公开(公告)号：US11491120B2

公开(公告)日：2022-11-08

申请号：US16761338

申请日：2018-11-09

申请人： The Trustees of Columbia University in the City of New York ,  The Research Foundation for Mental Hygiene, Inc.

发明人： Christine Ann Denny ,  Briana Kaying Chen

IPC分类号： A61K31/135 ,  A61P25/24 ,  A61K9/00 ,  A61K45/06

摘要： Methods for prophylactically treating a stress-induced affective disorder or stress-induced psychopathology in a subject are provided. Also provided are methods for inducing and/or enhancing stress resilience in a subject. In certain embodiments, an effective amount of (R,S)-ketamine or (2R, 6R)-hydroxynorketamine ((2R, 6R)-HNK) is administered to a female or male subject prior to a stressor.

公开(公告)号：US20220347650A1

公开(公告)日：2022-11-03

申请号：US17621752

申请日：2020-06-24

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Peter KELEMEN ,  Jennifer WILCOX ,  Noah McQUEEN ,  Greg DIPPLE ,  Phil RENFORTH

IPC分类号： B01J20/04 ,  B01J20/10 ,  B01J20/28 ,  B01J20/30 ,  B01J20/34 ,  B01D53/62 ,  B01D53/96 ,  B01D53/81

摘要： A plurality of carbonation plots are positioned in communication with atmospheric carbon dioxide to facilitate sequestration thereof via ambient weathering. The carbonation plots include a composition rich in metal oxides, which are positioned within the environment, such as on non-arable land, and exposed to the environment to react with carbon dioxide in the air and form metal carbonates. After about one year of exposure, the composition is recollected and calcined to produce a carbon dioxide stream and replenish the metal oxides, which can be redistributed in the carbonation plots to sequester additional carbon dioxide. The systems and methods of the present disclosure enable capture and redistribution of carbon dioxide for industrial-scale uses for very abundant quarry minerals and enable large-scale low-cost carbon capture projects for municipalities or corporations. CO2 removal from air via these methods and systems have a similar or lower cost than CO2 removal using DAC with synthetic sorbents or solvents.

公开(公告)号：US20220331490A1

公开(公告)日：2022-10-20

申请号：US17668332

申请日：2022-02-09

申请人： The Trustees of Columbia University in the City of New York

发明人： Helen H. Lu ,  Christopher Z. Mosher ,  Romare Antrobus ,  James C. Hone ,  Theanne Schiros ,  Yilin Yang

IPC分类号： A61L27/44

摘要： A fibrous polymeric scaffold for soft tissue engineering comprises electrospun fibers including a polymeric blend and graphite particles embedded therein.

公开(公告)号：US11474098B2

公开(公告)日：2022-10-18

申请号：US16228433

申请日：2018-12-20

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Steven Marx ,  Alexander Kushnir ,  Lin Yang ,  Alex Katchman ,  Henry M. Colecraft

IPC分类号： G01N33/50 ,  A61P9/00 ,  G01N33/68 ,  A61K31/4422

摘要： The present invention provides, inter alia, methods for identifying a candidate agent that can treat or ameliorate the effects of a heart condition caused by the effects of abnormal beta-adrenergic receptor activation on calcium levels in cardiomyocytes in a subject. Compositions that include the candidate agents identified by the methods disclosed, and methods of treating or ameliorating the effects of a heart condition in a subject by administering to the subject the candidate agents identified by the methods disclosed, are also provided.

公开(公告)号：US20220292657A1

公开(公告)日：2022-09-15

申请号：US17693166

申请日：2022-03-11

申请人： TERRAN BIOSCIENCES, INC. ,  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.

发明人： Samuel CLARK ,  Kenneth WENGLER ,  Guillermo HORGA HERNANDEZ

IPC分类号： G06T5/50 ,  G06T7/00 ,  G06T5/00 ,  A61B5/055 ,  G16H50/20

摘要： An exemplary system, method and computer-accessible medium for harmonizing neuromelanin (NM) data using combat directly on a NM database or using combat generated coefficients to harmonize future data can include, for example, receiving imaging information of a brain of the patient(s), from one MRI scanner, receiving imaging information of a brain of the patient(s), from a second MRI scanner and using combat to harmonize the data between scanners against a reference dataset. The Neuromelanin (NM) concentration of the patient(s) can then be determined based on the harmonized data. The NM concentration can be determined using a voxel-wise analysis procedure. The voxel-wise analysis procedure can be used to determine a topographical pattern(s) within a substantia nigra (SN) of the brain of the patient(s).

