公开(公告)号：US08729131B2

公开(公告)日：2014-05-20

申请号：US13635063

申请日：2011-03-17

申请人： Hanbin Shan ,  Zhedong Yuan ,  Xueyan Zhu ,  Peng Zhang ,  Hongjuan Pan ,  Xiong Yu

发明人： Hanbin Shan ,  Zhedong Yuan ,  Xueyan Zhu ,  Peng Zhang ,  Hongjuan Pan ,  Xiong Yu

IPC分类号： A01N37/18 ,  A61K31/16 ,  C07C233/00 ,  C07C235/00 ,  C07C237/00 ,  C07C239/00

CPC分类号： C07C233/18 ,  A61K31/165

摘要： The present invention relates to an agomelatine hydrochloride hydrate of formula I, preparation and use thereof, and to pharmaceutical composition containing it. The agomelatine hydrohalide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps. wherein X is Cl.

摘要翻译： 本发明涉及式I的盐酸阿维生素水合物，其制备和用途以及含有它的药物组合物。 通过本发明方法获得的氢溴酸阿尔美拉坦氢氧化物水合物的溶解度高于阿魏酸，因此更适用于制备药物制剂。 此外，该产品具有更高的稳定性和纯度。 使用本方法，可以通过简单的工艺获得高纯度的产品，没有任何复杂的步骤。 其中X是Cl。

公开(公告)号：US20130280123A1

公开(公告)日：2013-10-24

申请号：US13819249

申请日：2011-08-26

申请人： Tianniu Chen ,  Steven Bilodeau ,  Chimin Sheu ,  Mutsumi Nakanishi ,  Masahiro Matsuoka ,  Fumio Nakayama ,  Peng Zhang ,  Michael B. Korzenski ,  Emanuel I. Cooper ,  Kate Veccharelli ,  Makonnen Payne

发明人： Tianniu Chen ,  Steven Bilodeau ,  Chimin Sheu ,  Mutsumi Nakanishi ,  Masahiro Matsuoka ,  Fumio Nakayama ,  Peng Zhang ,  Michael B. Korzenski ,  Emanuel I. Cooper ,  Kate Veccharelli ,  Makonnen Payne

IPC分类号： C09C3/08

CPC分类号： C09C3/08 ,  B81C1/00619 ,  B81C1/00928 ,  H01L21/02082 ,  H01L21/302 ,  H01L21/306

摘要： Methods of reducing the capillary forces experienced by fragile high aspect ratio structures during drying to substantially prevent damage to said high aspect ratio structures during drying. They include modifying the surface of the high aspect ratio structures such that the forces are sufficiently minimized and as such less than 10% of the high aspect ratio features will have bent or collapsed during drying of the structure having said features thereon.

摘要翻译： 在干燥期间减少易碎的高纵横比结构所经受的毛细作用力的方法，以基本上防止在干燥过程中对所述高纵横比结构的损坏。 它们包括改变高纵横比结构的表面，使得力被充分地最小化，并且因此在其具有所述特征的结构的干燥期间，小于10％的高纵横比特征将具有弯曲或折叠。

公开(公告)号：US20130267738A1

公开(公告)日：2013-10-10

申请号：US13702388

申请日：2011-06-08

申请人： Peng Zhang ,  Yu Huang ,  Zhedong Yuan ,  Hanbin Shan ,  Xiong Yu

发明人： Peng Zhang ,  Yu Huang ,  Zhedong Yuan ,  Hanbin Shan ,  Xiong Yu

IPC分类号： C07C231/06 ,  C07C233/22

CPC分类号： C07C231/06 ,  C07C231/12 ,  C07C233/18 ,  C07C233/22 ,  C07C2602/10

摘要： The present invention relates to the intermediate compounds for preparation of agomelatine, as well as the preparation methods thereof. The intermediate of the present invention for preparation of agomelatine is compound A as shown in the following formula. Also provided are two novel intermediate compounds. When we use these new intermediate compounds to prepare agomelatine, it is simple to manipulate, well-controlled and with high purity, without complicated operations such as rectification and column chromatography separation, and suitable for industrial production. Meanwhile, the preparation methods of the two new intermediates themselves is simple and high yield, only using the most commonly-used 7-methoxy-tetralone as original starting material and undergoing one step of reaction to obtain the intermediates, followed by one more step of converting the intermediate compounds to desired product agomelatine. Said reaction processes are greatly simplified, with the reaction yield being improved and the difficulty in purification of previous method being overcome, as compare with the previous technique for preparation of agomelatine. Typically, the yield of the present invention is over 70%.

