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    THERMALLY DRIVEN KNUDSEN PUMP
    103.
    发明申请
    THERMALLY DRIVEN KNUDSEN PUMP 有权
    热驱动KNUDSEN PUMP

    公开(公告)号：US20120207625A1

    公开(公告)日：2012-08-16

    申请号：US13502411

    申请日：2010-10-22

    申请人： Shamus McNamara ,  Kunal Pharas ,  Chakravarthy Yamarthy ,  Alex Schultz

    发明人： Shamus McNamara ,  Kunal Pharas ,  Chakravarthy Yamarthy ,  Alex Schultz

    IPC分类号： F04B19/24 ,  F04B35/04

    CPC分类号： F04B43/043 ,  F04B19/006 ,  F04B19/24 ,  F04B37/06

    摘要： The present invention relates to thermally driven pumps. More specifically, one embodiment of the present invention relates to the use of a thermoelectric material to create a thermally driven, bi-directional pump, such as a micro pump, with no moving parts using the thermal transpiration effect (a Knudsen pump). One embodiment of the thermally driven pump of the present invention utilizes a thermoelectric material to assist with the thermal transpiration process resulting in a substantially symmetrical, bidirectional pump. A thermoelectric module is used to induce a temperature gradient across a nanoporous article having at least one nanochannel thus creating fluid flow via thermal transpiration across the nanochannel. The use of the thermoelectric module eliminates the need for a heat sink thereby making the pump substantially symmetrical and enabling bidirectional flow which is accomplished by reversing the polarity of the power supply to the thermoelectric module resulting in reversing the direction of heat transfer.A second embodiment of the thermally driven pump of the present invention comprises a uni-directional, pneumatic, micro fluidic, Knudsen pump which can be integrated into a lab-on-chip device and is configured to pump liquids. The Knudsen pump of the second embodiment is generally comprised of a channel system comprised of a nanochannel and a shallow channel embedded in a bottom substrate and capable of alignment in series with other channels within a lab-on-chip substrate. The nanochannel and shallow channel are both covered by a second substrate comprised of material conducive to finalize creation of the Knudsen channels. A heater is also included within the nanochannel to induce gas flow by thermal transpiration which pneumatically moves liquid through the channels of a lab-on-chip.

    摘要翻译： 本发明涉及热驱动泵。 更具体地，本发明的一个实施例涉及使用热电材料来创建热驱动的双向泵，例如微型泵，没有使用热蒸腾作用的运动部件（克努森泵）。 本发明的热驱动泵的一个实施例利用热电材料来辅助热蒸腾过程，从而产生基本对称的双向泵。 使用热电模块来诱导具有至少一个纳米通道的纳米多孔制品的温度梯度，从而通过穿过纳米通道的热蒸腾产生流体流动。 使用热电模块消除了对散热器的需要，从而使得泵基本上对称并且实现了双向流动，这是通过使向热电模块的电源的极性反转导致热传递方向反转而实现的。 本发明的热驱动泵的第二个实施例包括一个单向的，气动的，微流体的克努森泵，其可以被集成到片上实验室装置中并被配置成泵送液体。 第二实施例的Knudsen泵通常由通道系统组成，该通道系统由嵌入在底部衬底中的纳米通道和浅通道组成，并且能够与片上实验室衬底内的其它通道串联。 纳米通道和浅通道都被包含有助于最终确定克努森通道的产生的材料构成。 纳米通道中还包括一个加热器，以通过热蒸腾来诱导气体流动，其通过气动地将液体移动通过芯片实验室的通道。

    Chemical sensors for detecting hydrogen and methods of use
    105.
    发明授权
    Chemical sensors for detecting hydrogen and methods of use 有权
    用于检测氢的化学传感器及其使用方法

    公开(公告)号：US08168438B2

    公开(公告)日：2012-05-01

    申请号：US12279936

    申请日：2008-07-26

    申请人： Francis P. Zamborini ,  Francisco J. Ibanez

    发明人： Francis P. Zamborini ,  Francisco J. Ibanez

    IPC分类号： G01N33/00

    CPC分类号： G01N27/127 ,  Y10T436/19 ,  Y10T436/20 ,  Y10T436/22

    摘要： The presently-disclosed subject matter provides sensors and methods for detecting hydrogen by determining the conductivity of a chemiresistant film upon exposure to hydrogen, including for example chemiresistant films comprised of alkylamine-, alkylthiolate-, and/or surfactant-coated metal alloy nanoparticles.

