公开(公告)号：US5049477A

公开(公告)日：1991-09-17

申请号：US338089

申请日：1989-04-14

申请人： Koki Nakamura ,  Masayoshi Tsuboi ,  Keizo Koya

发明人： Koki Nakamura ,  Masayoshi Tsuboi ,  Keizo Koya

IPC分类号： G03C1/00 ,  C07D231/24 ,  C07D231/46 ,  C07D249/12 ,  C07D249/14 ,  C07D261/12 ,  C07D261/14 ,  C07D265/02 ,  C07D271/06 ,  C07D271/10 ,  C07D273/01 ,  C07D273/04 ,  C07D285/125 ,  C07D421/00 ,  C09K9/02 ,  G03C1/675 ,  G03C1/73 ,  G03C7/00 ,  G03C8/12 ,  G03C8/40 ,  G03F7/004

CPC分类号： G03C1/73

摘要： A radiation responsive composition containing a compound represented by the following formula (I) and a photoreducing agent capable of forming a redox couple together with said compound for many uses, e.g., image formation, etching, plating, etc.: ##STR1## wherein N represents a nitrogen atom; X represents an oxygen atom (--O--), a sulfur atom (--S--), or a nitrogen-containing group of formula, ##STR2## R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represents a mere bond, a substituted or unsubstituted alkyl, aryl, heterocyclic, acyl, aralkyl, alkenyl, alkynyl or carbamoyl group, or a sulfonyl group into which a substituted or unsubstituted alkyl or aryl group has been introduced, provided that at least one of the substituents R.sup.1 to R.sup.3 be a substituted or unsubstituted aryl or heterocyclic group and that two or more of R.sup.1, R.sup.2 and R.sup.3, or of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 when X represents a nitrogen containing group of formula, ##STR3## may be taken together to form a ring; UG represents a group to be released from said compound of formula (I) taking advantage of the N--X bond cleavage as a trigger, which takes place when a redox couple is formed between said compound of formula (I) and the photoreducing agent irradiated with radiant rays; and the solid lines represent bonds, while broken lines indicate that a bond may or may not be present, but at least one of the broken lines forms a bond.

摘要翻译： 含有由下式（I）表示的化合物和能够与所述化合物一起形成氧化还原对的许多用途的光致变化组合物，例如图像形成，蚀刻，电镀等。 ）其中N表示氮原子; X表示氧原子（-O-），硫原子（-S-）或式的含氮基团，R 1，R 2，R 3和R 4各自表示单键，取代或未取代的烷基 ，芳基，杂环，酰基，芳烷基，烯基，炔基或氨基甲酰基，或其中引入取代或未取代的烷基或芳基的磺酰基，条件是至少一个取代基R 1至R 3为取代或未取代的 芳基或杂环基，当X代表含氮基团时，R 1，R 2和R 3，或R 1，R 2，R 3和R 4中的两个或多个可以一起形成环; UG表示利用NX键断裂作为触发剂从式（I）化合物释放的基团，当在所述式（I）化合物与用辐射剂照射的光还原剂之间形成氧化还原对时发生 射线 而实线表示键，而虚线表示键可以存在或不存在，但至少一个虚线形成键。

公开(公告)号：US4942114A

公开(公告)日：1990-07-17

申请号：US189003

申请日：1988-05-02

申请人： Keisuke Shiba ,  Keizo Koya

发明人： Keisuke Shiba ,  Keizo Koya

IPC分类号： G03C7/26 ,  C07D213/64 ,  C07D213/70 ,  C07D215/38 ,  C07D249/12 ,  C07D249/14 ,  C07D249/20 ,  C07D249/22 ,  C07D251/20 ,  C07D251/42 ,  C07D251/52 ,  C07D261/12 ,  C07D261/14 ,  C07D261/20 ,  C07D263/56 ,  C07D271/06 ,  C07D273/01 ,  C07D273/04 ,  C07D311/86 ,  C07D311/92 ,  G03C1/06 ,  G03C1/815 ,  G03C7/305

CPC分类号： G03C1/8155 ,  G03C7/30541 ,  Y10S430/134 ,  Y10S430/156

摘要： A silver halide photographic material having at least one silver halide emulsion layer on a support, comprising a compound of formula (I):PWR--(Time).sub.t --FWA (I)in which PWR represents a group capable of releasing (Time).sub.t --FWA upon reduction; FWA represents a group which functions as a brightening agent; Time represents a group capable of releasing FWA through a reaction which follows the release of (Time).sub.t --FWA from PWR; and t represents an integer of 0 or 1.

