公开(公告)号：US20200079872A1

公开(公告)日：2020-03-12

申请号：US16548883

申请日：2019-08-23

Applicant: GENMAB A/S

Inventor： Joost J. NEIJSSEN ,  Bart DE GOEIJ ,  Edward Norbert VAN DEN BRINK ,  Aran Frank LABRIJN ,  Rene HOET ,  Janine SCHUURMAN ,  Paul PARREN ,  Jan VAN DE WINKEL

IPC: C07K16/30 ,  C07K16/40 ,  A61K45/06 ,  A61K39/395 ,  C07K16/28 ,  G01N33/574 ,  A61P35/00

Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US20200048304A1

公开(公告)日：2020-02-13

申请号：US16426647

申请日：2019-05-30

Applicant: GENMAB A/S

Inventor： Michael GRAMER ,  Amitava KUNDU ,  Ewald T. J. VAN DEN BREMER ,  Muriel VAN KAMPEN ,  Patrick PRIEM ,  Aran Frank LABRIJN ,  Joyce I. MEESTERS ,  Joost J. NEIJSSEN ,  Janine SCHUURMAN ,  Paul PARREN ,  Patrick VAN BERKEL ,  Werner L. VOS ,  Arnout F. GERRITSEN

IPC: C07K1/113 ,  C07K16/46 ,  C07K16/28

Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.

公开(公告)号：US20200017600A1

公开(公告)日：2020-01-16

申请号：US16512206

申请日：2019-07-15

Applicant: GENMAB A/S

Inventor： Bart De GOEIJ ,  Grietje ANDRINGA ,  Frank BEURSKENS ,  Janine SCHUURMAN ,  David P.E. SATIJN ,  Tahamtan AHMADI

IPC: C07K16/28 ,  A61P35/00

Abstract: Antibody variants comprising one or more mutations in the Fc region, particularly anti-CD38 antibodies comprising a mutation in one or more amino acid residues corresponding to E430, E345 and S440 in a human IgG1 heavy chain, wherein the amino acid residues are numbered according to the EU index.

公开(公告)号：US10407501B2

公开(公告)日：2019-09-10

申请号：US15110414

申请日：2015-01-08

Applicant: GENMAB A/S

Inventor： Edward Norbert Van Den Brink ,  Joost J. Neijssen ,  Aran Frank Labrijn ,  Joyce Meesters ,  Janine Schuurman ,  Isil Altintas ,  Paul Parren ,  Rik Rademaker

IPC: C07K16/28 ,  C07K16/10 ,  C07K16/32 ,  C07K16/42 ,  G01N33/68 ,  A61K39/00

Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.

公开(公告)号：US20180215827A1

公开(公告)日：2018-08-02

申请号：US15832337

申请日：2017-12-05

Applicant: GENMAB A/S

Inventor： Bart DE GOEIJ ,  Simone DE HAIJ ,  Thilo RIEDL ,  Rene HOET ,  Ole BAADSGAARD ,  Jan VAN DE WINKEL ,  David SATIJN ,  Paul PARREN ,  Aran Frank LABRIJN ,  Joyce MEESTERS ,  Janine SCHUURMAN ,  Edward N. VAN DEN BRINK

IPC: C07K16/28 ,  C07K16/32

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92

Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US20180044431A1

公开(公告)日：2018-02-15

申请号：US15626866

申请日：2017-06-19

Applicant: GENMAB A/S

Inventor： Sandra VERPLOEGEN ,  David P.E. SATIJN ,  Rene M.A. HOET ,  Paul PARREN ,  Jan VAN DE WINKEL ,  Vibeke Miller BREINHOLT ,  Eva EHRNROOTH ,  Ole BAADSGAARD ,  Tom VINK ,  Willam Karel BLEEKER ,  Mischa HOUTKAMP ,  Maroeska OUDSHOORN ,  Rob N. DE JONG

IPC: C07K16/36 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/36 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92

Abstract: Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US09663578B2

公开(公告)日：2017-05-30

申请号：US14317600

申请日：2014-06-27

Applicant: GENMAB A/S

Inventor： Edward Norbert Van Den Brink ,  Paul Parren ,  Jan Van De Winkel ,  Aran Frank Labrijn ,  Frank Everhardus Martinus Rebers ,  Esther Cornelia Wilhelmina Breij

IPC: A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/283 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/92

Abstract: Isolated monoclonal antibodies which bind to human CD32b and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US20170029521A1

公开(公告)日：2017-02-02

申请号：US15197496

申请日：2016-06-29

Applicant: GENMAB A/S

Inventor： Jan VAN DE WINKEL ,  Tom VINK ,  Janine SCHUURMAN ,  Paul PARREN ,  Rob AALBERSE ,  Marijn VAN DER NEUT KOLFSCHOTEN

IPC: C07K16/28 ,  A61K51/10 ,  A61K47/48

Abstract: The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).

Abstract translation: 本发明涉及稳定的IgG4抗体，涉及产生此类抗体的方法以及此类抗体作为药物的用途。 在一个主要方面，本发明涉及一种稳定的IgG4抗体，其包含重链和轻链，其中所述重链包含具有在位置（409）处的Arg残基取代的人IgG4恒定区， 位置（405）或位置（370）处的Lys残基。

公开(公告)号：US20160333095A1

公开(公告)日：2016-11-17

申请号：US15110414

申请日：2015-01-08

Applicant: GENMAB A/S

Inventor： Edward Norbert VAN DEN BRINK ,  Joost J. NEIJSSEN ,  Aran Frank LABRIJN ,  Joyce MEESTERS ,  Janine SCHUURMAN ,  Isil ALTINTAS ,  Paul PARREN ,  Rik RADEMAKER

IPC: C07K16/28 ,  C07K16/42 ,  C07K16/32 ,  G01N33/68

CPC classification number: C07K16/2809 ,  A61K2039/505 ,  C07K16/1063 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/32 ,  C07K16/4241 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/90 ,  C07K2317/92 ,  G01N33/6872 ,  G01N2333/7051

Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.

Abstract translation: 本发明涉及结合CD3的人源化或嵌合抗体。 此外，它还涉及双特异性抗体，组合物，药物组合物，所述抗体在治疗疾病中的用途，以及治疗方法。

公开(公告)号：US20160168247A1

公开(公告)日：2016-06-16

申请号：US14902757

申请日：2014-07-04

Applicant: GENMAB A/S

Inventor： Edward VAN DEN BRINK ,  Joost J. NEIJSSEN ,  Aran Frank LABRIJN ,  Joyce MEESTERS ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/28 ,  C07K16/32

Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.