公开(公告)号：US20080097542A1

公开(公告)日：2008-04-24

申请号：US11962708

申请日：2007-12-21

申请人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Angelo Auricchio

发明人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Angelo Auricchio

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/3682

摘要： A method and apparatus for predicting acute response to cardiac resynchronization therapy is disclosed. The method can comprise measuring a first interval during an intrinsic systolic cycle and measuring a second interval during a stimulated systolic cycle. The acute response can be predicted by comparing the percent change in duration between the first interval and the second interval against a pre-determined threshold value. The first and second time intervals can be measured using, for example, a surface ECG or, alternatively, an intracardiac electrogram. In one embodiment, the first interval can be the duration of an intrinsic QRS complex measured during a non-stimulated systolic cycle. Similarly, the second interval can be the duration of a stimulated QRS complex measured during a stimulated systolic cycle.

摘要翻译： 公开了用于预测心脏再同步治疗的急性反应的方法和装置。 该方法可以包括在本征收缩周期期间测量第一间隔并且在刺激的收缩期期间测量第二间隔。 可以通过将第一间隔和第二间隔之间的持续时间的百分比变化与预定阈值进行比较来预测急性反应。 第一和第二时间间隔可以使用例如表面ECG或者心内电描记图来测量。 在一个实施例中，第一间隔可以是在非刺激的收缩期期间测量的固有QRS复合物的持续时间。 类似地，第二间隔可以是在刺激的收缩期期间测量的受激QRS复合物的持续时间。

公开(公告)号：US07313433B2

公开(公告)日：2007-12-25

申请号：US10780794

申请日：2004-02-18

申请人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Angelo Aurichio

发明人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Angelo Aurichio

IPC分类号： A61B5/04

CPC分类号： A61N1/3627 ,  A61N1/3682

摘要： A method and apparatus for predicting acute response to cardiac resynchronization therapy is disclosed. The method can comprise measuring a first interval during an intrinsic systolic cycle and measuring a second interval during a stimulated systolic cycle. The acute response can be predicted by comparing the percent change in duration between the first interval and the second interval against a pre-determined threshold value. The first and second time intervals can be measured using, for example, a surface ECG or, alternatively, an intracardiac electrogram. In one embodiment, the first interval can be the duration of an intrinsic QRS complex measured during a non-stimulated systolic cycle. Similarly, the second interval can be the duration of a stimulated QRS complex measured during a stimulated systolic cycle.

摘要翻译： 公开了用于预测心脏再同步治疗的急性反应的方法和装置。 该方法可以包括在本征收缩周期期间测量第一间隔并且在刺激的收缩期期间测量第二间隔。 可以通过将第一间隔和第二间隔之间的持续时间的百分比变化与预定阈值进行比较来预测急性反应。 第一和第二时间间隔可以使用例如表面ECG或者心内电描记图来测量。 在一个实施例中，第一间隔可以是在非刺激的收缩期期间测量的固有QRS复合物的持续时间。 类似地，第二间隔可以是在刺激的收缩期期间测量的受激QRS复合物的持续时间。

公开(公告)号：US20070208386A1

公开(公告)日：2007-09-06

申请号：US11676339

申请日：2007-02-19

申请人： Andrew Kramer ,  Veerichetty Kadhiresan ,  Jiang Ding ,  Lawrence Baumann ,  Scott Vanderlinde

发明人： Andrew Kramer ,  Veerichetty Kadhiresan ,  Jiang Ding ,  Lawrence Baumann ,  Scott Vanderlinde

IPC分类号： A61N1/05

CPC分类号： A61N1/3627 ,  A61N1/3682

摘要： A method and system for setting the operating parameters of a cardiac rhythm management device in which a plurality of parameter optimization algorithms are available. A measured feature of an electrophysiological signal such as QRS width has been shown to be useful in selecting among certain parameter optimization algorithms. In one embodiment, one or more resynchronization pacing parameters are set based on one or both of the feature extracted from an electrogram signal and the value of a resynchronization pacing parameter which tends to minimize the intrinsic atrial rate.

摘要翻译： 一种用于设定多个参数优化算法可用的心律管理装置的操作参数的方法和系统。 电生理信号（如QRS宽度）的测量特征已被证明可用于某些参数优化算法中的选择。 在一个实施例中，基于从电描记信号提取的特征中的一个或两个以及倾向于使固有心房率最小化的再同步起搏参数的值来设置一个或多个再同步起搏参数。

公开(公告)号：US20070203526A1

公开(公告)日：2007-08-30

申请号：US11742655

申请日：2007-05-01

申请人： Jiang Ding ,  Julio Spinelli ,  Andrew Kramer

发明人： Jiang Ding ,  Julio Spinelli ,  Andrew Kramer

IPC分类号： A61N1/365

CPC分类号： A61N1/3684 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/368

摘要： A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.