摘要翻译： 本发明涉及用于制备agomelatine的中间体化合物及其制备方法。 本发明的用于制备agomelatine的中间体是下式所示的化合物A. 还提供两种新型中间体化合物。 当我们使用这些新的中间体化合物来制备agomelatine时，其操作简单，控制良好，纯度高，无需精馏和柱层析分离等复杂操作，适用于工业生产。 同时，两种新中间体本身的制备方法简单高产，仅使用最常用的7-甲氧基 - 四氢萘酮作为起始原料，经过一步反应得到中间体，再加入一步 将中间体化合物转化成所需的产物agomelatine。 所述反应过程被大大简化，与先前用于制备agMelatine的技术相比，反应产率提高并克服了先前方法的纯化困难。 通常，本发明的产率超过70％。

公开(公告)号：US08510535B2

公开(公告)日：2013-08-13

申请号：US12141983

申请日：2008-06-19

申请人： Yuefan Deng ,  Peng Zhang

发明人： Yuefan Deng ,  Peng Zhang

IPC分类号： G06F15/76

CPC分类号： G06F15/17337

摘要： The present invention provides a mixed torus and hypercube multi-rank tensor expansion method which can be applied to the communication subsystem of a parallel processing system. The said expansion method is based on the conventional torus and hypercube topologies. A mixed torus and hypercube multi-rank tensor expansion interconnection network is built up by means of supernodes equipped with expansion interfaces. This method not only provides more bisection bandwidth to the entire system but also improves the long-range communication and global operations. Affirmatively, this expansion method can achieve better scalability and flexibility for the parallel system for a given system size.

摘要翻译： 本发明提供了可应用于并行处理系统的通信子系统的混合环面和超立方体多等级张量展开方法。 所述扩展方法基于传统的环面和超立方体拓扑。 通过配备扩展接口的超节点，建立了混合环面和超立方体多级张量扩展互连网络。 该方法不仅可以为整个系统提供更多的二等分带宽，而且可以改善远程通信和全局操作。 肯定地说，这种扩展方法可以为给定系统大小的并行系统实现更好的可扩展性和灵活性。

公开(公告)号：US20130130975A1

公开(公告)日：2013-05-23

申请号：US13640720

申请日：2011-04-15

申请人： Zhaodan Cao ,  Yarong Lu ,  Daniel David Kaplan ,  Peng Zhang

发明人： Zhaodan Cao ,  Yarong Lu ,  Daniel David Kaplan ,  Peng Zhang

IPC分类号： A61K38/17

CPC分类号： A61K38/1709 ,  A61K9/0019 ,  C07K2319/30 ,  C12N2750/14143

摘要： Methods of treating individuals with a glucose metabolism disorder, and compositions thereof, are provided.

公开(公告)号：US20130012592A1

公开(公告)日：2013-01-10

申请号：US13635087

申请日：2011-03-17

申请人： Hanbin Shan ,  Zhedong Yuan ,  Xueyan Zhu ,  Peng Zhang ,  Hongjuan Pan ,  Xiong Yu

发明人： Hanbin Shan ,  Zhedong Yuan ,  Xueyan Zhu ,  Peng Zhang ,  Hongjuan Pan ,  Xiong Yu

IPC分类号： A61K31/16 ,  C07C231/12 ,  A61P25/20 ,  A61P25/18 ,  A61P25/00 ,  A61P25/24 ,  A61P9/00 ,  A61P1/00 ,  C07C233/25 ,  A61P25/22

CPC分类号： C07C233/18 ,  A61K31/165

摘要： The present invention relates to an agomelatine hydrobromide hydrate of formula I wherein X is Br, preparation and use thereof, and to pharmaceutical compositions containing it. The agomelatine hydrobromide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps.

摘要翻译： 本发明涉及其中X是Br的式I的氢溴酸阿尔美拉酸水合物，其制备和用途以及含有它的药物组合物。 通过本发明方法获得的氢溴酸氢溴酸水合物与阿魏酸相比具有显着增加的溶解度，因此更适用于制备药物制剂。 此外，该产品具有更高的稳定性和纯度。 使用本方法，可以通过简单的工艺获得高纯度的产品，没有任何复杂的步骤。

公开(公告)号：US20130005820A1

公开(公告)日：2013-01-03

申请号：US13635063

申请日：2011-03-17

申请人： Hanbin Shan ,  Zhedong Yuan ,  Xueyan Zhu ,  Peng Zhang ,  Hongjuan Pan ,  Xiong Yu

发明人： Hanbin Shan ,  Zhedong Yuan ,  Xueyan Zhu ,  Peng Zhang ,  Hongjuan Pan ,  Xiong Yu

IPC分类号： C07C233/18 ,  A61P25/22 ,  A61P25/24 ,  A61P3/00 ,  A61P9/12 ,  A61P25/18 ,  A61P25/00 ,  A61K31/165 ,  A61P9/00

CPC分类号： C07C233/18 ,  A61K31/165

摘要： The present invention relates to an agomelatine hydrochloride hydrate of formula I, preparation and use thereof, and to pharmaceutical composition containing it. The agomelatine hydrohalide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps. wherein X is Cl.

