公开(公告)号：US20180255286A1

公开(公告)日：2018-09-06

申请号：US15446194

申请日：2017-03-01

Applicant: Wally Haas ,  Jennifer Campbell-Correa ,  Matthew Hamilton ,  Stephen Hill ,  Jordan Peckham ,  Chuck Rumbolt

Inventor： Wally Haas ,  Jennifer Campbell-Correa ,  Matthew Hamilton ,  Stephen Hill ,  Jordan Peckham ,  Chuck Rumbolt

IPC: H04N13/04 ,  H01L51/52 ,  H01L27/32

CPC classification number: H04N13/351 ,  G02B26/08 ,  G02B27/225 ,  G02B2005/1804 ,  H01L27/3211 ,  H01L27/3244 ,  H01L51/5265 ,  H04N13/32 ,  H04N13/324 ,  H04N13/363 ,  H04N13/398 ,  H04N2213/001

Abstract: The present disclosure relates to a directional pixel for a high-angular resolution, wide field of view, multiple view display. The design teaches a directional pixel comprising a substrate, one or more pixel driving circuits, one or more nano- or micro-scale subpixels, and one or more directional optical guiding surfaces, wherein each of said one or more subpixels is comprised of a light emitting device emitting a light beam and an optical microcavity housing said light emitting device. The optical microcavity is comprised of a plurality of reflective surfaces to specifically manipulate and tune said light beam, wherein one or more of said reflective surfaces is a light propagating reflective surface which propagates said light beam out of said microcavity, and said light propagating reflective surface is connected to said one or more directional optical guiding surfaces to direct said light beam at a specific angle. A high-angular resolution, multiple-view light-field display is created by deploying a plurality of directional pixels into a directional pixel array system.

公开(公告)号：US08541453B2

公开(公告)日：2013-09-24

申请号：US13112115

申请日：2011-05-20

Applicant: Sara Sabina Hadida-Ruah ,  Peter Diederik Jan Grootenhuis ,  Mark Thomas Miller ,  Matthew Hamilton

Inventor： Sara Sabina Hadida-Ruah ,  Peter Diederik Jan Grootenhuis ,  Mark Thomas Miller ,  Matthew Hamilton

IPC: C07D231/40 ,  C07D233/88 ,  C07D263/48 ,  C07D271/113 ,  C07D277/46 ,  C07D277/54 ,  C07D277/82 ,  C07D285/135 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D493/10 ,  A61K31/454 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/433 ,  A61K31/4245 ,  A61K31/4178 ,  A61K31/422 ,  A61P11/00 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  A61P25/28 ,  A61P25/00 ,  A61P1/12 ,  A61P27/02 ,  A61P13/12

CPC classification number: C07D417/12 ,  C07D231/40 ,  C07D233/88 ,  C07D263/48 ,  C07D271/113 ,  C07D277/46 ,  C07D277/54 ,  C07D277/82 ,  C07D285/135 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D493/10

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：US08318733B2

公开(公告)日：2012-11-27

申请号：US13108077

申请日：2011-05-16

Applicant: Sara Sabina Hadida-Ruah ,  Matthew Hamilton ,  Mark Thomas Miller ,  Peter Diederik Jan Grootenhuis ,  Jinglan Zhou ,  Brian Richard Bear ,  Jason McCartney

Inventor： Sara Sabina Hadida-Ruah ,  Matthew Hamilton ,  Mark Thomas Miller ,  Peter Diederik Jan Grootenhuis ,  Jinglan Zhou ,  Brian Richard Bear ,  Jason McCartney

IPC: A61K31/5377 ,  A61K31/497 ,  A61K31/506 ,  A61K31/4418 ,  A61K31/443

CPC classification number: C07D405/12 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D405/14

Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：US07977322B2

公开(公告)日：2011-07-12

申请号：US11202278

申请日：2005-08-11

Applicant: Sara Hadida Ruah ,  Peter Grootenhuis ,  Mark Miller ,  Matthew Hamilton

Inventor： Sara Hadida Ruah ,  Peter Grootenhuis ,  Mark Miller ,  Matthew Hamilton

IPC: C07D277/00 ,  A01N57/00

CPC classification number: C07D417/12 ,  C07D231/40 ,  C07D233/88 ,  C07D263/48 ,  C07D271/113 ,  C07D277/46 ,  C07D277/54 ,  C07D277/82 ,  C07D285/135 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D493/10

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：US07846951B2

公开(公告)日：2010-12-07

申请号：US12183580

申请日：2008-07-31

Applicant: Mark T. Miller ,  Sarah S. Hadida Ruah ,  Peter D. J. Grootenhuis ,  Matthew Hamilton

Inventor： Mark T. Miller ,  Sarah S. Hadida Ruah ,  Peter D. J. Grootenhuis ,  Matthew Hamilton

IPC: A61K31/426 ,  A61K31/427 ,  A61K31/496 ,  A61K31/4439 ,  A61K31/4427

CPC classification number: C07D263/34 ,  A61K31/42 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  C07D277/56 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：US07598412B2

