公开(公告)号：US20160278911A1

公开(公告)日：2016-09-29

申请号：US15140108

申请日：2016-04-27

Applicant: KOWA COMPANY, LTD.

Inventor： Kazuharu NIWA ,  Yasuhiko SUZUKI ,  Masayoshi TANAKA

IPC: A61F2/16

CPC classification number: A61F2/167 ,  A61F2002/16905

Abstract: An intraocular lens insertion device having a configuration in such a manner that, with the displacement of a haptic toward the convex side of an optical portion, which can be deformed in a curved shape, restricted by an engaging part provided to the tip part of a plunger, the haptic is deformed in a curved shape in the direction in which the haptic approaches the optical portion. The configuration allows, when the intraocular lens is pushed out by the plunger, the haptic to enter a gap formed on the concave side of the optical portion which has been deformed in a curved shape.

Abstract translation: 一种眼内透镜插入装置，其具有这样的结构，即通过使触觉部朝向可弯曲形状变形的光学部分的凸侧移位，由设置在弯曲形状的顶端部的接合部限制 触发器在触觉件接近光学部分的方向上以弯曲的形状变形。 该结构允许当眼内透镜被柱塞推出时，触觉件进入形成在已经变形为弯曲形状的光学部分的凹侧上的间隙。

公开(公告)号：US20160256470A1

公开(公告)日：2016-09-08

申请号：US15060927

申请日：2016-03-04

Applicant: KOWA COMPANY, LTD.

Inventor： Isamu SAWAI

IPC: A61K31/551 ,  A61K31/382 ,  A61K31/542 ,  A61K9/00

CPC classification number: A61K31/551 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/18 ,  A61K31/382 ,  A61K31/433 ,  A61K31/542 ,  A61K45/06 ,  A61K47/02 ,  A61K2300/00

Abstract: Provided is a technology for suppressing discoloration of a halo-isoquinoline derivative-containing aqueous composition during high-temperature storage. Provided is an aqueous composition containing a compound of formula (1): wherein X is a halogen atom, a salt of the compound, or a solvate of the compound or the salt; and a carbonic anhydrase inhibitor.

Abstract translation: 提供了一种用于在高温保存期间抑制含卤代异喹啉衍生物的含水组合物变色的技术。 本发明提供含有式（1）化合物的水性组合物：其中X为卤素原子，化合物的盐或化合物或其盐的溶剂合物; 和碳酸酐酶抑制剂。

公开(公告)号：US20160136138A1

公开(公告)日：2016-05-19

申请号：US14903114

申请日：2014-07-09

Applicant: KOWA COMPANY, LTD.

Inventor： Haruki Shibata ,  Toshiaki Takizawa

IPC: A61K31/423

Abstract: The present invention provides a compound useful in the prevention and treatment of nonalcoholic fatty liver disease. The invention relates to a drug for the prevention and/or treatment of nonalcoholic fatty liver disease, the drug having as an active ingredient (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid, a salt thereof, or a solvate of these.

Abstract translation: 本发明提供了用于预防和治疗非酒精性脂肪性肝病的化合物。 本发明涉及一种用于预防和/或治疗非酒精性脂肪肝疾病的药物，该药物具有作为活性成分的（R）-2- [3 - [[N-（苯并恶唑-2-基）-N-3 - （4-甲氧基苯氧基）丙基]氨基甲基]苯氧基]丁酸，其盐或它们的溶剂合物。

公开(公告)号：US20160060203A1

公开(公告)日：2016-03-03

申请号：US14780625

申请日：2014-03-28

Applicant: KOWA COMPANY, LTD.

Inventor： Yukiyoshi YAMAZAKI

IPC: C07C51/41 ,  C07D263/58 ,  C07C67/08

CPC classification number: C07C51/412 ,  A61K31/423 ,  C07B57/00 ,  C07C67/08 ,  C07D263/58 ,  C07C51/487 ,  C07C59/01

Abstract: To provide a method for improving optical purity of an optically active 2-hydroxycarboxylic acid or a derivative thereof, which is useful as a raw material in the manufacture of medicines, agrochemicais, and industrial products. The method of the invention for improving purity of a hydroxycarboxylic acid of the following formula (1a) or (1b) or a derivative thereof includes the steps of reacting the hydroxycarboxylic acid of the following formula (1a) or (1b) with at least one optically inactive base selected from the group consisting of an alkali metal, alkoxide and a secondary amine in the presence of a solvent and, subsequently, performing recrystallization, to thereby form a hydroxycarboxylic acid salt of the following formula (IIIa) or (IIIb): wherein R1 represents a C1-8 alkyl group, and R2 represents an alkali metal or a secondary amine.

