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公开(公告)号:US10905663B2
公开(公告)日:2021-02-02
申请号:US14773088
申请日:2014-03-05
Applicant: THE UNIVERSITY OF CHICAGO
Inventor: Sharon Way , Benjamin Clayton , Brian Popko
IPC: A61K31/155 , A61K31/136 , A61K31/137 , A61K31/225 , A61K31/277 , A61K31/4409 , A61K38/21 , A61K9/00 , A61K38/03 , A61K39/395 , A61K45/06 , A61K39/00
Abstract: This invention discloses methods and compositions for the treatment of demyelinating disorders. Specifically, the invention relates to the use guanabenz or guanabenz derivative for treating demyelinating disorders.
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公开(公告)号:US20210017133A1
公开(公告)日:2021-01-21
申请号:US16947395
申请日:2020-07-30
Applicant: The University of Chicago
Inventor: Pedro Brugarolas , Brian Popko , Daniel Appelbaum , Chin-Tu Chen
IPC: C07D213/73 , A61K51/04 , C07D213/75 , C07B59/00
Abstract: The present disclosure provides novel compounds, including compounds that bind to potassium channels, methods for their manufacture, and methods for their use, including their use to diagnose and/or assess traumatic brain injury and use to treat dymeylinating diseases, and/or in vivo imaging of the central neverous system, and to diagnose and/or assess the progression of MS or other diseases.
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113.
公开(公告)号:US10803347B2
公开(公告)日:2020-10-13
申请号:US16206538
申请日:2018-11-30
Applicant: The University of Chicago
Inventor: Jason Salavon
IPC: G06K9/62 , G06F16/55 , G06N3/08 , G06N3/04 , G06F16/583
Abstract: An encoder artificial neural network (ANN) may be configured to receive an input image patch and produce a feature vector therefrom. The encoder ANN may have been trained with a first plurality of domain training images such that an output image patch visually resembling the input image patch can be generated from the feature vector. A generator ANN may be configured to receive the feature vector and produce a generated image patch from the first feature vector. The generator ANN may have been trained with feature vectors derived from a first plurality of domain training images and a second plurality of generative training images such that the generated image patch visually resembles the input image patch but is constructed of a newly-generated image elements visually resembling one or more image patches from the second plurality of generative training images.
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114.
公开(公告)号:US20200302540A1
公开(公告)日:2020-09-24
申请号:US16826000
申请日:2020-03-20
Inventor: Dacheng Xiu , Zheng Tracy Ke , Bryan Kelly
Abstract: Systems, methods, and computer-readable storage media facilitating automated testing of datasets including natural language data are disclosed. In the disclosed embodiments, rule sets may be used to condition and transform an input dataset into a format that is suitable for use with one or more artificial intelligence processes configured to extract parameters and classification information from the input dataset. The parameters and classes derived by the artificial intelligence processes may then be used to automatically generate various testing tools (e.g., scripts, test conditions, etc.) that may be executed against a test dataset, such as program code or other types of data.
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115.
公开(公告)号:US20200299641A1
公开(公告)日:2020-09-24
申请号:US16823737
申请日:2020-03-19
Applicant: LOYOLA UNIVERSITY OF CHICAGO
Inventor: Phong Le
IPC: C12N5/078 , C07K14/705 , C07K14/475 , G01N33/569 , C12N5/0783
Abstract: The present disclosure provides engineered thymic epithelial cells and cell lines, as well as extracellular vesicles derived therefrom. The disclosure also provides exosomes that display specific surface proteins, and provides methods for using said materials for treating subjects and for identifying cells.
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116.
