allowing comparison between the resulting CHF indicators from the multiple algorithm variations. The display also includes a population data selector to permit the user to select physiological data from a population that includes a different set of one or more patients or physiological data collected over a period of time from the patient. This permits optimization of an algorithm parameter or selection of a best performing algorithm.

摘要翻译： 系统评估可植入医疗装置的性能，例如通过使用远程外部服务器和用户界面以及存储充血性心力衰竭（CHF）患者群体的历史生理数据。 处理器耦合到患者数据存储装置，以对来自患者的相同的可植入生理数据应用多个算法变化，以产生相应的所得CHF指示符。 用户界面包括被配置为向用户显示信息的显示器，允许根据多个算法变化比较所得到的CHF指示符。 显示器还包括种群数据选择器，以允许用户从包括不同组的一个或多个患者或在患者的一段时间内收集的生理数据的群体中选择生理数据。 这允许优化算法参数或选择最佳执行算法。

公开(公告)号：US08532762B2

公开(公告)日：2013-09-10

申请号：US11312279

申请日：2005-12-20

申请人： Shelley Cazares ,  Carlos Ricci ,  Dan Li ,  Yayun Lin ,  Yi Zhang ,  Jaeho Kim ,  Joseph Bocek

发明人： Shelley Cazares ,  Carlos Ricci ,  Dan Li ,  Yayun Lin ,  Yi Zhang ,  Jaeho Kim ,  Joseph Bocek

IPC分类号： A61N1/365

CPC分类号： A61N1/3622 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/7264 ,  A61N1/3702 ,  A61N1/3962

摘要： Cardiac arrhythmias are classified based on the morphology of the arrhythmia episode beats. Templates are formed using morphological features of the cardiac beats of the episode. The arrhythmia episode is classified as a monomorphic tachyarrhythmia or polymorphic tachyarrhythmia based on the one or more templates. The arrhythmia episode may be classified based on a number templates formed from the arrhythmia episode. The templates are formed by determining a measure of similarity between morphological features of a cardiac beat to a template. The similarities can be determined based on a pairing rule that determines which beat morphologies are compared. Selection of therapy for treating the arrhythmia episode may depend on the historical success of a therapy at mitigating previous arrhythmias of the same type as the arrhythmia episode.

摘要翻译： 心律失常根据心律失常发作的形态进行分类。 使用情节心脏搏动的形态学特征形成模板。 基于一个或多个模板，心律失常发作被分类为单形性快速性心律失常或多态性快速性心律失常。 心律失常发作可以基于由心律失常发作形成的数字模板进行分类。 模板通过确定心跳的形态特征与模板之间的相似性的度量来形成。 可以基于确定哪些拍子形态进行比较的配对规则来确定相似度。 选择治疗心律失常发作的治疗可能取决于治疗在缓解与心律失常事件相同类型的以前心律失常方面的历史成功。

公开(公告)号：US07930022B2

公开(公告)日：2011-04-19

申请号：US11745016

申请日：2007-05-07

申请人： Yi Zhang ,  Allan C. Shuros ,  Dan Li

发明人： Yi Zhang ,  Allan C. Shuros ,  Dan Li

IPC分类号： A61N1/362

CPC分类号： A61N1/36521 ,  A61B5/02028 ,  A61B5/0464 ,  A61B5/0535 ,  A61B5/0538 ,  A61B5/7264

摘要： An implantable medical device detects a tachyarrhythmia of a heart. During the detected tachyarrhythmia, the device determines a local myocardial impedance. Using the local myocardial impedance, the device determines whether there is sufficient perfusion to the heart. The device can then either deliver a less aggressive device therapy in response to the detected tachyarrhythmia when there is sufficient perfusion to the heart, or deliver a more aggressive device therapy in response to the detected tachyarrhythmia when there is insufficient perfusion to the heart. The perfusion information can also be used to alter tachyarrhythmia detection or classification.

摘要翻译： 可植入医疗装置检测心脏的快速性心律失常。 在检测到的快速性心律失常期间，该装置确定局部心肌阻抗。 使用局部心肌阻抗，该装置确定心脏是否有足够的灌注。 然后，当心脏充分灌注时，该装置可以响应于检测到的快速性心律失常而递送较不激进的装置疗法，或者当心脏灌注不充分时响应于检测到的快速性心律失常而递送更积极的装置疗法。 灌注信息也可用于改变快速性心律失常检测或分类。

公开(公告)号：US20110071413A1

公开(公告)日：2011-03-24

申请号：US12888900

申请日：2010-09-23

申请人： Yi Zhang ,  Shibaji Shome ,  Kritika Gupta ,  Dan Li ,  Julie A. Thompson

发明人： Yi Zhang ,  Shibaji Shome ,  Kritika Gupta ,  Dan Li ,  Julie A. Thompson

IPC分类号： A61B5/0452 ,  A61N1/365

CPC分类号： A61B5/04525 ,  A61B5/0464

摘要： An apparatus comprises an ambulatory cardiac signal sensing circuit configured to provide an electrical cardiac signal representative of cardiac activity of a subject and processor. The processor includes a feature module, a correlation module, and an ischemia detection module. The feature module is configured to identify a fiducial feature in the cardiac signal and locate one or more cardiac features in the cardiac signal using the fiducial feature. The correlation module is configured to calculate a measure of similarity of morphology for a segment of the cardiac signal that includes the cardiac features. The ischemia detection module is configured to detect a change in the measure of similarity and determine whether the detected change in the measure of similarity is indicative of ischemia.

摘要翻译： 一种装置包括动态心脏信号感测电路，其被配置为提供代表对象和处理器的心脏活动的电心脏信号。 处理器包括特征模块，相关模块和缺血检测模块。 特征模块被配置为识别心脏信号中的基准特征并且使用基准特征来定位心脏信号中的一个或多个心脏特征。 相关模块被配置为计算包括心脏特征的心脏信号的片段的形态的相似度的度量。 缺血检测模块被配置为检测相似度测量的变化，并确定检测到的相似性测量的变化是否指示缺血。

公开(公告)号：US20080281367A1

公开(公告)日：2008-11-13

申请号：US11745016

申请日：2007-05-07

申请人： Yi Zhang ,  Allan C. Shuros ,  Dan Li

发明人： Yi Zhang ,  Allan C. Shuros ,  Dan Li

IPC分类号： A61N1/362

CPC分类号： A61N1/36521 ,  A61B5/02028 ,  A61B5/0464 ,  A61B5/0535 ,  A61B5/0538 ,  A61B5/7264

摘要： An implantable medical device detects a tachyarrhythmia of a heart. During the detected tachyarrhythmia, the device determines a local myocardial impedance. Using the local myocardial impedance, the device determines whether there is sufficient perfusion to the heart. The device can then either deliver a less aggressive device therapy in response to the detected tachyarrhythmia when there is sufficient perfusion to the heart, or deliver a more aggressive device therapy in response to the detected tachyarrhythmia when there is insufficient perfusion to the heart. The perfusion information can also be used to alter tachyarrhythmia detection or classification.

摘要翻译： 可植入医疗装置检测心脏的快速性心律失常。 在检测到的快速性心律失常期间，该装置确定局部心肌阻抗。 使用局部心肌阻抗，该装置确定心脏是否有足够的灌注。 然后，当心脏充分灌注时，该装置可以响应于检测到的快速性心律失常而递送较不激进的装置疗法，或者当心脏灌注不充分时响应于检测到的快速性心律失常而递送更积极的装置疗法。 灌注信息也可用于改变快速性心律失常检测或分类。