公开(公告)号：US20060283522A1

公开(公告)日：2006-12-21

申请号：US11510961

申请日：2006-08-28

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B67C3/00

CPC classification number: B65B7/161 ,  B65B3/003 ,  B65B7/00 ,  B65B37/06 ,  B65B43/54 ,  B65B51/22 ,  B65B55/04 ,  B65B55/08 ,  B65B57/00 ,  B65B65/02

Abstract: An apparatus is provided for needle filling and thermally resealing containers having stoppers that are needle penetrable for filling the containers with a substance, and are thermally resealable for thermally sealing a needle hole in the stopper upon withdrawal of a needle therefrom. A container support of the apparatus supports at least one container having a resealable stopper in a substantially fixed position during needle filling and thermally resealing a needle hole in the stopper upon withdrawal of a needle therefrom. A manifold is drivingly mounted over the container support and comprises (1) a needle cartridge including a needle for penetrating the resealable stopper and introducing a substance through the needle and into the container, a needle mount for mounting the needle cartridge on the manifold, and a needle cover releasably coupled to the needle mount for covering the needle during transportation, installation and/or removal of the needle cartridge from the manifold, and that is removable from the needle cartridge upon mounting the needle cartridge to the manifold. The manifold further includes a thermal source for heating a needle penetrated region of the stopper and, in turn, sealing a needle hole in the stopper.

Abstract translation: 提供了一种用于针头填充和热重新密封容器的装置，其具有用于针对物品填充容器的可穿刺的塞子，并且在从其中取出针时，可热再密封用于热封塞塞中的针孔。 装置的容器支撑件支撑至少一个具有可重新封闭的塞子的容器，该容器在针填充期间处于基本上固定的位置，并且在从针头中​​取出针时，在塞子中对针孔进行热再密封。 歧管被驱动地安装在容器支架上方，并且包括（1）针筒，其包括用于穿透可再密封塞子并将物质通过针引入容器的针，用于将针筒安装在歧管上的针座，以及 可拆卸地联接到针座的针罩，用于在从歧管运输，安装和/或移除针筒期间覆盖针头，并且当将针筒安装到歧管上时可从针筒上移除。 歧管还包括用于加热塞子的针穿入区域的热源，并且进而密封塞子中的针孔。

公开(公告)号：US20060225809A1

公开(公告)日：2006-10-12

申请号：US11374522

申请日：2006-03-13

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/04

CPC classification number: B65B3/022

Abstract: Apparatus is provided for molding and filling a container having a container body defining an opening in communication with an interior chamber for receiving a substance therein, and a stopper receivable within the opening for sealing the opening and substance received in the container. A barrier enclosure defines an aseptic chamber. A mold includes within the aseptic chamber plural mold cavities shaped to form the stopper and container body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the container body and stopper is movable relative to the mold to engage and de-mold the substantially sterile stoppers and container bodies from the mold cavities. A source of sterile air is in fluid communication with the aseptic chamber and directs a flow of sterile air into the aseptic chamber and over the sterile surfaces of the mold for maintaining the sterility of the mold surfaces and stopper and container bodies during de-molding thereof. First flexible barriers are coupled to the mold between the sterile surfaces and the molding machine to substantially prevent the passage of contaminants from the molding machine therethrough. A second flexible barrier is coupled to the tool between the engaging portion and a base portion of the tool to substantially prevent the passage of contaminants from the base portion of the tool therethrough. A needle filling and thermal resealing station is configured to receive the sealed, empty sterile containers, needle fill the interior chambers of the containers, and thermally reseal resulting needle holes in the stoppers.

