利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

192 条记录 (耗时 0.037 秒)

    Cycloalkenochromone
    142.
    发明授权
    Cycloalkenochromone 失效
    环烯酮色素

    公开(公告)号：US4221800A

    公开(公告)日：1980-09-09

    申请号：US863688

    申请日：1977-12-23

    申请人： Brian T. Warren ,  John W. Spicer ,  Thomas Miller

    发明人： Brian T. Warren ,  John W. Spicer ,  Thomas Miller

    IPC分类号： C07D311/86 ,  C07D311/94 ,  C07D335/16 ,  C07D257/04 ,  A61K31/35 ,  A61K31/41 ,  C07D311/78

    CPC分类号： C07D311/94 ,  C07D311/86 ,  C07D335/16

    摘要： Certain substituted cycloalkenochromones and pharmacologically acceptable salts thereof are disclosed as being useful in the treatment of allergies. The compounds have the structure: ##STR1## X is --O--, --S--, or --SO.sub.2. Y is from 1 to 4. R.sub.1 is H or alkyl, and R.sub.2 is H, alkyl, aryl, carboxyl, alkoxy, aralkoxy, or alkoxycarbonyl. When R.sub.1 is alkyl, R.sub.2 is hydrogen, alkyl or aryl. At least one of R.sub.2 and R.sub.3 is alkoxycarbonyl, carboxyl or tetrazolyl. R.sub.3 is carboxyl, alkylthio, alkylsulfonyl, alkylsulfinyl, alkoxycarbonyl, or tetrazolyl.

    摘要翻译： 公开了某些取代的环烯烃色素及其药理学上可接受的盐可用于治疗过敏。 该化合物具有以下结构：X是-O-，-S-或-SO 2。 Y为1至4. R1为H或烷基，R2为H，烷基，芳基，羧基，烷氧基，芳烷氧基或烷氧基羰基。 当R 1为烷基时，R 2为氢，烷基或芳基。 R2和R3中的至少一个是烷氧基羰基，羧基或四唑基。 R3是羧基，烷硫基，烷基磺酰基，烷基亚磺酰基，烷氧基羰基或四唑基。

    Retrieval Device
    143.
    发明申请
    Retrieval Device 有权

    公开(公告)号：US20210046616A1

    公开(公告)日：2021-02-18

    申请号：US16899004

    申请日：2020-06-11

    申请人： Thomas Miller ,  Timothy Miller

    发明人： Thomas Miller ,  Timothy Miller

    IPC分类号： B25B5/14 ,  A63B47/02 ,  F41B5/14 ,  B25B5/16

    摘要： A retrieval device may include a first plate and a second plate which may be movably coupled to a body via a first body fastener and a second body fastener, respectively. An upper plate connector and a lower plate connector may each be movably coupled to the first plate and a second plate with the lower plate connector positioned between the upper plate connector and the body fasteners. An optional tensioner may tension portions of the first plate and a second plate together. Upper gripper(s) may be coupled to the upper plate connector and lower gripper(s) may be coupled to the lower plate connector. The device may be movable between an open position, in which the upper gripper(s) and lower gripper(s) are positioned relatively distally from each other, and a closed position, in which the upper gripper(s) and lower gripper(s) are positioned relatively proximate to each other.

    Composite materials with multilayer laminate facing
    144.
    发明授权
    Composite materials with multilayer laminate facing 有权

    公开(公告)号：US10279570B2

    公开(公告)日：2019-05-07

    申请号：US14185655

    申请日：2014-02-20

    申请人： Thomas Miller ,  Timothy Johnson

    发明人： Thomas Miller ,  Timothy Johnson

    IPC分类号： B32B5/02 ,  B32B7/12 ,  B32B27/12

    摘要： A composite board with a multilayer laminated facer is presented having a nonwoven, a first polymer layer, and a second polymer layer. The laminate may be printed on the nonwoven, on the upper surface of the first polymer layer or inverted printed on the backside of an applied film. A number of configurations for the polymer layers are disclosed. The laminate may include exposed fibers on the lower surface or the nonwoven may be saturated. A removable peel-ply may be included. By controlling the placement and thickness of the polymer layers it is possible to tailor additive in the polymers such as colorants, opacifiers, UV stabilizers, and fire retardants to improve quality and reduce costs. In an alternate embodiment of the present invention, a first polymer layer is applied to the topside of the nonwoven and the second polymer is laminated to the first polymer layer as a preformed film. The laminated facer is thermally or adhesively bonded to the composite board.

