公开(公告)号：US20200302064A1

公开(公告)日：2020-09-24

申请号：US16358908

申请日：2019-03-20

Applicant: University of Florida Research Foundation, Inc.

Inventor： Swarup Bhunia ,  Jonathan William Cruz ,  Prabhat Kumar Mishra

IPC: G06F21/57 ,  G06F21/71

Abstract: A method and system for evaluating software tools that detect malicious hardware modifications is provided. In one embodiment, among others, a system comprises a computing device and an application. The application causes the computing device to at least receive hardware description language code that represents a circuit design and calculate a signal probability for one or more nodes in the circuit design. The application also causes the computing device to identify one or more rare nodes in the circuit design and generate a Trojan sample population. The application further causes the computing device to generate a feasible Trojan population and generate a Trojan test instance based at least in part on a random selection from the Trojan feasible population. Additionally, the application causes the computing device to generate modified hardware description code from the Trojan test instance.

公开(公告)号：US20200299370A1

公开(公告)日：2020-09-24

申请号：US16899307

申请日：2020-06-11

Applicant: University of Florida Research Foundation, Inc.

Inventor： Benoit Giasson ,  Todd Eliot Golde ,  Yona Levites

IPC: C07K16/18 ,  A61K51/00 ,  A61K49/00

Abstract: Disclosed herein are monoclonal antibodies targeting specific tau epitopes, particularly, phosphorylated tau epitopes. Also disclosed are methods of detecting tau protein in a subject, comprising performing an assay using the antibodies or antigen binding fragments thereof on the subject or on a biological sample obtained from the subject. Assay kits containing the disclosed antibodies are also provided. Further, methods of treating or preventing a tauopathy in a subject by administering to the subject tau antibodies or antigen-binding fragments thereof are provided.

公开(公告)号：US20200293730A1

公开(公告)日：2020-09-17

申请号：US16817282

申请日：2020-03-12

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Swarup Bhunia ,  Naren Vikram Masna ,  Soumyajit Mandal

IPC: G06K7/10

Abstract: This disclosure relates to tagging of materials and objects and analysis for authentication thereof. An example method includes analyzing separately a number of locations distributed across a given surface of a solid object according to one or more analysis technologies to determine feature data for each of the locations. The feature data are indicative of a respective chemical property and/or mechanical property of the solid object at each of the locations, corresponding to a feature tag, and the feature data depend on the one or more analysis technologies. The method also includes determining a tag signature for the solid object based on the feature data determined for each of the locations.

公开(公告)号：US10774407B2

公开(公告)日：2020-09-15

申请号：US15737339

申请日：2016-06-20

Applicant: University of Florida Research Foundation, Inc.

Inventor： Michele Viola Manuel

IPC: C22C30/04 ,  C22F1/00 ,  C22F1/10 ,  C22C1/02

Abstract: Disclosed herein is a shape memory alloy comprising 45 to 50 atomic percent nickel; and 1 to 30 atomic percent of at least one metalloid selected from the group consisting of germanium, antimony, zinc, gallium, tin, and a combination of one or more of the foregoing metalloids, with the remainder being titanium. The shape memory alloy may further contain aluminum. Disclosed herein too is a method of manufacturing the shape memory alloy.

公开(公告)号：US10772326B2

公开(公告)日：2020-09-15

申请号：US15271860

申请日：2016-09-21

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. ,  INTEGRATED PLANT GENETICS, INC.

Inventor： Dean W. Gabriel ,  Shujian Zhang

IPC: A01N35/02

Abstract: Methods and compositions based upon natural phenolic aromatic aldehydes (ex: cinnamaldehyde, benzaldehyde) are provided, which find use as curing agents for systemic bacterial infections of living plants, in particular against Gram negative bacteria and more particularly species of Liberibacter, including Ca. Liberibacter asiaticus. The curing agent compositions described are used synergistically with other antimicrobial compounds, such as those that plants manufacture or release as a result of biotic or abiotic stresses, including the application of the subject aldehydes, certain proteins, whether produced by recombinant methods or not, nanoparticles, nanoemulsions, or by natural essential oils such as carvacrol or allicin. The aromatic aldehydes have high volatility and exhibit phytotoxicity when applied above certain amounts. Systemic infections and infestations of a variety of plant parts can be treated, including those of leaves and roots. Methods of applying the compositions for agriculture use are disclosed.

公开(公告)号：US10765744B2

公开(公告)日：2020-09-08

申请号：US16093370

申请日：2017-04-21

Applicant: University of Florida Research Foundation, Inc.

Inventor： Carlos Rinaldi ,  Sun Hao ,  Brent S. Sumerlin

IPC: A61K41/00 ,  A61K47/69 ,  A61K47/60 ,  A61K47/52 ,  A61K9/107 ,  A61K47/34 ,  A61K47/02

Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MC-NC)), methods of making micelles, methods of using micelles, and the like.

