公开(公告)号：US20090293581A1

公开(公告)日：2009-12-03

申请号：US12455119

申请日：2009-05-28

Applicant: Charles Michael Nadin ,  David Cook

Inventor： Charles Michael Nadin ,  David Cook

IPC: G01D18/00 ,  G01M3/04 ,  H01J49/26

CPC classification number: G01F1/74 ,  G01F1/704 ,  G01M3/28 ,  G01M3/30

Abstract: A method of measuring the gas flow of an incondensable gas in a flowing mixture of said incondensable gas and a condensable gas comprising the steps of calibrating a leak detector; injecting a known quantity of gauge gas at a known mass flow rate into said flowing mixture of gases; drawing a sample of the said gauge mix off at a sample point; passing said sample through a condenser so as to remove said condensable gas from the gauge mix, resulting in a test mix; passing the said test mix into the leak detector so as to measure the concentration of the gauge gas within the test mix; and calculating the mass flow rate of said incondensable gas within said flowing mixture. There is also provided a method of measuring the rate of ingress of an incondensable gas at an ingress point along a flow path of a flowing mixture of said incondensable gas and a condensable gas.

Abstract translation: 一种测量所述不可冷凝气体和可冷凝气体的流动混合物中的不可冷凝气体的气体流量的方法，包括校准泄漏检测器的步骤; 将已知量的气体以已知的质量流速注入所述流动的气体混合物中; 在样品点处抽出所述量规混合物的样品; 使所述样品通过冷凝器，以从所述量规混合器中除去所述可冷凝气体，得到测试混合物; 将所述测试混合物通入泄漏检测器中，以测量测试混合物内的气体浓度; 以及计算所述流动混合物内的所述不可冷凝气体的质量流量。 还提供了一种测量沿着所述不可冷凝气体和可冷凝气体的流动混合物的流动路径的入口处的不可冷凝气体的进入速率的方法。

公开(公告)号：US20090012026A1

公开(公告)日：2009-01-08

申请号：US12067667

申请日：2006-09-20

Applicant: Ian David Cook ,  Angela Flannery ,  Rose Maciewicz

Inventor： Ian David Cook ,  Angela Flannery ,  Rose Maciewicz

IPC: A61K31/7105 ,  C12Q1/68 ,  G01N33/53 ,  A61P19/00 ,  G01N33/00 ,  C12Q1/02

CPC classification number: C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6872 ,  G01N2500/00 ,  G01N2800/105

Abstract: The present invention arises from the identification of an association between the TDOA gene and osteoarthritis (OA). It therefore relates to diagnostic techniques for determining a patient's susceptibility to develop OA by detecting all or part of the TDOA gene, its precursors or products (mRNA, cDNA, genomic DNA, or protein). In particular, the invention relates to methods and materials for analysing allelic variation in the TDOA gene, and to the use of TDOA polymorphisms in the identification of an individuals' risk to develop OA. The TDOA protein has been found to bind to α-paxillin, a protein involved in integrin signal transduction which itself is a process with strong links to OA. The invention is thus also directed to methods for identifying modulators of OA, which modulate the TDOA gene or interfere with TDOA:α-paxillin binding.

Abstract translation: 本发明来源于鉴定TDOA基因与骨关节炎（OA）之间的关联。 因此，它涉及通过检测全部或部分TDOA基因，其前体或产物（mRNA，cDNA，基因组DNA或蛋白质）来确定患者开发OA的易感性的诊断技术。 特别地，本发明涉及用于分析TDOA基因中的等位基因变异的方法和材料，以及用于鉴定个体发展OA的风险的TDOA多态性。 已经发现TDOA蛋白与α-桩蛋白结合，这是涉及整联蛋白信号转导的蛋白质，其本身是具有与OA的强连接的过程。 因此，本发明还涉及用于鉴定调节TDOA基因或干扰TDOA：α-桩蛋白结合的OA调节剂的方法。

公开(公告)号：US20080250655A1

公开(公告)日：2008-10-16

申请号：US12082963

申请日：2008-04-14

Applicant: David Cook

Inventor： David Cook

IPC: B25G1/00 ,  A47F7/00

CPC classification number: A47G21/14 ,  B25G1/10 ,  B25H3/04

Abstract: A knife includes a blade, and a handle. The handle includes a first wire form that is substantially U-shaped and is attached at only one end of the first wire form to the blade, and also includes a second wire form that is attached at only one end of the second wire form to the blade. The first wire form and the second wire form are substantially parallel elements of the single handle.

