利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

125 条记录 (耗时 0.025 秒)

    Quaternary polyamidoamines, the production thereof, corresponding agents and the use thereof
    103.
    发明授权
    Quaternary polyamidoamines, the production thereof, corresponding agents and the use thereof 失效
    第四纪聚酰胺胺，其制备，相应的试剂及其用途

    公开(公告)号：US07122618B2

    公开(公告)日：2006-10-17

    申请号：US10485262

    申请日：2002-08-12

    申请人： Helmut Witteler ,  Axel Sanner ,  John-Bryan Speakman ,  Christian Drohmann ,  Mathias Hahn ,  Werner Jaeger

    发明人： Helmut Witteler ,  Axel Sanner ,  John-Bryan Speakman ,  Christian Drohmann ,  Mathias Hahn ,  Werner Jaeger

    IPC分类号： C08G69/26 ,  A61K7/00 ,  A61K31/74 ,  A61K47/48

    CPC分类号： A61Q5/12 ,  A61K8/84 ,  A61Q5/06 ,  C08G73/0293

    摘要： The present invention relates to quaternized polyamidoamines which have at least one structural unit of the formula VII in which R1, R2, R4 are straight-chain or branched organic radicals optionally containing heteroatoms; R5 is hydrogen or alkyl, R7 is hydrogen or alkyl or two radicals R7 together form a radical having a meaning given for R4, b is an integer from 0 to 50, and c is an integer from 1 to 50. The invention also relates to the preparation of the quaternary polyamidoamines, to compositions which comprise these compounds, and to the use thereof for cosmetic and pharmaceutical purposes, and in the fields of crop protection and textile dyeing. The present invention also relates to the use of quaternized polyamidoamines of the ionene type as biostatic or biocide and thus also biocidal compositions based on quaternized polyamidoamines.

    摘要翻译： 本发明涉及具有式VII中至少一个结构单元的季铵化聚酰胺胺，其中R 1，R 2，R 4，4， 任选含有杂原子的直链或支链有机基团; R 5是氢或烷基，R 7是氢或烷基或两个基团R 7一起形成具有给定R 1的含义的基团， SUP> 4，b是0至50的整数，c是1至50的整数。本发明还涉及季戊聚酰胺胺的制备，包含这些化合物的组合物以及使用 用于化妆品和药物目的，以及作物保护和纺织品染色领域。 本发明还涉及紫罗烯类型的季铵化聚酰胺胺作为生物抑制剂或杀生物剂，因此也是基于季铵化聚酰胺胺的杀生物组合物的用途。

    Water-soluble or water-dispersible (co) polymers of hydroxyalkyl (meth) acrylates, a process for their preparation, and their use as coating agent, binder and/or film-forming excipient pharmaceutical dosage forms
    104.
    发明授权
    Water-soluble or water-dispersible (co) polymers of hydroxyalkyl (meth) acrylates, a process for their preparation, and their use as coating agent, binder and/or film-forming excipient pharmaceutical dosage forms 失效
    （甲基）丙烯酸羟烷基酯的水溶性或水分散性（共）聚合物，其制备方法及其作为包衣剂，粘合剂和/或成膜赋形剂药物剂型的用途

    公开(公告)号：US07049360B2

    公开(公告)日：2006-05-23

    申请号：US09964796

    申请日：2001-09-28

    申请人： Maximilian Angel ,  Axel Sanner ,  Karl Kolter

    发明人： Maximilian Angel ,  Axel Sanner ,  Karl Kolter

    IPC分类号： C08K3/20

    CPC分类号： A61K9/2846 ,  A61K9/2027 ,  C08F261/04

    摘要： The present invention relates to water-soluble or water-dispersible copolymers obtainable by free-radical polymerization of a) 80 to 20% by weight of hydroxy-C1–C6-alkyl (meth)acrylate and, where appropriate, one or more compounds of the formula (A) or (B) with R1=H, C1–C6-alkyl, R2=H, CH3 R3=C1–C24-alkyl or mixtures thereof in the presence of b) 20 to 80% by weight of polyvinyl alcohol (PVA) and c) where appropriate 0 to 20% by weight of other polymerizable compounds (C), a process for their preparation, and their use as coating agent, binder and/or film-forming excipient in pharmaceutical dosage forms.

    摘要翻译： 本发明涉及通过自由基聚合得到的水溶性或水分散性共聚物，该共聚物是a）80-20％（重量）的羟基-C 1 -C 6 - - （甲基）丙烯酸烷基酯和（如果合适的话）一种或多种式（A）或（B）的化合物，其中R 1 = H，C 1 -C C 1 -C 6烷基，R 2 = H，CH 3 3 R 3 = C 1〜 -C 24 - - - 烷基或其混合物，b）20-80％（重量）的聚乙烯醇（PVA）和c）适当时0-20％重量的其它可聚合化合物（C ），其制备方法，以及它们作为药物剂型中的包衣剂，粘合剂和/或成膜赋形剂的用途。

    Slow-release matrix pellets and the production thereof
    107.
    发明授权
    Slow-release matrix pellets and the production thereof 失效
    缓释基质颗粒及其制备

    公开(公告)号：US06290990B1

    公开(公告)日：2001-09-18

    申请号：US08727666

    申请日：1996-10-17

    申请人： Sven Grabowski ,  Joerg Rosenberg ,  Axel Sanner

    发明人： Sven Grabowski ,  Joerg Rosenberg ,  Axel Sanner

    IPC分类号： A61K916

    CPC分类号： A61K9/1652 ,  A61K9/1617 ,  A61K9/1694

    摘要： Slow-release matrix pellets with a spherical or lenticular shape and uniform maximum diameters in the range from 0.5 to 4 mm, composed of a) 0.1-87% by weight of at least one biologically active compound, b) 5-50% by weight of at least one water-insoluble polymer, c) 5-45% by weight of at least one lipophilic component as plasticizer for polymer b), d) 3-40% by weight of a natural or semisynthetic gel former, e) 0-50% by weight of one or more conventional formulation aids.

