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公开(公告)号:US20240000706A1
公开(公告)日:2024-01-04
申请号:US18364862
申请日:2023-08-03
Applicant: Fertin Pharma A/S
Inventor: Dorthe Schackinger Boesen , Heidi Ziegler Bruun , Bruno Provstgaard Nielsen , Kent Albin Nielsen , Rikke Pranger-Rasmussen
IPC: A61K9/00 , A61K31/465 , A61K47/26 , A61K47/32
CPC classification number: A61K9/0056 , A61K47/32 , A61K47/26 , A61K31/465
Abstract: A water-dissolvable compressed oral nicotine lozenge is disclosed, the oral nicotine lozenge comprising a first module and a second module, the first and the second modules being fused by compression, the first module being a lozenge module comprising at least one sugar alcohol and the second module being an FDT-module comprising at least one sugar alcohol and nicotine. Also, a method of manufacturing a water-dissolvable compressed oral nicotine lozenge is disclosed.
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公开(公告)号:US20230181478A1
公开(公告)日:2023-06-15
申请号:US17644182
申请日:2021-12-14
Applicant: Fertin Pharma A/S
Inventor: Kent Albin Nielsen , Rikke Pranger-Rasmussen , Dorthe Schackinger Boesen , Heidi Ziegler Bruun , Bruno Provstgaard Nielsen
IPC: A61K9/20 , A61K31/4439
CPC classification number: A61K9/2086 , A61K31/4439 , A61K9/2018 , A61K9/2009 , A61K9/2013
Abstract: A water-dissolvable nicotine tablet is disclosed, the nicotine tablet comprising at least a first compressed module and a second compressed module, wherein the first compressed module is an FDT-module and comprises nicotine, alkaline pH regulating agent, and disintegrant, and, wherein the second compressed module is a lozenge-module and comprises acidic pH regulating agent. Also, a method of manufacturing a nicotine tablet is disclosed.
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公开(公告)号:US11738016B2
公开(公告)日:2023-08-29
申请号:US16213641
申请日:2018-12-07
Applicant: Fertin Pharma A/S
Inventor: Bruno Provstgaard Nielsen , Kent Albin Nielsen
IPC: A61K31/465 , A61K9/00 , A61K9/20 , A61P25/34
CPC classification number: A61K31/465 , A61K9/006 , A61K9/0056 , A61K9/2009 , A61K9/2027 , A61K9/2095 , A61P25/34
Abstract: The invention relates to an orally disintegrating nicotine tablet for nicotine craving relief comprising a pressed powder formulation, the tablet being designed to disintegrate within a period of less than 60 seconds upon oral administration, the powder formulation comprising an amount of nicotine and a pH regulating agent.
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公开(公告)号:US20210106521A1
公开(公告)日:2021-04-15
申请号:US16599629
申请日:2019-10-11
Applicant: Fertin Pharma A/S
Inventor: Dorthe Schackinger Boesen , Heidi Ziegler Bruun , Bruno Provstgaard Nielsen , Kent Albin Nielsen , Rikke Pranger-Rasmussen
IPC: A61K9/00 , A61K31/465 , A61K47/26 , A61K47/32
Abstract: A water-dissolvable compressed oral nicotine lozenge is disclosed, the oral nicotine lozenge comprising a first module and a second module, the first and the second modules being fused by compression, the first module being a lozenge module comprising at least one sugar alcohol and the second module being an FDT-module comprising at least one sugar alcohol and nicotine. Also, a method of manufacturing a water-dissolvable compressed oral nicotine lozenge is disclosed.
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公开(公告)号:US10251426B2
公开(公告)日:2019-04-09
申请号:US15516324
申请日:2014-10-03
Applicant: FERTIN PHARMA A/S
Inventor: Bruno Provstgaard Nielsen
IPC: A24F47/00
Abstract: An electronic nicotine delivery system (ENDS) is disclosed, said electronic nicotine delivery system (ENDS) comprising a mouth piece (MP), an atomizer arrangement (AA), a power supply (PS), a nicotine container (NC), an additive container (AC), the atomizer arrangement (AA) comprising an inlet (NCI) from the nicotine container (NC) and an inlet (ACI) from the additive container (AC), the atomizer arrangement (AA) comprising two separate atomizers, a first atomizer (FA) and a second atomizer (SA), the first atomizer producing nicotine-containing aerosols having a first mass median aerodynamic diameter (FMMAD) and the second atomizer producing additive-containing aerosols having a second mass median aerodynamic diameter (SMMAD) and wherein the second mass median aerodynamic diameter (SMMAD) is greater than the first mass median aerodynamic diameter (FMMAD), the atomizers being electrically connected to the power supply (PS). Furthermore, a method of producing a mixture of aerosols, an aerosol mixture and a use of an electronic nicotine delivery system (ENDS) is disclosed.