Abstract translation: 提供一种用于提高光学活性的2-羟基羧酸或其衍生物的光学纯度的方法，其可用作制造药物，农用化学品和工业产品中的原料。 本发明提高下式（1a）或（1b）的羟基羧酸的纯度或其衍生物的方法包括以下步骤：使下式（1a）或（1b）的羟基羧酸与至少一种 在溶剂存在下，选自碱金属，醇盐和仲胺的光学非活性碱，然后进行重结晶，从而形成下式（IIIa）或（IIIb）的羟基羧酸盐： 其中R1表示C1-8烷基，R2表示碱金属或仲胺。

公开(公告)号：US20150325014A1

公开(公告)日：2015-11-12

申请号：US14761973

申请日：2014-01-20

Applicant: KOWA COMPANY, LTD.

Inventor： Toshiaki NAKAGAWA

IPC: G06T11/00 ,  G06T5/50 ,  G06T5/00

CPC classification number: G06T11/008 ,  A61B3/12 ,  G06T5/002 ,  G06T5/50 ,  G06T2207/10004 ,  G06T2207/10101 ,  G06T2207/20216 ,  G06T2207/30041 ,  H04N1/409 ,  H04N5/21 ,  H04N5/357

Abstract: An average image producing means 52 produces an average image from all or some of a plurality of images captured at the same location. A noise extracting means 53 extracts a noise pixel on the basis of the result of a comparison between the pixel values of the pixels in the captured images and the pixel values of the pixels at the same position in the average image. An interpolating means 54 interpolates the pixel value of the noise pixel included in the captured images using the pixel values of other pixels to produce a noise-eliminated image.

Abstract translation: 平均图像产生装置52从在同一位置拍摄的多个图像的全部或一些中产生平均图像。 噪声提取装置53基于拍摄图像中的像素的像素值与平均图像中的相同位置处的像素的像素值之间的比较结果来提取噪声像素。 内插装置54使用其他像素的像素值内插包含在拍摄图像中的噪声像素的像素值，以产生噪声去除图像。

公开(公告)号：US20150313709A1

公开(公告)日：2015-11-05

申请号：US14648119

申请日：2013-11-29

Applicant: KOWA COMPANY, LTD.

Inventor： Kenichi Kobayashi

IPC: A61F2/16

CPC classification number: A61F2/167 ,  A61F2/1678

Abstract: The intraocular lens insertion tool includes a nozzle main body having a nozzle portion 15, a stage portion capable of disposing the intraocular lens 2 in the nozzle main body, and a plunger 60 that presses the intraocular lens 2 set in the stage portion by a leading end, thereby releasing the intraocular lens 2 into an eyeball. The leading end portion 10a of the nozzle portion 15 is obliquely cut so that, as it goes to the front side from the optical axis rear side of intraocular lens 2, the position of the end surface is located on the front side, and at the leading end 61d of the plunger 60, a protruding portion 61e is provided which protrudes to the front side so as to be able to place the surface of the optical axis rear side of the intraocular lens 2.

Abstract translation: 眼内透镜插入工具包括具有喷嘴部分15的喷嘴主体，能够将眼内透镜2设置在喷嘴主体中的台部，以及柱塞60，其将设置在台部中的眼内透镜2通过前端 从而将眼内透镜2释放到眼球内。 喷嘴部15的前端部10a被倾斜切割，从而当从眼内透镜2的光轴后侧向前侧移动时，端面的位置位于前侧， 柱塞60的前端61d设置有突出部61e，其突出到前侧，以能够放置眼内透镜2的光轴后侧的表面。

公开(公告)号：USD742014S1

公开(公告)日：2015-10-27

申请号：US29483212

申请日：2014-02-26

Applicant: KOWA COMPANY, LTD.

Designer： Shouta Yabe ,  Yuuki Arai ,  Naoki Kambe

公开(公告)号：US20150301052A1

公开(公告)日：2015-10-22

申请号：US14399853

申请日：2013-05-07

Applicant: KOWA COMPANY, LTD.

