公开(公告)号：US20050271601A1

公开(公告)日：2005-12-08

申请号：US10859264

申请日：2004-06-02

Applicant: Nebojsa Milanovich ,  Abdul Gaffar ,  Michael Prencipe ,  Thomas Boyd

Inventor： Nebojsa Milanovich ,  Abdul Gaffar ,  Michael Prencipe ,  Thomas Boyd

IPC: A61K8/33 ,  A61K8/81 ,  A61Q11/00 ,  A61K9/16 ,  A61K9/50

CPC classification number: A61K8/33 ,  A61K8/81 ,  A61K8/8164 ,  A61K2800/52 ,  A61Q11/00

Abstract: An anti-staining, antibacterial dentifrice comprises an anti-staining effective amount of an orally acceptable polymer or copolymer that comprises a plurality of monomeric groups of formula (I) wherein (a) one of A and A′ is hydrogen and the other is a moiety (X)n(R)m, (b) n in individual such moieties is independently 0 or 1, (c) linking groups X if present independently comprise an oxygen, sulfur, nitrogen, phosphorus or silicon atom, (d) where n is 0, m is 1, and where n is 1, m is independently an integer from 1 to 3 as determined by X, (e) terminal groups R are independently hydrogen or C1-18 organic radicals, and (f) M and M′ are independently selected from hydrogen, alkali metal and ammonium; said polymer or copolymer having an average molecular weight of at least about 1,000. The dentifrice further comprises an antibacterial effective amount of an orally acceptable halogenated diphenylether antibacterial agent, and an antibacterial enhancing effective amount of an orally acceptable polyvinylmethylether/maleic anhydride copolymer.

Abstract translation: 抗污染的抗菌洁齿剂包括抗染色有效量的口服可接受的聚合物或共聚物，其包含多个式（I）的单体基团，其中（a）A和A'之一是氢，另一个是 部分（X）单独的这些部分中的（b）n独立地为0或1，（c）连接基团X（如果存在）独立地包含氧 ，硫，氮，磷或硅原子，（d）其中n为0，m为1，n为1，m为独立地为1至3的整数，（e）端基R独立地为 氢或C 1-18个有机基团，和（f）M和M'独立地选自氢，碱金属和铵; 所述聚合物或共聚物的平均分子量至少约为1,000。 洁齿剂还包含抗菌有效量的口服可接受的卤化二苯醚抗菌剂，以及抗菌增强有效量的口服可接受的聚乙烯基甲基醚/马来酸酐共聚物。

公开(公告)号：US20050214720A1

公开(公告)日：2005-09-29

申请号：US10811724

申请日：2004-03-29

Applicant: Nebojsa Milanovich ,  Ryan Cameron ,  John Curtis ,  Ravi Subramanyam ,  Michael Prencipe

Inventor： Nebojsa Milanovich ,  Ryan Cameron ,  John Curtis ,  Ravi Subramanyam ,  Michael Prencipe

IPC: A61K8/22 ,  A61Q11/00 ,  A61C5/00

CPC classification number: A61K8/22 ,  A61K2800/88 ,  A61Q11/00

Abstract: A method for whitening a dental surface comprises nonsimultaneously applying a whitening composition to the surface, the whitening composition comprising at least one orally acceptable peroxy compound, and directing a volume of up to about 2.5 ml of an atomized activating composition on to the surface, wherein the activating composition comprises, in the volume so directed, a peroxy compound activating effective amount of at least one orally acceptable basifying agent, and wherein applying the whitening composition and directing the activating composition are separated by an interval not greater than a peroxy compound activating effective interval. The atomized composition can be directed on to the dental surface before or after application of the whitening composition.