摘要翻译： 一种卤化银照相材料，其在载体上具有至少一个卤化银乳剂层，其包含式（I）化合物：PWR-（时间）t-FWA（I），其中PWR表示能够释放（时间）t -FWA减量 FWA表示作为增白剂起作用的基团; 时间表示能够通过PWR释放（Time）t-FWA后的反应释放FWA的组; t表示0或1的整数。

公开(公告)号：US5424442A

公开(公告)日：1995-06-13

申请号：US078110

申请日：1993-06-18

申请人： Keizo Koya ,  Toshinao Ukai ,  Haruo Takei

发明人： Keizo Koya ,  Toshinao Ukai ,  Haruo Takei

IPC分类号： G03C1/12 ,  C09B23/00 ,  C09B23/01 ,  C09B69/06 ,  G03C1/26 ,  G03C1/40 ,  C07D277/62

CPC分类号： C09B69/06 ,  C09B23/0075 ,  G03C1/26

摘要： A water-soluble methine compound represented by the following general formula (I): ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents a non-metallic atomic group required for forming a 5-membered or 6-membered nitrogen-containing heterocyclic ring; R.sub.1 and R.sub.2, which may be the same or different, each represents an alkyl group; Q.sub.1 and Q.sub.2 each represents an atomic group required, in combination, for forming a 4-thiazolidinone ring, a 5-thiazolidinone ring, a 4-imidazolidinone ring, a 4-oxazolidinone ring, a 5-oxazolidinone ring, a 5-imidazolidinone ring or a 4-dithiolanone ring; L.sub.1, L.sub.2, L.sub.3, L.sub.4 and L.sub.5, which may be the same or different, each represents a methine group; R represents a hydrogen atom, an alkyl group, an aryl group or a heterocyclic group; m represents 1 or 2; i and h each represents 0 or 1; l represents 1 or 2; and j and k each represents 0, 1, 2 or 3.A photographic silver halide emulsion containing said methine compound added in the form of an aqueous solution is also disclosed.

摘要翻译： 由以下通式（I）表示的水溶性次甲基化合物：其中Z1和Z2可以相同或不同，分别表示形成一个或多个所需的非金属原子团 5元或6元含氮杂环; R 1和R 2可以相同或不同，各自表示烷基; Q1和Q2各自表示组合形成4-噻唑烷酮环，5-噻唑烷酮环，4-咪唑啉酮环，4-恶唑烷酮环，5-恶唑烷酮环，5-咪唑啉酮环所需的原子团 或4-二硫戊环酮环; L1，L2，L3，L4和L5可以相同或不同，表示次甲基; R表示氢原子，烷基，芳基或杂环基; m表示1或2; i和h各自表示0或1; l表示1或2; 并且j和k各自表示0,1,2或3.还公开了含有以水溶液形式加入的次甲基化合物的照相卤化银乳剂。

公开(公告)号：US5096801A

公开(公告)日：1992-03-17

申请号：US503643

申请日：1990-04-03

申请人： Keizo Koya ,  Kozo Sato ,  Yoshiharu Yabuki ,  Hiroshi Hara

发明人： Keizo Koya ,  Kozo Sato ,  Yoshiharu Yabuki ,  Hiroshi Hara

IPC分类号： G02F1/1335 ,  G03F1/56 ,  G03F7/00 ,  G03F7/028

CPC分类号： G03F1/56 ,  G02F1/133516 ,  G03F7/0007 ,  G03F7/028

摘要： A novel color image recording method is provided, which comprises exposing to light a light-sensitive material obtained by dispersing a composition containing at least a photopolymerization initiator, a color image-forming substance and a polymerizable compound in a hydrophilic binder and then coating said dispersion on a support, subjecting said polymerizable compound in the exposed portions to polymerization, and then (a) eluting said color image-forming substance contained in the unpolymerized polymerizable compound in the unexposed portions with an alkaline aqueous solution or (b) subjecting said color image-forming substance contained in the unpolymerized polymerizable compound in the unexposed portions to chemical change so that it is discolored, thereby forming dye images.