Abstract translation: 提供了用于模制和填充具有容器主体的容器的容器，该容器主体限定与用于容纳物质的内部室相连通的开口，以及可接收在开口内的止动件，用于密封容纳在容器中的开口和物质。 隔离罩限定了无菌室。 模具包括在无菌室内的多个模具腔，其形状形成止动器和容器主体，以及基本上无菌的表面，其围绕并邻近模腔周边延伸。 一种包括端臂工具的装配装置具有可与容器主体和止动件中的每一个接合的接合部分，可相对于模具移动，从而将基本上无菌的止动器和容器主体与模具腔接合并脱模。 无菌空气源与无菌室流体连通，并将无菌空气流引导到无菌室和模具的无菌表面上，以保持模具表面和塞子和容器主体在其脱模期间的无菌性 。 第一柔性屏障耦合到无菌表面和成型机之间的模具，以基本上防止来自成型机的污染物通过其中。 第二柔性屏障在接合部分和工具的基部之间联接到工具，以基本上防止污染物从工具的基部通过其中。 针填充和热再密封台被构造成接收密封的空的无菌容器，针填充容器的内部腔室，并且对止动器中的针孔加热再密封。

公开(公告)号：US20060191594A1

公开(公告)日：2006-08-31

申请号：US11408704

申请日：2006-04-21

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/04

CPC classification number: A61J1/2096 ,  A61J1/1406 ,  A61J1/1468 ,  A61J1/18 ,  A61L2/08 ,  B29C65/16 ,  B29C65/1616 ,  B29C65/1619 ,  B29C65/1654 ,  B29C65/1677 ,  B29C65/18 ,  B29C66/001 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/12461 ,  B29C66/1312 ,  B29C66/342 ,  B29C66/534 ,  B29C66/5344 ,  B29C66/542 ,  B29C66/612 ,  B29C66/71 ,  B29C66/73755 ,  B29C66/7392 ,  B29C66/73921 ,  B29C66/7394 ,  B29C66/8322 ,  B29C67/004 ,  B29L2031/7158 ,  B29L2031/753 ,  B65B3/003 ,  B65B7/161 ,  B65D51/002 ,  B29C65/00 ,  B29K2025/08 ,  B29K2023/00

Abstract: A device and method are provided for needle penetrating and filling a chamber with a predetermined substance, and laser resealing a resulting needle hole in the device. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation at a predetermined wavelength and power thereto. The needle penetrable and laser resealable portion defines a predetermined wall thickness in an axial direction thereof, and includes a thermoplastic that substantially prevents the formation of particles released into the chamber from the needle penetrable and laser resealable portion during penetration by and withdrawal of the needle. The thermoplastic includes a predetermined amount of pigment that allows the thermoplastic to substantially absorb laser radiation at the predetermined wavelength, substantially prevent the passage of radiation through the predetermined wall thickness thereof, and hermetically seal a needle aperture formed in the needle penetration region thereof in a predetermined time period.

公开(公告)号：US20060169722A1

公开(公告)日：2006-08-03

申请号：US11295251

申请日：2005-12-05

Applicant: Daniel Py ,  Julian Chan ,  Benoit Adamo

Inventor： Daniel Py ,  Julian Chan ,  Benoit Adamo

IPC: B65D37/00

CPC classification number: B67D1/0004 ,  B65B39/004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/10 ,  B67D1/108 ,  B67D1/1279 ,  B67D3/04 ,  B67D2001/0827 ,  F04B43/1238 ,  F04B53/1037 ,  Y10T137/7761

Abstract: An apparatus has a valve body defining a first passageway, a valve seat, and a flow aperture extending through the valve body and coupled in fluid communication with the first passageway. A valve cover of the apparatus is formed of an elastic material and includes a cover base mounted on the valve body and fixedly secured against movement relative thereto, and a valve portion overlying the valve seat. The valve portion defines a predetermined radial thickness and forms an interference fit with the valve seat. The valve portion and the valve seat define a normally closed, axially-extending valve opening therebetween. The valve portion is movable between a normally closed position with the valve portion engaging the valve seat, and an open position with at least a segment of the valve portion spaced away from the valve seat to connect the valve opening in fluid communication with the flow aperture to thereby allow the passage of fluid from the flow aperture through the valve opening. A hermetically sealed variable-volume storage chamber stores therein multiple portions of the fluid and is connectible in fluid communication with the one-way valve assembly. A pump is coupled between the variable-volume storage chamber and the one-way valve assembly, and is configured to pump discrete portions of fluid from the variable-volume storage chamber, through the flow aperture, and through the valve opening to dispense the portions of fluid through the valve assembly.