摘要翻译： 本发明涉及式I的盐酸阿维生素水合物，其制备和用途以及含有它的药物组合物。 通过本发明方法获得的氢溴酸阿尔美拉坦氢氧化物水合物的溶解度高于阿魏酸，因此更适用于制备药物制剂。 此外，该产品具有更高的稳定性和纯度。 使用本方法，可以通过简单的工艺获得高纯度的产品，没有任何复杂的步骤。 其中X是Cl。

公开(公告)号：US20120315274A1

公开(公告)日：2012-12-13

申请号：US13519557

申请日：2011-01-07

申请人： Zhaodan Cao ,  Yarong Lu ,  Peng Zhang ,  Daniel David Kaplan

发明人： Zhaodan Cao ,  Yarong Lu ,  Peng Zhang ,  Daniel David Kaplan

IPC分类号： A61K38/17 ,  A61P3/10 ,  A61K39/395 ,  A61P3/00

CPC分类号： A61K38/1709

摘要： Methods of treating individuals with a glucose metabolism disorder such as diabetes, hyperglycemia, hyperinsulinemia or obesity by administering human FAM3D (family with sequence similarity 3, member D) are provided. Specifically a method of treating hyperglycemia resulting in a reduction of plasma glucose is provided. Additionally, a method of treating hyperinsulinemia resulting in a reduction of plasma glucose is provided. In addition, a method of treating glucose intolerance resulting in an increased glucose tolerance is provided. Pharmaceutical compositions are provided.

摘要翻译： 提供了通过施用人FAM3D（具有序列相似性3，成员D的家族）来治疗患有葡萄糖代谢紊乱例如糖尿病，高血糖症，高胰岛素血症或肥胖症的个体的方法。 具体地说，提供了治疗导致血浆葡萄糖降低的高血糖症的方法。 此外，提供了治疗导致血浆葡萄糖降低的高胰岛素血症的方法。 此外，提供了治疗葡萄糖耐受不良的方法，其导致葡萄糖耐量增加。 提供药物组合物。

公开(公告)号：US08306124B2

公开(公告)日：2012-11-06

申请号：US10584844

申请日：2004-07-08

申请人： Wen Gao ,  Junhao Zheng ,  Siwei Ma ,  Xiangyang Ji ,  Peng Zhang ,  Yan Lu

发明人： Wen Gao ,  Junhao Zheng ,  Siwei Ma ,  Xiangyang Ji ,  Peng Zhang ,  Yan Lu

IPC分类号： H04N7/12

CPC分类号： H04N19/132 ,  H04N19/176 ,  H04N19/51 ,  H04N19/61 ,  H04N19/70

摘要： An encoding method for skipped macroblocks in a video image includes the steps of: adding one indication bit into a picture header for indicating a coding mode for skipped macroblocks in a current image; selecting the coding mode for a macroblock type in the current image according to the number of skipped macroblocks, if it is a run_length coding, then setting the indication bit of the picture header as a status indicating a run_length coding, and encoding the macroblock type in the image by the run_length coding mode; if it is a joint coding, then setting the indication bit of the picture header as status indicating a joint coding and encoding the macroblock type in the image by the joint coding mode of the number of skipped macroblocks and the macroblock type; finally, encoding other data in the current macroblock and writing data into a code stream.

摘要翻译： 视频图像中的跳过宏块的编码方法包括以下步骤：将一个指示位添加到用于指示当前图像中的跳过宏块的编码模式的图像头中; 根据跳过的宏块的数量，选择当前图像中的宏块类型的编码模式，如果是长度编码，则将图像头的指示位设置为指示运行长度编码的状态，并将宏块类型编码 图像由run_length编码模式; 如果是联合编码，则通过跳过的宏块的数量和宏块类型的联合编码模式将图像头的指示位设置为指示图像中的宏块类型的联合编码和编码的状态; 最后，编码当前宏块中的其他数据并将数据写入代码流。

公开(公告)号：US08227395B2

公开(公告)日：2012-07-24

申请号：US12846369

申请日：2010-07-29

申请人： Peng Zhang ,  Danielle Megan King Curzi ,  Eugene Joseph Karwacki, Jr. ,  Leslie Cox Barber

发明人： Peng Zhang ,  Danielle Megan King Curzi ,  Eugene Joseph Karwacki, Jr. ,  Leslie Cox Barber

IPC分类号： C11D1/00

CPC分类号： G03F7/322 ,  G03F7/0048 ,  G03F7/091 ,  G03F7/16 ,  G03F7/168 ,  G03F7/3021 ,  G03F7/32 ,  G03F7/38 ,  G03F7/40 ,  G03F7/425 ,  Y10S134/902

摘要： Process solutions comprising one or more surfactants are used to reduce the number of defects in the manufacture of semiconductor devices. In certain preferred embodiments, the process solution of the present invention may reduce post-development defects such as pattern collapse when employed as a rinse solution either during or after the development of the patterned photoresist layer. Also disclosed is a method for reducing the number of pattern collapse defects on a plurality of photoresist coated substrates employing the process solution of the present invention.

摘要翻译： 使用包含一种或多种表面活性剂的工艺溶液来减少半导体器件制造中的缺陷数量。 在某些优选实施方案中，当在图案化光致抗蚀剂层的显影期间或之后，当用作冲洗溶液时，本发明的工艺溶液可以减少显影后缺陷，例如图案塌陷。 还公开了一种减少使用本发明的工艺溶液的多个光致抗蚀剂涂覆的基材上的图案塌陷缺陷的数量的方法。