公开(公告)号：US10765358B2

公开(公告)日：2020-09-08

申请号：US16152690

申请日：2018-10-05

Applicant: University of Florida Research Foundation, Inc.

Inventor： Hind Sattar Hussein

IPC: A61B5/00 ,  A61C19/04 ,  G09B19/24 ,  A61B5/107 ,  G09B23/28

Abstract: A dental instrument configured to measure a degree of tapering of a side wall of a tooth is described. The dental instrument may include a handle and a taper measuring component coupled to a distal end of the handle. The taper measuring component includes a first, second, and third elongated member. A bottom surface may be formed at a coupling point of the second and third elongated member, where the second elongated member is configured to be substantially vertical when the bottom surface is placed adjacent to a tooth, and the third elongated member projecting radially from the second elongated member at a predefined angle. The third elongated member is shaped and positioned to rest substantially flush along the at least one side wall of the tooth when a degree of tapering of the tooth is substantially similar to the angle, and may include a measuring component.

公开(公告)号：US10750746B2

公开(公告)日：2020-08-25

申请号：US16192248

申请日：2018-11-15

Applicant: University of Florida Research Foundation, Inc. ,  STC.UNM

Inventor： David G. Whitten ,  Kirk S. Schanze ,  Anand Parthasarathy ,  Eunkyung Ji ,  Motokatsu Ogawa ,  Thomas S. Corbitt ,  Dimitri Dascier ,  Ying Wang ,  Linnea K. Ista ,  Eric H. Hill

IPC: A01N43/90 ,  C07C217/14 ,  C07C309/11 ,  A01N25/10 ,  C07D409/14 ,  C07C217/20 ,  C07C309/24 ,  C07D333/16 ,  C07D487/08 ,  C08G61/02 ,  C08G75/00 ,  C08G61/12 ,  A01N25/08 ,  A01N33/10 ,  A01N33/12 ,  A01N41/04 ,  A01N43/10

Abstract: The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.

公开(公告)号：US20200255560A1

公开(公告)日：2020-08-13

申请号：US16648159

申请日：2018-08-24

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Adam S. Veige

IPC: C08F110/06 ,  C08G61/08 ,  C08F138/00 ,  C08F110/14

Abstract: Macrocyclic polyalkene homopolymers and copolymers can be formed and converted to macrocyclic polyalkanes or macrocyclic poly(alkane-co-alkene) upon hydrogenation or, when the macrocyclic polyalkene is reacted with an alkene in the presence of an olefin metathesis catalyst, to a macrocyclic poly(alkane-co-alkene) comprising vicinal —C(═CR2)—'s. Upon hydrogenation of a macrocyclic poly(alkane-co-alkene) comprising vicinal —C(═CR2)-'s, macrocyclic poly(alkane)s or poly(alkane-co-alkene)s with isolated —C(═CR2)- groups can be provided, depending on the degree of hydrogenation. The poly(alkane-co-alkene)s with isolated —C(═CR2)- units can be used to form poly(macrocyclic poly(alkane-co-alkene))s, poly(macrocyclic poly(alkane))s, and/or bi-, tri-, and/or multi-macrocyclic poly(alkane-co-alkene)s or bi-, tri-, and/or multi-macrocyclic poly(alkane)s.

公开(公告)号：US10731164B2

公开(公告)日：2020-08-04

申请号：US15397231

申请日：2017-01-03

Applicant: University of Florida Research Foundation, Inc.

Inventor： Adam S. Veige ,  Mary E. Garner ,  Weijia Niu

IPC: A61K35/35 ,  C12N5/077 ,  C12N15/115 ,  A61K47/54 ,  A61K31/555

Abstract: An aptamer-N-heterocyclic-carbene metal complex conjugate (aptamer-NHCM conjugate) or an aptamer-bis-N-heterocyclic-carbene metal complex conjugate (aptamer-bis-NHCM conjugate) includes an aptamer coupled through a hydrolytically stable bond to an N-heterocyclic-carbene metal complex (NHCM) or a bis-N-heterocyclic-carbene metal complex (bis-NHCM). The aptamer-NHCM conjugate is prepared where the chosen aptamer displays selective binding to a cell specific receptor, such that the cytotoxic NHCM can be directed specifically to cells responsible for a target disease (e.g., a specific cancer type). A method of preparing the aptamer-N-heterocyclic-carbene metal complex conjugate involves installing a coupling group to an N-heterocyclic-carbene metal complex that can specifically bond with a functional group on an aptamer; the bond, covalent or non-covalent, is stable hydrolytically in the absence of an environment that promotes intentional cleavage of the bond.