Abstract translation: 一种装置具有限定第一通道，阀座和延伸穿过阀体并与第一通道流体连通地联接的流动孔的阀体。 该装置的阀盖由弹性材料形成，并且包括安装在阀体上的盖基座，并且固定地抵靠其相对移动，以及覆盖在阀座上的阀部分。 阀部分限定预定的径向厚度并与阀座形成过盈配合。 阀部分和阀座限定了其间的常闭的，轴向延伸的阀开口。 阀部分可以在与阀座接合的阀部分的常闭位置和打开位置之间移动，打开位置具有与阀座间隔开的阀部分的至少一段，以连接与开口流体连通的阀开口 从而允许流体从流动孔通过阀开口。 气密密封的可变容积储存室在其中存储有多个流体部分，并可与单向阀组件流体连通。 泵连接在可变容积存储室和单向阀组件之间，并且构造成从可变容积储存室通过流动孔泵送离散的流体部分，并且通过阀开口分配部分 的流体通过阀组件。

公开(公告)号：US20060151051A1

公开(公告)日：2006-07-13

申请号：US11295274

申请日：2005-12-05

Applicant: Daniel Py ,  Julian Chan ,  Benoit Adamo

Inventor： Daniel Py ,  Julian Chan ,  Benoit Adamo

IPC: B65B1/04

CPC classification number: B67D1/0004 ,  B65B39/004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/10 ,  B67D1/108 ,  B67D1/1279 ,  B67D3/04 ,  B67D2001/0827 ,  F04B43/1238 ,  F04B53/1037 ,  Y10T137/7761

Abstract: An apparatus has a valve body defining a first passageway, a valve seat, and a flow aperture extending through the valve body and coupled in fluid communication with the first passageway. A valve cover of the apparatus is formed of an elastic material and includes a cover base mounted on the valve body and fixedly secured against movement relative thereto, and a valve portion overlying the valve seat. The valve portion defines a predetermined radial thickness and forms an interference fit with the valve seat. The valve portion and the valve seat define a normally closed, axially-extending valve opening therebetween. The valve portion is movable between a normally closed position with the valve portion engaging the valve seat, and an open position with at least a segment of the valve portion spaced away from the valve seat to connect the valve opening in fluid communication with the flow aperture to thereby allow the passage of fluid from the flow aperture through the valve opening. A hermetically sealed variable-volume storage chamber stores therein multiple portions of the fluid and is connectible in fluid communication with the one-way valve assembly. A pump is coupled between the variable-volume storage chamber and the one-way valve assembly, and is configured to pump discrete portions of fluid from the variable-volume storage chamber, through the flow aperture, and through the valve opening to dispense the portions of fluid through the valve assembly.

Abstract translation: 一种装置具有限定第一通道，阀座和延伸穿过阀体并与第一通道流体连通地联接的流动孔的阀体。 该装置的阀盖由弹性材料形成，并且包括安装在阀体上的盖基座，并且固定地抵靠其相对移动，以及覆盖在阀座上的阀部分。 阀部分限定预定的径向厚度并与阀座形成过盈配合。 阀部分和阀座限定了其间的常闭的，轴向延伸的阀开口。 阀部分可以在与阀座接合的阀部分的常闭位置和打开位置之间移动，打开位置具有与阀座间隔开的阀部分的至少一段，以连接与开口流体连通的阀开口 从而允许流体从流动孔通过阀开口。 气密密封的可变容积储存室在其中存储有多个流体部分，并可与单向阀组件流体连通。 泵连接在可变容积存储室和单向阀组件之间，并且构造成从可变容积储存室通过流动孔泵送离散的流体部分，并且通过阀开口分配部分 的流体通过阀组件。