Abstract translation: 美白牙齿表面的方法包括将美白组合物同时施用于表面，美白组合物包含至少一种口服可接受的过氧化合物，并将一定体积的至多约2.5ml雾化的活化组合物引导至表面，其中 活化组合物包括在如此定向的体积中活化有效量的至少一种口服可接受的碱化剂的过氧化合物，并且其中施用所述增白组合物并引导所述活化组合物以不大于过氧化合物活化的有效间隔 间隔。 雾化组合物可以在施用美白组合物之前或之后被引导到牙齿表面。

公开(公告)号：US20050175956A1

公开(公告)日：2005-08-11

申请号：US10776554

申请日：2004-02-11

Applicant: Bruce Russell ,  Diego Hoic ,  Michael Prencipe

Inventor： Bruce Russell ,  Diego Hoic ,  Michael Prencipe

IPC: A61B5/00 ,  A61C3/00 ,  A61C5/00

CPC classification number: A61B5/0088 ,  A61C19/066

Abstract: A toothpaste formulation contains an oxidizing agent as a whitening ingredient. The activation of the oxidizing agent occurs through the use of a toothbrush having a source of light energy which includes LED's in the bristle field of the toothbrush. The toothbrush could be a manual toothbrush or a powered toothbrush.

Abstract translation: 牙膏制剂含有氧化剂作为增白成分。 通过使用具有光能源的牙刷将氧化剂的活化发生，该牙刷包括位于牙刷刷毛区域中的LED。 牙刷可以是手动牙刷或动力牙刷。

公开(公告)号：US20050036957A1

公开(公告)日：2005-02-17

申请号：US10754065

申请日：2004-01-07

Applicant: Michael Prencipe ,  Suman Chopra ,  Michael Collins

Inventor： Michael Prencipe ,  Suman Chopra ,  Michael Collins

IPC: A61C19/06 ,  A61K8/22 ,  A61K8/81 ,  A61K8/891 ,  A61Q11/00 ,  A61K7/20

CPC classification number: A61C19/066 ,  A61K8/18 ,  A61K8/22 ,  A61K8/8176 ,  A61K8/891 ,  A61Q11/00

Abstract: A dental tray with a hydrophobic tooth whitening formulation where the tooth whitening formulation is substantially non-water soluble, and a method of using this dental tray to whiten the teeth. The tooth whitening formulation is primarily comprised of a hydrophobic polymer and a peroxide or a peroxide yielding compound. Preferably the hydrophobic polymer is the condensation product of a silicone resin and an organosiloxane. The dental tray is formed to encompass the front and the rear surfaces of the teeth. The dental tray is comprised of a thermoplastic or thermoset polymer. The teeth whitening formulation is placed into the dental tray and the tray placed against the teeth to be whitened. This is for a sufficient period of time to at least partially whiten teeth. This can be a period of time from about 0.5 hour to 2 hours or more. The substantially non-aqueous tooth whitening formulation is effective over a longer period of time since it is not significantly diluted or removed from the dental tray during the treatment time.

Abstract translation: 具有疏水牙齿美白配方的牙科托盘，其中牙齿美白配方基本上是非水溶性的，以及使用该牙科托盘来使牙齿变白的方法。 牙齿美白制剂主要由疏水性聚合物和过氧化物或产生过氧化物的化合物组成。 优选地，疏水性聚合物是有机硅树脂和有机硅氧烷的缩合产物。 牙托被形成为包围牙齿的前表面和后表面。 牙科托盘由热塑性或热固性聚合物组成。 将牙齿美白配制剂放入牙托中，并将放置在牙齿上的托盘白化。 这是足够的时间来至少部分地美白牙齿。 这可以是约0.5小时至2小时或更长时间。 基本上非水性牙齿美白制剂在较长时间内是有效的，因为在治疗时间内没有显着稀释或从牙盘中除去。

公开(公告)号：US06315986B1

公开(公告)日：2001-11-13

申请号：US08854504

申请日：1997-05-12

Applicant: Michael Wong ,  Michael Prencipe ,  Jeffrey M. Miller ,  Claude L. Benz

Inventor： Michael Wong ,  Michael Prencipe ,  Jeffrey M. Miller ,  Claude L. Benz

IPC: A61K716

CPC classification number: A61Q11/00 ,  A61K8/02 ,  A61K8/0237

Abstract: A striped dentifrice stable to color bleeding, wherein at least one dentifrice component contains a colorant entrained in a matrix of synthetic wax particles having a melting point range as measured by DSC is between about 40° C. and about 135° C. and the peak endotherm temperature is at least about 65° C., whereby on storage no off-taste is detected in the dentifrice nor is there any observable colorant bleeding into any other dentifrice component.

