公开(公告)号：US20160106643A1

公开(公告)日：2016-04-21

申请号：US14887774

申请日：2015-10-20

Applicant: Colgate-Palmolive Company

Inventor： John Vaughn ,  Iraklis Pappas ,  Long Pan

IPC: A61K8/26 ,  A61Q15/00 ,  C01F7/00 ,  A61K8/20 ,  A61K8/19 ,  C01F7/56 ,  A61K8/28 ,  A61K8/44

CPC classification number: A61K8/26 ,  A61K8/19 ,  A61K8/20 ,  A61K8/28 ,  A61K8/42 ,  A61K8/44 ,  A61K2800/58 ,  A61Q15/00 ,  C01F7/002 ,  C01F7/56 ,  C01P2002/86 ,  C01P2002/87

Abstract: An antiperspirant active composition comprising an aluminum salt, the aluminum salt (i) having an aluminum to chloride molar ratio of 0.3:1 to 3:1; and (ii) having a species of polyhydroxyoxoaluminum cation detectable it 76 ppm by 27Al NMR that is present in a relative abundance on a 27Al NMR spectrograph that is greater than an other polyhydroxyoxoaluminum cation detectable by 27Al NMR. Also, disclosed are methods of making the antiperspirant active.

Abstract translation: 一种止汗活性组合物，其包含铝盐，所述铝盐（i）的铝与氯化物的摩尔比为0.3:1至3:1; 和（ii）具有聚羟基氧化铝阳离子的物质，其可通过27Al NMR检测到76ppm，其在27Al NMR光谱仪上的相对丰度存在，其大于可通过27Al NMR检测的其它聚羟基氧代铝阳离子。 此外，公开了使止汗剂活性的方法。

公开(公告)号：US20160000666A1

公开(公告)日：2016-01-07

申请号：US14770142

申请日：2013-03-15

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Long Pan ,  Venda Porter Maloney ,  Kristen Reale ,  Suman Chopra ,  James G. Masters ,  Shaotang Yuan ,  Laurence Du-Thumm

IPC: A61K8/26 ,  A61Q11/00

CPC classification number: A61K8/26 ,  A61K6/007 ,  A61K8/365 ,  A61K8/44 ,  A61K33/06 ,  A61Q11/00

Abstract: Described herein are oral care compositions comprising an effective amount of aluminum chlorohydrate suspended in a carrier for preventing, reducing or inhibiting dentinal hypersensitivity, the aluminum chlorohydrate exhibiting a SEC chromatogram having a SEC Peak 4 to Peak 3 intensity ratio of at least 7 and a Peak 4 intensity greater than a Peak 5 intensity; and methods of using the same.

Abstract translation: 本文描述的是包含悬浮在载体中的有效量的氯化铝水合物以防止，减少或抑制牙质过敏的口腔护理组合物，其具有SEC峰4至峰3强度比至少为7的SEC色谱图和峰值 4强度大于峰5强度; 及其使用方法。

公开(公告)号：US20150335552A1

公开(公告)日：2015-11-26

申请号：US14653300

申请日：2012-12-19

Applicant: Colgate-Palmolive Company

Inventor： Zhiqiang Liu ,  Long Pan ,  Shaotang Yuan ,  Jairajh Mattai ,  James G. Masters

IPC: A61K8/44 ,  A61K8/27 ,  A61Q11/00

CPC classification number: A61K8/44 ,  A61K8/0216 ,  A61K8/20 ,  A61K8/27 ,  A61K2800/45 ,  A61K2800/58 ,  A61Q11/00

Abstract: Described herein are methods of cleaning a tooth comprising administering a composition comprising a zinc amino acid halide complex to the oral cavity; and retaining the composition in the oral cavity for a time sufficient to form a precipitate.

Abstract translation: 本文描述了清洁牙齿的方法，包括向口腔施用包含锌氨基酰卤配合物的组合物; 并将组合物保持在口腔中足以形成沉淀物的时间。

公开(公告)号：US20150328096A1

公开(公告)日：2015-11-19

申请号：US14653876

申请日：2012-12-19

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： LaTonya Kirkpatrick-Liverman ,  Zhiqiang Liu ,  Long Pan ,  Ying Yang ,  Guofeng Xu ,  Michael A. Stranick ,  Zhigang Hao

IPC: A61K8/27 ,  C07C229/12 ,  A61Q11/00 ,  A61K8/44 ,  A61K8/21

CPC classification number: A61K8/27 ,  A61K8/21 ,  A61K8/416 ,  A61K8/44 ,  A61K2800/74 ,  A61Q11/00 ,  C07C229/12

Abstract: The invention provides oral care compositions comprising a mixture of tetrabasic zinc halide and trimethylglycine, in free or orally acceptable salt form. Methods of making and using the compositions are also provided.

