公开(公告)号：US08076458B2

公开(公告)日：2011-12-13

申请号：US12049581

申请日：2008-03-17

申请人： So Ohta ,  Hiroshi Ando ,  Masayo Suzuki ,  Shinobu Kawamoto ,  Mariko Nakano ,  Kazuyasu Nakamura

发明人： So Ohta ,  Hiroshi Ando ,  Masayo Suzuki ,  Shinobu Kawamoto ,  Mariko Nakano ,  Kazuyasu Nakamura

IPC分类号： C07K16/00 ,  G01N33/53

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by a Claudin-3 (hereinafter referred to as “CLDN3”) gene, or a method for using the same. Accordingly, the present invention provides a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of an extracellular region of CLDN4 and binds to the extracellular region; a monoclonal antibody or an antibody fragment thereof, which specifically recognizes three-dimensional structure of both of extracellular regions of CLDN3 and CLDN4 and binds to the extracellular regions; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtained by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by CLDN4 gene and/or CLDN3 gene using the antibody or the antibody fragment.

摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用作与由紧密连接蛋白-4（以下称为“CLDN4”）基因编码的多肽相关的疾病的诊断剂或治疗剂，或者由 紧密连接蛋白-3（以下称为“CLDN3”）基因或其使用方法。 因此，本发明提供特异性识别CLDN4的细胞外区域的三维结构并结合细胞外区域的单克隆抗体或其抗体片段; 单克隆抗体或其抗体片段，其特异性识别CLDN3和CLDN4的细胞外区域的三维结构并结合细胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用抗体或抗体片段的与CLDN4基因和/或CLDN3基因编码的多肽有关的疾病的诊断剂或治疗剂。

公开(公告)号：US08945870B2

公开(公告)日：2015-02-03

申请号：US13584478

申请日：2012-08-13

申请人： Norihiko Shiraishi ,  Akiko Furuya ,  Hiroe Toki ,  Hiroshi Ando ,  Masayo Suzuki ,  Tsuguo Kubota

发明人： Norihiko Shiraishi ,  Akiko Furuya ,  Hiroe Toki ,  Hiroshi Ando ,  Masayo Suzuki ,  Tsuguo Kubota

IPC分类号： C07H21/04 ,  C12N15/09 ,  C12N15/12 ,  C12N15/13 ,  C12N15/63 ,  C12N5/07 ,  C12N5/10 ,  C12N5/12 ,  C07K16/28 ,  G01N33/68 ,  C07K16/30 ,  G01N33/574 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K16/28 ,  A61K39/39533 ,  A61K2039/505 ,  C07H21/04 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C12N5/12 ,  C12N15/09 ,  C12N15/63 ,  C12N2800/10 ,  G01N33/574 ,  G01N33/6872 ,  G01N33/6893

摘要： An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred to as “ASCT2”) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure of an extracellular region of ASCT2 and binds to the extracellular region, or an antibody fragment thereof; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof, and a diagnostic agent using the antibody or the antibody fragment thereof.

摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用于治疗或诊断与ASC系统ASC氨基酸转运蛋白2有关的疾病（以下称为“ASCT2”）或使用该抗体的方法。 本发明提供特异性识别ASCT2细胞外区域的天然三维结构并结合细胞外区域或其抗体片段的单克隆抗体; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂，以及使用该抗体或其抗体片段的诊断剂。

公开(公告)号：US08268592B2

公开(公告)日：2012-09-18

申请号：US12505133

申请日：2009-07-17

申请人： Norihiko Shiraishi ,  Akiko Furuya ,  Hiroe Toki ,  Hiroshi Ando ,  Masayo Suzuki ,  Tsuguo Kubota

发明人： Norihiko Shiraishi ,  Akiko Furuya ,  Hiroe Toki ,  Hiroshi Ando ,  Masayo Suzuki ,  Tsuguo Kubota

IPC分类号： C07K16/00 ,  C07K16/28 ,  C12N5/12 ,  C12P21/08

CPC分类号： C07K16/28 ,  A61K39/39533 ,  A61K2039/505 ,  C07H21/04 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C12N5/12 ,  C12N15/09 ,  C12N15/63 ,  C12N2800/10 ,  G01N33/574 ,  G01N33/6872 ,  G01N33/6893

摘要： An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred to as “ASCT2”) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure of an extracellular region of ASCT2 and binds to the extracellular region, or an antibody fragment thereof; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof, and a diagnostic agent using the antibody or the antibody fragment thereof.

摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用于治疗或诊断与ASC系统ASC氨基酸转运蛋白2有关的疾病（以下称为“ASCT2”）或使用该抗体的方法。 本发明提供特异性识别ASCT2细胞外区域的天然三维结构并结合细胞外区域或其抗体片段的单克隆抗体; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂，以及使用该抗体或其抗体片段的诊断剂。

公开(公告)号：US20100196392A1

公开(公告)日：2010-08-05

申请号：US12505133

申请日：2009-07-17

申请人： Norihiko SHIRAISHI ,  Akiko Furuya ,  Hiroe Toki ,  Hiroshi Ando ,  Masayo Suzuki ,  Tsuguo Kubota

发明人： Norihiko SHIRAISHI ,  Akiko Furuya ,  Hiroe Toki ,  Hiroshi Ando ,  Masayo Suzuki ,  Tsuguo Kubota

IPC分类号： A61K39/395 ,  C07K16/00 ,  C12N5/00 ,  C12N15/13 ,  C12N15/63 ,  C12N5/07 ,  C12P21/00 ,  G01N33/53 ,  A61P35/00

CPC分类号： C07K16/28 ,  A61K39/39533 ,  A61K2039/505 ,  C07H21/04 ,  C07K16/30 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C12N5/12 ,  C12N15/09 ,  C12N15/63 ,  C12N2800/10 ,  G01N33/574 ,  G01N33/6872 ,  G01N33/6893

摘要： An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred to as “ASCT2”) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure of an extracellular region of ASCT2 and binds to the extracellular region, or an antibody fragment thereof; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof, and a diagnostic agent using the antibody or the antibody fragment thereof.

摘要翻译： 本发明的目的是提供一种单克隆抗体，其可用于治疗或诊断与ASC系统ASC氨基酸转运蛋白2有关的疾病（以下称为“ASCT2”）或使用该抗体的方法。 本发明提供特异性识别ASCT2细胞外区域的天然三维结构并结合细胞外区域或其抗体片段的单克隆抗体; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂，以及使用该抗体或其抗体片段的诊断剂。

公开(公告)号：US20090054508A1

公开(公告)日：2009-02-26

申请号：US11814753

申请日：2006-01-27

申请人： Yutaka Kanda ,  Hiromi Ando ,  Keiko Kawashima ,  Takamasa Sugita ,  Masayo Suzuki ,  Hisashi Tagaya ,  Tomoyuki Nakazato ,  Yoshinori Yamashita ,  Takeshi Takahashi ,  Shinji Nara ,  Hiroaki Nakamura

发明人： Yutaka Kanda ,  Hiromi Ando ,  Keiko Kawashima ,  Takamasa Sugita ,  Masayo Suzuki ,  Hisashi Tagaya ,  Tomoyuki Nakazato ,  Yoshinori Yamashita ,  Takeshi Takahashi ,  Shinji Nara ,  Hiroaki Nakamura

IPC分类号： A61K31/416 ,  A61P3/10

CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/10 ,  C07D495/04

摘要： The present invention provides a type I insulin-like growth factor receptor (IGF-1R) inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I): {wherein R1 represents —NR4R5 [wherein R4 represents a hydrogen atom or the like, R5 represents substituted or unsubstituted lower alkyl, —C(═O)R6 (wherein R6 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or the like], or the like, and R2 and R3 may be the same or different and each represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, or the like} or a pharmaceutically acceptable salt thereof, and the like.

摘要翻译： 本发明提供一种I型胰岛素样生长因子受体（IGF-1R）抑制剂，其包含作为活性成分的由式（I）表示的吲唑衍生物：其中R 1表示-NR 4 R 5 [其中R 4表示氢原子或 R 5表示取代或未取代的低级烷基，-C（-O）R 6（其中R 6表示取代或未取代的低级烷基，取代或未取代的芳基等）等，等等，R2和R3 可以相同或不同，各自表示氢原子，羟基，取代或未取代的低级烷氧基等}或其药学上可接受的盐等。

公开(公告)号：US07605272B2

公开(公告)日：2009-10-20

申请号：US11814753

申请日：2006-01-27

申请人： Yutaka Kanda ,  Hiromi Ando ,  Keiko Kawashima ,  Takamasa Sugita ,  Masayo Suzuki ,  Hisashi Tagaya ,  Tomoyuki Nakazato ,  Yoshinori Yamashita ,  Takeshi Takahashi ,  Shinji Nara ,  Hiroaki Nakamura

发明人： Yutaka Kanda ,  Hiromi Ando ,  Keiko Kawashima ,  Takamasa Sugita ,  Masayo Suzuki ,  Hisashi Tagaya ,  Tomoyuki Nakazato ,  Yoshinori Yamashita ,  Takeshi Takahashi ,  Shinji Nara ,  Hiroaki Nakamura

IPC分类号： C07D231/56 ,  C07D211/06 ,  C07D413/10 ,  C07D403/10 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/5377

CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/10 ,  C07D495/04

摘要： The present invention provides a type I insulin-like growth factor receptor (IGF-1R) inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I): {wherein R1 represents —NR4R5 [wherein R4 represents a hydrogen atom or the like, R5 represents substituted or unsubstituted lower alkyl, —C(═O)R6 (wherein R6 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or the like], or the like, and R2 and R3 may be the same or different and each represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, or the like} or a pharmaceutically acceptable salt thereof, and the like.

摘要翻译： 本发明提供一种I型胰岛素样生长因子受体（IGF-1R）抑制剂，其包含作为活性成分的由式（I）表示的吲唑衍生物：其中R 1表示-NR 4 R 5 [其中R 4表示氢原子或 R 5表示取代或未取代的低级烷基，-C（-O）R 6（其中R 6表示取代或未取代的低级烷基，取代或未取代的芳基等），R 2和R 3可以相同 或不同的，并且各自表示氢原子，羟基，取代或未取代的低级烷氧基等}或其药学上可接受的盐等。