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公开(公告)号：US20250034336A1
公开(公告)日：2025-01-30
申请号：US18716560
申请日：2022-12-16
Inventor： Wallace Gregory Sawyer , Brent S. Sumerlin , Duy T. Nguyen , Jared Ian Bowman
Abstract: The present disclosure provides for microgels, microgel compositions, methods of making microgels and microgel compositions, methods of using microgels and microgel compositions, and the like. The present disclosure provides for microgel compositions having a plurality of agent functionalized microgel particles that have a neutral charge. The agent functionalized microgel particles can be made of a polymer, where the polymer can be functionalized with an activated functional group that are quenched or bonded to at least one type of agent through the activated functional group. The agent functionalized microgel particles can have a longest dimension of about 5 to 150 μm and an aspect ratio of about 1 to 1.5.
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公开(公告)号：US20230076717A1
公开(公告)日：2023-03-09
申请号：US17898545
申请日：2022-08-30
Inventor： Cullen L. Davidson , Wallace G. Sawyer , Brent S. Sumerlin , Juan M. Urueña Vargas
IPC: C08L33/24
Abstract: The present disclosure provides for compositions including at least one type of water-soluble polymer, methods of making the water-soluble polymer, structures having the water-soluble polymer disposed thereof, and methods of use thereof.
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公开(公告)号：US11311630B2
公开(公告)日：2022-04-26
申请号：US16937014
申请日：2020-07-23
Inventor： Carlos Rinaldi , Sun Hao , Brent S. Sumerlin
Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MCNC)), methods of making micelles, methods of using micelles, and the like.
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公开(公告)号：US10765744B2
公开(公告)日：2020-09-08
申请号：US16093370
申请日：2017-04-21
Inventor： Carlos Rinaldi , Sun Hao , Brent S. Sumerlin
Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MC-NC)), methods of making micelles, methods of using micelles, and the like.
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公开(公告)号：US20180273743A1
公开(公告)日：2018-09-27
申请号：US15995849
申请日：2018-06-01
Abstract: Described herein are embodiments of compositions and methods relating to three-dimensional (3D) printing. Some embodiments are directed to a composition comprising a polymer with one or more dormant functional groups. According to some embodiments, the polymer may be formed through a controlled radical polymerization method. Some embodiments are directed to a composition comprising a polymer with one or more pendent crosslinkable groups. In some cases, the composition may be used as an “ink” for 3D printing. For example, the composition may be injected into a medium. The composition and/or medium may, in some embodiments, further comprise an initiator and/or a crosslinker. After injection of the composition into the medium, the one or more dormant functional groups and/or one or more pendent crosslinkable groups may be activated, and the polymer may be crosslinked. In certain cases, the crosslinked polymer may be removed from the medium to produce a freestanding three-dimensional structure.
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Patent Agency Ranking
公开(公告)号：US20250002655A1
公开(公告)日：2025-01-02
申请号：US18771001
申请日：2024-07-12
Inventor： Brent S. Sumerlin , William L.A. Brooks , Christopher Deng
Abstract: Boronic acid monomers, methods of making boronic acid monomer, and the like, are provided. Embodiments of the present disclosure are advantageous in that the boronic acid monomers are water soluble at a neutral pH, which is uncommon for boronic acids. As a result, the boronic acid monomers can be used in aqueous polymerization reactions with other hydrophilic monomers to yield polymers including boronic acids and esters.
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公开(公告)号：US12065546B2
公开(公告)日：2024-08-20
申请号：US17211255
申请日：2021-03-24
Inventor： Brent S. Sumerlin , William L. A. Brooks , Christopher Deng
Abstract: Boronic acid monomers, methods of making boronic acid monomer, and the like, are provided. Embodiments of the present disclosure are advantageous in that the boronic acid monomers are water soluble at a neutral pH, which is uncommon for boronic acids. As a result, the boronic acid monomers can be used in aqueous polymerization reactions with other hydrophilic monomers to yield polymers including boronic acids and esters.
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公开(公告)号：US20210214507A1
公开(公告)日：2021-07-15
申请号：US17211255
申请日：2021-03-24
Inventor： Brent S. Sumerlin , William L.A. Brooks , Christopher Deng
Abstract: Boronic acid monomers, methods of making boronic acid monomer, and the like, are provided. Embodiments of the present disclosure are advantageous in that the boronic acid monomers are water soluble at a neutral pH, which is uncommon for boronic acids. As a result, the boronic acid monomers can be used in aqueous polymerization reactions with other hydrophilic monomers to yield polymers including boronic acids and esters.
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公开(公告)号：US10814605B2
公开(公告)日：2020-10-27
申请号：US15995849
申请日：2018-06-01
IPC: C08L33/24 , B33Y10/00 , C08F120/54 , C08F2/38 , B33Y70/00 , C08L25/06 , B29C64/118 , C08F12/08 , C08F20/18 , C08F20/56
Abstract: Described herein are embodiments of compositions and methods relating to three-dimensional (3D) printing. Some embodiments are directed to a composition comprising a polymer with one or more dormant functional groups. According to some embodiments, the polymer may be formed through a controlled radical polymerization method. Some embodiments are directed to a composition comprising a polymer with one or more pendent crosslinkable groups. In some cases, the composition may be used as an “ink” for 3D printing. For example, the composition may be injected into a medium. The composition and/or medium may, in some embodiments, further comprise an initiator and/or a crosslinker. After injection of the composition into the medium, the one or more dormant functional groups and/or one or more pendent crosslinkable groups may be activated, and the polymer may be crosslinked. In certain cases, the crosslinked polymer may be removed from the medium to produce a freestanding three-dimensional structure.
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10.发明申请公开(公告)号：US20200010798A1
公开(公告)日：2020-01-09
申请号：US16492293
申请日：2018-03-09
Inventor： Wallace Gregory Sawyer , Sangwoo Park , Christopher S. O'Bryan , Christopher P. Kabb , Brent S. Sumerlin , Thomas Ettor Angelini
Abstract: Microgel particles for use in a three-dimensional cell growth medium are described. The microgel particles may be swellable and may have properties conducive to improved function and health of cells distributed within the three-dimensional cell growth medium. Related compositions, systems, and methods are also described. Also provided is a plurality of microgel particles and a liquid cell culture medium, wherein the microgel particles are swelled with the liquid cell culture medium to form a granular gel. Also provided is a method of preparing a three-dimensional cell growth medium is disclosed. The method may comprise: mixing a plurality of microgel particles, such as those described above, in a liquid cell culture medium. Also provided is a method of placing cells in a three-dimensional cell growth medium is disclosed. Also provided is a method of synthesizing a protein is disclosed.
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