Abstract translation: 本发明提供包含游离或口服可接受的盐形式的四元卤化锌和三甲基甘氨酸的混合物的口腔护理组合物。 还提供了制备和使用组合物的方法。

公开(公告)号：US20150132241A1

公开(公告)日：2015-05-14

申请号：US14306182

申请日：2014-06-16

Applicant: Colgate-Palmolive Company

Inventor： Long Pan

IPC: A61K8/41 ,  A61K8/28 ,  A61Q15/00 ,  A61K8/26

CPC classification number: A61K8/416 ,  A61K8/26 ,  A61K8/28 ,  A61K8/44 ,  A61Q15/00

Abstract: An aluminum salt composition comprising (a) an aluminum salt having an aluminum to chloride molar ratio of about 0.3:1 to about 3:1, an OH:Al molar ratio of about 2:1 to about 2.6:1, exhibiting a Size Exclusion Chromatography (SEC) chromatogram having a SEC Peak 4 to Peak 3 intensity ratio of at least 7, and a Peak 4 intensity greater than a Peak 5 intensity in aqueous solution, and (b) at least one buffer chosen from an amino acid, glycine, and betaine, wherein a molar ratio of buffer to aluminum is about 0.1:1 to about 3:1.

Abstract translation: 一种铝盐组合物，其包含（a）铝与氯化物摩尔比为约0.3:1至约3:1的铝盐，OH:Al摩尔比为约2:1至约2.6:1，表现出尺寸排除 具有SEC峰4至峰3强度比至少为7的色谱（SEC）色谱图和高于水溶液中峰5强度的峰4强度，和（b）至少一种选自氨基酸，甘氨酸 和甜菜碱，其中缓冲液与铝的摩尔比为约0.1:1至约3:1。

公开(公告)号：US20140170086A1

公开(公告)日：2014-06-19

申请号：US13944208

申请日：2013-07-17

Applicant: Colgate-Palmolive Company

Inventor： Long Pan ,  Shaotang Yuan ,  Jairajh Mattai ,  James G. Masters

IPC: C11D3/16

CPC classification number: C11D3/168 ,  A61K8/27 ,  A61K8/44 ,  A61K2800/45 ,  A61K2800/58 ,  A61Q19/10 ,  C11D17/08

Abstract: A method for indicating release of an antibacterial agent or for indicating an amount of time for cleansing skin with an aqueous cleansing composition comprising a surfactant and a zinc X halide complex, wherein X is an amino acid or trimethylglycine, wherein the method comprises washing skin with the cleansing composition and water for a time until the zinc X halide complex precipitates from the aqueous cleansing composition.

Abstract translation: 一种用于指示使用包含表面活性剂和锌X卤化物配合物的水性清洁组合物来表示抗菌剂释放或用于指示用于清洁皮肤的时间量的方法，其中X是氨基酸或三甲基甘氨酸，其中所述方法包括用 清洁组合物和水一直到锌X卤化物复合物从水性清洁组合物中沉淀出来。

公开(公告)号：US20140127151A1

公开(公告)日：2014-05-08

申请号：US14154216

申请日：2014-01-14

Applicant: Colgate-Palmolive Company

Inventor： Iraklis Pappas ,  Michael C. Fitzgerald ,  Long Pan

IPC: A61K8/41 ,  A61K8/42 ,  A61Q15/00 ,  A61K8/26

CPC classification number: A61K8/416 ,  A61K8/26 ,  A61K8/42 ,  A61K8/44 ,  A61K2800/31 ,  A61K2800/58 ,  A61Q15/00

Abstract: A method of producing an anhydrous antiperspirant composition comprising (a) providing a mixture of at least one antiperspirant active including a metal salt, and an anhydrous carrier for the at least one antiperspirant active in which the at least one antiperspirant active is dissolved, the carrier comprising a eutectic mixture of at least one basic compound selected from a basic amide and a basic amine and at least one member chosen from a cation and zwitterion; and (b) heating the mixture to form a stabilized eutectic system of the at least one antiperspirant active and the anhydrous carrier, and wherein the at least one antiperspirant active, the at least one basic compound and the at least one member chosen from a cation and zwitterion form a ternary eutectic system.

Abstract translation: 一种制备无水止汗组合物的方法，其包含（a）提供至少一种止汗剂活性物质（包括金属盐）的混合物和至少一种其中所述至少一种止汗活性剂溶解的止汗活性剂的无水载体，所述载体 包括至少一种选自碱性酰胺和碱性胺的碱性化合物和选自阳离子和两性离子的至少一种的共晶混合物; 和（b）加热所述混合物以形成所述至少一种止汗活性剂和所述无水载体的稳定的共晶体系，并且其中所述至少一种止汗活性剂，所述至少一种碱性化合物和至少一种选自阳离子 并且两性离子形成三元共晶体系。