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    Methods and solutions for cleaning dentures
    92.
    发明授权
    Methods and solutions for cleaning dentures 失效
    清洁假牙的方法和解决方案

    公开(公告)号：US5980641A

    公开(公告)日：1999-11-09

    申请号：US876149

    申请日：1997-06-13

    申请人： Henryk P. Jakubowski

    发明人： Henryk P. Jakubowski

    IPC分类号： A61K8/365 ,  A61Q11/02 ,  B08B3/12 ,  C11D3/16 ,  C11D3/20 ,  C11D3/33 ,  C11D7/26 ,  C11D11/00 ,  C11D17/00 ,  A61K9/46

    CPC分类号： A61Q11/02 ,  A61K8/365 ,  B08B3/12 ,  C11D11/007 ,  C11D17/0073 ,  C11D3/2075 ,  C11D3/33 ,  C11D7/265 ,  A61C17/036

    摘要： A method for cleaning dentures in which a solution of about 5% carboxylic acid, an artificial sweetener and a flavoring is prepared, the dentures are placed therein and agitated. After agitation, the dentures are removed from the solution and are insertable into a wearer's mouth immediately without being rinsed, brushed or soaked. The solution is prepared by placing an amount of 25% a carboxylic acid solution in an amount of water equivalent to five times the amount of the 25% carboxylic acid solution or filling a receptacle with a known amount of water and placing a tablet having the sweetener, flavoring and an amount of carboxylic acid sufficient to provide the amount of water with a 5% carboxylic acid concentration into the receptacle. If used in combination with an ultrasonic cleaning apparatus, the solution is placed in a tank of the ultrasonic cleaning apparatus, and an ultrasonic transducer in the ultrasonic cleaning apparatus directs ultrasonic vibrations into the tank to agitate the dentures.

    摘要翻译： 一种用于清洁义齿的方法，其中制备约5％羧酸，人造甜味剂和调味剂的溶液，将义齿放置在其中并搅拌。 搅拌后，将义齿从溶液中取出，可立即插入穿戴者的嘴里而不进行冲洗，刷洗或浸泡。 通过将25％的羧酸溶液的量相当于25％羧酸溶液的量的5倍或用已知量的水填充容器，并将含有甜味剂的片剂 ，调味剂和一定量的羧酸，其足以提供具有5％羧酸浓度的水量到容器中。 如果与超声波清洗装置结合使用，则将溶液放置在超声波清洗装置的槽中，并且超声波清洗装置中的超声波换能器将超声波振动引导到罐中以搅拌假牙。

    Method for making fast-melt tablets
    93.
    发明授权
    Method for making fast-melt tablets 失效
    快速成型片的制作方法

    公开(公告)号：US5939091A

    公开(公告)日：1999-08-17

    申请号：US40749

    申请日：1998-03-18

    申请人： Anthony B. Eoga ,  Kirti H. Valia

    发明人： Anthony B. Eoga ,  Kirti H. Valia

    IPC分类号： A61K9/00 ,  A61K9/46

    CPC分类号： A61K9/0056 ,  Y10S514/819

    摘要： A process for making a fast melt tablet and a powdered material is disclosed. The process includes providing a powdered material with a density of from 0.2 to about 0.55 grams and precompacting the material to increase the density prior to compacting the powdered material into a fast melt tablet.

    摘要翻译： 公开了一种制备快速熔融片剂和粉末材料的方法。 该方法包括提供密度为0.2至约0.55克的粉末材料，并在将粉末材料压实成快速熔融片剂之前预先压制材料以增加密度。

    Lubricants for use in tabletting
    95.
    发明授权
    Lubricants for use in tabletting 失效
    用于压片的润滑剂

    公开(公告)号：US5922351A

    公开(公告)日：1999-07-13

    申请号：US127433

    申请日：1993-09-27

    申请人： Lawrence J. Daher

    发明人： Lawrence J. Daher

    IPC分类号： A61K9/20 ,  A61K9/46

    CPC分类号： A61K9/0007 ,  A61K9/2009 ,  A61K9/2013 ,  Y10S514/96

    摘要： The invention provides a number of new water soluble lubricants and lubricant formulations which facilitate the production of tablets. In particular calcium and potassium sorbates and micronized combinations of polyethylene glycol with calcium ascorbate or with trisodium citrate or mixtures thereof are useful as lubricants, particularly in tablet compositions containing ingredients where rapid dissolution in an aqueous environment is desired for activity or desired for aesthetic purposes. A method is provided for surface treating calcium sorbate with docusate sodium, Simethicone Emulsion, USP or with lecithin to provide particularly useful tablet lubricants. The above lubricant(s) and lubricant formulations have fewer limitations and improved functionality in comparison to standard lubricants presently known. In addition, the lubricant(s) provided may be used with known hydrophobic lubricants to decrease the amount of the hydrophobic lubricant required for lubrication.

    摘要翻译： 本发明提供了许多新的水溶性润滑剂和促进片剂生产的润滑剂制剂。 特别是聚乙二醇与抗坏血酸钙或柠檬酸三钠或其混合物的钙和钾山梨酸钙和钾的微粉化组合可用作润滑剂，特别是在含有在水性环境中需要快速溶解于水性环境中用于活性或期望用于美学目的的成分的片剂组合物中。 提供了用多库酯钠，二甲硅油乳剂，USP或卵磷脂来表面处理山梨酸酯以提供特别有用的片剂润滑剂的方法。 与目前已知的标准润滑剂相比，上述润滑剂和润滑剂配方具有较少的限制和改进的功能。 此外，所提供的润滑剂可以与已知的疏水润滑剂一起使用以减少润滑剂所需的疏水润滑剂的量。

    Effervescent systems with simplified packaging requirements
    96.
    发明授权
    Effervescent systems with simplified packaging requirements 失效
    具有简化包装要求的泡腾系统

    公开(公告)号：US5912012A

    公开(公告)日：1999-06-15

    申请号：US927554

    申请日：1997-09-06

    申请人： Edward J. Carlin ,  Felix M. Garruto, Jr.