公开(公告)日：2009-10-06

申请号：US10961485

申请日：2004-10-08

Applicant: Sara S. Hadida Ruah ,  Ashvani K. Singh ,  Mark T. Miller ,  Matthew Hamilton ,  Peter D. J. Grootenhuis

Inventor： Sara S. Hadida Ruah ,  Ashvani K. Singh ,  Mark T. Miller ,  Matthew Hamilton ,  Peter D. J. Grootenhuis

IPC: C07C229/00 ,  C07C233/00

CPC classification number: C07D307/87 ,  A61K31/00 ,  A61K31/335 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435 ,  A61K31/495 ,  A61K45/06 ,  C07C233/22 ,  C07C233/60 ,  C07C233/65 ,  C07C233/73 ,  C07C235/34 ,  C07C235/46 ,  C07C235/48 ,  C07C311/16 ,  C07C311/17 ,  C07C323/60 ,  C07C2601/08 ,  C07D209/42 ,  C07D213/82 ,  C07D215/54 ,  C07D217/26 ,  C07D231/14 ,  C07D231/56 ,  C07D237/28 ,  C07D261/20 ,  C07D307/68 ,  C07D307/85 ,  C07D333/32 ,  C07D333/70 ,  C07D407/12

Abstract: The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.

Abstract translation: 本发明提供了可用作ABC转运蛋白活性调节剂的式I化合物或其药学上可接受的盐，其中RB，n，B，RC，RD，RE，A和Z通常在下面的类别和亚类中进行描述。 本发明还提供了与式I相关的药物组合物，方法和试剂盒，其用作调节剂，以及用于治疗与ABC转运蛋白相关的疾病和疾病状况。

公开(公告)号：US20090018140A1

公开(公告)日：2009-01-15

申请号：US12183580

申请日：2008-07-31

Applicant: Mark T. Miller ,  Sarah S. Hadida Ruah ,  Peter D.J. Grootenhuis ,  Matthew Hamilton

Inventor： Mark T. Miller ,  Sarah S. Hadida Ruah ,  Peter D.J. Grootenhuis ,  Matthew Hamilton

IPC: A61K31/426 ,  A61K31/4439 ,  A61K31/496 ,  A61P43/00

CPC classification number: C07D263/34 ,  A61K31/42 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  C07D277/56 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：US20080113985A1

公开(公告)日：2008-05-15

申请号：US11594431

申请日：2006-11-08

Applicant: Sara S. Hadida Ruah ,  Matthew Hamilton ,  Mark Miller ,  Peter D.J. Grootenhuis ,  Brian Bear ,  Jason McCartney ,  Jinglan Zhou

Inventor： Sara S. Hadida Ruah ,  Matthew Hamilton ,  Mark Miller ,  Peter D.J. Grootenhuis ,  Brian Bear ,  Jason McCartney ,  Jinglan Zhou

IPC: A61K31/443 ,  A61K31/5377 ,  A61P25/00 ,  A61P3/00 ,  C07D401/12 ,  C07D413/14

CPC classification number: C07D405/12 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D405/14

Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：US20080019915A1

公开(公告)日：2008-01-24

申请号：US11804726

申请日：2007-05-18

Applicant: Sara Hadida-Ruah ,  Matthew Hamilton ,  Mark Miller ,  Peter Grootenhuis ,  Brian Bear ,  Jason McCartney ,  Jinglan Zhou ,  Frederick van Goor

Inventor： Sara Hadida-Ruah ,  Matthew Hamilton ,  Mark Miller ,  Peter Grootenhuis ,  Brian Bear ,  Jason McCartney ,  Jinglan Zhou ,  Frederick van Goor

IPC: A61K49/00 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4525 ,  A61K31/454 ,  A61P21/00 ,  A61P25/28 ,  A61P35/00 ,  C07D405/12 ,  C07D405/04 ,  C07D401/14 ,  C07D401/02 ,  C07D211/04 ,  A61P7/12 ,  A61P7/02 ,  A61P7/00 ,  A61P43/00 ,  C12Q1/18 ,  C07D413/14 ,  C07D413/02 ,  C07D405/14 ,  A61P3/10 ,  A61P25/16 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377

CPC classification number: C07D405/12 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D405/14

Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：US20060052358A1

公开(公告)日：2006-03-09

申请号：US11047366

申请日：2005-01-31

Applicant: Sarah Ruah ,  Peter Grootenhuis ,  Mark Miller ,  Matthew Hamilton

Inventor： Sarah Ruah ,  Peter Grootenhuis ,  Mark Miller ,  Matthew Hamilton

IPC: A61K31/55 ,  A61K31/454 ,  A61K31/433 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/421

CPC classification number: C07D231/40 ,  C07D233/46 ,  C07D233/88 ,  C07D263/48 ,  C07D271/10 ,  C07D271/113 ,  C07D277/40 ,  C07D277/46 ,  C07D277/54 ,  C07D277/82 ,  C07D285/135 ,  C07D317/60 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D493/10

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.