Abstract translation: 对颜色渗色稳定的条纹洁齿剂，其中至少一种洁齿剂组分含有夹带在通过DSC测量的熔点范围的合成蜡颗粒的基质中的着色剂在约40℃至约135℃之间，峰值 吸热温度为至少约65℃，由此在保存时，在洁牙剂中没有检测到异味，也没有任何可观察到的着色剂渗透到任何其它洁齿剂组分中。

公开(公告)号：US5756073A

公开(公告)日：1998-05-26

申请号：US747690

申请日：1996-11-12

Applicant: Jeffrey M. Miller ,  Mike Wong ,  Michael Prencipe ,  Richard J. Crawford

Inventor： Jeffrey M. Miller ,  Mike Wong ,  Michael Prencipe ,  Richard J. Crawford

IPC: A61K8/02 ,  A61K9/50 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/20

CPC classification number: A61Q11/00 ,  A61K8/02 ,  A61K8/0237

Abstract: A striped dentrifrice stable color bleeding, wherein at least one component contains a colorant entrained in the matrix of substantially non-fracturable, partially cross-linked melamine-urea-formaldehyde condensation polymer particles, whereby on storage the colorant does not bleed any color into any other dentifrice component. The dentifrice may also contain a formaldehyde scavenger to bind-up any formaldehyde released from the particles.

Abstract translation: 条纹牙齿稳定的颜色渗色，其中至少一种成分含有夹带在基本上不可断裂的部分交联的三聚氰胺 - 脲 - 甲醛缩聚物颗粒的基质中，由此在存储时，着色剂不会将任何颜色排放到任何 其他洁齿剂组分。 洁牙剂还可以含有甲醛清除剂，以粘合从颗粒释放的任何甲醛。

公开(公告)号：US5730959A

公开(公告)日：1998-03-24

申请号：US790348

申请日：1997-01-24

Applicant: Michael Prencipe ,  Michael A. Collins

Inventor： Michael Prencipe ,  Michael A. Collins

IPC: A61K8/24 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18 ,  A61K7/20

CPC classification number: A61K8/24 ,  A61Q11/00

Abstract: A storage stable aqueous oral composition which is effective against calculus which contains an orally acceptable vehicle having incorporated therein from about 10% to up to about 15% by weight water, an effective anticalculus combination of about 0.5 to about 2% by weight of a water soluble pyrophosphate salt and about 0.5 to about 3% by weight of a water soluble polyphosphate salt. The presence in the composition of relatively high amounts of water affect the stability of the composition.

Abstract translation: 一种储存稳定的含水口服组合物，其对于结石是有效的，其含有约10％至至多约15％重量的水掺入其中的口服可接受的载体，约0.5至约2％重量的水的有效抗结石组合 可溶性焦磷酸盐和约0.5至约3重量％的水溶性多磷酸盐。 在组合物中存在相当大量的水会影响组合物的稳定性。

公开(公告)号：US5698182A

公开(公告)日：1997-12-16

申请号：US735163

申请日：1996-10-22

Applicant: Michael Prencipe ,  James G. Masters ,  Vincent O. Drago

Inventor： Michael Prencipe ,  James G. Masters ,  Vincent O. Drago

IPC: A61K8/24 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/20

CPC classification number: A61K8/24 ,  A61Q11/00

Abstract: A method for inhibiting dental calculus concomitant with tooth whitening is disclosed wherein there is applied to the teeth an oral composition containing in a vehicle an amount of a anticalculus phosphate salt and an amount of calcium peroxide effective to whiten teeth, the vehicle containing about 4 to about 9% by weight water and an amount of calcined alumina effective to heighten the whitening effect of the CaO2, and allowing the composition to remain on the teeth for a time sufficient to effect whitening thereof.