    发明人： Edward J. Carlin ,  Felix M. Garruto, Jr.

    IPC分类号： A61K9/46 ,  A61K9/20

    CPC分类号： A61K9/0007

    摘要： A three layer effervescent tablet includes a first layer carrying a first effervescent reactant, and a second layer carrying a second effervescent reactant, with the first and second layers, separated by an interposed layer of a material which does not react with either effervescent reactant. This provides an effervescent tablet that does not require any of the special material, handling, or packaging considerations normally needed for effervescent tablets.

    摘要翻译： 三层泡腾片包括承载第一泡腾反应物的第一层和承载第二泡腾反应物的第二层，其中第一层和第二层由不与泡腾反应物反应的材料的中间层隔开。 这提供了泡腾片，其不需要泡腾片通常需要的任何特殊材料，处理或包装注意事项。

    Fast-melt tablet and method of making same
    97.
    发明授权
    Fast-melt tablet and method of making same 失效
    快熔片及其制作方法

    公开(公告)号：US5807577A

    公开(公告)日：1998-09-15

    申请号：US562057

    申请日：1995-11-22

    申请人： Aomar Ouali

    发明人： Aomar Ouali

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/46

    CPC分类号： A61K9/0007 ,  A61K9/0056 ,  A61K9/2068 ,  Y10S514/819

    摘要： There is provided an improved, fast-melting solid dosage form which readily disintegrates when placed in the mouth. The solid dosage form preferably being a tablet comprising the following primary ingredients whose proportions are calculated as weight percent on the total weight of the tablet: (a) from about 30 to 50 weight percent, of a pharmaceutically acceptable active ingredient component; (b) an effervescent couple consisting of about 3 to 5 weight percent of an effervescence base about 3 to 5 weight percent of an effervescence acid suitable for achieving a gas evolving reaction with the effervescence base upon being contacted with an aqueous solution such as saliva; (c) about 40 to 50 weight percent of a pharmaceutically acceptable starch as a bulking and disintegrating agent; (d) about 3 to 5 weight percent of a tablet lubricant. Additionally, the tablet may comprise flavoring agents. The tablet is formed of granules of a mixture of the active ingredient component, the effervescence base, and the starch, admixed to a powderous blend of the remaining ingredients, subsequently compressed in tablet form. Also provided is a method of making the solid dosage form of the present invention.

    摘要翻译： 提供了一种改进的，快速熔化的固体剂型，其在置于口中时容易崩解。 固体剂型优选为片剂，其包含以下主要成分，其比例以片剂总重量的重量百分数计算：（a）约30至50重量％的药学上可接受的活性成分组分; （b）泡腾对，其由约3至5重量％的泡腾碱组成，约3至5重量％的泡腾酸，其适于在与水溶液如唾液接触时实现与泡腾碱的气体放出反应; （c）约40至50重量％的作为膨胀和崩解剂的药学上可接受的淀粉; （d）约3至5重量％的片剂润滑剂。 此外，片剂可以包含调味剂。 片剂由活性成分组分，泡腾基质和淀粉的混合物的颗粒形成，与剩余成分的粉末混合物混合，随后以片剂形式压制。 还提供了制备本发明的固体剂型的方法。

    Effervescent ranitidine formulations
    99.
    发明授权
    Effervescent ranitidine formulations 失效
    泡腾雷尼替丁配方

    公开(公告)号：US5728401A

    公开(公告)日：1998-03-17

    申请号：US837488

    申请日：1997-04-16

    申请人： Farhan Ahmed ,  Chetan Rajsharad ,  Himadri Sen

    发明人： Farhan Ahmed ,  Chetan Rajsharad ,  Himadri Sen

    IPC分类号： A61K9/46 ,  A61K31/341

    CPC分类号： A61K31/341 ,  A61K9/0007

    摘要： An effervescent pharmaceutical composition for oral use in the treatment of a condition mediated through histamine H.sub.2 receptors contains a therapeutically effective amount of ranitidine or a physiologically acceptable salt thereof, about 25-70% by weight of disodium citrate, and about 20-50% by weight of sodium bicarbonate. Optionally, the effervescent composition may also Include about 0.5-25% by weight of an edible organic acid such as fumaric acid. Preferably, the effervescent composition is in the form of a tablet. Additional excipients for the effervescent composition include about 2-10% by weight of glycine, a flavoring agent, a sweetening agent, a binding agent, and/or a lubricant.

    摘要翻译： 用于口服用于治疗由组胺H2受体介导的病症的泡腾药物组合物含有治疗有效量的雷尼替丁或其生理上可接受的盐，约25-70重量％柠檬酸二钠，约20-50％ 重量的碳酸氢钠。 任选地，泡腾组合物还可以包括约0.5-25重量％的可食用有机酸如富马酸。 优选地，泡腾组合物是片剂的形式。 用于泡腾组合物的附加赋形剂包括约2-10重量％的甘氨酸，调味剂，甜味剂，粘合剂和/或润滑剂。