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公开(公告)号：US11573228B2
公开(公告)日：2023-02-07
申请号：US17309892
申请日：2019-12-17
Applicant: Colgate-Palmolive Company
Inventor： Camille Zenobia , Harsh Mahendra Trivedi , Ying Yang
IPC: G01N33/50 , G01N33/68 , G01N33/569
Abstract: Methods of determining one or more ratios of chemokines in gingival crevicular fluid of an individual selected from the group consisting of: MIF:MIP1a, MIF:CXCL1; MIF:CXCL5; M1F:CXCL8; MIF:CXCL2; and MIF:CXCL6 and methods of identifying an individual as having gingivitis comprising determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Methods of treating individuals who are identified as having gingivitis by determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Also disclosed are methods of monitoring the treatment individuals who have gingivitis.
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公开(公告)号：US09925130B2
公开(公告)日：2018-03-27
申请号：US14653308
申请日：2012-12-19
Applicant: Colgate-Palmolive Company
Inventor： Long Pan , Jairajh Mattai , Shamim Ansari , Jianhong Qiu , James G. Masters , Ying Yang
IPC: A61K8/27 , A61K8/20 , A61K8/44 , A61Q15/00 , A61Q17/00 , A61Q19/00 , A61Q19/10 , A61Q5/00 , A61Q5/02 , A61Q5/12
CPC classification number: A61K8/27 , A61K8/20 , A61K8/44 , A61K2800/58 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q15/00 , A61Q17/005 , A61Q19/00 , A61Q19/10
Abstract: A personal care composition for application to the skin or hair comprising a cosmetically acceptable carrier and zinc X halide precursors wherein the precursors are a zinc ion source, an X source, and a halide source, wherein the halide source can be part of the zinc ion source, the X source, or a halogen acid, wherein the precursors can complex into the zinc X halide when the composition is applied to the skin or hair, wherein X is an amino acid or trimethylglycine. Methods of making and using the compositions are also provided. When the precursors complex into a zinc X halide, the complex can be used to deliver zinc salts to block perspiration and provide antibacterial effects.
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公开(公告)号：US09775792B2
公开(公告)日：2017-10-03
申请号：US14653882
申请日：2012-12-19
Applicant: Colgate-Palmolive Company
Inventor： Zhiqiang Liu , Long Pan , Ying Yang , Guofeng Xu , Michael A. Stranick
CPC classification number: A61K8/27 , A61K8/20 , A61K8/21 , A61K8/44 , A61K2800/58 , A61K2800/92 , A61Q11/00
Abstract: Described herein are oral care compositions comprising a tetrabasic zinc halide and an amino acid; along with methods of making and using the same.
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公开(公告)号：US20160008254A1
公开(公告)日：2016-01-14
申请号：US14652780
申请日：2012-12-19
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Zhigang Hao , Ying Yang , Zhiqiang Liu , Xu Guofeng , Paul Joseph Vincenti
CPC classification number: A61K8/58 , A61K8/27 , A61K8/55 , A61K8/676 , A61K33/30 , A61K2800/58 , A61Q11/00
Abstract: Provided herein is an oral care composition comprising an orally-acceptable aqueous vehicle and an antimicrobial ingredient, wherein the antimicrobial ingredient comprises a zinc ascorbylphosphate and methods for treating or preventing a disease or disorder of the oral cavity using the oral care compositions disclosed herein.
Abstract translation: 本文提供了包含口服可接受的水性载体和抗微生物成分的口腔护理组合物，其中所述抗微生物成分包含抗坏血酸磷酸锌和使用本文公开的口腔护理组合物治疗或预防口腔疾病或病症的方法。
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公开(公告)号：US20150328117A1
公开(公告)日：2015-11-19
申请号：US14653292
申请日：2012-12-19
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Long Pan , Jairajh Mattai , Shamin Ansari , Jianhong Qiu , James G. Masters , Ying Yang
CPC classification number: A61K8/58 , A61K8/27 , A61K8/44 , A61Q15/00 , A61Q17/005
Abstract: The invention provides a personal care composition for application to the skin which comprises a personal care composition for application to the skin or hair comprising a zinc X halide and a cosmetically acceptable base, wherein X is an amino acid or trimethylglycine. Methods of making and using the compositions are also provided. The zinc X halide is can be used to deliver zinc salts to block perspiration and provide antibacterial effects.
