公开(公告)号：US10987418B2

公开(公告)日：2021-04-27

申请号：US16484366

申请日：2018-02-05

Applicant: XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

Inventor： Tianying Zhang ,  Quan Yuan ,  Xueran Guo ,  Minxi Wei ,  Xiaozhen Kang ,  Jun Zhang ,  Ningshao Xia

IPC: A61K39/39 ,  C07H21/04 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  A61K39/29 ,  A61P31/20 ,  C07K14/005 ,  C12N7/00

Abstract: The invention relates to a polypeptide carrier for presenting a target polypeptide, and use thereof. In particular, the invention relates to a nucleic acid molecule, comprising a nucleotide sequence encoding a polypeptide carrier, and being used for insertion of a nucleotide sequence encoding a target polypeptide. In addition, the invention further relates to a recombinant protein comprising the polypeptide carrier and a target polypeptide. Furthermore, the invention further relates to use of the nucleic acid molecule and the recombinant protein. In addition, the invention further relates to a vaccine or a pharmaceutical composition useful for preventing, alleviating or treating HBV infection or a disease associated with HBV infection (e.g., hepatitis B), comprising a recombinant protein comprising the polypeptide carrier of the invention and an epitope from HBV.

公开(公告)号：US20210095703A1

公开(公告)日：2021-04-01

申请号：US16746037

申请日：2020-01-17

Applicant: CMT Membrane Technology (Xiamen) Co., Ltd. ,  Xiamen Jiarong Technology Corp., Ltd. ,  Xiamen University of Technology

Inventor： Rushun Wang ,  Zhiqun Yuan ,  Jing Zhou ,  Bin Yan ,  Zhipeng Ma ,  Tingliang Zhong

IPC: F15D1/00

Abstract: The present invention discloses a deflector disc of a disc tube membrane module, including a deflector disc body, radial water distribution ribs, an inner support ring and an outer support ring. a first end and a second end of the radial water distribution rib are respectively fixedly connected with an inner edge of the deflector disc body and an outer edge of the inner support ring, an annular boss is arranged on the front side of the inner support ring, a seal ring groove is respectively arranged at corresponding positions of the front side and back side of the inner support ring multiple yielding water collecting grooves are annularly and uniformly distributed on the inner surface of the inner support ring and an inner edge of the outer support ring is fixedly connected with an outer edge of the deflector disc body.

公开(公告)号：US20210061865A1

公开(公告)日：2021-03-04

申请号：US16944724

申请日：2020-07-31

Applicant: Xiamen University

Inventor： Kejian WANG ,  Yanchao CHEN ,  Fangyi CHEN ,  Ying YANG ,  Hui PENG ,  Huiyun CHEN

IPC: C07K14/435 ,  A23K10/20

Abstract: Provided is an antimicrobial peptide Sparamosin from Scylla paramamosain. The Sparamosin mature peptide and its functional domain Sparamosin26-54 were synthesized by solid-phase synthesis with a purity of over 95%. Both Sparamosin and Sparamosin26-54 exhibit strong antimicrobial activity. More importantly, Sparamosin26-54 has strong antifungal activity and could inhibit the growth of a variety of yeasts and filamentous fungi. Based on the potent antimicrobial activities of Sparamosin and Sparamosin26-54, both peptides could be developed as alternatives for conventional antibiotics, antimicrobial agents, feed additives in aquaculture and livestock, preservatives, and mold inhibitors.