    摘要翻译： 目前公开的主题提供了通过在暴露于氢气时确定化学耐久性膜的电导率来检测氢的传感器和方法，包括例如由烷基胺，烷基硫醇盐和/或表面活性剂涂覆的金属合金纳米颗粒组成的化学阻燃膜。

    PFKFB4 Inhibitors And Methods Of Using The Same
    109.
    发明申请
    PFKFB4 Inhibitors And Methods Of Using The Same 有权
    PFKFB4抑制剂及其使用方法

    公开(公告)号：US20100267815A1

    公开(公告)日：2010-10-21

    申请号：US12761773

    申请日：2010-04-16

    申请人： Sucheta Telang ,  Jason Chesney

    发明人： Sucheta Telang ,  Jason Chesney

    IPC分类号： A61K31/7105 ,  C12N5/00 ,  C07H21/02

    CPC分类号： A61K31/7105 ,  A61K31/00 ,  A61K31/713 ,  A61K2300/00

    摘要： Methods of reducing expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) and methods of treating a cancer in a cell are provided, the methods including contacting a cell with an effective amount of a PFKFB4 inhibitor. Short hairpin RNA (shRNA) and small interfering RNA (siRNA) inhibitors of PFKFB4 and their methods of use are also provided.

    摘要翻译： 提供了减少6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶4（PFKFB4）的表达的方法以及在细胞中治疗癌症的方法，包括使细胞与有效量的PFKFB4抑制剂接触 。 还提供了短发夹RNA（shRNA）和PFKFB4的小干扰RNA（siRNA）抑制剂及其使用方法。

    ULTRASOFT ATOMIC FORCE MICROSCOPY DEVICE AND METHOD
    110.
    发明申请
    ULTRASOFT ATOMIC FORCE MICROSCOPY DEVICE AND METHOD 审中-公开
    超声原子力显微镜装置及方法

    公开(公告)号：US20100257643A1

    公开(公告)日：2010-10-07

    申请号：US12709118

    申请日：2010-02-19

    申请人： Ronald Reifenberger ,  Arvind Raman ,  Laura Butler Biedermann ,  Mehdi M. Yazdanpanah

    发明人： Ronald Reifenberger ,  Arvind Raman ,  Laura Butler Biedermann ,  Mehdi M. Yazdanpanah

    IPC分类号： G01Q60/24

    CPC分类号： G01Q60/38 ,  G01Q20/02

    摘要： A preferred embodiment of the invention provides an ultra-soft atomic force microscope device that has a nanoneedle cantilever that terminates in a smaller diameter nanofiber tip. Deflection of the nanoneedle cantilever is measured directly by a laser Doppler vibrometer. The invention simultaneously provides a very low mass nanoneedle cantilever arm with a very small diameter nanofiber tip, while being able to image the vibration and displacement. An AFM device of the invention simultaneously provides a ultra low mass and soft cantilever, the ability to accurately and directly measure vibration and deflection of the very small diameter nanoneedle cantilever with the laser Doppler vibrometer, and a sharp nanofiber tip that provides sub nanometer resolution.

    摘要翻译： 本发明的优选实施方案提供了一种超柔性原子力显微镜装置，其具有终止于较小直径的纳米纤维尖端的纳米针悬臂。 通过激光多普勒测振仪直接测量纳米针悬臂的偏转。 本发明同时提供了具有非常小直径的纳米纤维尖端的非常低质量的纳米针悬臂，同时能够对振动和位移进行成像。 本发明的AFM装置同时提供超低质量和软悬臂，使用激光多普勒振动计准确且直接地测量非常小直径的纳米针悬臂的振动和偏转的能力，以及提供亚纳米分辨率的锋利的纳米纤维尖端。