公开(公告)号：US20070021487A1

公开(公告)日：2007-01-25

申请号：US10552503

申请日：2004-01-06

Applicant: Mohammad Salman ,  Naresh Kumar ,  Pakala Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Chugh

Inventor： Mohammad Salman ,  Naresh Kumar ,  Pakala Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Chugh

IPC: A61K31/403 ,  C07D209/02

CPC classification number: C07D209/52 ,  C07D403/06

Abstract: This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0]hexanes, as well as pharmaceutical compositions containing such compounds and methods of treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 具体地，本发明涉及氮杂二环化合物的衍生物，包括例如6-取代的氮杂双环[3.1.0]己烷，以及含有这些化合物的药物组合物和治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20060111425A1

公开(公告)日：2006-05-25

申请号：US10520572

申请日：2003-04-11

Applicant: Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Sarma ,  Shankar Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Silamkoti ,  Anita Chugh

Inventor： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Sarma ,  Shankar Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Silamkoti ,  Anita Chugh

IPC: A61K31/403 ,  C07D403/02 ,  C07D209/02

CPC classification number: C07D401/12 ,  C07D209/52 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.

公开(公告)号：US06949586B2

公开(公告)日：2005-09-27

申请号：US10102147

申请日：2002-03-20

Applicant: Sukhdev Swami Handa ,  Om Parkash Suri ,  Vishwa Nath Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Vikram Bhardwaj ,  Bupinder Singh ,  Bal Krishan Chandan

Inventor： Sukhdev Swami Handa ,  Om Parkash Suri ,  Vishwa Nath Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Vikram Bhardwaj ,  Bupinder Singh ,  Bal Krishan Chandan

IPC: A61K31/12 ,  A61K31/19 ,  A61K35/00 ,  A61K36/24 ,  A61K36/48 ,  A61P1/16 ,  A61K35/78

CPC classification number: A61K36/24 ,  A61K36/48 ,  A61K2300/00

Abstract: The present invention relates to a synergistic hepatoprotective pharmaceutical composition comprising an effective amount of trans-tetracos-15-enoic acid (TCA) and Apocynin (APO), the present invention also relates to a method of treatment for hepatotoxicity in mammals and humans.

Abstract translation: 本发明涉及包含有效量的反式二十四碳-15-辛酸（TCA）和阿扑炔（APO））的协同肝保护药物组合物，本发明还涉及一种治疗哺乳动物和人类肝毒性的方法。

公开(公告)号：US06932300B2

公开(公告)日：2005-08-23

申请号：US10481868

申请日：2002-06-21

Applicant: Naresh Kumar

Inventor： Naresh Kumar

IPC: B64D17/46

CPC classification number: B64D17/46

Abstract: The invention provides a device for closing parachute packs, each of which has a plurality of flaps and a closing cord (36), the device (10) being characterised by a base (12) for bearing on a flap in one direction during the packing operation, and by a mechanism (18, 22) adapted to draw a pull cord (34) connectable to the closing cord (36) in substantially an opposite direction to allow the flaps to be secured relative to the closing cord (36) by a pin.

Abstract translation: 本发明提供了一种用于关闭降落伞包装件的装置，每个装置具有多个翼片和闭合绳索（36），该装置（10）的特征在于在包装期间沿一个方向承载在翼片上的底座（12） 操作，以及适于沿大致相反的方向拉出可连接到关闭绳索（36）的拉绳（34）的机构（18,22），以允许翼片相对于关闭绳索（36）被固定 销。

公开(公告)号：US06835848B1

公开(公告)日：2004-12-28

申请号：US10221113

申请日：2003-01-06

Applicant: Prosenjit Bose ,  Naresh Kumar ,  Taro Kiyoto

Inventor： Prosenjit Bose ,  Naresh Kumar ,  Taro Kiyoto

IPC: C07C22900

CPC classification number: C07C227/16 ,  C07C229/34 ,  C07C2601/02

Abstract: The present invention relates to a new and industrially advantageous one-pot process for the preparation of alkyl 3-cyclopropyl amino-2-[2,4-dibromo-3-(difluoromethoxy) benzoyl]-2-propenoates of in which R represents methyl or ethyl, which are valuable intermediates for the production of highly active antibacterial quinolone medicaments.

Abstract translation: 本发明涉及用于制备3-环丙基氨基-2- [2,4-二溴-3-（二氟甲氧基）苯甲酰基] -2-丙烯酸烷基酯的新的和工业上有利的一锅法，其中R代表甲基或 乙基，它们是生产高活性抗菌喹诺酮药物的有价值的中间体。

公开(公告)号：US06441226B1

公开(公告)日：2002-08-27

申请号：US09467201

申请日：1999-12-20

Applicant: Mohammad Salman ,  Vijay Kumar Kaul ,  J. Suresh Babu ,  Naresh Kumar

Inventor： Mohammad Salman ,  Vijay Kumar Kaul ,  J. Suresh Babu ,  Naresh Kumar

IPC: C07C6116

CPC classification number: C07C403/20 ,  C07C51/09 ,  C07C51/353 ,  C07C2601/16 ,  C07D309/32 ,  C07C57/26

Abstract: The present invention relates to a process for the preparation of 13-cis isomer of Vitamin A acid, commonly known as isotretinoin, in a single step.

Abstract translation: 本发明涉及在单一步骤中制备维生素A酸（通常称为异维A酸）的13-顺式异构体的方法。

公开(公告)号：US4986517A

公开(公告)日：1991-01-22

申请号：US453998

申请日：1989-12-20

Applicant: David A. Ford ,  Gordon J. S. Higginbotham ,  David R. Pugh ,  Naresh Kumar

Inventor： David A. Ford ,  Gordon J. S. Higginbotham ,  David R. Pugh ,  Naresh Kumar

IPC: B22D37/00 ,  B22D39/00 ,  B22D41/05

CPC classification number: B22D41/05 ,  B22D39/00

Abstract: Apparatus for pouring molten metal comprises a water cooled copper crucible 15 which has a recess adjacent its top and a pouring spout 16 positioned in the recess just below the level of the surface of the melt. The recess defines a lip above the spout which helps to ensure that there is a constant pressure head above the spout. Pivotally mounted on the lip, and biased to assume a horizontal position irrespective of the angle of tilt of the crucible is an induction coil 21. The coil induces currents in the surface of the melt and thereby moves the dross away from the pouring spout. The crucible 15 pours into a constant head hopper 22 and the opening and closing of the crucible pouring spout 16 and the angle of tilt of the crucible are controlled to ensure constant pressure head in the hopper.

Abstract translation: 用于浇注熔融金属的设备包括水冷铜坩埚15，其具有邻近其顶部的凹部和位于刚好在熔体表面的水平面下方的凹部中的倾倒口16。 凹口限定出口上方的唇缘，这有助于确保在喷嘴上方有恒定的压力头。 偏心地安装在唇缘上并被偏置以呈现水平位置，而与坩埚的倾斜角度无关的是感应线圈21.线圈在熔体的表面中引起电流，从而将浮渣从倾倒口移出。 将坩埚15倒入恒定的顶部料斗22中，并且控制坩埚倾倒咀16的打开和关闭以及坩埚的倾斜角度以确保料斗中的恒定压力头。