Abstract translation: 刀包括刀片和手柄。 手柄包括基本上U形的第一线形，并且仅在第一线形的一端附接到叶片，并且还包括第二线形，其仅在第二线形的一端附接到 刀。 第一线形式和第二线形式是单个手柄的基本上平行的元件。

公开(公告)号：US20080134956A1

公开(公告)日：2008-06-12

申请号：US11636790

申请日：2006-12-11

Applicant: David Cook ,  Steve Tononi ,  Jagadeesh Krishnamurthy ,  Chris Arms

Inventor： David Cook ,  Steve Tononi ,  Jagadeesh Krishnamurthy ,  Chris Arms

IPC: G01D11/28

CPC classification number: G01D11/28 ,  G01D13/265 ,  Y10S116/05

Abstract: A gauge has a face plate which includes indicia thereon to indicate specific values of a parameter. A laser system is disposed behind and/or in front of the face plate to project a beam onto the face plate to indicate the value of a parameter. A stepper motor moves the beam based upon the output of a sensor which monitors the parameter.

公开(公告)号：US20080022703A1

公开(公告)日：2008-01-31

申请号：US11495281

申请日：2006-07-28

Applicant: David Cook ,  Ramesh Janardhanam ,  Natarajan Venkatakrishnan

Inventor： David Cook ,  Ramesh Janardhanam ,  Natarajan Venkatakrishnan

IPC: F25C1/00 ,  F25D17/04 ,  F25C5/18

CPC classification number: F25C1/04 ,  F25B2600/112 ,  F25C2400/10 ,  F25C2600/04

Abstract: A refrigerator includes a housing defining a freezer storage compartment, an evaporator operatively coupled to the freezer storage compartment and configured to cool the freezer storage compartment, and an evaporator fan positioned to move air across the evaporator. The refrigerator also includes an ice maker positioned within the freezer storage compartment, a dispenser in flow communication with the ice maker and configured to dispense ice, and a control system configured to receive a signal from said dispenser indicating dispensing of a first amount of ice from the dispenser, the control system configured to activate the evaporator fan in response to the signal, the evaporator fan operating continuously for a time period upon activation.

Abstract translation: 冰箱包括限定冷冻库储存室的壳体，可操作地联接到冷冻库储存室并构造成冷却冷藏库储存室的蒸发器和定位成使空气移动通过蒸发器的蒸发器风扇。 冰箱还包括位于冷藏库储存室内的制冰机，与制冰机流体连通并配置成分配冰的分配器，以及配置成从所述分配器接收来自所述分配器的信号的控制系统，其指示从第 所述分配器，所述控制系统被配置为响应于所述信号而激活所述蒸发器风扇，所述蒸发器风扇在激活时持续一段时间。

公开(公告)号：US07307055B2

公开(公告)日：2007-12-11

申请号：US10501177

申请日：2003-01-16

Applicant: Andrew David Cook ,  Edward Mathew Cooney ,  Michael Vincent Monticello

Inventor： Andrew David Cook ,  Edward Mathew Cooney ,  Michael Vincent Monticello

IPC: C11D17/04 ,  C11D1/83 ,  B08B1/00

CPC classification number: A47L17/08 ,  A47L13/17 ,  C11D1/143 ,  C11D1/72 ,  C11D1/83 ,  C11D3/14 ,  C11D3/222 ,  C11D17/049

Abstract: Disclosed herein is a cleaning article as an article of manufacture which includes a substrate onto which a cleaning composition is partially impregnated, leaving a portion of the substrate not impregnated with the composition. The impregnated part or side of the substrate is used to clean surfaces, especially vitro-ceramic surfaces while the unimpregnated part or side of the substrate is then used to dry and buff the cleaned surface.

Abstract translation: 本文公开了作为制品的清洁制品，其包括其上部分浸渍有清洁组合物的基底，使基底的一部分未浸渍该组合物。 衬底的浸渍部分或侧面用于清洁表面，特别是体外陶瓷表面，同时衬底的未浸渍部分或侧面用于干燥和抛光清洁表面。

公开(公告)号：US20070275152A1

公开(公告)日：2007-11-29

申请号：US10574975

申请日：2004-10-05

Applicant: David Cook ,  Mark Newcomb ,  Michael Beaver

Inventor： David Cook ,  Mark Newcomb ,  Michael Beaver

IPC: A23L1/20

CPC classification number: A23K20/121 ,  A23K10/30

Abstract: The present disclosure describes a certain isoflavone-enhanced domestic animal feed compositions and methods of producing such feed compositions. In one particular implementation, a feed composition includes a soy meal that is no more than about 20 weight percent of the feed composition. This soy meal has a soy isoflavone content that provides the feed composition with a soy isoflavone concentration, normalized to an aglycone content of about 250-1400 parts per million on a weight basis (ppm), e.g., about 800-1200 ppm. Feed compositions in certain adaptations have demonstrated some advantages over feeds with lower isoflavone content.

