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公开(公告)号：US07371229B2
公开(公告)日：2008-05-13
申请号：US10353769
申请日：2003-01-28
IPC分类号： A61K9/22
CPC分类号： H01M2/0202 , A61M2005/14513 , A61N1/30 , B01D61/427 , H01M10/425 , H01M10/484
摘要： The present invention is disclosed herein as an electrochemical cell having a cell housing with a first half cell and a second half cell, and an ion selective membrane between the cells. The electrochemical cell further has a first electrode positioned within the first half cell, a second electrode positioned within the second half cell, an electrolyte in electrical communication with both the first electrode and the second electrode. The electrodes of the cell are configured so that the electrochemical cell maintains a substantially constant salt concentration level throughout operation. The cell is preferably used in conjunction with an implantable fluid delivery apparatus. A method for using the device is additionally disclosed.
摘要翻译： 本发明在此被公开为具有具有第一半电池和第二半电池的电池壳体的电化学电池以及电池之间的离子选择性膜。 电化学电池还具有位于第一半单元内的第一电极，位于第二半单元内的第二电极，与第一电极和第二电极电连通的电解质。 电池的电极被配置为使得电化学电池在整个操作中保持基本上恒定的盐浓度水平。 细胞优选与可植入流体输送装置结合使用。 另外公开了一种使用该装置的方法。
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公开(公告)号：US06918901B1
公开(公告)日：2005-07-19
申请号：US08988292
申请日：1997-12-10
CPC分类号： A61M37/0015 , A61B17/205 , A61M2037/0023 , A61M2037/0046
摘要： An agent delivery or sampling device (2) comprising a member (6) having a plurality of blades (4) for piercing the skin and a connecting medium (65) covering at least a part of the skin contacting side (48) of the member (6) for increasing transdermal flux of an agent.
摘要翻译： 一种药剂输送或取样装置（2），包括具有用于刺穿皮肤的多个叶片（4）的构件（6）和覆盖该构件的皮肤接触侧（48）的至少一部分的连接介质 （6）用于增加药剂的经皮通量。
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公开(公告)号：US20050126912A1
公开(公告)日：2005-06-16
申请号：US10906433
申请日：2005-02-18
申请人： Felix Theeuwes , Jeremy Wright
发明人： Felix Theeuwes , Jeremy Wright
CPC分类号： B01D61/427 , A61M5/14276 , A61M2005/14513
摘要： An electro-osmotic cell capable of substantially reducing zero-current transport is disclosed, wherein the cell includes a cell housing having a first half cell and a second half cell, with an ion selective membrane therebetween, a first electrode positioned within the first half cell, a second electrode positioned within the second half cell, an electrolyte in electrical communication with the first electrode and the second electrode, and a wiring apparatus electrically connecting the first electrode and the second electrode, wherein the wiring apparatus has one or more structures used for counteracting salt concentration increases within the electro-osmotic cell. Such a cell may be used within an electro-osmotic fluid delivery device, along with a fluid inlet, a piston member adjacent the electro osmotic cell, and a drug reservoir adjacent the piston member, wherein the drug reservoir includes a sealed compartment having an exit port. A method for using such a device is similarly disclosed.
摘要翻译： 公开了能够显着减少零电流输送的电渗透电池，其中电池包括具有第一半电池和第二半电池的电池壳体，其间具有离子选择性膜，位于第一半电池内的第一电极 位于所述第二半单元内的第二电极，与所述第一电极和所述第二电极电连通的电解质，以及电连接所述第一电极和所述第二电极的布线装置，其中所述布线装置具有用于 在电渗透细胞内抵消盐浓度增加。 这样的细胞可以与电渗透流体递送装置一起使用，以及流体入口，邻近电渗透细胞的活塞构件和邻近活塞构件的药物储存器，其中药物储存器包括密封隔室，其具有出口 港口。 类似地公开了使用这种装置的方法。
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公开(公告)号：US06872292B2
公开(公告)日：2005-03-29
申请号：US10353770
申请日：2003-01-28
CPC分类号： B01D61/427 , A61M5/14276 , A61M2005/14513
摘要： An electro-osmotic cell capable of substantially reducing zero-current transport is disclosed, wherein the cell includes a cell housing having a first half cell and a second half cell, with an ion selective membrane therebetween, a first electrode positioned within the first half cell, a second electrode positioned within the second half cell, an electrolyte in electrical communication with the first electrode and the second electrode, and a wiring apparatus electrically connecting the first electrode and the second electrode, wherein the wiring apparatus has one or more structures used for counteracting salt concentration increases within the electro-osmotic cell. Such a cell may be used within an electro-osmotic fluid delivery device, along with a fluid inlet, a piston member adjacent the electro osmotic cell, and a drug reservoir adjacent the piston member, wherein the drug reservoir includes a sealed compartment having an exit port. A method for using such a device is similarly disclosed.
