公开(公告)号：US20080267953A1

公开(公告)日：2008-10-30

申请号：US11634209

申请日：2006-12-06

申请人： Atsushi Ochiai ,  Emi Hosaka ,  Kazuyasu Nakamura ,  Akiko Furuya ,  Yuji Ohki

发明人： Atsushi Ochiai ,  Emi Hosaka ,  Kazuyasu Nakamura ,  Akiko Furuya ,  Yuji Ohki

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12P21/02 ,  A61P35/00 ,  C12N15/85 ,  C12N15/13 ,  C12N5/16

CPC分类号： C07K16/28 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/732

摘要： An antibody which binds to a polypeptide encoded by human PERP (p53 apoptosis effector related to PMP-22) gene which is considered to be related to incidence of cancer or the like is desired. The present invention provides a gene recombinant antibody which has no consensus sequence of an N-linked sugar chain in a variable region, specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by the PERP gene and binds to the extracellular region. The antibody is useful for treatment of various diseases expressing a polypeptide encoded by the PERP gene.

摘要翻译： 需要与被认为与癌症等发生相关的人PERP（PMP-22）相关的p53凋亡效应基因编码的多肽结合的抗体。 本发明提供了在可变区中不具有N-连接糖链的共有序列的基因重组抗体，特异性地识别由PERP基因编码的多肽的细胞外区域的三维结构并结合到细胞外区域。 该抗体可用于治疗表达由PERP基因编码的多肽的各种疾病。

公开(公告)号：US08093362B2

公开(公告)日：2012-01-10

申请号：US11634209

申请日：2006-12-06

申请人： Atsushi Ochiai ,  Emi Hosaka ,  Kazuyasu Nakamura ,  Akiko Furuya ,  Yuji Ohki

发明人： Atsushi Ochiai ,  Emi Hosaka ,  Kazuyasu Nakamura ,  Akiko Furuya ,  Yuji Ohki

IPC分类号： C07K16/00 ,  C12P21/08 ,  C12P21/04 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K16/28 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/732

摘要： An antibody which binds to a polypeptide encoded by human PERP (p53 apoptosis effector related to PMP-22) gene which is considered to be related to incidence of cancer or the like is desired. The present invention provides a gene recombinant antibody which has no consensus sequence of an N-linked sugar chain in a variable region, specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by the PERP gene and binds to the extracellular region. The antibody is useful for treatment of various diseases expressing a polypeptide encoded by the PERP gene.

摘要翻译： 需要与被认为与癌症等发生相关的人PERP（PMP-22）相关的p53凋亡效应基因编码的多肽结合的抗体。 本发明提供了在可变区中不具有N-连接糖链的共有序列的基因重组抗体，特异性地识别由PERP基因编码的多肽的细胞外区域的三维结构并结合到细胞外区域。 该抗体可用于治疗表达由PERP基因编码的多肽的各种疾病。

公开(公告)号：US08076458B2

公开(公告)日：2011-12-13

申请号：US12049581

申请日：2008-03-17

申请人： So Ohta ,  Hiroshi Ando ,  Masayo Suzuki ,  Shinobu Kawamoto ,  Mariko Nakano ,  Kazuyasu Nakamura

发明人： So Ohta ,  Hiroshi Ando ,  Masayo Suzuki ,  Shinobu Kawamoto ,  Mariko Nakano ,  Kazuyasu Nakamura

IPC分类号： C07K16/00 ,  G01N33/53

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as “CLDN3”) gene, or a method for using the same. Accordingly, the present invention provides a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of an extracellular region of CLDN4 and binds to the extracellular region; a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of both of extracellular regions of CLDN3 and CLDN4 and binds to the extracellular regions; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtained by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by CLDN4 gene and/or CLDN3 gene using the antibody or the antibody fragment.

摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用作与由紧密连接蛋白-4（以下称为“CLDN4”）基因编码的多肽相关的疾病的诊断剂或治疗剂，或者由 紧密连接蛋白-3（以下称为“CLDN3”）基因或其使用方法。 因此，本发明提供特异性识别CLDN4的细胞外区域的三维结构并结合细胞外区域的单克隆抗体或其抗体片段; 单克隆抗体或其抗体片段，其特异性识别CLDN3和CLDN4的细胞外区域的三维结构并结合细胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用抗体或抗体片段的与CLDN4基因和/或CLDN3基因编码的多肽有关的疾病的诊断剂或治疗剂。

公开(公告)号：US20090202556A1

公开(公告)日：2009-08-13

申请号：US12049581

申请日：2008-03-17

申请人： So OHTA ,  Hiroshi ANDO ,  Masayo SUZUKI ,  Shinobu KAWAMOTO ,  Mariko NAKANO ,  Kazuyasu Nakamura

发明人： So OHTA ,  Hiroshi ANDO ,  Masayo SUZUKI ,  Shinobu KAWAMOTO ,  Mariko NAKANO ,  Kazuyasu Nakamura

IPC分类号： A61K39/395 ,  C07K16/00 ,  C12N5/12 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12P21/08 ,  C12Q1/68 ,  A61P35/00

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as “CLDN3”) gene, or a method for using the same. Accordingly, the present invention provides a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of an extracellular region of CLDN4 and binds to the extracellular region; a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of both of extracellular regions of CLDN3 and CLDN4 and binds to the extracellular regions; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtained by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by CLDN4 gene and/or CLDN3 gene using the antibody or the antibody fragment.

摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用作与由紧密连接蛋白-4（以下称为“CLDN4”）基因编码的多肽相关的疾病的诊断剂或治疗剂，或者由 紧密连接蛋白-3（以下称为“CLDN3”）基因或其使用方法。 因此，本发明提供特异性识别CLDN4的细胞外区域的三维结构并结合细胞外区域的单克隆抗体或其抗体片段; 单克隆抗体或其抗体片段，其特异性识别CLDN3和CLDN4的细胞外区域的三维结构并结合细胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用抗体或抗体片段的与CLDN4基因和/或CLDN3基因编码的多肽有关的疾病的诊断剂或治疗剂。