公开(公告)号：US5395836A

公开(公告)日：1995-03-07

申请号：US222938

申请日：1994-04-05

申请人： Junichi Shimada ,  Takashi Kuwabara ,  Tohru Yasuzawa ,  Hiroshi Magara ,  Hiromi Nonaka ,  Hideaki Kusaka ,  Fumio Suzuki

发明人： Junichi Shimada ,  Takashi Kuwabara ,  Tohru Yasuzawa ,  Hiroshi Magara ,  Hiromi Nonaka ,  Hideaki Kusaka ,  Fumio Suzuki

IPC分类号： C07D473/04 ,  A61K31/52 ,  C07D473/06

CPC分类号： C07D473/04 ,  Y10S514/869

摘要： There is provided a novel xanthine Compound(I) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represent hydroxy-substituted, oxo-substituted or unsubstituted lower alkyl, Y is a single bond or alkylene, and Q is ##STR2## wherein R.sup.3 and R.sup.4 are the same or different and each represent hydrogen or hydroxy, n is 0 or 1; provided that when both of R.sup.3 and R.sup.4 are hydrogen, at least one of R.sup.1 and R.sup.2 is hydroxy-substituted or oxo-substituted lower alkyl; or a pharmaceutically acceptable salt thereof.The xanthine compound has adenosine A.sub.1 receptor antagonizing activity, and thus shows diuretic effect, renal-protecting effect, bronchodilatory effect, cerebral function improving effect and anti-dementia effect.

摘要翻译： 提供了一种新颖的黄嘌呤化合物（I）其中R 1和R 2相同或不同，各自表示羟基取代的，取代或未取代的低级烷基，Y是单键或亚烷基，Q 其中R 3和R 4相同或不同，各自表示氢或羟基，n为0或1; 条件是当R 3和R 4都是氢时，R 1和R 2中的至少一个是羟基取代的或氧代取代的低级烷基; 或其药学上可接受的盐。 黄嘌呤化合物具有腺苷A1受体拮抗活性，因此具有利尿作用，肾保护作用，支气管扩张作用，脑功能改善作用和抗痴呆作用。

公开(公告)号：US5391760A

公开(公告)日：1995-02-21

申请号：US120330

申请日：1993-09-14

申请人： Hiroshi Murakami ,  Susumu Yamamoto ,  Yoshihiro Iwasawa ,  Fumio Suzuki ,  Isao Hashiba

发明人： Hiroshi Murakami ,  Susumu Yamamoto ,  Yoshihiro Iwasawa ,  Fumio Suzuki ,  Isao Hashiba

IPC分类号： C07D521/00 ,  C07D231/12

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Disclosed herein is a process for producing N-alkylpyrazoles represented by the formula (1), which comprises reacting an alkali metal or an alkali metal-containing base with N- unsubstituted pyrazoles represented by the formula (2), to form an alkali metal salt thereof and, subsequently, reacting the obtained alkali metal salt with an alkylating agent. ##STR1##

摘要翻译： 本文公开了一种制备由式（1）表示的N-烷基吡唑的方法，其包括使碱金属或含碱金属的碱与由式（2）表示的N-未取代的吡唑反应形成碱金属盐 然后使得到的碱金属盐与烷基化剂反应。 R1：H，C1-C4烷基R2：C1-C4烷基n：1-3的整数

公开(公告)号：US5290782A

公开(公告)日：1994-03-01

申请号：US839690

申请日：1992-02-24

申请人： Fumio Suzuki ,  Junichi Shimada ,  Akio Ishii ,  Tetsuji Ohno ,  Akira Karasawa ,  Kazuhiro Kubo ,  Hiromi Nonaka

发明人： Fumio Suzuki ,  Junichi Shimada ,  Akio Ishii ,  Tetsuji Ohno ,  Akira Karasawa ,  Kazuhiro Kubo ,  Hiromi Nonaka

IPC分类号： C07D473/06 ,  C07D473/08 ,  C07D473/20 ,  C07D473/22 ,  C07D473/02 ,  A61K31/52

CPC分类号： C07D473/06 ,  C07D473/08 ,  C07D473/20 ,  C07D473/22

摘要： Novel xanthine compounds represented by the following formula: ##STR1## wherein each of X.sup.1 and X.sup.2 independently represents oxygen or sulfur; and Q represents; ##STR2## where ----- represents a single bond or a double bond; Y represents a single bond or alkylene, n represents 0 or 1, each of W.sup.1 and W.sup.2 independently represents hydrogen, lower alkyl or amino, Z represents --CH.sub.2 -, --O--, --S-- or --NH--; represents ##STR3## each of R.sup.1 and R.sup.2 independently represents hydrogen, lower alkyl, allyl or propargyl; and R.sup.3 represents hydrogen or lower alkyl, and when Q represents the groups other than ##STR4## each of R.sup.1, R.sup.2 and R.sup.3 independently represents hydrogen or lower alkyl;provided that when Q is ##STR5## then R.sup.1 R.sup.2 and R.sup.3 are notsimultaneously methyl; and pharmaceutically acceptable salts thereof have a diuretic effect, a renal-protecting effect and a bronchodilatory effect.