摘要翻译： 公开了能够显着减少零电流输送的电渗透电池，其中电池包括具有第一半电池和第二半电池的电池壳体，其间具有离子选择性膜，位于第一半电池内的第一电极 位于所述第二半单元内的第二电极，与所述第一电极和所述第二电极电连通的电解质，以及电连接所述第一电极和所述第二电极的布线装置，其中所述布线装置具有用于 在电渗透细胞内抵消盐浓度增加。 这样的细胞可以与电渗透流体递送装置一起使用，以及流体入口，邻近电渗透细胞的活塞构件和邻近活塞构件的药物储存器，其中药物储存器包括密封隔室，其具有出口 港口。 类似地公开了使用这种装置的方法。
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公开(公告)号：US06718201B1
公开(公告)日：2004-04-06
申请号：US08952367
申请日：1997-11-17
IPC分类号： A61N130
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/325
摘要： An electrotransport device and method of operating same provides a pulsed DC current of specified frequency and duration which transforms the skin into a higher electrotransport delivery efficiency state.
摘要翻译： 电输送装置及其操作方法提供指定频率和持续时间的脉冲直流电流，其将皮肤转变成更高的电输送输送效率状态。
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公开(公告)号：US06544252B1
公开(公告)日：2003-04-08
申请号：US09472600
申请日：1999-12-27
申请人： Felix Theeuwes , Ben Eckenhoff
发明人： Felix Theeuwes , Ben Eckenhoff
IPC分类号： A61K922
CPC分类号： A61K9/0004
摘要： An osmotic delivery system having a space efficient piston. The capsule has an interior holding the piston, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The moveable seal separates the osmotic agent from the beneficial agent. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.
摘要翻译： 具有空间高效活塞的渗透输送系统。 胶囊具有保持活塞的内部，有益剂和渗透剂。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封件将渗透剂与有益剂分离。 活塞具有容纳渗透剂的至少一部分的凹部。 渗透剂通过半透水体吸收来自周围环境的液体，引起活塞移动，从而导致有益剂从胶囊的输送。
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公开(公告)号：US06368315B1
公开(公告)日：2002-04-09
申请号：US09339465
申请日：1999-06-23
申请人： Edward M. Gillis , Felix Theeuwes
发明人： Edward M. Gillis , Felix Theeuwes
IPC分类号： A61M2500
CPC分类号： A61M25/0026 , A61M25/0032 , A61M2025/0036 , A61M2025/0056 , A61M2025/0063
摘要： The present invention features a composite catheter comprising an elongate outer member and an elongate inner member positioned within the outer member so that the inner and outer members define an interstitial space. The outer member has a size and other characteristics that facilitate handling and implantation of the composite catheter, while the inner diameter of the inner member has the size and other characteristics suitable for delivery of a drug through a lumen of the inner member. The interstitial space imparts flexibility to the composite catheter by, for example, removing material from the cross-sectional area that would otherwise provide additional stiffness to the catheter, and/or by accommodating movement of the outer member relative to the inner member.
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118.发明授权公开(公告)号：US06289242B1
公开(公告)日：2001-09-11
申请号：US09335283
申请日：1999-06-16
IPC分类号： A61N130
CPC分类号： A61N1/0448 , A61N1/0444 , Y10S977/949
摘要： An electrotransport apparatus using dispersed ion exchange material (19,83) is disclosed. The ion exchange material (19,83) may be dispersed in either the donor electrode assembly (10), the counter electrode assembly (10) or both electrode assemblies. The dispersed ion exchange material (83) comprises mobile ionic species (84-2) and substantially immobile ionic species (P). The dispersed ion exchange material (83, 84-2) interacts with competitive species (86) generated during electrotransport to render those species substantially immobile (87). Electrotransport devices exhibiting reduced polarization are also disclosed.
摘要翻译： 公开了一种使用分散离子交换材料（19,83）的电转运装置。 离子交换材料（19,83）可以分散在供体电极组件（10），对电极组件（10）或两个电极组件中。 分散的离子交换材料（83）包括移动离子物质（84-2）和基本上不可移动的离子物质（P）。 分散的离子交换材料（83,84-2）与在电输运期间产生的竞争物种（86）相互作用以使这些物质基本上不可移动（87）。 还公开了表现出减小的极化的电子传输器件。
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公开(公告)号：US5320598A
公开(公告)日：1994-06-14
申请号：US881953
申请日：1992-05-12
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/044
摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).
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公开(公告)号：US5298017A
公开(公告)日：1994-03-29
申请号：US998154
申请日：1992-12-29
申请人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
发明人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： An iontophoretic agent delivery device, having a layered structure and peripheral insulation, wherein ion transport occurs through two opposing surfaces of said device. The device is especially suited to agent delivery through body surfaces exposed to body fluids. A method of delivering an agent through a body surface exposed to body fluids is also disclosed.
摘要翻译： 一种具有分层结构和外围绝缘的离子电渗疗剂输送装置，其中通过所述装置的两个相对的表面进行离子转运。 该装置特别适用于通过暴露于体液的身体表面的药剂递送。 还公开了通过暴露于体液的身体表面递送药剂的方法。
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