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公开(公告)号：US20230101316A1
公开(公告)日：2023-03-30
申请号：US17423586
申请日：2020-01-16
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Samuel John THOMPSON, III , Mustapha SOUKRI
Abstract: The present disclosure provides novel solid sorbents synthesized by the reaction of polyamines with polyaldehyde phosphorus dendrimer (P-dendrimer) compounds for metal sequestration. The sorbents are highly stable and exhibit desirable thermodynamics and reaction kinetics with a wide variety of metals including heavy metals and rare earth elements. The sorbents can be easily regenerated for repeated use to extract metals from an aqueous solution. The materials are stable to aqueous and organic media, as well as strong acid and bases. The sorbents maintain full capacity over many cycles of use.
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公开(公告)号：US11612854B2
公开(公告)日：2023-03-28
申请号：US17357319
申请日：2021-06-24
Applicant: Research Triangle Institute
Inventor： Paul David Mobley , Marty Lail
Abstract: The disclosure provides an apparatus, as well as associated systems and methods for removing acid gas components from gas streams. The disclosure provides a rotating packed bed (RPB)-based absorber with a non-aqueous liquid solvent contained therein for treatment of the gas streams, wherein the non-aqueous liquid solvent captures acid components from the gas stream. Various advantages, e.g., with respect to spatial considerations and associated expenses can be realized using the apparatus, systems, and methods described herein.
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公开(公告)号：US20230091922A1
公开(公告)日：2023-03-23
申请号：US17937450
申请日：2022-10-02
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Yanan Zhang , Thuy Nguyen
Abstract: Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.
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公开(公告)号：US20220410063A1
公开(公告)日：2022-12-29
申请号：US17357319
申请日：2021-06-24
Applicant: Research Triangle Institute
Inventor： Paul David Mobley , Marty Lail
Abstract: The disclosure provides an apparatus, as well as associated systems and methods for removing acid gas components from gas streams. The disclosure provides a rotating packed bed (RPB)-based absorber with a non-aqueous liquid solvent contained therein for treatment of the gas streams, wherein the non-aqueous liquid solvent captures acid components from the gas stream. Various advantages, e.g., with respect to spatial considerations and associated expenses can be realized using the apparatus, systems, and methods described herein.
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公开(公告)号：US11518971B2
公开(公告)日：2022-12-06
申请号：US16695550
申请日：2019-11-26
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Leah Marie Johnson , Ninell Pollas Mortensen , Ginger Denison Rothrock , Nicolas D. Huffman
Abstract: A three-dimensional cell growth containment article is described, which includes a molded body channelized by removal of sacrificial channelizing element(s) therefrom, so that the molded body contains one or more channel(s) therein, with a matrix material in at least one of such channel(s) that is supportive of three-dimensional cell growth in the matrix material. A method for making such articles is also described, in which a molded body is formed with one or more sacrificial channelizing element(s) therein, following which the sacrificial channelizing element(s) are removed. The three-dimensional cell growth containment articles of the present disclosure may be utilized in any applications in which there exists a need to reproducibly generate three-dimensional cellular structures, e.g., islet transplantation for diabetes treatment, transplantation of hormone secreting cells, cellular scaffolds for wound healing, and generation of tissue engineering structures to regain structural usefulness for orthopedic applications.
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Patent Agency Ranking
公开(公告)号：US20220280483A1
公开(公告)日：2022-09-08
申请号：US17637659
申请日：2020-08-28
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Rangan MAITRA , Sanju NARAYANAN , Kenneth S. REHDER , Scott P. RUNYON
IPC: A61K31/415 , A61K31/496 , A61K31/4418 , A61P11/00
Abstract: The present disclosure provides a method for treating idiopathic pulmonary fibrosis in a patient in need thereof comprising administering a therapeutically effective amount of an apelin receptor agonist.
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127.发明授权公开(公告)号：US11413572B2
公开(公告)日：2022-08-16
申请号：US16905055
申请日：2020-06-18
Applicant: Research Triangle Institute
Inventor： Aravind V. Rayer Rabindran , Vijay Gupta , Paul D. Mobley , Jak Tanthana , Shaojun Zhou , Finn Andrew Tobiesen , Thor Mejdell , Andreas Grimstvedt , Geir Haugen
Abstract: A method with corresponding systems for reducing emission of amines to the atmosphere. The method includes a a) introducing a gas containing CO2 into an absorber; b) flowing the flue gas through an absorber having an absorbent with a water-lean solution having less than 50% water and one or more amines, with the absorbent capturing the CO2 and forming a reduced CO2 content gas having a baseline CO2 content; and c) washing the reduced CO2 content gas in a wash column with a wash solution comprising carbonic acid formed by addition of gaseous CO2 into the wash solution. In this method, the washing removes the amines from the reduced CO2 content gas and produces a reduced amine content gas exiting from the wash column.
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公开(公告)号：US11406971B2
公开(公告)日：2022-08-09
申请号：US17041944
申请日：2019-03-26
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Ignacio Luz Minguez , Mustapha Soukri , Marty Lail , John R Carpenter , Sameer Parvathikar , Michael Carpenter
IPC: B01J29/035 , C07F15/00 , C07F15/04 , C07F9/00 , C07F11/00 , C07F1/12 , C07F7/28 , C07F15/02 , C07F5/00 , C07F7/00 , C07F15/06 , C07F5/06
Abstract: The present disclosure provides methods of making confined nanocatalysts within mesoporous materials (MPMs). The methods utilize solid state growth of nanocrystalline metal organic frameworks (MOFs) followed by controlled transformation to generate nanocatalysts in situ within the mesoporous material. The disclosure also provides applications of the nanocatalysts to a wide variety of fields including, but not limited to, liquid organic hydrogen carriers, synthetic liquid fuel preparation, and nitrogen fixation.
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公开(公告)号：US20220008869A1
公开(公告)日：2022-01-13
申请号：US17286451
申请日：2019-10-30
Applicant: Research Triangle Institute
Inventor： Zachary Doubrava HENDREN , Young Chul CHOI , Gyu Dong KIM
Abstract: A membrane assembly for separating a feed liquid into a permeate and a retentate includes a semipermeable membrane and conductive members for applying a voltage effective for charging a semipermeable surface of the membrane, thereby reducing or preventing fouling or scaling of the membrane. The conductive members may be positioned adjacent to the semipermeable membrane, and may be configured as feed spacers or permeate spacers. Alternatively or additionally, the membrane may be electrically conductive. Power from an external source may be supplied to one or more of the conductive members, or also the membrane if conductive, which may be done wirelessly. One or more membrane assemblies may be provided in a container. One or more membrane assemblies may be provided in a stacked configuration, or wrapped around a tube in a spiral configuration.
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公开(公告)号：US11084781B2
公开(公告)日：2021-08-10
申请号：US16612680
申请日：2018-05-10
Applicant: Research Triangle Institute
Inventor： Yanan Zhang , Thuy Nguyen , Nadezhda German
IPC: C07C275/38 , C07D205/04 , C07D207/335 , C07D211/38 , C07D213/643 , C07D215/12 , C07D239/26 , C07D295/135 , C07D333/20 , C07D487/08 , C07D491/107 , A61P25/30
Abstract: The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.
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