    摘要翻译： 具有球形或透镜形状的缓释基质颗粒和0.5至4mm范围内的均匀最大直径，由a）0.1-87重量％的至少一种生物活性化合物组成，b）5-50重量％ 至少一种水不溶性聚合物，c）5-45重量％的至少一种亲脂性组分作为聚合物b）的增塑剂，d）3-40重量％的天然或半合成凝胶成型剂，e）0-50 重量％的一种或多种常规制剂助剂。

    Compositions which contain active substances and are in the form of solid particles
    109.
    发明授权
    Compositions which contain active substances and are in the form of solid particles 失效
    含有活性物质并呈固体颗粒形式的组合物

    公开(公告)号：US5641516A

    公开(公告)日：1997-06-24

    申请号：US511489

    申请日：1995-08-07

    申请人： Sven Grabowski ,  Axel Sanner ,  Joerg Rosenberg

    发明人： Sven Grabowski ,  Axel Sanner ,  Joerg Rosenberg

    IPC分类号： A01N25/10 ,  A01N25/12 ,  A61K9/14 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26

    CPC分类号： A61K9/146 ,  A61K9/2095

    摘要： Compositions which contain active substances and are in the form of solid particles can be obtained by intimately mixing the active substance with a water-soluble melt composed ofa) 10-90% by weight of a water-soluble polymer A with a viscosity V.sub.a of 1,000-120,000 cps andb) 10-90% by weight of a water-soluble polymer B with a viscosity V.sub.b of 1-500 cpsas carrier substance, where the viscosities V.sub.a and V.sub.b are those of a 2% by weight aqueous solution at 20.degree. C., measured by the ASTM D 2363-72 capillary method (European Pharmacopoeia, Vol. III, p. 37), and processing the melt with shaping to give the particles.

    摘要翻译： 包含活性物质并且为固体颗粒形式的组合物可以通过将活性物质与由水溶性聚合物A的10-90重量％组成的水溶性熔体紧密混合而获得，其中粘度Va为 1,000-120,000cps和b）10-90重量％的粘度Vb为1-500cps的水溶性聚合物B作为载体物质，其中粘度Va和Vb是2重量％水溶液中的粘度 通过ASTM D 2363-72毛细管法（欧洲药典，第III卷，第37页）测量，并通过成型加工熔体以得到颗粒。

    Solid depot drug form
    110.
    发明授权
    Solid depot drug form 失效
    固体贮库药物形式

    公开(公告)号：US5552159A

    公开(公告)日：1996-09-03

    申请号：US125133

    申请日：1993-09-23

    申请人： Winfried Mueller ,  Reinhard Spengler ,  Sven Grabowski ,  Axel Sanner

    发明人： Winfried Mueller ,  Reinhard Spengler ,  Sven Grabowski ,  Axel Sanner

    IPC分类号： A61K9/20 ,  A61K9/22

    CPC分类号： A61K9/2095 ,  A61K9/2027 ,  A61K9/2054

    摘要： A solid depot drug form produced by melt extrusion at from 50.degree. to 200.degree. C. and continuous shaping of a mixture of from 0.1 to 70% by weight, based on the finished depot form, of a pharmaceutical active ingredient with a polymer melt of the following composition:a) at least 6% by weight, based on the complete depot form, of at least one water-insoluble poly(meth) acrylate with a glass transition temperature Tg in the range from -60.degree. to 180.degree. C.,b) a water-soluble hydroxyalkylcellulose or hydroxy-alkylmethylcellulose with 2 or 3 carbons in the hydroxyalkyl, or an N-vinylpyrrolidone polymer with from 0 to 50% by weight of vinyl acetate or a mixture of the two in the ratio a):b) =5:95 to 95:5, andc) 0-30% by weight, based on the finished depot form, of one or more conventional pharmaceutical auxiliaries.

    摘要翻译： 一种固体贮库药物形式，其通过在50℃至200℃的熔融挤出而制备，并且基于最终的贮库形式连续成型0.1至70重量％的混合物，药物活性成分与聚合物熔体 以下组合物：a）至少6重量％，基于完整的储存形式，至少一种水不溶性聚（甲基）丙烯酸酯的玻璃化转变温度Tg在-60℃至180℃的范围内。 ，b）在羟烷基中具有2或3个碳原子的水溶性羟烷基纤维素或羟基烷基甲基纤维素，或0-50重量％乙酸乙烯酯的N-乙烯基吡咯烷酮聚合物或两者的混合物，其比例a）： b）= 5:95至95:5，和c）基于成品仓库形式的一种或多种常规药物助剂的0-30重量％。