Inventor： Taisuke Hirono ,  Yuka Sugiura

IPC: G01N33/579

CPC classification number: G01N33/579 ,  G01N2333/96433 ,  G01N2333/96463 ,  G01N2400/24 ,  G01N2400/50

Abstract: Provided is a technique for achieving a higher measurement accuracy in the detection of an organism-originated physiologically active substance or the measurement of the concentration of the organism-originated physiologically active substance in a hyaluronic acid preparation. The present invention relates to a measurement method for detecting an organism-originated physiologically active substance or measuring the concentration of the organism-originated physiologically active substance in a hyaluronic acid preparation by mixing the hyaluronic acid preparation with an AL reagent to allow the organism-originated physiologically active substance in the hyaluronic acid preparation and an AL to react with each other. A mixed solution of the hyaluronic acid preparation with the AL reagent is diluted with an aqueous electrolyte solution, and a specific protein having a higher affinity for the organism-originated physiologically active substance than that of hyaluronic acid is added to the mixed solution.

Abstract translation: 提供了在透明质酸制剂中检测生物来源的生理活性物质或测定生物体起始生理活性物质的浓度的技术。 本发明涉及通过将透明质酸制剂与AL试剂混合以使生物来源的透明质酸制剂通过透明质酸制剂检测生物体产生的生理活性物质或测量生物体起始生理活性物质的浓度的测量方法 透明质酸制剂中的生理活性物质和AL彼此反应。 将透明质酸制剂与AL试剂的混合溶液用电解质水溶液稀释，向混合溶液中加入对生物体起始生理活性物质的亲和力高于透明质酸的特异性蛋白质。

公开(公告)号：US20140362459A1

公开(公告)日：2014-12-11

申请号：US14374099

申请日：2012-12-26

Applicant: KOWA COMPANY LTD.

Inventor： Tosao Tohjima

IPC: G02B7/04

CPC classification number: G02B7/04 ,  G02B7/08 ,  G02B7/09 ,  G02B7/102 ,  G03B17/12

Abstract: A lens barrel has a telescopic structure in which an inner barrel and an outer barrel move relative to each other. A plurality of ring retainers (201 and 202) are disposed at different positions with respect to the optical axis direction between an inner barrel (11) and an outer barrel (12) to support a number of bearing balls (30) so that the bearing balls (30) roll in contact with the inner barrel (11) and the outer barrel (12). The retainers (201 and 202) are supported floatingly in a direction parallel to the optical axis in accordance with the rolling movement of the bearing balls (30). The inner barrel (11) and the outer barrel (12), which move relative to each other, are supported by the ball bearings.

Abstract translation: 镜筒具有伸缩结构，其中内筒和外筒相对于彼此移动。 多个环形保持器（201和202）设置在内筒（11）和外筒（12）之间相对于光轴方向的不同位置，以支撑多个轴承滚珠（30），使得轴承 滚珠（30）与内筒（11）和外筒（12）接触。 保持器（201和202）根据轴承滚珠（30）的滚动运动沿着平行于光轴的方向被浮动地支撑。 相对于彼此移动的内筒（11）和外筒（12）由球轴承支撑。

公开(公告)号：US20140288474A1

公开(公告)日：2014-09-25

申请号：US14298346

申请日：2014-06-06

Applicant: Kowa Company, Ltd. ,  Advancing Inc. ,  DMChain Cooperative

Inventor： Hidetaka OKADA ,  Hitoshi OJIMA ,  Hidenori KASENO

IPC: A61F5/02

CPC classification number: A61F5/028 ,  A61F5/024 ,  A61F5/03

Abstract: A supporter includes a body section having a back-contact section, a first auxiliary band section of which one end is fixed to the top end of a left side of the back-contact section and the other end is fixed to the bottom end of a right side of the back-contact section, a second auxiliary band section forming a pair with the first auxiliary band section, a first ring arranged to slide between the one end and the other end of the first auxiliary band section, a second ring forming a pair with the first ring, a first adjustment band section of which one end is fixed to loops on a right end side of the body section and the other end can be fastened to loops on the right end side of the body section, and a second adjustment band section forming a pair with the first adjustment band section.

Abstract translation: 支撑体包括具有背接触部分的主体部分，第一辅助带部分，其一端固定到后接触部分的左侧的顶端，另一端固定到底接触部分的底端 所述后接触部分的右侧，与所述第一辅助带部分形成一对的第二辅助带部分，布置成在所述第一辅助带部分的一端和另一端之间滑动的第一环，形成 与第一环对置，第一调节带部分，其一端被固定在环绕在主体部分的右端侧上，另一端可以紧固到主体部分的右端侧上的环，并且第二调节带部分 调整带段与第一调整带段形成一对。