公开(公告)号：US10913040B2

公开(公告)日：2021-02-09

申请号：US15826433

申请日：2017-11-29

Applicant: XIAMEN UNIVERSITY

Inventor： Jun Li ,  Qunhong Liu ,  Wenxin Wei ,  Bao Zhu ,  Xiaohui Hu ,  Hongtao Wang ,  Yuzhong Su ,  Yanzhen Hong

IPC: C01B31/24 ,  B01J3/04 ,  B01J10/00 ,  B01J19/24 ,  B01J19/26 ,  C01F11/18 ,  C01B32/60 ,  B01J4/00 ,  B01J19/18

Abstract: A pressurized carbonation reaction apparatus and method thereof are provided. The apparatus comprises: an atomizing gas tank, a plurality of compressors, a plurality of buffer tanks, a plurality of pre-heaters, a pressurized liquid tank, a nozzle, a raw material tank, a carbon dioxide tank, a high-pressure reactor, a raw product tank, a feed pump, a plurality of pressure display gauges, a plurality of temperature controllers with display gauges and a plurality of back pressure valves. The method comprises: dissolving a solid material in a solvent, and storing a resulting liquid material in the raw material tank; introducing gas in the carbon dioxide tank to the high-pressure reactor, controlling temperatures of the high-pressure reactor and the pressurized liquid tank, and pumping, by the feed pump, the liquid material into the pressurized liquid tank to ensure a pressure difference between the pressurized liquid tank and the high-pressure reactor; opening a second check valve, and ensuring that the liquid material reacts with a carbon dioxide atmosphere in the high-pressure reactor after being atomized via the nozzle under a stable pressure difference between the high-pressure reactor and the pressurized liquid tank; and ensuring that when the liquid material in the high-pressure reactor is at a corresponding liquid level, a fifth check valve is opened and discharge continues to obtain a reaction product.

公开(公告)号：US10782255B2

公开(公告)日：2020-09-22

申请号：US16315084

申请日：2018-01-08

Applicant: XIAMEN UNIVERSITY

Inventor： Yanqin Lin ,  Qing Zeng ,  Jinyong Chen ,  Zhong Chen

IPC: G01V3/00 ,  G01N24/08 ,  G01R33/46

Abstract: This invention provides a NMR multi-dimensional method for measuring coupling constants within several coupling networks. At first, a 90° hard pulse was performed to flip the magnetization from the Z axis to the XY plane. After t1/2, a selective 180° pulse is implemented with a simultaneous Z-direction gradient, thus reversing different protons at different slices. Then the PSYCHE element is implemented. After another t1/2, the gradient G1 and Gp are implemented. At last, the EPSI readout is used to simultaneously record both the chemical-shift and the spatial information. As a result, from different specific slices, we can extract the scalar couplings between the proton reversed at this slice and other protons. These couplings lead to splittings in the indirect dimension, from which relevant coupling constants can be measured.

公开(公告)号：US20200224320A1

公开(公告)日：2020-07-16

申请号：US16641780

申请日：2018-08-17

Applicant: XIAMEN UNIVERSITY

Inventor： Nanfeng ZHENG ,  Jian PENG ,  Shuqiang HAO ,  Binghui WU ,  Xiaoliang FANG

IPC: C23F11/12 ,  C22C9/00 ,  C23F11/16

Abstract: An anticorrosion treatment method for a copper-containing material comprises: carrying out a sealed and pressurized reaction on a copper-containing material and a stabilizer in presence of a polar solvent and any assistant, the stabilizer being a compound capable of providing formates, so that the formates are adsorbed on the surface of the copper-containing material. In the method, formates are modified on the surface of the copper-containing material, accordingly, the oxidation resistance capability and the stability of the copper-containing material can be significantly improved while the electrical conductivity of the copper-containing material is not reduced, and the corrosion resistance of the copper-containing material and especially, the salt and alkali corrosion resistance of the copper-containing material are significantly improved.

公开(公告)号：US10689434B2

公开(公告)日：2020-06-23

申请号：US15766593

申请日：2016-10-09

Applicant: XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

Inventor： Wenxin Luo ,  Bing Zhou ,  Juan Zhang ,  Quan Yuan ,  Tianying Zhang ,  Jun Zhang ,  Ningshao Xia

IPC: C07K16/08 ,  A61K39/00

Abstract: The invention provides an antibody (in particular, a humanized antibody) against hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding the same, a method for preparing the same, and a pharmaceutical composition comprising the same. The invention also provides use of the antibody and pharmaceutical composition. The antibody and pharmaceutical composition according to the invention can be used for preventing and/or treating HBV infection or a disease associated with HBV infection (such as Hepatitis B), for neutralizing HBV virulence in a subject (such as human), or for reducing the serum level of HBV DNA and/or HBsAg in a subject.