Abstract translation: 本公开描述了某种异黄酮增强的家畜饲料组合物和生产这种饲料组合物的方法。 在一个具体实施方案中，饲料组合物包括不超过饲料组合物约20重量％的大豆粉。 该大豆粉具有大豆异黄酮含量，其为饲料组合物提供大豆异黄酮浓度，其标准化为基于重量（ppm）的约250-1400ppm（例如约800-1200ppm）的糖苷配基含量。 某些适应性的饲料组合物已经显示出具有较低异黄酮含量的饲料的一些优点。

公开(公告)号：US20070251129A1

公开(公告)日：2007-11-01

申请号：US11786825

申请日：2007-04-13

Applicant: David Cook ,  Ben Covell

Inventor： David Cook ,  Ben Covell

IPC: E02F1/00

CPC classification number: E02F9/2203 ,  B66F9/0655 ,  B66F9/22 ,  E02F9/2207 ,  E02F9/2217 ,  E02F9/2221

Abstract: A method of operating a hydraulic system of a loader arm carrying a working implement, the system having a ride improvement system and a selection valve connected to first and second chambers of a ram which operates the loader arm. A check valve assembly is provided, with the check valve assembly being responsive to pressure changes in the second chamber. The check valve assembly, when closed, prevents fluid from passing between the first chamber to the selection valve. Means are provided communicating the fluid pressure in the second chamber to the check valve, with the means responsive to pressure changes in the second chamber to open the check valve. The selection valve is operable to raise the loader arm with the system arranged to permit passage of fluid between the first chamber and the accumulator while permitting fluid to pass from the second chamber to a low pressure region.

公开(公告)号：US07175134B2

公开(公告)日：2007-02-13

申请号：US10994930

申请日：2004-11-22

Applicant: Dayu Hsu ,  William David Cook

Inventor： Dayu Hsu ,  William David Cook

IPC: B64C25/00

CPC classification number: B64C25/505

Abstract: A hydraulic system for steering an aircraft while taxiing selectively applies pressurized fluid to different ports of a hydraulic motor to turn a landing gear wheel either left or right. Shimmy of the landing gear attached to the wheel is dampened by a device that is coupled across the hydraulic lines that are connected to the motor. That device has a piston in a bore with one hydraulic line connected via an orifice to a first chamber on one side of the piston and the other hydraulic line connected via a different orifice to a second chamber on the other side of the piston. The piston stroke is limited to control the effective oscillation damping amplitude. The shimmy produces an oscillating pressure differential in the two hydraulic lines which is dampened by the device.

Abstract translation: 用于在滑行时转向飞行器的液压系统选择性地将加压流体施加到液压马达的不同端口，以使起落架左或右转动。 连接在车轮上的起落架的垫片被连接在与马达连接的液压管路上的装置所吸收。 该装置在孔中具有活塞，其中一个液压管路经由孔口连接到活塞一侧上的第一室，而另一个液压管线通过不同的孔口连接到活塞另一侧上的第二室。 活塞行程受限于控制有效振荡阻尼振幅。 振动在两个液压管路中产生振荡压差，这两个液压管路被设备遏制。

公开(公告)号：US20070031457A1

公开(公告)日：2007-02-08

申请号：US11173770

申请日：2005-06-30

Applicant: Thomas Dubensky ,  Daniel Portnoy ,  Richard Calendar ,  John Hearst ,  David Cook

Inventor： Thomas Dubensky ,  Daniel Portnoy ,  Richard Calendar ,  John Hearst ,  David Cook

IPC: A61K39/07 ,  C12N1/21

CPC classification number: A61K39/07 ,  A61K2039/522 ,  C12N1/36 ,  C12N9/00 ,  C12N9/14

Abstract: A variety of modified Bacillus anthracis bacteria useful in vaccines are provided. For instance, asporogenic strains of Bacillus anthracis are provided. In addition, Bacillus anthracis strains attenuated in their ability to repair their nucleic acid, such as in their nucleic acid excision repair ability or recombination repair ability, are provided. Strains expressing an antigen, such as protective antigen, under the control of a heterologous promoter and/or an inducible promoter are also provided. Bacillus anthracis bacteria comprising mutations in toxin genes are further provided. Vaccine compositions comprising the bacteria, methods of making the modified strains, and methods of using the vaccines are also provided.

Abstract translation: 提供了用于疫苗的各种改良的炭疽芽孢杆菌。 例如，提供了炭疽芽孢杆菌的异源菌株。 此外，提供了在其核酸修复能力或重组修复能力方面减弱其核酸修复能力的炭疽杆菌菌株。 还提供了在异源启动子和/或诱导型启动子控制下表达抗原（例如保护性抗原）的菌株。 还提供了包含毒素基因突变的炭疽芽孢杆菌。 还提供了包含细菌的疫苗组合物，制备修饰菌株的方法和使用疫苗的方法。