公开(公告)号:US20200283391A1
公开(公告)日:2020-09-10
申请号:US16063877
申请日:2016-12-20
Applicant: The University Of Chicago
Inventor: Rima McLeod , Martin McPhillie , Colin W.G. Fishwick , Hernan Alejandro Lorenzi , Kai Wang , Taek-Kyun Kim , Yong Zhou , Leroy E. Hood , Ying Zhou , Kamal El Bissati , James Gordon , Mark Hickman , QiGui Li , Craig Roberts
IPC: C07D215/233 , C07D487/04 , C07D401/12 , C07D405/12 , A61P33/06 , C07D471/04
Abstract: Disclosed herein; are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
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公开(公告)号:US10755942B2
公开(公告)日:2020-08-25
申请号:US15685609
申请日:2017-08-24
Inventor: Do Han Kim , Hyo Seon Suh , Priya Moni , Karen K. Gleason , Paul Franklin Nealey
IPC: H01L21/308 , C23C16/46 , H01L21/311 , H01L21/3065 , G03F7/00 , H01L21/02
Abstract: Disclosed is a method for the fabrication of polymeric topcoat via initiated chemical vapor deposition (iCVD) or photoinitiated chemical vapor deposition (piCVD) in conjunction with directed self-assembly (DSA) of block copolymers to generate high resolution patterns. A topcoat deposited by iCVD or piCVD allows for conformal, ultra-thin, uniform, pinhole-free coatings. iCVD or piCVD topcoat enables the use of a diversity of block copolymer (BCP) materials for DSA and facilitates the direct and seamless integration of the topcoats for a pattern transfer process.
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118.
公开(公告)号:US20200250483A1
公开(公告)日:2020-08-06
申请号:US16774343
申请日:2020-01-28
Applicant: The University of Chicago
Inventor: Nicolas Y. Masse , Gregory D. Grant , David J. Freedman
Abstract: A computing device may receive a first set of training data for training an ANN to predict output data for a first task, and may train the ANN with the first set of training data by only adjusting values of weights associated with a first subset of neurons, the first subset selected based on an identity of the first task. The computing device may receive a second, different set of training data for training the ANN to predict output data for a second task, and may train the ANN with the second set of training data by only adjusting values of weights associated with a second subset of neurons, the second subset selected based on an identity of the second task. During training, adjusting of the value of any weight may entail weight stabilization that depends on whether there has been any training for one or more previous tasks.
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公开(公告)号:US20200248207A1
公开(公告)日:2020-08-06
申请号:US16574984
申请日:2019-09-18
Applicant: THE UNIVERSITY OF CHICAGO
Inventor: Laurens Mets
Abstract: Provided herein is an isolated Methanothermobacter microorganism that is (a) a microorganism of Methanothermobacter thermautotrophicus strain UC 120910, deposited on Dec. 21, 2010, with the American Type Culture Collection (ATCC) under ATCC® Patent Deposit Designation No. PTA-11561, (b) a variant of the microorganism of Methanothermobacter thermautotrophicus strain UC 120910, or (c) a progeny of the microorganism of Methanothermobacter thermautotrophicus strain UC 120910, wherein the variant or progeny retains the phenotypic characteristics of the microorganism of Methanothermobacter thermautotrophicus strain UC 120910. Also provided herein is a substantially pure culture or monoculture comprising the Methanothermobacter microorganism of the disclosure. A system for converting electric power into methane, comprising a biological reactor having at least a cathode, an anode, a presently disclosed Methanothermobacter microorganism, water, and carbon dioxide, and method of using the system for converting electricity into methane are further provided herein.
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公开(公告)号:US10729699B2
公开(公告)日:2020-08-04
申请号:US16374157
申请日:2019-04-03
Applicant: The University of Chicago
Inventor: Russell Z. Szmulewitz , Suzanne D. Conzen
IPC: A61K31/567 , A61K31/4166 , A61K31/437 , A61K31/569 , A61K31/573 , A61K45/06 , A61N5/10
Abstract: Embodiments of the invention are directed to the treatment of subjects with prostate cancer, in particular those with castration resistant prostate cancer, with glucocorticoid receptor antagonists. The prostate cancer may be one that has become resistant to androgen deprivation therapy, for example, by increase in glucocorticoid receptor expression and/or activity.
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