公开(公告)号：US07192584B2

公开(公告)日：2007-03-20

申请号：US09927703

申请日：2001-08-10

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/28

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: The invention relates to anti-TNF antibodies, fragments, regions and derivatives thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in methods of treating psoriasis, as well as polynucleotides coding for murine and chimeric anti-TNF antibodies, and methods of producing anti-TNF antibodies, fragments, regions and derivatives thereof.

Abstract translation: 本发明涉及对人类肿瘤坏死因子-α（TNFalpha）特异性的抗TNF抗体，其片段，区域和衍生物，可用于治疗牛皮癣的方法，以及编码鼠和嵌合抗TNF抗体的多核苷酸 以及产生抗TNF抗体，其片段，区域和衍生物的方法。

公开(公告)号：US07135179B2

公开(公告)日：2006-11-14

申请号：US11181030

申请日：2005-07-13

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/28

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07128908B2

公开(公告)日：2006-10-31

申请号：US11179359

申请日：2005-07-12

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/28

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

公开(公告)号：US20060180563A1

公开(公告)日：2006-08-17

申请号：US11185954

申请日：2005-07-20

Applicant: David Knight

Inventor： David Knight

IPC: B66C23/68

CPC classification number: B66F9/0655 ,  B66C23/90 ,  B66F17/003 ,  E02F3/286 ,  E02F9/24

Abstract: A method of operating a machine which has a boom mounted at or adjacent one end to a body of the machine, and the boom having at the other end, a load handling implement, the boom including at least two sections with one of the sections, being telescoped within the other, there being at least one extension actuator to adjust the extent of telescoping, and the boom being moveable by at least one lift actuator for movement between a lowered position to a raised position, the method including preventing the relative extension of the boom sections to provide a minimum overlap between the boom sections when the boom is at the lowered position which is greater than the minimum overlap permitted when the boom is at a raised position.

Abstract translation: 一种操作机器的方法，所述机器具有安装在所述机器的主体上或其一端附近的悬臂，并且所述悬臂在另一端具有负载处理工具，所述起重臂包括具有所述部分中的一个的至少两个部分， 在另一个内部被伸缩，存在至少一个延伸致动器以调节伸缩的程度，并且悬臂可由至少一个提升致动器移动，以在降低位置到升高位置之间移动，所述方法包括防止 所述悬臂段在所述悬臂处于所述下降位置时提供所述悬臂段之间的最小重叠，所述下降位置大于所述悬臂在升高位置时允许的最小重叠。

公开(公告)号：US20060037207A1

公开(公告)日：2006-02-23

申请号：US10919500

申请日：2004-08-17

Applicant: David Knight

Inventor： David Knight

IPC: G01B5/20

CPC classification number: E04F21/0076 ,  E04F21/20

Abstract: The invention is a device used to measure and mark floor tile that must be cut to fit around obstructions. A key feature of the invention is that it has removable elements that make it possible to use the device with tile of any size. A second key feature is a plurality of telescoping members that can be extended to varying lengths in order to describe the perimeter geometry that must be duplicated by cutting away a portion of the tile. The invention is compatible with all tile and similar flat floor or wall coverings, such as pavers or carpet squares.

Abstract translation: 本发明是用于测量和标记必须切割以适应围绕障碍物的地板砖的装置。 本发明的一个关键特征在于它具有可移动元件，使得可以使用具有任何尺寸的瓦片的设备。 第二个关键特征是多个伸缩构件，其可以延伸到不同长度，以便描述通过切除瓦片的一部分而必须重复的周边几何形状。 本发明与所有瓷砖和类似的平的地板或墙壁覆盖物（例如摊铺机或地毯方块）兼容。

公开(公告)号：US20060024310A1

公开(公告)日：2006-02-02

申请号：US11195589

申请日：2005-08-02

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07H21/04

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US20060018906A1

公开(公告)日：2006-01-26

申请号：US11181030

申请日：2005-07-13

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C12N5/06 ,  C07H21/02 ,  C07H21/04 ,  C12P21/06 ,  C07K16/24

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

公开(公告)号：US20050196838A1

公开(公告)日：2005-09-08

申请号：US10975740

申请日：2004-10-28

Applicant: Jill Giles-Komar ,  David Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

Inventor： Jill Giles-Komar ,  David Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A01H1/00 ,  A01K67/027 ,  A61K20060101 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P20060101 ,  A61P17/06 ,  A61P25/00 ,  A61P37/00 ,  A61P43/00 ,  C07K20060101 ,  C07K16/24 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/13 ,  C12P21/08 ,  G01N20060101 ,  C07H21/04 ,  C12N5/06

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to an anti-IL-12 antibody, including isolated nucleic acids that encode an anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

Abstract translation: 本发明涉及抗IL-12抗体，包括编码抗IL-12抗体，IL-12，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用方法，包括 治疗组合物，方法和装置。

公开(公告)号：US20050079183A1

公开(公告)日：2005-04-14

申请号：US10653706

申请日：2003-09-02

Applicant: Robert Jordan ,  Carrie Wagner ,  David Knight

Inventor： Robert Jordan ,  Carrie Wagner ,  David Knight

IPC: A61K38/00 ,  C07K14/315 ,  C07K14/47 ,  C07K16/00 ,  C07K16/46 ,  C12P21/08 ,  A61K39/395 ,  C07K16/44

CPC classification number: C07K14/3153 ,  A61K38/00 ,  C07K14/4713 ,  C07K16/00 ,  C07K16/46 ,  C07K2319/00

Abstract: Reduced-immunogenic fusion compounds are disclosed. The fusion compounds of the invention comprise immunogenic compounds linked to auto-antigenic sequences which render the compound less immunogenic. In addition, a method of reducing the immunogenicity of an immunogenic compound is disclosed. The method comprises linking an auto-antigenic sequence to an otherwise immunogenic compound. Recombinant nucleotide sequence encoding auto-antigenic sequences are also disclosed.

Abstract translation: 公开了减少免疫原性的融合化合物。 本发明的融合化合物包含与自身抗原序列连接的免疫原性化合物，其使得化合物免疫原性降低。 此外，公开了降低免疫原性化合物的免疫原性的方法。 该方法包括将自身抗原序列与另外的免​​疫原性化合物连接。 还公开了编码自身抗原序列的重组核苷酸序列。

公开(公告)号：US20050037008A1

公开(公告)日：2005-02-17

申请号：US10957134

申请日：2004-09-30

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K38/00 ,  C07K14/525 ,  C07K16/24 ,  C07K16/30 ,  A61K39/395

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。