公开(公告)号：US20200002503A1

公开(公告)日：2020-01-02

申请号：US16567295

申请日：2019-09-11

Applicant: Xiamen University

Inventor： Lizong DAI ,  Chao LIU ,  Guorong CHEN ,  Jiamei HUANG ,  Zhongyu LI ,  Conghui YUAN ,  Yiting XU ,  Birong ZENG ,  Wei'ang LUO

IPC: C08K3/36 ,  C08K9/06 ,  C08K9/08 ,  C08K9/10 ,  C08L63/00

Abstract: The present disclosure discloses a method of manufacturing silicon dioxide nanoparticles modified by a polymer containing phosphorus and nitrogen, which relates to organic/inorganic hybrid nanoparticles, dispersing SiO2 in an organic solvent, then adding THPS, stirring, and finally adding p-phenylenediamine, reacting, centrifuging, washing, and drying to obtain silicon dioxide nanoparticles modified by a polymer containing phosphorus and nitrogen. The silicon dioxide nanoparticles modified by the polymer containing phosphorus and nitrogen have effects in flame retardancy, strengthening effect of polymer matrixes, and are expected to be widely used in the halogen-free synergistic flame retardancy of polymer materials.

公开(公告)号：US20190285396A1

公开(公告)日：2019-09-19

申请号：US16183737

申请日：2018-11-08

Applicant: Xiamen University

Inventor： Bin YAO ,  Zhiqin CAI ,  Binqiang CHEN

IPC: G01B5/20 ,  G06T7/13 ,  G06T7/00

Abstract: A method for extracting a gear tooth profile edge based on an engagement-pixel image edge tracking method includes defining a transmission ratio relationship between a cutter and an envelope tooth profile, setting a cutter profile step size and an envelope step size, acquiring instantaneous contact images at different engaging times, and performing a binarization processing on each curve envelope cluster image; sweeping a boundary of an envelope curve cluster, acquiring pixel points of the edge; preliminarily tracking a tooth profile edge, and then performing a secondary extraction and compensation on the pixel points; calibrating coordinates of a cutter profile; extracting a pixel coordinate of an instantaneous engaging point; converting the pixel points among different instantaneous engaging images; extracting a final tooth profile coordinate of the gear, and performing a tooth shape error analysis and a contact line error analysis.

公开(公告)号：US20190284344A1

公开(公告)日：2019-09-19

申请号：US16463697

申请日：2017-11-23

Applicant: XIAMEN UNIVERSITY

Inventor： Lizong DAI ,  Ting CHEN ,  Cheng LIU ,  Shicheng WANG ,  Guorong CEHN ,  Conghui YUAN ,  Yiting XU ,  Birong ZENG ,  Wei'ang LUO ,  Kaibin HE

IPC: C08G77/46 ,  C07F9/09 ,  C08G77/395 ,  C08G59/40 ,  C08G59/24 ,  C08G59/50 ,  C08G59/56

Abstract: Disclosed are a fluorine-silicon-containing polyphosphate ester and method for preparation thereof, having a chemical structural formula of: wherein R 1 is R 2 is n=10˜100. The fluorine-silicon-containing polyphosphate ester of the present invention uses silicon phosphorus and fluorine for improving flame retardancy. Phosphorus catalyzes the system to form a phosphorus-rich carbon layer, performing a protective-layer function and thereby preventing further breakdown of the epoxy resin. The silicon-containing epoxy resin forms a silica-containing carbon layer during the process of combustion, strengthening the carbon-layer structure and further improving the protective function of the carbon-layer. The introduction of elemental fluorine improves the thermal stability of the epoxy resin, thereby improving the flame retardancy performance of the system.