摘要翻译： 由下式表示的新型黄嘌呤化合物：其中X1和X2各自独立地表示氧或硫; 和Q表示; 其中-----表示单键或双键; Y表示单键或亚烷基，n表示0或1，W1和W2各自独立地表示氢，低级烷基或氨基，Z表示-CH2 - ， - O - ， - S-或-NH-。 R1和R2各自表示氢，低级烷基，烯丙基或炔丙基; 且R 3表示氢或低级烷基，并且当Q表示除R1之外的基团时，R 1，R 2和R 3各自独立地表示氢或低级烷基; 条件是当Q为时，则R1 + L，R2和R3不同时为甲基; 及其药学上可接受的盐具有利尿作用，肾脏保护作用和支气管扩张作用。

公开(公告)号：US5248684A

公开(公告)日：1993-09-28

申请号：US703849

申请日：1991-05-21

申请人： Fumio Suzuki ,  Hiroaki Hayashi ,  Yoshikazu Miwa ,  Akio Ishii ,  Shunji Ichikawa ,  Ichiro Miki

发明人： Fumio Suzuki ,  Hiroaki Hayashi ,  Yoshikazu Miwa ,  Akio Ishii ,  Shunji Ichikawa ,  Ichiro Miki

IPC分类号： A61K31/435 ,  A61K31/4375 ,  A61K31/46 ,  A61K31/47 ,  A61K31/4704 ,  A61P1/08 ,  A61P25/04 ,  A61P25/06 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P43/00 ,  C07D451/04 ,  C07D451/12 ,  C07D451/14 ,  C07D519/00

CPC分类号： C07D451/04 ,  C07D451/12 ,  C07D451/14

摘要： There is disclosed a heterocyclic compound represented by general formula: ##STR1## wherein R.sup.1 represents hydrogen, lower alkyl or aryl; R.sup.2 represents hydrogen, hydroxyl or lower alkyl; A represents CH or N; X represents --O-- or --NH--; R.sup.3 represents hydrogen, hydroxyl or lower alkyl; R.sup.4 represents lower alkyl; represents 0 or 1, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US5066087A

公开(公告)日：1991-11-19

申请号：US490026

申请日：1990-03-07

申请人： Ryozo Yamauchi ,  Noboru Kawakami ,  Fumio Suzuki

发明人： Ryozo Yamauchi ,  Noboru Kawakami ,  Fumio Suzuki

IPC分类号： G02B6/28 ,  G02B6/34

CPC分类号： G02B6/29332 ,  G02B6/2835

摘要： The optical fiber coupler of the present invention is characterized in that, for a defined section in which two or more component optical fibers are thermally fused and elongated thereby forming a fused-elongated region which constitutes the optical fiber coupler, that at least one of the component optical fibers is formed from a single mode optical fiber material employed within a parameter range in which the mode field diameter increases monotonically with decrease in the diameter of the optical fiber core. The optical fiber coupler is further characterized in that, when using optical fibers from which a portion of the coating material has been removed thereby exposing the cladding, and by aligning two or more of such component optical fibers side by side in a plane and mutually thermally fusing the exposed cladding of adjacent optical fibers, after which the fused region is drawn out, thereby forming a fused-elongated region which constitutes the optical fiber coupler, for such an optical fiber coupler, optical fiber material is used in which the softening temperature of the core is higher than that of the cladding, and further, for the drawing out of the mutually fused sections, the tension employed is such that by virtue of remaining stress, the refractive index of the core is reduced.

摘要翻译： 本发明的光纤耦合器的特征在于，对于其中两个或更多个组件光纤被热熔合和拉长的限定部分，由此形成构成光纤耦合器的熔融拉长区域，至少一个 分量光纤由单模光纤材料形成，该单模光纤材料在模场直径随着光纤芯直径的减小而单调增加的参数范围内使用。 光纤耦合器的特征还在于，当使用从其中去除了一部分涂层材料的光纤而使包层暴露的光纤，并且通过将两个或更多个这种组件光纤并排在一个平面中并相互热 熔化相邻光纤的暴露的包层，之后将熔融区域拉出，从而形成构成光纤耦合器的熔融 - 伸长区域，对于这种光纤耦合器，使用光纤材料，其中软化温度 该芯高于包层的芯，此外，为了从相互熔合的部分拉出，所使用的张力使得由于剩余应力，芯的折射率降低。

