公开(公告)号：US20230339863A1

公开(公告)日：2023-10-26

申请号：US17796419

申请日：2021-01-29

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： George AMATO ,  Rangan MAITRA ,  Scott P. RUNYON

IPC: C07D231/56

CPC classification number: C07D231/56

Abstract: The present disclosure includes peripheral partial agonists of one or more CB receptors, including modulation of CB1, both with and without CB2 selectivity. The compounds of the present disclosure may be useful in the treatment of diseases and disorders mediated by a CB-signaling pathway, including but not limited to pain, gastrointestinal disorders, metabolic disorders, and liver disorders, such as alcoholic steatohepatitis or nonalcoholic steatohepatitis (NASH).

公开(公告)号：US20190315693A1

公开(公告)日：2019-10-17

申请号：US16448976

申请日：2019-06-21

Applicant: Research Triangle Institute

Inventor： Scott P. RUNYON ,  Rangan MAITRA ,  Sanju NARAYANAN ,  James Barnwell THOMAS

IPC: C07D231/14 ,  C07D405/12 ,  A61K45/06 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/422 ,  C07D403/12 ,  A61K31/496 ,  C07D413/12 ,  C07D407/12 ,  C07D403/06 ,  A61K31/454

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

公开(公告)号：US20190322644A1

公开(公告)日：2019-10-24

申请号：US16341597

申请日：2017-10-11

Applicant: Research Triangle Institute

Inventor： Scott P. RUNYON ,  Rangan MAITRA ,  Sanju NARAYANAN ,  Kenneth S. REHDER

IPC: C07D401/12 ,  C07D403/12 ,  C07D417/14 ,  C07D233/90 ,  C07D401/04 ,  C07D249/10 ,  C07D401/14

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.

公开(公告)号：US20220280483A1

公开(公告)日：2022-09-08

申请号：US17637659

申请日：2020-08-28

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Rangan MAITRA ,  Sanju NARAYANAN ,  Kenneth S. REHDER ,  Scott P. RUNYON

IPC: A61K31/415 ,  A61K31/496 ,  A61K31/4418 ,  A61P11/00

Abstract: The present disclosure provides a method for treating idiopathic pulmonary fibrosis in a patient in need thereof comprising administering a therapeutically effective amount of an apelin receptor agonist.

公开(公告)号：US20210070767A1

公开(公告)日：2021-03-11

申请号：US17082650

申请日：2020-10-28

Applicant: Research Triangle Institute

Inventor： Scott P. RUNYON ,  Rangan MAITRA ,  Sanju NARAYANAN ,  James Barnwell THOMAS ,  Kenneth S. REHDER ,  Srinivas OLEPU

IPC: C07D491/107 ,  C07D403/12 ,  C07D231/14 ,  C07D403/06 ,  C07D407/12 ,  C07D413/12 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/08 ,  C07D487/08

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

公开(公告)号：US20240174638A1

公开(公告)日：2024-05-30

申请号：US18278656

申请日：2022-02-15

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Scott P. RUNYON ,  Rangan MAITRA ,  Sanju NARAYANAN

IPC: C07D401/14 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K45/06 ,  A61P9/00 ,  A61P11/00 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D401/14 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K45/06 ,  A61P9/00 ,  A61P11/00 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

公开(公告)号：US20180265518A1

公开(公告)日：2018-09-20

申请号：US15983519

申请日：2018-05-18

Applicant: Research Triangle Institute

Inventor： Scott P. RUNYON ,  Rangan MAITRA ,  Sanju NARAYANAN ,  James Barnwell THOMAS ,  Kenneth S. REHDER ,  Srinivas OLEPU

IPC: C07D491/107 ,  C07D403/04 ,  A61K31/5377 ,  C07D401/12 ,  C07D403/14 ,  C07D405/12 ,  C07D417/04 ,  C07D409/04 ,  C07D403/12 ,  C07D417/12 ,  C07D403/06 ,  C07D231/14 ,  C07D471/08 ,  C07D413/12 ,  C07D401/14 ,  C07D417/14 ,  A61K45/06 ,  C07D487/08 ,  C07D407/12 ,  A61K31/55 ,  A61K31/427 ,  A61K31/422 ,  A61K31/415 ,  A61K31/4245 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/439 ,  C07D413/04

CPC classification number: C07D491/107 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D231/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D407/12 ,  C07D409/04 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/08 ,  C07D487/08

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.