Abstract translation: 本发明提供了一种用于皮肤应用的个人护理组合物，其包含用于皮肤或头发的个人护理组合物，其包含锌X卤化物和美容上可接受的碱，其中X为氨基酸或三甲基甘氨酸。 还提供了制备和使用组合物的方法。 锌X卤化物可用于输送锌盐以阻止出汗并提供抗菌效果。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20150328095A1
公开(公告)日：2015-11-19
申请号：US14653308
申请日：2012-12-19
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Long Pan , Jairajh Mattai , Shamim Ansari , Jianhong Qiu , James G. Masters , Ying Yang
IPC: A61K8/27 , A61K8/20 , A61K8/44 , A61Q17/00 , A61Q19/10 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q15/00 , A61Q19/00
CPC classification number: A61K8/27 , A61K8/20 , A61K8/44 , A61K2800/58 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q15/00 , A61Q17/005 , A61Q19/00 , A61Q19/10
Abstract: A personal care composition for application to the skin or hair comprising a cosmetically acceptable carrier and zinc X halide precursors wherein the precursors are a zinc ion source, an X source, and a halide source, wherein the halide source can be part of the zinc ion source, the X source, or a halogen acid, wherein the precursors can complex into the zinc X halide when the composition is applied to the skin or hair, wherein X is an amino acid or trimethylglycine. Methods of making and using the compositions are also provided. When the precursors complex into a zinc X halide, the complex can be used to deliver zinc salts to block perspiration and provide antibacterial effects.
Abstract translation: 一种用于皮肤或毛发的个人护理组合物，其包含美容上可接受的载体和锌X卤化物前体，其中所述前体是锌离子源，X源和卤化物源，其中所述卤化物源可以是锌离子的一部分 源，X源或卤素酸，其中当将组合物施用于皮肤或毛发时，前体可以复合成锌X卤化物，其中X是氨基酸或三甲基甘氨酸。 还提供了制备和使用组合物的方法。 当前体复合成锌X卤化物时，该配合物可用于递送锌盐以阻止汗水并提供抗菌效果。
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7.发明申请ORAL CARE PRODUCTS COMPRISING A TETRABASIC ZINC-AMINO ACID-HALIDE COMPLEX 有权口服保健产品，包含一种四乙酰胺 - 氨基酸 - 卤化物复合物公开(公告)号：US20150328111A1
公开(公告)日：2015-11-19
申请号：US14653882
申请日：2012-12-19
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Zhiqiang Liu , Long Pan , Ying Yang , Guofeng Xu , Michael A. Stranick
CPC classification number: A61K8/27 , A61K8/20 , A61K8/21 , A61K8/44 , A61K2800/58 , A61K2800/92 , A61Q11/00
Abstract: Described herein are oral care compositions comprising a tetrabasic zinc halide and an amino acid; along with methods of making and using the same.
Abstract translation: 本文描述的是包含四元卤化锌和氨基酸的口腔护理组合物; 以及制作和使用方法。
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公开(公告)号：US10583074B2
公开(公告)日：2020-03-10
申请号：US15828511
申请日：2017-12-01
Applicant: Colgate-Palmolive Company
Inventor： Shao Peng Xu , Peng Yan , Ying Yang
Abstract: Oral care compositions including a hemostatic agent, wherein the hemostatic agent includes a mixture of oleanic acid and eugenol. Methods of making and using these compositions are also described.
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公开(公告)号：US09861563B2
公开(公告)日：2018-01-09
申请号：US14653876
申请日：2012-12-19
Applicant: Colgate-Palmolive Company
Inventor： LaTonya Kilpatrick-Liverman , Zhiqiang Liu , Long Pan , Ying Yang , Guofeng Xu , Michael A. Stranick , Zhigang Hao
CPC classification number: A61K8/27 , A61K8/21 , A61K8/416 , A61K8/44 , A61K2800/74 , A61Q11/00 , C07C229/12
Abstract: The invention provides oral care compositions comprising a mixture of tetrabasic zinc halide and trimethylglycine, in free or orally acceptable salt form. Methods of making and using the compositions are also provided.
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10.发明授权公开(公告)号：US12203926B2
公开(公告)日：2025-01-21
申请号：US17309896
申请日：2019-12-17
Applicant: Colgate-Palmolive Company
Inventor： Camille Zenobia , Harsh Mahendra Trivedi , Ying Yang , Carlo Daep , James Masters
Abstract: An oral biology model which comprises biofilm, oral epithelial tissue and a suspension of neutrophil-like cells in media is disclosed. The biofilm, which comprises oral bacteria, is produced by culturing oral bacteria on a solid substrate. The oral epithelial tissue may be gingival epithelial tissue to model the gingival crevice or buccal epithelial tissue to model the oral check. The suspension of neutrophil-like cells in media comprises neutrophil-like cells that are differentiated HL60 cells induced to a neutrophil-like phenotype by treatment with retinoic acid. Methods of using the oral biology model to test and compare compounds and formulations or to screen compounds and formulations for their effect on release of inflammatory signals, their effect on biofilm and oral bacteria and/or their effect on the cellular components are disclosed.
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