公开(公告)号：US08423140B2

公开(公告)日：2013-04-16

申请号：US12787630

申请日：2010-05-26

申请人： Barun Maskara ,  Lili Liu ,  Guy Alvarez ,  Scott A. Meyer

发明人： Barun Maskara ,  Lili Liu ,  Guy Alvarez ,  Scott A. Meyer

IPC分类号： A61N1/08

CPC分类号： A61N1/36564

摘要： A system and method for detecting and treating symptoms of early decompensation utilizing a cardiac rhythm management. The system applies an electrical stimulus to the patient's heart at a first set of pacing parameters including a lower rate limit (LRL) setting, and acquires a coronary venous pressure (CVP) signal from a pressure sensor implanted in a coronary vein of the patient. An average coronary venous end diastolic pressure (CV-EDP) value is calculated from the CVP signal. The system monitors the average CV-EDP value over a predetermined interval, and dynamically adjusts the LRL setting responsive to the detection of a first or a second predetermined event based on the average CV-EDP value.

摘要翻译： 一种利用心律管理检测和治疗早期失代偿症状的系统和方法。 该系统以包括较低速率限制（LRL）设置在内的第一组起搏参数对患者的心脏施加电刺激，并从植入患者冠状静脉的压力传感器获取冠状静脉压（CVP）信号。 根据CVP信号计算平均冠状静脉舒张末期压（CV-EDP）值。 该系统在预定间隔内监视平均CV-EDP值，并且响应于基于平均CV-EDP值的第一或第二预定事件的检测动态地调整LRL设置。

公开(公告)号：US20120308108A1

公开(公告)日：2012-12-06

申请号：US13488280

申请日：2012-06-04

申请人： Matthew J. Everett ,  Scott A. Meyer ,  Paul F. Stetson ,  Yan Zhou

发明人： Matthew J. Everett ,  Scott A. Meyer ,  Paul F. Stetson ,  Yan Zhou

IPC分类号： G06K9/78

CPC分类号： A61B5/0066 ,  G06T7/0014 ,  G06T19/00 ,  G06T2200/24 ,  G06T2207/10101 ,  G06T2207/30041 ,  G06T2210/41

摘要： The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.

摘要翻译： 本发明公开了一种用于产生相对于拟合的参考表面的组织层/边界的仰角图或图像的方法，包括以下步骤：发现和分割所需的组织层/边界; 将平滑的参考表面拟合到分段的组织层/边界; 计算相对于拟合参考表面的相同或其它组织层/边界的高度; 并产生相对于拟合表面的高程图。 高程可以以各种方式显示，包括三维表面效果图，地形轮廓图，轮廓图，面孔颜色图和面对灰度图。 也可以将高程组合并同时显示另一个组织层/边界依赖的图像数据集，以提供用于诊断的附加信息。

公开(公告)号：US20120045101A1

公开(公告)日：2012-02-23

申请号：US13283445

申请日：2011-10-27

申请人： Matthew J. Everett ,  Scott A. Meyer ,  Paul F. Stetson ,  Yan Zhou

发明人： Matthew J. Everett ,  Scott A. Meyer ,  Paul F. Stetson ,  Yan Zhou

IPC分类号： G06K9/00

CPC分类号： A61B5/0066 ,  G06T7/0014 ,  G06T19/00 ,  G06T2200/24 ,  G06T2207/10101 ,  G06T2207/30041 ,  G06T2210/41

摘要： The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.

公开(公告)号：US08078276B2

公开(公告)日：2011-12-13

申请号：US12494628

申请日：2009-06-30

申请人： Yanting Dong ,  Jiang Ding ,  Douglas R. Daum ,  Scott A. Meyer ,  Yinghong Yu

发明人： Yanting Dong ,  Jiang Ding ,  Douglas R. Daum ,  Scott A. Meyer ,  Yinghong Yu

IPC分类号： A61N1/365

CPC分类号： A61N1/368 ,  A61N1/3682 ,  A61N1/371

摘要： A method and system for determining an optimum atrioventricular delay (AVD) interval and/or ventriculo-ventricular delay (VVD) intervals for delivering ventricular resynchronization pacing in an atrial tracking or atrial sequential pacing mode. Evoked response electrograms recorded at different AVD and VVD intervals are used to determine the extent of paced and intrinsic activation.