摘要翻译： 心脏节律管理系统基于在多个电极处的去极化基准点的检测之间的相对定时或基于在多个电极之间的去极化基准点的检测之间的延迟来选择与特定心室相关联的多个电极中的一个，以及 在与相同或不同的心室相关联的另一电极处检测参考去极化基准点。 随后的收缩诱导刺激疗法从所选择的电极递送。

公开(公告)号：US20070179546A1

公开(公告)日：2007-08-02

申请号：US11567933

申请日：2006-12-07

申请人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Andrew Kramer

发明人： Yinghong Yu ,  Jiang Ding ,  Julio Spinelli ,  Andrew Kramer

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36564 ,  A61N1/3682

摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

摘要翻译： 用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟 心室起搏脉冲的最佳时机。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

公开(公告)号：US20070129781A1

公开(公告)日：2007-06-07

申请号：US11549676

申请日：2006-10-16

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/365

CPC分类号： A61N1/36578 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/3684

摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.

摘要翻译： 公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。 可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。 加速度计响应于心室壁位置的运动产生信号。 然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。 可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。 可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

公开(公告)号：US07215997B2

公开(公告)日：2007-05-08

申请号：US10744900

申请日：2003-12-22

申请人： Yinghong Yu ,  Jiang Ding ,  Joseph M. Pastore

发明人： Yinghong Yu ,  Jiang Ding ,  Joseph M. Pastore

IPC分类号： A61N1/365

CPC分类号： A61N1/365

摘要： A cardiac rhythm management system includes an implantable device executing a dynamic pacing algorithm after an myocardial infarction (MI) event. The dynamic pacing algorithm dynamically adjusts one or more pacing parameters based on a person's gross physical activity level. Examples of the one or more pacing parameters include atrioventricular pacing delays and pacing channels/sites. The dynamic pacing algorithm provides for improved hemodynamic performance when a person's metabolic need is high, and post MI remodeling control when the person's metabolic need is low.

摘要翻译： 心律管理系统包括在心肌梗死（MI）事件之后执行动态起搏算法的可植入装置。 动态起搏算法根据人的总身体活动水平动态调整一个或多个起搏参数。 一个或多个起搏参数的示例包括房室起搏延迟和起搏通道/部位。 当人的代谢需求高时，动态起搏算法提供改善的血液动力学性能，并且当人的代谢需求低时，进行后重建控制。

公开(公告)号：US20070066734A1

公开(公告)日：2007-03-22

申请号：US11229110

申请日：2005-09-16

申请人： Jiang Ding ,  Christian Lenges ,  Christopher Simone ,  Brian Auman

发明人： Jiang Ding ,  Christian Lenges ,  Christopher Simone ,  Brian Auman

IPC分类号： C08G69/08 ,  C08K3/38 ,  C08K3/22 ,  B60C1/00

CPC分类号： C08G73/10 ,  H05K1/0346 ,  H05K1/0373 ,  Y10T428/31681 ,  Y10T428/31721

摘要： The present invention is directed to the use polycyclic diamines. These diamines, when polymerized with dianhydrides, and optionally other non-polycyclic diamines are used to form new polyamic acids. The polyamic acids can be imidized to form a new class of useful polyimide resins and polyimide films, particularly in electronics type applications.

摘要翻译： 本发明涉及使用多环二胺。 当用二酸酐和任选的其它非多环二胺聚合时，这些二胺用于形成新的聚酰胺酸。 聚酰胺酸可以被酰亚胺化以形成一类新的有用的聚酰亚胺树脂和聚酰亚胺薄膜，特别是在电子类应用中。

公开(公告)号：US07184835B2

公开(公告)日：2007-02-27

申请号：US10735267

申请日：2003-12-12

申请人： Andrew P. Kramer ,  Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli

发明人： Andrew P. Kramer ,  Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/365 ,  A61N1/3682

摘要： A pacing system provides for optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal. A look-up table relating the timing of such electrical or mechanical events to atrio-ventricular delay time intervals is provided for programming the pacing system.

摘要翻译： 起搏系统提供用于参数的最佳血液动力学心脏功能，例如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）或行程体积（主动脉脉压），用于计算房室延迟的系统 心室起搏脉冲的最佳时机。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。 提供了将这种电气或机械事件的时间与心房延迟时间间隔相关联的查找表，用于对起搏系统进行编程。

公开(公告)号：US20060161209A1

公开(公告)日：2006-07-20

申请号：US11037309

申请日：2005-01-18

申请人： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

发明人： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/362

CPC分类号： A61N1/365 ,  A61N1/36592

摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.

摘要翻译： 心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。 产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。 在一个实施例中，当HRV参数被认为对继续治疗有潜在危害时，将HRV参数用作安全检查以停止电疗法。