公开(公告)号：US11439325B2

公开(公告)日：2022-09-13

申请号：US16457730

申请日：2019-06-28

申请人： THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY ,  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Damiano Zanotto ,  Sunil K. Agrawal ,  Huanghe Zhang

IPC分类号： A61B5/11 ,  A61B5/103 ,  A61B5/00

摘要： A quantitative gait training and/or analysis system includes one or more footwear modules that may include a piezoresistive sensor, an inertial sensor and an independent logic unit. The footwear module functions to permit the extraction of gait kinematics and evaluation thereof in real time, or data may be stored for later reduction and analysis. Embodiments relating to calibration-based estimation of kinematic gait parameters are described.

公开(公告)号：US11439312B2

公开(公告)日：2022-09-13

申请号：US16093775

申请日：2017-04-23

申请人： The Trustees of Columbia University in the City of New York

发明人： Andreas H. Hielscher ,  Christopher J. Fong ,  Jennifer Hoi ,  Hyun K. Kim ,  Michael Khalil

IPC分类号： A61B5/05 ,  A61B5/026 ,  A61B5/00 ,  A61B5/02 ,  A61B5/022 ,  A61B5/021 ,  A61B5/0245 ,  A61B5/24 ,  A61B5/0225 ,  A61B5/1455

摘要： A plurality of modules are simultaneously positioned at locations that correspond to different angiosomes. Each of these modules has a front surface shaped and dimensioned for contacting a person's skin, a plurality of different-wavelength light sources aimed in a forward direction, and a plurality of light detectors aimed to detect light arriving from in front of the front surface. Each module is supported by a support structure (e.g., a strap or a clip) that is shaped and dimensioned to hold the front surface adjacent to the person's skin at a respective position. Perfusion in each of the angiosomes is monitored using these modules, and the surgeon can rely on this information to guide his or her intervention.

公开(公告)号：US11437236B2

公开(公告)日：2022-09-06

申请号：US16069150

申请日：2017-01-09

申请人： The Trustees of Columbia University in the City of New York

发明人： James S. Im ,  Wenkai Pan

IPC分类号： H01L21/02 ,  B23K26/00 ,  B23K26/354 ,  B23K26/082 ,  B23K26/0622 ,  B23K26/08 ,  H01L27/12 ,  H01L29/66 ,  H01L29/786 ,  B23K103/16 ,  B23K103/00 ,  B23K101/40 ,  B23K26/06 ,  B23K26/073

摘要： Methods and systems for crystallizing a thin film provide a laser beam spot that is continually advanced across the thin film to create a sustained complete or partial molten zone that is translated across the thin film, and crystallizes to form uniform, small-grained crystalline structures or grains.

公开(公告)号：US20220273929A1

公开(公告)日：2022-09-01

申请号：US17726193

申请日：2022-04-21

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Elisa E. Konofagou

IPC分类号： A61M37/00 ,  A61B8/08

摘要： The present subject matter relates to techniques for opening target tissue. The disclosed system can include a navigation guidance device configured to locate and/or monitor the target tissue, a single-element transducer for stimulating the target tissue with focused ultrasound (FUS), and a processor configured to determine a cavitation mode. The navigation guidance device can include a cavitation detector and an arm. The single-element transducer can be attached to the arm and be configured to induce the FUS with a predetermined parameter to open the target tissue.

公开(公告)号：US20220273184A1

公开(公告)日：2022-09-01

申请号：US17636018

申请日：2020-08-17

申请人： Terran Biosciences, Inc. ,  The Trustees of Columbia University in the City of New York ,  The Research Foundation for Mental Hygiene, Inc.

发明人： Samuel CLARK ,  Guillermo HORGA HERNANDEZ ,  Clifford Mills CASSIDY ,  Kenneth WENGLER

IPC分类号： A61B5/055 ,  A61B5/00 ,  G01N33/68

摘要： A neuromelanin sensitive magnetic resonance imaging (“MRI”) technique, method and computer-accessible medium for measuring the extent of, providing a diagnosis of, monitoring the treatment of, assessing novel treatments for, or determining a prognosis related to Parkinson's disease.