    Fairlead latch device
    146.
    发明授权
    Fairlead latch device 有权
    Fairlead闩锁装置

    公开(公告)号：US08915205B2

    公开(公告)日：2014-12-23

    申请号：US13335832

    申请日：2011-12-22

    申请人： Thomas Miller ,  Charlie O'Rourke

    发明人： Thomas Miller ,  Charlie O'Rourke

    IPC分类号： B63B21/18 ,  B63B21/10

    CPC分类号： B63B21/10 ,  B63B21/18 ,  B63B21/50

    摘要： A self-aligning fairlead latch device is provided for guiding and securing an anchor chain between an offshore structure and an anchor. The fairlead latch device includes a latch housing pivotally mounted to a fairlead housing. The latch housing includes one or more latches for securing the anchor chain in place. The fairlead latch device further includes an upper retainer component that is coupled to an upper support structure and a lower support structure. The coupling of the upper retainer component to the support structures allow the fairlead latch device to be relocated by lifting of the device from the support structures.

    摘要翻译： 提供了一种自对准的会话闩锁装置，用于在海上结构和锚之间引导和固定锚链。 通道闩锁装置包括可枢转地安装到整流罩壳体上的闩锁壳体。 闩锁壳体包括用于将锚链固定在适当位置的一个或多个闩锁。 所述通道闩锁装置还包括联接到上支撑结构和下支撑结构的上保持器部件。 上部保持器部件与支撑结构的联接允许通过从支撑结构提升装置来将导轨闩锁装置重新定位。

    Trifluoromethylsulfonamide gamma secretase inhibitor
    148.
    发明授权
    Trifluoromethylsulfonamide gamma secretase inhibitor 有权
    三氟甲基磺酰胺γ分泌酶抑制剂

    公开(公告)号：US08609897B2

    公开(公告)日：2013-12-17

    申请号：US13145190

    申请日：2010-01-29

    申请人： Matthew Daniels ,  Jed Hubbs ,  Thomas Miller

    发明人： Matthew Daniels ,  Jed Hubbs ,  Thomas Miller

    IPC分类号： C07C311/01 ,  A61K31/18

    CPC分类号： C07D233/42 ,  C07C317/30 ,  C07C2601/14 ,  C07D295/185

    摘要： The present invention is directed to a novel trifluoromethylsulfonamide derivative which inhibits the processing of APP by the putative γ-secretase and thus is useful in the treatment or prevention of Alzheimer's disease. This compound possesses favorable pharmacokinetic properties in higher species (rhesus) and thus can be dosed on an intermittent dosing regiment (e.g., once weekly). When dosed on such a regiment the compound exhibits significant and continuous Aβ lowering without the manifestation of Notch associated gastrointestinal toxicity for extended periods, e.g., 7 days. Pharmaceutical compositions and methods of use are also included.

    摘要翻译： 本发明涉及一种新的三氟甲基磺酰胺衍生物，其抑制由推定的γ-分泌酶处理APP，因此可用于治疗或预防阿尔茨海默氏病。 该化合物在较高种类（恒河猴）中具有有利的药代动力学性质，因此可以间歇给药剂量（例如每周一次）给药。 当给予这样一个团体时，该化合物显示出显着和连续的Abeta降低，而不延长Notch相关的胃肠道毒性的表现，例如7天。 还包括药物组合物和使用方法。

    DEVICE FOR DETERMINING MATERIAL PROPERTIES
    149.
    发明申请
    DEVICE FOR DETERMINING MATERIAL PROPERTIES 有权
    用于确定材料特性的装置