Abstract translation: 公开了一种与牙齿美白同时抑制牙结石的方法，其中向牙齿施用含有载体​​中的一种口服抗微凝胶磷酸盐和一种有效增白牙齿的量的过氧化钙，该载体含有约4至 约9重量％的水和一定量的煅烧氧化铝有效地提高了CaO 2的增白效果，并使组合物保留在牙齿上足以实现其美白的时间。

公开(公告)号：US5334375A

公开(公告)日：1994-08-02

申请号：US914083

申请日：1992-07-16

Applicant: Nuran Nabi ,  Michael Prencipe ,  Abdul Gaffar

Inventor： Nuran Nabi ,  Michael Prencipe ,  Abdul Gaffar

IPC: A61K8/00 ,  A61K8/19 ,  A61K8/21 ,  A61K8/24 ,  A61K8/25 ,  A61K8/33 ,  A61K8/34 ,  A61K8/36 ,  A61K8/37 ,  A61K8/40 ,  A61K8/42 ,  A61K8/60 ,  A61K8/72 ,  A61K8/81 ,  A61K8/86 ,  A61K8/90 ,  A61K8/92 ,  A61K31/05 ,  A61K31/055 ,  A61K31/085 ,  A61K31/235 ,  A61K31/765 ,  A61K31/795 ,  A61K31/80 ,  A61P1/02 ,  A61P31/04 ,  A61P43/00 ,  A61Q11/00 ,  A61Q11/02 ,  A61K7/16 ,  A61K7/18

CPC classification number: A61K8/24 ,  A61K8/0216 ,  A61K8/347 ,  A61K8/42 ,  A61K8/81 ,  A61K8/8164 ,  A61K8/8182 ,  A61Q11/00

Abstract: An oral composition containing a substantially water insoluble noncationic antibacterial antiplaque agent such as triclosan and a synthetic cross-linked polymer such as cross-linked poly (methylvinyl ether/maleic acid or anhydride) as antibacterial-enhancing agent to enhance delivery of said antibacterial agent to, and the retention thereof on, oral surfaces, and a method of promoting oral hygiene therewith.

Abstract translation: 一种口服组合物，其含有基本上不溶于水的非阳离子抗菌抗斑剂（如三氯生）和合成交联聚合物如交联聚（甲基乙烯基醚/马来酸酐或酸酐）作为抗菌增强剂，以增强所述抗菌剂的递送 ，以及其在口腔表面上的保留，以及促进口腔卫生的方法。

公开(公告)号：US5296215A

公开(公告)日：1994-03-22

申请号：US078527

申请日：1993-06-16

Applicant: Michael R. Burke ,  Michael Prencipe ,  James M. Buchanan

Inventor： Michael R. Burke ,  Michael Prencipe ,  James M. Buchanan

IPC: A61K20060101 ,  A61K8/46 ,  A61K8/60 ,  A61K31/70 ,  A61Q11/00 ,  C22C38/42 ,  A61K7/16 ,  A61K7/18 ,  A61K7/22

CPC classification number: A61K8/466 ,  A61K8/604 ,  A61Q11/00

Abstract: An oral composition of acceptable taste substantially non-irritating to oral tissue and stable to viscosity change during storage is disclosed wherein the composition contains a surfactant system comprised of a sodium lauryl sulfoacetate surfactant purified to contain less than 18% by weight impurities and an C.sub.12 -C.sub.22 alkyl glycoside.

Abstract translation: 公开了一种口服组合物，其口服组合物对口腔组织基本上无刺激性并且对储存期间的粘度变化稳定，其中组合物含有由纯化至少含18重量％杂质和C12- C22烷基糖苷。