公开(公告)号：USD521045S1

公开(公告)日：2006-05-16

申请号：US29219253

申请日：2004-12-13

Applicant: Daniel Py

Designer： Daniel Py

公开(公告)号：US07000960B2

公开(公告)日：2006-02-21

申请号：US10851865

申请日：2004-05-21

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61F9/00

CPC classification number: A61F9/0061 ,  A45C11/005 ,  A45C15/00

Abstract: A contact lens applicator has an elongated housing defining an interior chamber for storing contact lenses, first and second triggers mounted on the housing, a depressor for depressing each eyelid where the depressor is drivingly coupled to the triggers, a pair of opposing wing-shaped members projecting outwardly from opposite sides of the rollers for providing a support surface for facilitating locating the apparatus over the eye, and a pusher assembly slidably mounted within the interior chamber for engaging a contact lens holder and applying a contact lens thereon to the eye when the triggers are actuated. The contact lens is stored in a cartridge within the elongated housing. The lens holder is movable within the cartridge upon actuating the pusher, and includes a predetermined amount of saline or other solution for defining appropriate conditions for storing the lens.

公开(公告)号：US20050173020A1

公开(公告)日：2005-08-11

申请号：US11103803

申请日：2005-04-11

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B55/08 ,  A61B20060101 ,  A61L2/08 ,  B65B1/04 ,  B65B3/04 ,  B65B7/28 ,  B65B55/02 ,  B65B55/04 ,  B67C3/00

CPC classification number: B65B3/04 ,  A61L2/08 ,  A61L2/087 ,  A61L2/24 ,  A61L2202/14 ,  B65B3/003 ,  B65B7/16 ,  B65B7/161 ,  B65B55/025 ,  B65B55/08 ,  B65B55/16

Abstract: A sterile filling machine and related method are provided for sterile filling a container with a substance. The container includes a heat resealable stopper and a chamber for receiving the substance therein. The sealed, empty containers are subjected to radiation capable of penetrating through the stopper and chamber for sterilizing the container. The previously sterilized containers are then transported through an e-beam chamber, wherein an electron beam is directed onto a penetrable surface of the stopper to sterilize the penetrable surface. A needle is mounted within the e-beam chamber and moved into engagement with the stopper to pierce the sterilized penetrable surface of the stopper and inject the substance through the needle and into the chamber of the container. The needle is then withdrawn from the stopper and the filled container is transported outside of the e-beam chamber. Laser energy is then transmitted onto the penetrated surface of the stopper to fuse the stopper material and hermetically re-seal the stopper.

Abstract translation: 提供了一种无菌灌装机及相关方法，用于无菌填充具有物质的容器。 容器包括可热再封塞的塞子和用于在其中容纳物质的腔室。 密封的空容器经受能够穿过塞子和室的辐射，以对容器进行灭菌。 先前灭菌的容器然后通过电子束室传送，其中电子束被引导到塞子的可穿透表面上以对可穿透表面进行消毒。 针安装在电子束室内并与止动器接合，以刺穿塞子的消毒的可渗透表面并将物质通过针头注入容器的腔室。 然后将针从止动器中取出，并将填充的容器运送到电子束室外部。 然后将激光能量传递到塞子的穿透表面上，以使塞子材料熔化并密封地重新密封塞子。

公开(公告)号：US20050155987A1

公开(公告)日：2005-07-21

申请号：US10976349

申请日：2004-10-28

Applicant: Daniel Py ,  Norbert Assion ,  Julian Chan

Inventor： Daniel Py ,  Norbert Assion ,  Julian Chan

IPC: A45D40/26 ,  B65D25/40 ,  B65D35/06 ,  B65D35/08 ,  B65D35/38 ,  B65D35/44 ,  B65D35/50 ,  B65D37/00 ,  B65D47/20

CPC classification number: B65D47/205 ,  A45D40/26 ,  B65D35/06 ,  B65D35/08 ,  B65D35/38 ,  B65D83/0055

