中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

342 records (took 0.044 seconds)

    2-AMINOPYRIDINE KINASE INHIBITORS
    113.
    发明申请
    2-AMINOPYRIDINE KINASE INHIBITORS 失效
    2-氨基吡啶激酶抑制剂

    公开(公告)号：US20090197862A1

    公开(公告)日：2009-08-06

    申请号：US12365325

    申请日：2009-02-04

    Applicant: Arno G. Steinig ,  Mark J. Mulvihill ,  Jing Wang ,  Douglas S. Werner ,  Qinghua Weng ,  Julie Kan ,  Heather Coate ,  Xin Chen

    Inventor： Arno G. Steinig ,  Mark J. Mulvihill ,  Jing Wang ,  Douglas S. Werner ,  Qinghua Weng ,  Julie Kan ,  Heather Coate ,  Xin Chen

    IPC: A61K31/4439 ,  C07D401/14 ,  C07D417/14 ,  C07D451/02 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/4545

    CPC classification number: C07D417/14 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D451/04

    Abstract: 2-Aminopyridine compounds having the structure of Formula I, and pharmaceutically acceptable salts of these compounds. Compounds of Formula I inhibit the activity of tyrosine kinase enzymes in animals, including humans, and are useful in the treatment and/or prevention of various diseases and conditions. In particular, compounds disclosed herein are inhibitors of kinases, in particular, but not limited to, KDR, Tie-2, Flt3, FGFR3, Ab1, Aurora A, c-Src, IGF-1R, ALK, c-MET, RON, PAK1, PAK2, and TAK1, and can be used in the treatment of proliferative diseases, such as, but not limited to, cancer. The present invention is also directed to a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The present invention is further directed to a method of treating a patient having a condition which is mediated by protein kinase activity by administering to the patient a therapeutically effective amount of the above-mentioned pharmaceutical composition.

    Abstract translation: 具有式I结构的2-氨基吡啶化合物和这些化合物的药学上可接受的盐。 式I的化合物抑制动物（包括人）中酪氨酸激酶的活性，并且可用于治疗和/或预防各种疾病和病症。 特别地，本文公开的化合物是激酶抑制剂，特别是但不限于KDR，Tie-2，Flt3，FGFR3，Ab1，Aurora A，c-Src，IGF-1R，ALK，c-MET，RON， PAK1，PAK2和TAK1，并且可用于治疗增殖性疾病，例如但不限于癌症。 本发明还涉及包含治疗有效量的式I化合物或其药学上可接受的盐和药学上可接受的载体的药物组合物。 本发明还涉及通过向患者施用治疗有效量的上述药物组合物来治疗具有由蛋白激酶活性介导的病症的患者的方法。

    System and method for revealing occluded objects in an image dataset
    114.
    发明申请
    System and method for revealing occluded objects in an image dataset 有权
    用于显示图像数据集中的遮挡对象的系统和方法

    公开(公告)号：US20090110239A1

    公开(公告)日：2009-04-30

    申请号：US11980033

    申请日：2007-10-30

    Applicant: Xin Chen ,  William Gale

    Inventor： Xin Chen ,  William Gale

    IPC: G06K9/00 ,  G06K9/36

    CPC classification number: G06T11/001 ,  G06T15/205

    Abstract: Disclosed are a system and method for identifying objects in an image dataset that occlude other objects and for transforming the image dataset to reveal the occluded objects. In some cases, occluding objects are identified by processing the image dataset to determine the relative positions of visual objects. Occluded objects are then revealed by removing the occluding objects from the image dataset or by otherwise de-emphasizing the occluding objects so that the occluded objects are seen behind it. A visual object may be removed simply because it occludes another object, because of privacy concerns, or because it is transient. When an object is removed or de-emphasized, the objects that were behind it may need to be “cleaned up” so that they show up well. To do this, information from multiple images can be processed using interpolation techniques. The image dataset can be further transformed by adding objects to the images.

    Abstract translation: 公开了一种用于识别封闭其他对象的图像数据集中的对象并用于变换图像数据集以显露遮挡对象的系统和方法。 在某些情况下，通过处理图像数据集以确定可视对象的相对位置来识别遮挡对象。 然后通过从图像数据集中移除遮挡物体或通过其他方式去除遮挡物体来遮蔽遮挡物体，以便在其后面看到遮挡的物体。 视觉对象可能被删除，因为它隐藏另一个对象，因为隐私问题，或因为它是暂时的。 当对象被删除或去除强调时，其后面的对象可能需要“清理”，以使它们显示得很好。 为此，可以使用插值技术来处理来自多个图像的信息。 通过向图像中添加对象可以进一步转换图像数据集。

    Optical fiber with large effective area
    115.
    发明申请
    Optical fiber with large effective area 失效
    光纤有效面积大

    公开(公告)号：US20080304800A1

    公开(公告)日：2008-12-11

    申请号：US12070845

    申请日：2008-02-21

    Applicant: Scott Robertson Bickham ,  Dana Craig Bookbinder ,  Xin Chen ,  Ming-Jun Li ,  Snigdharaj Kumar Mishra ,  Daniel Aloysius Nolan ,  Pushkar Tandon

    Inventor： Scott Robertson Bickham ,  Dana Craig Bookbinder ,  Xin Chen ,  Ming-Jun Li ,  Snigdharaj Kumar Mishra ,  Daniel Aloysius Nolan ,  Pushkar Tandon

