摘要:
The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below.The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
摘要:
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要:
Systems and methods for administering trade orders are described. An embodiment comprises receiving, from a first server operated by a first trader, a communication including a first trade order and one or more selection criteria, the first trade order including at least one of a specified instrument, a specified quantity, and a specified price; determining that a database of trade orders does not contain a trade order matching the first trade order; identifying a plurality of traders satisfying the selection criteria; sending, to a plurality of second servers, a query including at least one of the specified instrument, the specified quantity, and the specified price; receiving, from a one of the plurality of second servers operated on behalf of a second trader, a positive response to the query; and facilitating execution of a trade between the first trader and the second trader for the specified instrument at the specified price.
摘要:
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要:
Improved approaches to allow a portable electronic device to dynamically present location-specific information while the portable electronic device is at a predetermined location are disclosed. In one embodiment, the portable electronic device has a display that can display the location-specific information and has wireless capabilities for use in receiving the location-specific information from the server. The location-specific information can, for example, augment other information that is to be presented on the display. In one embodiment, the location-specific information can be information pertaining to a media item being played in an establishment, such as a store, where the portable electronic device is located.
摘要:
A communication system having a first station and a second station in communication over a wireless communications link. The first station is operative during a communication session to assemble signals from multiple data sources into a common data stream and to transmit the data stream as frame-based communication signals to the second station. The first station comprises a dynamically configurable multiplexer that is operative during a communication session (1) to generate the common data stream by multiplexing the signals in accordance with a plurality of control parameters and assemble said signals according to frames, (2) to dynamically modify the plurality of control parameters in accordance with changes in wireless link conditions and (3) to generate control signals identifying modifications to the control parameters. The first station is operative to transmit to said second station the signals assembled according to frames and the control signals
摘要:
Scheduling of threads in a multi-core system is performed using per-processor queues for each core to hold threads with fixed affinity for each core. Cores are configured to pick the highest priority thread among the global run queue, which holds threads without affinity, and their respective per-processor queue. To select between two threads with same priority on both queues, the threads are assigned sequence numbers based on their time of arrival. The sequence numbers may be weighted for either queue to prioritize one over the other.