公开(公告)号：US06362011B1

公开(公告)日：2002-03-26

申请号：US09243215

申请日：1999-02-02

申请人： Richard J. Massey ,  Mark T. Martin ,  Liwen Dong ,  Ming Lu ,  Alan Fischer ,  Fabian Jameison ,  Pam Liang ,  Robert Hoch ,  Jonathan K. Leland

发明人： Richard J. Massey ,  Mark T. Martin ,  Liwen Dong ,  Ming Lu ,  Alan Fischer ,  Fabian Jameison ,  Pam Liang ,  Robert Hoch ,  Jonathan K. Leland

IPC分类号： G01N33551

CPC分类号： C01B31/0213 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/152 ,  C01B32/174 ,  C01B2202/34 ,  C01B2202/36 ,  C07K17/06 ,  D01F9/12 ,  D01F11/14 ,  G01N21/69 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/582 ,  G01N2030/8863 ,  G11C13/025 ,  H01M4/60 ,  Y10S435/968 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S977/737 ,  Y10S977/742

摘要： Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.

摘要翻译： 石墨纳米管，其包括通过化学取代官能化的管状富勒烯（通常称为“巴氏管”）和原纤维，被用作电致化学发光测定中的固体支持物。 石墨纳米管在用于测定之前用官能团生物分子进行化学修饰。 电化学发光钌络合物与官能团生物分子修饰的纳米管的关联允许通过多种形式检测包括核酸，抗原，酶和酶底物的分子。

公开(公告)号：US5866434A

公开(公告)日：1999-02-02

申请号：US611347

申请日：1996-03-06

申请人： Richard J. Massey ,  Mark T. Martin ,  Liwen Dong ,  Ming Lu ,  Alan Fischer ,  Fabian Jameison ,  Pam Liang ,  Robert Hoch ,  Jonathan K. Leland

发明人： Richard J. Massey ,  Mark T. Martin ,  Liwen Dong ,  Ming Lu ,  Alan Fischer ,  Fabian Jameison ,  Pam Liang ,  Robert Hoch ,  Jonathan K. Leland

IPC分类号： B01J20/281 ,  A61K47/04 ,  B01J20/20 ,  B01J21/18 ,  B01J32/00 ,  C01B31/02 ,  C07K16/44 ,  C07K17/06 ,  D01F9/12 ,  D01F11/14 ,  G01N21/69 ,  G01N21/76 ,  G01N21/78 ,  G01N30/88 ,  G01N33/543 ,  G01N33/553 ,  G01N33/573 ,  G01N33/58 ,  H01M4/60 ,  G01N33/551 ,  C12Q1/32 ,  C12Q1/37

CPC分类号： C01B31/0213 ,  B82Y30/00 ,  B82Y40/00 ,  C01B31/0273 ,  C07K17/06 ,  D01F11/14 ,  D01F9/12 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/582 ,  H01M4/60 ,  C01B2202/34 ,  C01B2202/36 ,  G01N2030/8863 ,  G01N21/69 ,  G01N21/76 ,  G11C13/025 ,  Y10S435/968 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S977/737 ,  Y10S977/742

摘要： Graphitic nanotubes, which include tubular fullerenes (commonly called "buckytubes") and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.