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公开(公告)号：US07745636B2
公开(公告)日：2010-06-29
申请号：US12029680
申请日：2008-02-12
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号： C07D233/02 , A01N43/50
CPC分类号： C07D403/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号：US07741347B2
公开(公告)日：2010-06-22
申请号：US12120494
申请日：2008-05-14
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Lawrence G. Hamann , Clint A. James , David R. Langley , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Gan Wang , Fukang Yang
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Lawrence G. Hamann , Clint A. James , David R. Langley , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Gan Wang , Fukang Yang
IPC分类号： A61K31/4196 , A61K31/4245 , A61K31/4164 , C07D271/10 , C07D249/08
CPC分类号： C07D413/14 , C07D403/04 , C07D403/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译： 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号：US07714019B2
公开(公告)日：2010-05-11
申请号：US12417050
申请日：2009-04-02
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D403/06 , C07D403/04 , C07D403/12 , C07D403/14 , C07D471/04
摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
摘要翻译： 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本发明涉及酰胺哌嗪衍生物。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。
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公开(公告)号：US20100080772A1
公开(公告)日：2010-04-01
申请号：US12569466
申请日：2009-09-29
申请人： Makonen Belema , Van N. Nguyen , Michael Serrano-Wu , Denis R. St. Laurent , Yuping Qiu , Min Ding , Nicholas A. Meanwell , Lawrence B. Snyder
发明人： Makonen Belema , Van N. Nguyen , Michael Serrano-Wu , Denis R. St. Laurent , Yuping Qiu , Min Ding , Nicholas A. Meanwell , Lawrence B. Snyder
IPC分类号： A61K38/20 , A61K38/21 , A61K31/70 , A61K31/7088 , A61K31/5377 , A61K31/47 , C07D413/04 , C07D217/00 , C07D215/00
CPC分类号： C07D207/16 , A61K31/401 , A61K31/4015 , A61K31/47 , A61K31/5377 , A61K31/70 , A61K31/7088 , C07C233/62 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/14 , C07D487/08
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号：US07659270B2
公开(公告)日：2010-02-09
申请号：US11835485
申请日：2007-08-08
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号： A61K31/4178 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4353 , A61K31/4427 , C07D213/02 , C07D295/00 , C07D277/02 , C07D249/08 , C07D241/02 , C07D239/02
CPC分类号： C07D401/14 , C07D403/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号：US20090233925A1
公开(公告)日：2009-09-17
申请号：US12368465
申请日：2009-02-10
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号： A61K31/5377 , C07D413/14 , A61P31/12
CPC分类号： C07D403/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译： 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号：US20090202483A1
公开(公告)日：2009-08-13
申请号：US12358308
申请日：2009-01-23
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号： A61K38/21 , C07D403/14 , A61K38/05 , A61K31/708 , A61P31/12
CPC分类号： C07D403/14 , C07D405/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号：US07572810B2
公开(公告)日：2009-08-11
申请号：US11749445
申请日：2007-05-16
申请人： Tao Wang , Ying Han , John F. Kadow , Zhongxing Zhang , Nicholas A. Meanwell
发明人： Tao Wang , Ying Han , John F. Kadow , Zhongxing Zhang , Nicholas A. Meanwell
IPC分类号： A61K31/445 , A61K31/4545 , A61P31/12 , C07D215/20 , C07D295/00
CPC分类号： A61K31/445 , A61K31/4545 , A61K45/06 , C07D211/70 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/06 , C07D413/14 , A61K2300/00
摘要： This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.
摘要翻译： 本公开提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本公开涉及具有独特抗病毒活性的烯烃哌啶衍生物。 更具体地，本公开涉及可用于治疗HIV和AIDS的化合物。
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公开(公告)号：US07399758B2
公开(公告)日：2008-07-15
申请号：US11507731
申请日：2006-08-22
申请人： Nicholas A. Meanwell , Robert G. Gentles , Min Ding , John A. Bender , John F. Kadow , Piyasena Hewawasam , Thomas W. Hudyma , Xiaofan Zheng
发明人： Nicholas A. Meanwell , Robert G. Gentles , Min Ding , John A. Bender , John F. Kadow , Piyasena Hewawasam , Thomas W. Hudyma , Xiaofan Zheng
IPC分类号： A61P31/00 , A61K31/55 , C07D223/14
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US20080050336A1
公开(公告)日：2008-02-28
申请号：US11835462
申请日：2007-08-08
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号： A61K38/20 , A61K31/4164 , A61K31/517 , A61P31/00 , C07D403/02 , C07D401/00 , A61K38/46 , A61K31/715
CPC分类号： C07D233/64 , A61K31/4178 , A61K45/06 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07F5/025 , C07F7/0812
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译： 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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