公开(公告)号：US5064938A

公开(公告)日：1991-11-12

申请号：US617265

申请日：1990-11-23

申请人： Fumio Suzuki ,  Hideaki Habara ,  Yutaro Fukuda ,  Haruki Sato ,  Hiromasa Inada

发明人： Fumio Suzuki ,  Hideaki Habara ,  Yutaro Fukuda ,  Haruki Sato ,  Hiromasa Inada

IPC分类号： C08F6/22 ,  C08J3/16

CPC分类号： C08J3/16 ,  C08F6/22

摘要： The invention discloses a process for the production of a particulate polymer which contains few fine particles and has a narrow particle size distribution and a controlled bulk specific gravity. Characteristic features of the process of this invention reside in that a polymer latex obtained by emulsion polymerization is successively processed through the following steps (I) and (II):Step (I) The polymer latex is coagulated into a slurry in which particles thus coagulated are dispersed in water.Step (II) The slurry obtained in Step (I), an organic liquid almost insoluble in water and incapable of dissolving the polymer and water are mixed for granulation under the conditions that(a) The proportion of water in the whole mixture is 50-85 wt. %,(b) The amount of the organic liquid is 15-150 parts by weight per 100 parts by weight of the polymer in the polymer latex, and(c) The temperature T (.degree.C.) of the whole mixture is maintained for 0.5 minute to 1 hour on average within the range of the following equation:A-40.ltoreq.T.ltoreq.A wherein A means the azeotropic temperature (.degree.C.) of the mixture.In the above process, control of the interfacial tension between the organic liquid and the dispersion medium of the slurry within a specific range has made it possible to control the particle size of the resulting particulate polymer to a desired level.

摘要翻译： 本发明公开了一种生产微粒聚合物的方法，该颗粒聚合物含有很少的细颗粒，并且具有窄的粒度分布和受控的体积比重。 本发明方法的特征在于通过乳液聚合获得的聚合物胶乳通过以下步骤（I）和（II）连续加工：步骤（I）将聚合物胶乳凝结成浆料，其中由此凝结的颗粒 分散在水中。 步骤（II）将步骤（I）中获得的浆料，几乎不溶于水并且不能溶解聚合物和水的有机液体在以下条件下混合制粒，（a）整个混合物中的水的比例为50- 85重量％ ％，（b）有机液体的量相对于聚合物胶乳中的聚合物每100重量份为15-150重量份，（c）保持整个混合物的温度T（℃）为 在下列等式的范围内平均0.5分钟至1小时：A-40

公开(公告)号：US5029961A

公开(公告)日：1991-07-09

申请号：US431676

申请日：1989-11-02

申请人： Fumio Suzuki ,  Tohru Arikawa ,  Noboru Kawakami ,  Yoshio Kikuchi ,  Kuniharu Himeno ,  Osamu Fukuda

发明人： Fumio Suzuki ,  Tohru Arikawa ,  Noboru Kawakami ,  Yoshio Kikuchi ,  Kuniharu Himeno ,  Osamu Fukuda

IPC分类号： G02B6/28

CPC分类号： G02B6/283 ,  G02B6/2826 ,  G02B6/2843

摘要： An optical fiber coupler is disclosed, which comprises two polished substrates each of which comprises a grooved substrate having a polished surface on the open side end thereof and adapted to hold therein an optical fiber and an optical fiber comprising a core, a cladding and two stress-applying parts arranged in the cladding so as to sandwich the core, a part of the optical fiber being polished off such that the polished surface of the fiber is close to the core so as to allow leakage of light power propagating in the core to the outside, the polished optical fiber being embedded in the grooved substrate and fixed thereto in such a manner that the polished surface of the grooved substrate is in flush with the polished surface of the polished optical fiber, with the two polished substrates being in close contact with each other at the polished surfaces thereof to allow coupling of light power, wherein said polished optical fiber is of a construction such that the polished surface thereof is perpendicular to the polarization principal axis X defined as the direction connecting the centers of said stress-applying parts. Also, a process for manufacturing the optical fiber coupler is disclosed.