Abstract: A container including a nozzle and body depending therefrom. The body is preferably tubular and defines an interior which retains a product to be dispensed. A cap engages the nozzle to prevent inadvertent release of the product. In order to dispense the product, the cap is removed and pressure is applied to the body and the nozzle allows release of the product. The nozzle releases the product without exposing the remaining product to the external atmosphere, thus the sterility of the interior of the body is maintained and the shelf life of the product is increased. The nozzle includes an inner body, coupled to the tubular body, surrounded by a flexible outer cover. A seam between the inner body and flexible outer cover forms a one-way release valve wherein a portion of the seam remains closed during dispensing the product.

Abstract translation: 一种容器，其包括从其排出的喷嘴和主体。 主体优选地是管状的并且限定保持要分配的产品的内部。 盖子与喷嘴接合以防止产品的意外释放。 为了分配产品，盖被去除并且压力施加到主体上，并且喷嘴允许释放产品。 喷嘴释放产品而不将剩余的产品暴露于外部大气，从而维持身体内部的不整洁性并且提高了产品的保质期。 该喷嘴包括一个连接到管状主体的内部主体，被一个柔性的外盖包围。 内体和柔性外盖之间的接缝形成单向释放阀，其中在分配产品期间，接缝的一部分保持关闭。

公开(公告)号：US06796510B2

公开(公告)日：2004-09-28

申请号：US10729745

申请日：2003-12-05

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B05B1700

CPC classification number: B05B11/0067 ,  B05B1/3436 ,  B05B11/00412 ,  B05B11/007 ,  B05B11/0072 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3094

Abstract: An aerosol tip mechanism for an aerosol-type dispenser for dispensing liquid content has a flexible outer shell, a rigid cap portion composed of lower and upper portions, and a rigid nozzle portion having a rigid shaft received within the outlet portion of the flexible outer shell. The rigid shaft interfaces the outlet portion of the outer shell, forming a first normally-closed one-way valve. The lower and upper portions of the rigid cap portion form boots adapted to receive an outlet portion of the flexible outer shell, the boots thereby constraining a lateral motion of the outlet portion of the outer shell, and symmetrically centering the outlet portion around the rigid shaft of the nozzle. The rigid nozzle portion includes a plurality of liquid channels for delivering liquid from a reservoir to a swirling chamber defined within the rigid cap portion, which liquid channels are configured to minimize energy losses of the liquid and promote a more homogeneous fluid particle size in the dispensed aerosol. The aerosol tip mechanism provides for long-term sterility of the stored fluid, which in turn allows for preservation of the sterility of non-chemically preserved formulations, which may be in the form of suspension or liquid gels.

Abstract translation: 用于分配液体内容物的气溶胶型分配器的气溶胶喷嘴机构具有柔性外壳，由下部和上部组成的刚性盖部分，以及刚性喷嘴部分，其具有容纳在柔性外壳的出口部分内的刚性轴 。 刚性轴与外壳的出口部分接合，形成第一常闭单向阀。 刚性盖部分的下部和上部形成适于容纳柔性外壳的出口部分的靴子，靴子因此约束外壳的出口部分的横向运动，并且将出口部分对称地对准刚性轴 的喷嘴。 刚性喷嘴部分包括多个液体通道，用于将液体从储存器输送到限定在刚性盖部分内的旋转室，该液体通道被配置为使液体的能量损失最小化，并促使在分配的液体中更均匀的流体颗粒尺寸 气雾剂。 气溶胶末端机构提供储存的流体的长期无菌性，这又允许保持非化学保存的制剂的无菌性，其可以是悬浮液或液体凝胶的形式。