    IPC: G02B6/02

    CPC classification number: G02B6/02014 ,  G02B6/02019 ,  G02B6/02357 ,  G02B6/02366 ,  G02B6/0365 ,  G02B6/03661 ,  G02B6/03688

    Abstract: An optical fiber comprising: a glass core extending from a centerline to a radius R1; a glass cladding surrounding and in contact with the core, the cladding comprising:a first annular region extending from R1 to a radius R2, the first annular region comprising a radial width, W2=R2−R1, a second annular region extending from R2 to a radius R3, the second annular region comprising a radial width, W3=R3−R2, and a third annular region extending from R3 to an outermost glass radius R4; wherein (i) the core comprises a maximum relative refractive index, Δ1MAX, relative to the third annular region; (ii) wherein the first annular region comprises a radial width W2; and (iii) the second annular region comprises a minimum relative refractive index, Δ3MIN, relative to the third annular region wherein Δ1MAX>Δ2MAX>Δ3MIN, and Δ2MIN>Δ3MIN; and the core and the cladding provide a fiber with cable cutoff less than 1500 nm, dispersion at 1550 nm less than 12 ps/nm/km, effective area at 1550 nm greater than 60 μm2, and preferably greater than 70 μm2. The second annular cladding region may contain a plurality of randomly dispersed holes.

    Abstract translation: 一种光纤，包括：从中心线延伸到半径R1的玻璃芯; 围绕并与芯接触的玻璃包层，所述包层包括：从R1延伸到半径R2的第一环形区域，所述第一环形区域包括径向宽度W2 = R2-R1，从R2延伸到第二环形区域 半径R3，第二环形区域包括径向宽度，W3 = R3-R2，以及从R3延伸到最外侧玻璃半径R4的第三环状区域; 其中（i）所述芯包括相对于所述第三环形区域的最大相对折射率Delta1MAX; （ii）其中所述第一环形区域包括径向宽度W2; 和（iii）第二环形区域包括相对于第三环形区域的最小相对折射率Delta3MIN，其中Delta1MAX> Delta2MAX> Delta3MIN和Delta2MIN> Delta3MIN; 并且芯和包层提供具有小于1500nm的电缆截止的光纤，在1550nm处的色散小于12ps / nm / km，在1550nm处的有效面积大于60mum2，优选大于70mum2。 第二环形包层区域可以包含多个随机分布的孔。

    Large effective area fiber
    116.
    发明申请
    Large effective area fiber 有权
    大面积纤维有效面积

    公开(公告)号：US20080279517A1

    公开(公告)日：2008-11-13

    申请号：US12151171

    申请日：2008-05-05

    Applicant: Scott Robertson Bickham ,  Dana Craig Bookbinder ,  Xin Chen ,  Ming-Jun Li ,  Snigdharaj Kumar Mishra ,  Daniel Aloysius Nolan

    Inventor： Scott Robertson Bickham ,  Dana Craig Bookbinder ,  Xin Chen ,  Ming-Jun Li ,  Snigdharaj Kumar Mishra ,  Daniel Aloysius Nolan

    IPC: G02B6/028

    CPC classification number: G02B6/0365 ,  G02B6/02019

    Abstract: An optical fiber according to an embodiment of the present invention comprises: a glass core extending from a centerline to a radius R1 wherein R1 is greater than about 5 μm; a glass cladding surrounding and in contact with the core, the cladding comprising: (i) a first annular region extending from the radius R1 to a radius R2, the first annular region comprising a radial width, W2=R2−R1, (ii) a second annular region extending from the radius R2 to a radius R3, and comprising a radial width, W3=R3−R2, and (iii) a third annular region surrounding the second annular region and extending from the radius R3 to an outermost glass radius R4; wherein the core comprises a maximum relative refractive index, Δ1MAX, relative to the third annular region, and wherein Δ1MAX is greater than about 0.1% and less than about 0.3%; the first annular region has a refractive index delta Δ2(r) is less than about 0.025%; wherein the second annular region comprises a minimum relative refractive index, Δ3MIN, relative to the third annular region;wherein Δ1MAX>Δ2MAX>Δ3MIN, and Δ2MIN>Δ3MIN

    Abstract translation: 根据本发明实施例的光纤包括：从中心线延伸到半径R 1的玻璃芯，其中R 1>大于5μm; 围绕并与芯接触的玻璃包层，所述包层包括：（i）从半径R 1> 1半径R 2> 2延伸的第一环形区域，第一 包括径向宽度的第二环形区域，（ii）从半径R < SUB> 2 到半径R 3 3，并且包括径向宽度，W 3 3 = R 3→N < 2，和（iii）围绕第二环形区域并从半径R 3 3延伸到最外侧玻璃半径R 4的第三环形区域; 其中所述芯包括相对于所述第三环形区域的最大相对折射率，Δ1MAX1，并且其中Δ1MAX1大于约0.1％且小于约0.3％ ; 第一环形区域具有小于约0.025％的折射率差ΔΔ2（r）; 其中所述第二环形区域包括相对于所述第三环形区域的最小相对折射率，Δ3 NIN; 其中Delta 1MAX 增量2MAX 三角洲3MIN和三角洲2MIN 三角洲3IN > <0; 并且其中所述芯和所述包层提供具有小于1500nm的电缆截止的光纤，并且在1550nm处的有效面积大于95μm2，并且在20℃下的弯曲损耗为<= 0.5dB / mm直径心轴。

Patent Agency Ranking