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公开(公告)号:US20170251727A1
公开(公告)日:2017-09-07
申请号:US15516324
申请日:2014-10-03
Applicant: FERTIN PHARMA A/S
Inventor: Bruno Provstgaard Nielsen
IPC: A24F47/00
CPC classification number: A24F47/008
Abstract: An electronic nicotine delivery system (ENDS) is disclosed, said electronic nicotine delivery system (ENDS) comprising a mouth piece (MP), an atomizer arrangement (AA), a power supply (PS), a nicotine container (NC), an additive container (AC), the atomizer arrangement (AA) comprising an inlet (NCI) from the nicotine container (NC) and an inlet (ACI) from the additive container (AC), the atomizer arrangement (AA) comprising two separate atomizers, a first atomizer (FA) and a second atomizer (SA), the first atomizer producing nicotine-containing aerosols having a first mass median aerodynamic diameter (FMMAD) and the second atomizer producing additive-containing aerosols having a second mass median aerodynamic diameter (SMMAD) and wherein the second mass median aerodynamic diameter (SMMAD) is greater than the first mass median aerodynamic diameter (FMMAD), the atomizers being electrically connected to the power supply (PS). Furthermore, a method of producing a mixture of aerosols, an aerosol mixture and a use of an electronic nicotine delivery system (ENDS) is disclosed.
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公开(公告)号:US09028803B2
公开(公告)日:2015-05-12
申请号:US14109127
申请日:2013-12-17
Applicant: Fertin Pharma A/S
Inventor: Bruno Provstgaard Nielsen , Jesper Neergard
IPC: A61K9/68 , A61K31/465 , A61K31/787 , A23G4/06 , A23G4/12
CPC classification number: A61K31/465 , A23G4/066 , A23G4/12 , A61K9/0058 , A61K31/787
Abstract: The present invention relates to a chewing gum having a high Surface Area to Volume ratio (SAV ratio), wherein said chewing gum comprises a water insoluble gum base matrix, a water soluble bulk portion and nicotine, wherein the gum base matrix, nicotine and the bulk portion are mixed and extruded to form a final extruded chewing gum product having a SAV ratio above 0.7, and wherein sustained release of nicotine is facilitated by adding 0.1-10% of C8-C10 triglycerides by weight of the chewing gum.
Abstract translation: 本发明涉及具有高表面积/体积比(SAV比)的口香糖,其中所述口香糖包括水不溶性胶基基质,水溶性本体部分和尼古丁,其中胶基基质,尼古丁和 将本体部分混合并挤出以形成具有高于0.7的SAV比率的最终挤出的口香糖产品,并且其中通过加入0.1-10%的口香糖重量的C8-C10甘油三酯来促进尼古丁的持续释放。
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公开(公告)号:US12194149B2
公开(公告)日:2025-01-14
申请号:US18464911
申请日:2023-09-11
Applicant: Fertin Pharma A/S
Inventor: Kent Albin Nielsen , Rikke Pranger-Rasmussen , Dorthe Schackinger Boesen , Heidi Ziegler Bruun , Bruno Provstgaard Nielsen
IPC: A61K9/20 , A61K31/4439
Abstract: A water-dissolvable nicotine tablet is disclosed, the nicotine tablet comprising at least a first compressed module and a second compressed module, wherein the first compressed module is an FDT-module and comprises nicotine, alkaline pH regulating agent, and disintegrant, and, wherein the second compressed module is a lozenge-module and comprises acidic pH regulating agent. Also, a method of manufacturing a nicotine tablet is disclosed.
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公开(公告)号:US20250009651A1
公开(公告)日:2025-01-09
申请号:US18766089
申请日:2024-07-08
Applicant: Fertin Pharma A/S
Inventor: Helle Wittorff , Bruno Provstgaard Nielsen , Helle Martinussen
IPC: A61K9/00 , A61K9/20 , A61K31/465 , A61K47/36
Abstract: A dissolvable orally adhering nicotine tablet for sustained delivery of nicotine is disclosed, the tablet is a multilayer tablet comprising a first layer and a second layer, wherein the first layer is a mucoadhesive layer comprising a mucoadhesive, and wherein the second layer comprises at least one sugar alcohol and nicotine.
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公开(公告)号:US20210345656A1
公开(公告)日:2021-11-11
申请号:US16770375
申请日:2018-12-07
Applicant: Fertin Pharma A/S
Inventor: Bruno Provstgaard Nielsen , Kent Albin Nielsen
Abstract: The invention relates to an oral nicotine formulation for use in the alleviation of nicotine craving, the formulation comprising a content of nicotine and a content of a pH regulating agent, wherein the formulation is designed for the content of nicotine to dissolve in the oral saliva within a period of less than 90 seconds upon oral administration, and wherein at least 40% by weight of the nicotine is absorbed through the oral mucosa.
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