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    Color diffusion transfer photographic element
    1.
    发明授权
    Color diffusion transfer photographic element 失效
    彩色扩散转印照相材料

    公开(公告)号：US4939066A

    公开(公告)日：1990-07-03

    申请号：US115070

    申请日：1987-10-30

    申请人： Masaharu Toriuchi ,  Keizo Koya

    发明人： Masaharu Toriuchi ,  Keizo Koya

    IPC分类号： C07D261/12 ,  C07D413/12 ,  G03C7/00 ,  G03C7/305 ,  G03C8/08 ,  G03C8/40

    CPC分类号： C07D413/12 ,  C07D261/12 ,  G03C7/30594 ,  G03C8/08 ,  Y10S430/158

    摘要： A color diffusion transfer photographic material comprises a base having thereon at least one silver halide emulsion layer and a dye image-receiving layer, at least one layer thereof containing a dye-releasing redox compound and at least one layer thereof containing a development inhibitor-releasing compound represented by the following general formula (I):A--Time).sub.t DIG (I)wherein A represents ##STR1## linked to --Time).sub.t DIG through at least one of R.sup.1, R.sup.2 and EAG; R.sup.1 and R.sup.2, which may be the same or different, each represents a single bond or a substituent other than a hydrogen atom, provided that R.sup.1 and R.sup.2 may be linked to form a ring; EAG represents an electron-accepting group; Time represents a group capable of releasing DIG after EAG accepts an electron; DIG represents a development inhibitor precursor; and t is an integer of 0 or 1.

    摘要翻译： 彩色扩散转印照相材料包括其上具有至少一个卤化银乳剂层和染料影像接收层的基底，其至少一层含有释放染料的氧化还原化合物和至少一层含有显影抑制剂释放 通过R1，R2和EAG中的至少一个，由以下通式（I）代表的化合物：A-time）tDIG（I）其中A表示与-Time连接的时间）tDIG; R 1和R 2可以相同或不同，各自表示单键或除氢原子以外的取代基，条件是R 1和R 2可以连接形成环; EAG代表电子接受基团; 时间表示EAG接受电子后能释放DIG的组; DIG代表发育抑制剂前体; t为0或1的整数。

    Bis(thio-hydrazide amide) salts for treatment of cancers
    10.
    发明授权
    Bis(thio-hydrazide amide) salts for treatment of cancers 有权
    用于治疗癌症的双（硫代酰肼）酰胺盐

    公开(公告)号：US08048925B2

    公开(公告)日：2011-11-01

    申请号：US12871587

    申请日：2010-08-30

    申请人： Keizo Koya ,  Lijun Sun ,  Elena Kostik ,  Farid Vaghefi ,  Shoujun Chen ,  Noriaki Tatsuta ,  Guiqing Liang ,  Takayo Inoue ,  Zhi-Qiang Xia

    发明人： Keizo Koya ,  Lijun Sun ,  Elena Kostik ,  Farid Vaghefi ,  Shoujun Chen ,  Noriaki Tatsuta ,  Guiqing Liang ,  Takayo Inoue ,  Zhi-Qiang Xia

    IPC分类号： A61K31/16

    CPC分类号： C07D305/14 ,  C07C327/56 ,  C07C2601/02

    摘要： Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. Z is —O or —S. M+ is a pharmaceutically acceptable monovalent cation and M2+ is a pharmaceutically acceptable divalent cation.Also, disclosed are pharmaceutical compositions comprising a bis(thio-hydrazide amide) disalt described above. Further disclosed are methods of treating a subject with cancer. The methods comprise the step of administering an effective amount of a bis(thio-hydrazide amide) disalt described above.

    摘要翻译： 公开了由结构式（I）表示的双（硫代 - 酰肼酰胺）二醛：Y是共价键或取代或未取代的直链烃基。 R 1 -R 4独立地为-H，脂族基团，取代的脂族基团，芳基或取代的芳基，或者R 1和R 3与它们所键合的碳原子和氮原子一起，和/或R 2和R 4 与它们所键合的碳原子和氮原子一起形成任选地与芳环稠合的非芳族杂环。 Z是-O或-S。 M +是药学上可接受的一价阳离子，M2 +是药学上可接受的二价阳离子。 还公开了包含上述双（硫代 - 酰肼酰胺）二盐的药物组合物。 进一步公开的是用癌症治疗受试者的方法。 所述方法包括施用有效量的上述双（硫代 - 酰肼酰胺）二盐的步骤。