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    MENINGOCOCCAL INFECTION AND MODIFIED NEISSERIA LACTAMICA
    141.
    发明申请
    MENINGOCOCCAL INFECTION AND MODIFIED NEISSERIA LACTAMICA 审中-公开

    公开(公告)号：US20190307874A1

    公开(公告)日：2019-10-10

    申请号：US16062867

    申请日：2016-12-15

    Applicant: University of Southampton

    Inventor： Jay Robert Laver ,  Robert Charles Read

    IPC: A61K39/095 ,  C12N15/74

    Abstract: The invention relates to a modified Neisseria lactamica, wherein the modified Neisseria lactamica is transformed with recombinant DNA encoding a heterologous protein; a method of prophylactic treatment for pathogenic infection of a subject comprising nasopharyngeal inoculation of a modified Neisseria lactamica; a method of reducing or preventing meningococcal colonisation of a subject; a method of modifying the microbiome of a subject; a wild-type Neisseria lactamica for use for the prophylactic treatment of meningococcal infection of a subject or reducing colonisation of a subject, wherein the prophylactic treatment comprises nasopharyngeal inoculation of the wild-type Neisseria lactamica; associated nucleic acid for mutagenesis of Neisseria lactamica; methods of mutagenesis; outer membrane vesicle (OMV) vaccines; and associated compositions and methods thereof.

    FLUID FLOW DEVICE AND METHOD FOR MAKING THE SAME
    144.
    发明申请
    FLUID FLOW DEVICE AND METHOD FOR MAKING THE SAME 审中-公开

    公开(公告)号：US20190168217A1

    公开(公告)日：2019-06-06

    申请号：US16306255

    申请日：2017-05-10

    Applicant: University of Southampton

    Inventor： Robert EASON ,  Collin SONES ,  loannis KATIS ,  Peijun HE

    IPC: B01L3/00 ,  D21H25/06

    Abstract: Techniques for making fluid flow devices are described. The technique is based on radiation-induced conversion of a radiation-sensitive substance from a first state to a second state. With adjustment of the radiation parameters such as power and scan speed we can control the depths of barriers that are formed within a substrate which can produce 3D flow paths. We have used this depth-variable patterning protocol for stacking and sealing of multilayer substrates, for assembly of backing layers for two-dimensional (2D) lateral flow devices and for fabrication of 3D devices. Since the 3D flow paths can be formed via a single laser-writing process by controlling the patterning parameters, this is a distinct improvement over other methods that require multiple complicated and repetitive assembly procedures.

    PEPTIDE-INDUCED NK CELL ACTIVATION
    146.
    发明申请
    PEPTIDE-INDUCED NK CELL ACTIVATION 审中-公开

    公开(公告)号：US20180325979A1

    公开(公告)日：2018-11-15

    申请号：US15774681

    申请日：2016-11-09

    Applicant: UNIVERSITY OF SOUTHAMPTON

    Inventor： Salim Iqbal KHAKOO

    IPC: A61K38/03 ,  C07K14/18 ,  C12N5/0783 ,  A61K35/17 ,  C12N15/62

    Abstract: The invention relates to a peptide capable of activating NK cell-mediated immunity, the peptide comprising or consisting of the amino acid sequence XnAX2X1, Wherein Xn is an amino acid sequence of between 5 and 12 residues, and X1 is any amino acid; or leucine or phenylalanine; and X2 is alanine, threonine or serine. The invention further relates to an MHC class I molecule and the peptide, nucleic acids encoding the peptide, activated NK cells, and related compositions and methods, including use in methods of treatment.

    POLARISATION MICROSCOPE
    147.
    发明申请
    POLARISATION MICROSCOPE 审中-公开

    公开(公告)号：US20180246307A1

    公开(公告)日：2018-08-30

    申请号：US15758546

    申请日：2016-09-07

    Applicant: University of Southampton

    Inventor： Edward Thomas Foss ROGERS ,  Peter John Shand SMITH

    IPC: G02B21/00 ,  G01N21/21

    CPC classification number: G02B21/0068 ,  G01N21/21 ,  G01N2201/0675 ,  G02B21/0032 ,  G02B21/0072 ,  G02B21/0092 ,  G02B27/58

    Abstract: A super-resolution scanning confocal polarisation contrast microscope is provided. The microscope has a laser light source (1), sample stage (10) for mounting a sample 6 and detector (8). A polarisation controller (3) is used to set the polarisation state of the light beam to any one of a defined set of different polarisation states. A spatial light modulator (5) modulates the light beam in amplitude and/or phase to focus a sub-diffraction-limit central spot on the sample together with unwanted sidebands. A scanning confocal scheme is used with a pin hole 9 in front of the detector (8) so that only that portion of the light is detected which has comes from the central spot, while rejecting light that has been scattered by the sample from the sidebands. Polarisation contrast images with sub-diffraction limit resolution can thus be acquired.

    OPTICAL FIBRE ASSEMBLY AND METHOD OF MAKING AN OPTICAL FIBRE ASSEMBLY
    149.
    发明申请
    OPTICAL FIBRE ASSEMBLY AND METHOD OF MAKING AN OPTICAL FIBRE ASSEMBLY 审中-公开

    公开(公告)号：US20170139133A1

    公开(公告)日：2017-05-18

    申请号：US15319964

    申请日：2015-06-17

    Applicant: University of Southampton

    Inventor： Christopher Holmes ,  Peter George Robin Smith ,  James Christopher Gates ,  Lewis Glynn Carpenter

    IPC: G02B6/122 ,  G02B6/36 ,  G02B6/34

    Abstract: A method of forming an optical fibre assembly, comprises providing a planar substrate made of a first material; positioning an optical fibre with an outer layer of a first glass material on a surface of the substrate to form a pre-assembly; depositing a further glass material such as silica soot onto the pre-assembly, over at least a part of the optical fibre and adjacent parts of the substrate surface; and heating the pre-assembly to consolidate the further glass material into an amorphous volume in contact with at least parts of the surface of the substrate and the outer layer of the optical fibre, thereby bonding the optical fibre to the substrate to create the optical fibre assembly.

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