摘要翻译： 提供一种新颖的彩色图像记录方法，其包括通过将含有至少一种光聚合引发剂，彩色成像物质和可聚合化合物的组合物分散在亲水性粘合剂中而获得的感光材料曝光，然后涂布所述分散体 在支持体上使暴露部分中的所述可聚合化合物进行聚合，然后（a）用碱性水溶液洗脱未曝光部分中包含的未聚合的可聚合化合物中的所述彩色图像形成物质，或（b）使所述彩色图像 包含在未曝光部分中的未聚合的可聚合化合物中的化合物质化学变化，使其变色，从而形成染料图像。

公开(公告)号：US5073473A

公开(公告)日：1991-12-17

申请号：US467292

申请日：1990-01-16

申请人： Keizo Koya ,  Yoshio Idota

发明人： Keizo Koya ,  Yoshio Idota

IPC分类号： G03C8/06

CPC分类号： G03C8/06 ,  Y10S430/156

摘要： A method for forming an image by silver salt diffusion transfer is described, comprises processing an imagewise exposed photosensitive element provided with a layer of photosensitive silver halide emulsion on a support, and an image-receiving element provided with an image-receiving layer containing a silver-precipitating agent on a support, with an alkali processing composition in the presence of a silver halide solvent, to convert at least part of the unexposed silver halide in the emulsion layer into a transferable silver complex salt, to transfer at least part of said complex salt into the image-receiving layer, and to form an image in the image-receiving layer; the processing being carried out in the presence of at least one compound as described.

摘要翻译： 描述了通过银盐扩散转移形成图像的方法，包括在载体上处理具有感光卤化银乳剂层的图像曝光感光元件，以及设置有包含银的图像接收层的图像接收元件 在载体上，在卤化银溶剂存在下用碱处理组合物将所述乳液层中的至少部分未曝光的卤化银转化为可转移的银络合盐，以将至少部分所述复合物 盐进入图像接收层，并在图像接收层中形成图像; 该处理在至少一种所述化合物存在下进行。

公开(公告)号：US5071729A

公开(公告)日：1991-12-10

申请号：US188778

申请日：1988-04-29

申请人： Keizo Koya ,  Shigeru Ohno ,  Yoshisada Nakamura

发明人： Keizo Koya ,  Shigeru Ohno ,  Yoshisada Nakamura

IPC分类号： G03C7/26 ,  C07D231/20 ,  C07D231/56 ,  C07D413/14 ,  C07F1/08 ,  C07F15/00 ,  C07F15/04 ,  C07F15/06 ,  G03C7/305 ,  G03C7/32

CPC分类号： G03C7/30541 ,  Y10S430/156

摘要： A silver halide photographic material comprising a support having provided thereon at least one silver halide emulsion layer, wherein the silver halide photographic material contains a compound having discoloration inhibitory activity represented by formula (I):PWR--Time).sub.t MCAP (I)wherein PWR represents a group capable of releasing (Time).sub.t -MCAP upon being reduced; Time represents a group which is released from PWR in the form of (Time).sub.t -MCAP and then releases MCAP through a subsequent reaction; t represents 0 or 1; and MCAP represents a group having discoloration inhibitory activity.

摘要翻译： 一种卤化银照相材料，包括在其上提供有至少一个卤化银乳剂层的载体，其中所述卤化银照相材料含有由式（I）表示的具有变色抑制活性的化合物：PWR-Time）tMCAP（I）其中PWR表示 一个能够在减少时释放（时间）t-MCAP的组; 时间表示从PWR以（时间）t-MCAP的形式释放的组，然后通过随后的反应释放MCAP; t表示0或1; 并且MCAP表示具有变色抑制活性的基团。