摘要翻译： 一种用于确定用于在心房跟踪或心房顺序起搏模式中递送心室再同步起搏的最佳房室延迟（AVD）间隔和/或心室 - 心室延迟（VVD）间隔的方法和系统。 以不同的AVD和VVD间隔记录的诱发反应电图用于确定起搏和内在激活的程度。

公开(公告)号：US20110264158A1

公开(公告)日：2011-10-27

申请号：US13094416

申请日：2011-04-26

申请人： Yanting Dong ,  Allan C. Shuros ,  Jiang Ding ,  Scott A. Meyer ,  Shibaji Shome

发明人： Yanting Dong ,  Allan C. Shuros ,  Jiang Ding ,  Scott A. Meyer ,  Shibaji Shome

IPC分类号： A61N1/362

CPC分类号： A61N1/371 ,  A61B5/0031 ,  A61B5/04525 ,  A61B5/7264 ,  A61N1/3712 ,  A61N1/37247

摘要： This document discusses, among other things, a system and method for generating a stimulation energy to provide His-bundle stimulation for a cardiac cycle, receiving electrical information from the heart over at least a portion of the cardiac cycle, determining a characteristic of at least a portion of the received electrical information for the cardiac cycle, and classifying the cardiac cycle using the determined characteristic.

摘要翻译： 本文件尤其涉及用于产生刺激能量以提供心跳周期的His束刺激的系统和方法，在心脏周期的至少一部分上从心脏接收电信息，确定至少一个特征 所接收的用于心动周期的电信息的一部分，并且使用所确定的特征对心动周期进行分类。

公开(公告)号：US20110261320A1

公开(公告)日：2011-10-27

申请号：US13091836

申请日：2011-04-21

申请人： Martin Hacker ,  Scott A. Meyer

发明人： Martin Hacker ,  Scott A. Meyer

IPC分类号： A61B3/11 ,  A61B3/14 ,  A61B3/113 ,  A61B3/10

CPC分类号： A61B3/152

摘要： A solution for attaining high-precision and reproducible measurements during opthalmological biometry and imaging includes an illumination unit for producing a fixation marker, a device for transmitting the light of the produced fixation marker into the eye, a measurement device and a control unit. The illumination unit includes a device for the targeted change of the beam direction of the produced fixation marker. A camera for the detection of the line of vision of the eye is connected to the control unit. The control unit determines the sufficient congruity between detected line of vision and displayed beam direction of the produced fixation marker and, in dependence of the degree of probability of the congruity, triggers a measurement. The suggested arrangement is applicable for opthalmological diagnostic devices, which exhibit a camera and a measuring system, whereby measurements can be taken in all areas of the eye.

摘要翻译： 用于在眼科生物测定和成像期间获得高精度和可再现的测量的解决方案包括用于产生固定标记的照明单元，用于将产生的定影标记的光透射到眼睛中的装置，测量装置和控制单元。 照明单元包括用于靶向改变所产生的定影标记的光束方向的装置。 用于检测眼睛视线的相机连接到控制单元。 控制单元确定检测到的视线与所产生的固定标记的显示光束方向之间的足够的一致性，并且根据一致性概率的程度触发测量。 该建议的布置适用于展示相机和测量系统的眼科诊断装置，由此可以在眼睛的所有区域进行测量。

公开(公告)号：US20110144511A1

公开(公告)日：2011-06-16

申请号：US13027612

申请日：2011-02-15

申请人： Yi Zhang ,  Scott A. Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos Alberto Ricci

发明人： Yi Zhang ,  Scott A. Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos Alberto Ricci

IPC分类号： A61B5/0402

CPC分类号： A61B5/04011 ,  A61B5/7203

摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.

摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断和除颤和/或起搏疗法。 信号处理器接收与多个源相关联的多个复合信号，执行源分离，并且基于源分离产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号矢量。 信号分离的方法包括检测心脏信号矢量相对于基线的特征的变化。 可以选择一个或多个载体和/或激活序列，并且可以存储和跟踪与载体和/或激活序列相关联的信息。

公开(公告)号：US20110043757A1

公开(公告)日：2011-02-24

申请号：US12861672

申请日：2010-08-23

申请人： Matthew J. Everett ,  Claus Flachenecker ,  Martin Hacker ,  Scott A. Meyer ,  Keith E. O'Hara ,  RicK A. Williams

发明人： Matthew J. Everett ,  Claus Flachenecker ,  Martin Hacker ,  Scott A. Meyer ,  Keith E. O'Hara ,  RicK A. Williams

IPC分类号： A61B3/15 ,  A61B3/12

CPC分类号： A61B3/102 ,  A61B3/113

摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.

摘要翻译： 行扫描成像器用于确定被摄体的运动。 将来自行扫描成像器的每行图像数据与参考图像进行比较。 参考图像中匹配线的位置显示了被摄体的位移。 可以基于每行图像数据来确定当前被摄体位移。 所得到的位移信息可用于将其他光束正确地放置在被摄体上。 该方法可以应用于跟踪人眼以便于用光束辐射进行测量，成像或处理。

公开(公告)号：US07765004B2

公开(公告)日：2010-07-27

申请号：US11116565

申请日：2005-04-28

申请人： Kevin John Stalsberg ,  Yanting Dong ,  Scott A. Meyer ,  John Michael Voegele ,  Derek Daniel Bohn ,  Eric Keith Enrooth ,  Clayton Scott Foster ,  David William Yost

发明人： Kevin John Stalsberg ,  Yanting Dong ,  Scott A. Meyer ,  John Michael Voegele ,  Derek Daniel Bohn ,  Eric Keith Enrooth ,  Clayton Scott Foster ,  David William Yost

IPC分类号： A61N1/08

CPC分类号： A61N1/371 ,  A61B5/0452 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7264

摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.

摘要翻译： 用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。 意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。 融合/噪声管理过程包括在相对高的能量级别进行起搏，直到在融合之后检测到捕获，不确定或可能错误的起搏响应分类。 可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

公开(公告)号：US07761162B2

公开(公告)日：2010-07-20

申请号：US11010973

申请日：2004-12-13

申请人： Yanting Dong ,  Scott A. Meyer ,  Qingsheng Zhu

发明人： Yanting Dong ,  Scott A. Meyer ,  Qingsheng Zhu

IPC分类号： A61N1/365

CPC分类号： A61N1/3712

摘要： Approaches to automatically classifying a cardiac response to pacing involve discriminating between a captured response and non-capture with intrinsic activation. A capture detection system senses for morphological characteristics of a cardiac signal associated with the pacing pulse. The cardiac signal may be sensed using a defibrillation electrode during one or more time intervals following delivery of the pacing pulse. If a first characteristic of the cardiac signal achieves a threshold value, the system continues to sense the cardiac signal and detects a second characteristic. The cardiac pacing response is determined based on at least one of the first and the second cardiac signal characteristics.

摘要翻译： 自动分类心脏起搏应答的方法涉及通过内在激活区分被捕获的应答和非捕获。 捕获检测系统感测与起搏脉冲相关的心脏信号的形态特征。 可以在递送起搏脉冲之后的一个或多个时间间隔期间使用除颤电极来感测心脏信号。 如果心脏信号的第一特征达到阈值，则系统继续感测心脏信号并检测第二特征。 基于第一和第二心脏信号特征中的至少一个确定心脏起搏响应。