    公开(公告)号：US20130269444A1

    公开(公告)日：2013-10-17

    申请号：US13538628

    申请日：2012-06-29

    申请人： Itai Einav ,  Pierre Rognon ,  Thomas Miller

    发明人： Itai Einav ,  Pierre Rognon ,  Thomas Miller

    IPC分类号： G01N1/10 ,  G01B5/30 ,  G01P15/00 ,  G01L3/00

    CPC分类号： G01B5/30 ,  G01N3/24 ,  G01N11/10 ,  G01N2203/0284

    摘要： A device for determining material properties includes a bottom panel extending from a first end to a second end of the device, for supporting a material to be tested. A closed loop flexible wall extends upwardly from the panel and is in operational engagement with a flexible wall idle means towards the first end of the device and a flexible wall driving means in spaced relation with the flexible wall idle means. The flexible wall driving means causes movement of the closed loop flexible wall along a predetermined closed loop path. The flexible wall driving means and the means of driving it are arranged at a position outside of a material containment area of the device.

    摘要翻译： 用于确定材料性质的装置包括从装置的第一端延伸到第二端的底板，用于支撑待测材料。 闭环柔性壁从面板向上延伸并且朝向装置的第一端与柔性壁空闲装置可操作地接合，以及与柔性壁空闲装置间隔开的柔性壁驱动装置。 柔性壁驱动装置使得闭环柔性壁沿预定的闭环路径移动。 柔性壁驱动装置和驱动装置布置在设备的材料容纳区域外部的位置。

    Calibration of portable devices in a shared virtual space
    150.
    发明授权
    Calibration of portable devices in a shared virtual space 有权
    在共享虚拟空间中校准便携式设备

    公开(公告)号：US08537113B2

    公开(公告)日：2013-09-17

    申请号：US12973827

    申请日：2010-12-20

    申请人： George Weising ,  Thomas Miller

    发明人： George Weising ,  Thomas Miller

    IPC分类号： G09G5/08

    CPC分类号： G06T7/70 ,  A63F3/02 ,  A63F9/24 ,  A63F13/00 ,  A63F13/40 ,  A63F13/50 ,  A63F2009/2457 ,  G06F3/011 ,  G06F3/012 ,  G06F3/017 ,  G06F3/0304 ,  G06F3/0346 ,  G06F3/04815 ,  G06T7/20 ,  G06T19/006 ,  G06T2207/10028 ,  G09G5/08 ,  G09G2320/0261 ,  H04N5/23258

    摘要： Methods, systems, and computer programs for generating an interactive space viewable through at least a first and a second device are presented. The method includes an operation for detecting from the first device a location of the second device or vice versa. Further, synchronization information data is exchanged between the first and the second device to identify a reference point in a three-dimensional (3D) space relative to the physical location of the devices in the 3D space. The devices establish the physical location in the 3D space of the other device when setting the reference point. The method further includes an operation for generating views of an interactive scene in the displays of the first and second devices. The interactive scene is tied to the reference point and includes virtual objects. The view in the display shows the interactive scene as observed from the current location of the corresponding device. Moving the device in the 3D space causes the view to change according to the perspective from the current location.

    摘要翻译： 提出了用于生成通过至少第一和第二设备可观看的交互式空间的方法，系统和计算机程序。 该方法包括用于从第一设备检测第二设备的位置或反之亦然的操作。 此外，在第一和第二设备之间交换同步信息数据，以相对于3D空间中的设备的物理位置来识别三维（3D）空间中的参考点。 当设置参考点时，设备在其他设备的3D空间中建立物理位置。 该方法还包括用于在第一和第二设备的显示器中生成交互式场景的视图的操作。 交互式场景与参考点相关，包括虚拟对象。 显示屏中的视图显示了从相应设备的当前位置观察到的交互式场景。 在3D空间中移动设备会导致视图根据当前位置的角度进行更改。