公开(公告)号：US4957848A

公开(公告)日：1990-09-18

申请号：US192097

申请日：1988-05-10

申请人： Osamu Takahashi ,  Koichi Koyama ,  Keizo Koya

发明人： Osamu Takahashi ,  Koichi Koyama ,  Keizo Koya

IPC分类号： G03C8/18 ,  G03C8/40

CPC分类号： G03C8/18 ,  G03C8/4033 ,  G03C8/408

摘要： A heat-developable color light-sensitive material is disclosed, comprising a support having thereon at least one layer containing a light-sensitive silver halide, a binder, a compound containing a color moiety represented by formula (A), and a compound or a precursor thereof which reacts with an oxidized compound formed from the compound of formula (A), thereby converting the oxidized compound into a nondiffusible form, said compound of formula (A) being represented by ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 each represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, an acylamino group, an alkylthio group, an arylthio group, or a halogen atom, provided that at least one of R.sub.1, R.sub.2, and R.sub.3 represents a hydrogen atom; X represents a chemical bond or a divalent linking group; Dye represents an image-forming dye moiety; and G represents a hydroxyl group or a group capable of forming a hydroxyl group upon heating and/or by the action of a base.The material provides an image having a low minimum density in highlight areas, and excellent color separation and image preservability.

公开(公告)号：USH817H

公开(公告)日：1990-09-04

申请号：US188576

申请日：1988-04-29

申请人： Masaharu Toriuchi ,  Keizo Koya

发明人： Masaharu Toriuchi ,  Keizo Koya

IPC分类号： G03C7/26 ,  C07D231/20 ,  C07D231/56 ,  C07D233/42 ,  C07D233/72 ,  C07D249/12 ,  C07D249/14 ,  C07D257/04 ,  C07D261/12 ,  C07D261/14 ,  C07D261/20 ,  C07D265/02 ,  C07D275/00 ,  C07D285/16 ,  C07D291/00 ,  C07D521/00 ,  G03C1/06 ,  G03C7/30 ,  G03C7/305

CPC分类号： G03C7/3003 ,  G03C7/30541

摘要： A photographic light-sensitive material comprising a support having provided thereon at least one silver halide emulsion layer, wherein said light-sensitive material contains:(1) a compound represented by formula (I):PWR--Time--.sub.t PUG (I) wherein PWR represents a group capable of releasing (Time--.sub.t PUG upon being reduced; PUG represents a photographically useful group; Time represents a group capable of releasing PUG through a reaction subsequent to the release from PWR in the form of --Time--.sub.t PUG; and t represents 0 or 1, and(2) a polymer comprising at least 10 repeating units derived from the same monomer and having a molecular weight of 1000 or more. The photographic light-sensitive material exhibits both high activity of a compound capable of releasing a photographically useful group during development processing and preservation stability before development processing.

公开(公告)号：US08815945B2

公开(公告)日：2014-08-26

申请号：US13642275

申请日：2011-04-20

申请人： Masazumi Nagai ,  Ronald K. Blackman ,  Patricia E. Rao ,  Yumiko Wada ,  Keizo Koya

发明人： Masazumi Nagai ,  Ronald K. Blackman ,  Patricia E. Rao ,  Yumiko Wada ,  Keizo Koya

IPC分类号： A61K45/06 ,  A61K31/19 ,  A61K31/337

CPC分类号： A61K31/30 ,  A61K31/00 ,  A61K31/16 ,  A61K31/18 ,  A61K31/19 ,  A61K31/195 ,  A61K31/28 ,  A61K31/337 ,  A61K31/555 ,  A61K45/06 ,  A61K2300/00

摘要： Improved cancer treatments with bis[thiohydrazide amide] compounds such as elesclomol, in particular for identifying patient populations that would benefit from such treatments.

摘要翻译： 改进的双[硫代酰肼]化合物如elesclomol的癌症治疗，特别是用于鉴定将受益于这种治疗的患者群体。

公开(公告)号：US20110245577A1

公开(公告)日：2011-10-06

申请号：US13078573

申请日：2011-04-01

申请人： Keizo Koya

发明人： Keizo Koya

IPC分类号： A61M36/00

CPC分类号： A61K31/16 ,  A61K31/165 ,  A61K31/337 ,  A61K41/0052 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed herein are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with hyperthermia treatment. Also disclosed are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with radiotherapy.

摘要翻译： 本文公开了与双热（硫代酰肼）酰胺或其互变异构体，药学上可接受的盐，溶剂合物，包合物或前药，与热疗治疗结合治疗增殖性疾病如癌症的方法。 还公开了与放射治疗组合的双（硫代 - 酰肼）酰胺或其互变异构体，药学上可接受的盐，溶剂合物，包合物或前药治疗增殖性疾病如癌症的方法。