摘要翻译： 公开了一种光纤耦合器，其包括两个抛光衬底，每个衬底包括在其开放侧端具有抛光表面的开槽衬底，并且适于保持光纤和包括芯，包层和两个应力的光纤 将布置在包层中的部件布置成夹住芯部，将光纤的一部分抛光，使得光纤的抛光表面靠近芯部，以便允许将在芯部中传播的光功率泄漏到 抛光后的光纤被嵌入到带槽的基板中并以固定的方式固定，使得凹槽基板的抛光表面与抛光光纤的抛光表面齐平，两个抛光的基板与 彼此在其抛光表面处以允许光功率的耦合，其中所述抛光光纤具有这样的结构， eof垂直于被定义为连接所述应力施加部分的中心的方向的偏振主轴线X. 另外，公开了一种光纤耦合器的制造方法。

公开(公告)号：US4977241A

公开(公告)日：1990-12-11

申请号：US140670

申请日：1987-12-24

申请人： Teruhiko Sugimori ,  Fumio Suzuki ,  Hideaki Habara ,  Hiromasa Inada

发明人： Teruhiko Sugimori ,  Fumio Suzuki ,  Hideaki Habara ,  Hiromasa Inada

IPC分类号： C08F6/00 ,  C08C1/065 ,  C08F6/18 ,  C08J3/12 ,  C08J3/16

CPC分类号： C08C1/065 ,  C08F6/18 ,  C08J3/12 ,  C08J3/16 ,  C08J2321/02

摘要： Disclosed herein is a particulate polymer prepared by the agglomeration of polymer particles contained in a polymer latex. The particulate polymer is composed of primary particles having particle sizes of at least 20 .mu.m and/or secondary particles formed by the agglomeration of at least some of the primary particles and is in the form of a compact mass substantially free of voids. The particulate polymer is prepared by coagulating the polymer latex in the presence of a coagulant and an organic liquid having low solubility in water. The particulate polymer has a high bulk specific gravity and contains few fine particles. It is thus easy to handle and allows the consumption of energy to be reduced in the drying step.

公开(公告)号：US4939785A

公开(公告)日：1990-07-03

申请号：US200101

申请日：1988-05-31

申请人： Yoshitoshi Murata ,  Masahiko Hirono ,  Toshihiko Shibata ,  Fumio Suzuki ,  Mitsuo Sato ,  Tadao Hashimoto

发明人： Yoshitoshi Murata ,  Masahiko Hirono ,  Toshihiko Shibata ,  Fumio Suzuki ,  Mitsuo Sato ,  Tadao Hashimoto

IPC分类号： H04W84/16

CPC分类号： H04W84/16

摘要： In a radio communication network system for use in carrying out communication with a plurality of radio telephone sets in a service zone by the use of a control channel and a plurality of speech channels, a connecting equipment unit (CE) is selectively operable in cooperation with a radio control unit (RCU) in a speech mode of forming a speech path through a selected one of the speech channels and an additional mode of selectively monitoring the control and the speech channels. The additional mode may be divided into first and second control modes for allowing and rejecting reception of a call with the control channel monitored, respectively. Alternatively, either a rest mode or a combination of rest and initial program loading modes may be added to the additional mode. A plurality of the connecting equipment units may be located in a single service zone and selectively put into the speech and the additional modes with only one of the connecting equipment units kept in the first control mode.

公开(公告)号：US4874841A

公开(公告)日：1989-10-17

申请号：US898018

申请日：1986-08-19

申请人： Teruhiko Sugimori ,  Fumio Suzuki ,  Hideaki Habara ,  Hiromasa Inada

发明人： Teruhiko Sugimori ,  Fumio Suzuki ,  Hideaki Habara ,  Hiromasa Inada

IPC分类号： C08F6/00 ,  C08C1/065 ,  C08F6/18 ,  C08J3/12 ,  C08J3/16

CPC分类号： C08C1/065 ,  C08F6/18 ,  C08J3/12 ,  C08J3/16 ,  C08J2321/02

摘要： Disclosed herein is a particulate polymer prepared by the agglomeration of polymer particles contained in a polymer latex. The particulate polymer is composed of primary particles having particle sizes of at least 20 .mu.m and/or secondary particles formed by the agglomeration of at least some of the primary particles and is in the form of a compact mass substantially free of voids. The particulate polymer is prepared by coagulating the polymer latex in the presence of a coagulant and an organic liquid having low solubility in water. The particulate polymer has a high bulk specific gravity and contains few fine particles. It is thus easy to handle and allows the consumption of energy to be reduced in the drying step.

摘要翻译： 本文公开了通过聚合物胶乳中包含的聚合物颗粒的聚集制备的颗粒聚合物。 颗粒状聚合物由至少20μm的粒径的一次粒子和/或由至少一些初级粒子附聚形成的二次粒子组成，并且呈基本上不含空隙的致密质量的形式。 颗粒聚合物通过在凝结剂和在水中溶解度低的有机液体存在下使聚合物胶乳凝结来制备。 颗粒聚合物具有高堆积比重并且几乎没有细颗粒。 因此，易于处理并允许在干燥步骤中减少能量的消耗。