公开(公告)号：US20250009732A1

公开(公告)日：2025-01-09

申请号：US18766023

申请日：2024-07-08

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff ,  Bruno Provstgaard Nielsen ,  Helle Martinussen

IPC: A61K31/465 ,  A61K9/00 ,  A61K9/20 ,  A61K9/24

Abstract: A dissolvable orally adhering nicotine tablet for sustained delivery of nicotine is disclosed, the tablet is a multilayer tablet comprising a first layer and a second layer, wherein the first layer is a mucoadhesive layer comprising a mucoadhesive, nicotine, and at least one sugar alcohol, and wherein the second layer comprises at least one sugar alcohol.

公开(公告)号：US20250009650A1

公开(公告)日：2025-01-09

申请号：US18765955

申请日：2024-07-08

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/4045 ,  A61K31/465 ,  A61K31/522

Abstract: A dissolvable orally adhering tablet for sustained release is disclosed, the tablet comprising an active ingredient, wherein the tablet is a multilayer tablet comprising a first layer and a second layer, the first layer being a mucoadhesive layer comprising a natural gum mucoadhesive and the second layer comprising at least one sugar alcohol.

公开(公告)号：US20250000820A1

公开(公告)日：2025-01-02

申请号：US18343849

申请日：2023-06-29

Applicant: FERTIN PHARMA A/S

Inventor： Bruno Provstgaard Nielsen ,  Helle Martinussen

IPC: A61K31/137 ,  A61K9/00 ,  A61K9/20 ,  A61K31/167 ,  A61K31/485

Abstract: The invention relates an oral tablet suitable for active pharmaceutical ingredients comprising an intragranular portion and an extragranular portion. The intragranular portion comprising a plurality of granules each comprising one or more active pharmaceutical ingredients; one or more binders; and one or more excipients comprising one or more sweeteners in an amount of at least 20% by weight of the plurality of granules. The extragranular portion comprising a population of particles comprising non-directly compressible (non-DC) sweetener particles, the non-DC sweetener particles having not been granulated prior to tableting and providing the oral tablet with a plurality of discrete non-DC areas evenly distributed in the oral tablet or at least one module of the oral tablet.

公开(公告)号：US12156943B2

公开(公告)日：2024-12-03

申请号：US17039185

申请日：2019-05-15

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/20 ,  A61K9/00 ,  A61K31/465 ,  A61K45/06

Abstract: The invention relates to a tablet dosage form for buccal absorption of active ingredients comprising a population of particles and an active ingredient to be released in the oral cavity for absorption through the oral mucosa, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas.

公开(公告)号：US12115155B2

公开(公告)日：2024-10-15

申请号：US16770345

申请日：2018-12-07

Applicant: Fertin Pharma A/S

Inventor： Bruno Provstgaard Nielsen ,  Kent Albin Nielsen

IPC: A61K31/465 ,  A61K9/00 ,  A61K9/14 ,  A61K47/32

CPC classification number: A61K31/465 ,  A61K9/0053 ,  A61K9/146 ,  A61K47/32

Abstract: The invention relates to an oral nicotine formulation for use in the alleviation of nicotine craving, the formulation comprising a content of nicotine and a content of a pH regulating agent, wherein the formulation provides a peak saliva concentration of nicotine of more than 0.3 mg/mL and a peak saliva pH of more than 7.5 during the first 120 seconds upon oral administration.

公开(公告)号：US12005058B2

公开(公告)日：2024-06-11

申请号：US18348891

申请日：2023-07-07

Applicant: Fertin Pharma A/S

Inventor： Bruno Provstgaard Nielsen ,  Kent Albin Nielsen

IPC: A61K31/465 ,  A61K9/00 ,  A61K9/20 ,  A61P25/34

CPC classification number: A61K31/465 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/2009 ,  A61K9/2027 ,  A61K9/2095 ,  A61P25/34

Abstract: The invention relates to an orally disintegrating nicotine tablet for nicotine craving relief comprising a pressed powder formulation, the tablet being designed to disintegrate within a period of less than 60 seconds upon oral administration, the powder formulation comprising an amount of nicotine and a pH regulating agent.

公开(公告)号：US20240000713A1

公开(公告)日：2024-01-04

申请号：US18464911

申请日：2023-09-11

Applicant: Fertin Pharma A/S

Inventor： Kent Albin Nielsen ,  Rikke Pranger-Rasmussen ,  Dorthe Schackinger Boesen ,  Heidi Ziegler Bruun ,  Bruno Provstgaard Nielsen

IPC: A61K9/20 ,  A61K31/4439

CPC classification number: A61K9/2086 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K31/4439

Abstract: A water-dissolvable nicotine tablet is disclosed, the nicotine tablet comprising at least a first compressed module and a second compressed module, wherein the first compressed module is an FDT-module and comprises nicotine, alkaline pH regulating agent, and disintegrant, and, wherein the second compressed module is a lozenge-module and comprises acidic pH regulating agent. Also, a method of manufacturing a nicotine tablet is disclosed.

公开(公告)号：US11786473B2

公开(公告)日：2023-10-17

申请号：US17644182

申请日：2021-12-14

Applicant: Fertin Pharma A/S

Inventor： Kent Albin Nielsen ,  Rikke Pranger-Rasmussen ,  Dorthe Schackinger Boesen ,  Heidi Ziegler Bruun ,  Bruno Provstgaard Nielsen

IPC: A61K9/20 ,  A61K31/4439

CPC classification number: A61K9/2086 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K31/4439

Abstract: A water-dissolvable nicotine tablet is disclosed, the nicotine tablet comprising at least a first compressed module and a second compressed module, wherein the first compressed module is an FDT-module and comprises nicotine, alkaline pH regulating agent, and disintegrant, and, wherein the second compressed module is a lozenge-module and comprises acidic pH regulating agent. Also, a method of manufacturing a nicotine tablet is disclosed.

公开(公告)号：US11730757B2

公开(公告)日：2023-08-22

申请号：US17040444

申请日：2019-03-21

Applicant: Fertin Pharma A/S

Inventor： Jesper Neergaard

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/20 ,  A61K31/192 ,  A61K9/68 ,  A61K31/167

CPC classification number: A61K33/10 ,  A61K9/0053 ,  A61K9/0058 ,  A61K9/20 ,  A61K9/2009 ,  A61K9/2031 ,  A61K31/167 ,  A61K31/192

Abstract: The invention relates to a solid pharmaceutical tablet for oral delivery, the tablet comprising calcium carbonate in an amount of more than 30% by weight of the tablet and organic water-insoluble components in an amount of more than 20% by weight of the tablet, wherein the tablet is designed to be masticated into a coherent residual containing the organic water-insoluble components, and wherein the tablet is adapted to release more than 80% of the calcium carbonate within 5 minutes of mastication.

公开(公告)号：US11406630B2

公开(公告)日：2022-08-09

申请号：US16065986

申请日：2018-06-25

Applicant: Fertin Pharma A/S

Inventor： Heidi Ziegler Bruun

IPC: A61K31/465 ,  A61K47/22 ,  A61K47/38 ,  A61K9/00 ,  A47L9/28 ,  A24B15/16 ,  A61K47/12 ,  A61K47/32

Abstract: A pouch designed for administration of an active ingredient in the oral cavity is disclosed, the pouch containing a matrix composition including a combination of nicotine and a water-soluble composition.