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141.发明申请公开(公告)号：US20190085396A1
公开(公告)日：2019-03-21
申请号：US16084946
申请日：2016-09-09
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Jessica Richman , Daniel Almonacid , Siavosh Rezvan Behbahani
IPC: C12Q1/6883 , C12Q1/689 , G06F19/22 , G06F19/24 , G16H50/20
Abstract: Methods, compositions, and systems are provided for detecting one or more a gastrointestinal issues by characterizing the microbiome of an individual, monitoring such effects, and/or determining, displaying, or promoting a therapy for the gastrointestinal issue. Methods, compositions, and systems are also provided for generating and comparing microbiome composition and/or functional diversity datasets. Methods, compositions, and systems are also provided for generating a characterization model and/or therapy model for constipation issues, diarrhea issues, hemorrhoids issues, bloating issues, and lactose intolerance issues.
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142.发明申请公开(公告)号：US20190078142A1
公开(公告)日：2019-03-14
申请号：US16115542
申请日：2018-08-28
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Elisabeth Bik , Sara W. Bird , Luis E. Leon , Pamela A. Nieto , Victor Alegria-Mera , Cristian Bravo , Juan P. Cardenas , Paulo Covarrubias , Sarah L. Gupta , Kira Harman , Juan Jimenez , Felipe Melis-Arcos , Camila F. Navas , Harold Nunez , Eduardo Olivares , Nicolas Ordenes-Aenishanslins , Francisco J. Ossandon , Ignacio Varas , Patricia Vera-Wolf , Donna Marie B. Hongo , Laurens Kraal , Nathaniel A. Walton , Amanda Morton , Juan P. Bustamante , Kwasi Addae , Graham Gass , Katia Soto-Liebe , Juan A. Ugalde , Eduardo H. Morales , Daniel Almonacid , Jessica Richman
Abstract: Embodiments of a method and/or system for characterizing one or more female reproductive system-related conditions can include determining a microorganism dataset associated with a set of subjects; and/or performing a characterization process associated with the one or more female reproductive system-related conditions, based on the microorganism dataset, where performing the characterization process can additionally or alternatively include performing a female reproductive system-related characterization process for the one or more female reproductive system-related conditions, and/or determining one or more therapies.
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公开(公告)号：US20190062010A1
公开(公告)日：2019-02-28
申请号：US16115536
申请日：2018-08-28
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Jessica Richman , Daniel Almonacid , Constance Norris , Rodrigo Ortiz
Abstract: Embodiments of a device for protecting and sealing the opening of a container. This device is a one-piece made plug for a flask or container, comprising at least one passing channel, and at least one structural flow regulator barrier, allowing the passing of solid elements. The structural regulator barrier comprises at least a gate to regulate the passing and connection between the inside space and the outside space of the container in a unidirectional and/or bidirectional way. An embodiment includes a method and a mold for manufacturing such a device.
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公开(公告)号：US20190050534A1
公开(公告)日：2019-02-14
申请号：US16047840
申请日：2018-07-27
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Jessica Richman , Daniel Almonacid , Inti Pedroso , Victoria Dumas , Paz Tapia , Rodrigo Ortiz , Catalina Valdivia , Victor Alegria , Elisabeth M. Bik , Maureen Hitschfeld
IPC: G06F19/24 , C12Q1/6888 , G06F19/12 , G16H70/60
Abstract: Embodiments of a method and/or system for characterizing one or more microorganism-related conditions can include: determining a microorganism dataset associated with a set of subjects; and with a set of microsome characterization modules, applying analytical techniques to perform a characterization process for the one or more microorganism-related conditions based on the microorganism dataset.
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公开(公告)号：US20180362967A1
公开(公告)日：2018-12-20
申请号：US16013858
申请日：2018-06-20
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Jessica Richman , Daniel Almonacid , Juan Jimenez , Rodrigo Ortiz , Eduardo Morales , Paulo Covarrubias , Eduardo Olivares , Nicolas Ordenes , Luis Leon
IPC: C12N15/10
Abstract: Embodiments of a method 100 and/or system 200 or library preparation for sequencing associated with microorganisms can include: preparing a set of unique molecular identifier (UMI)-based molecules associated with one or more targets; preparing a set of sequencing-based primers; generating a set of tagged target molecules based on the set of UMI-based molecules and one or more samples associated with the one or more targets; and/or generating a set of sequencing-ready tagged target molecules based on the tagged target molecules and the set of sequencing-based primers.
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Patent Agency Ranking
146.发明申请公开(公告)号：US20180311310A1
公开(公告)日：2018-11-01
申请号：US15914925
申请日：2018-03-07
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Jessica Richman , Daniel Almonacid , Melissa Alegria , Valeria Marquez , Eduardo Morales , Rodrigo Ortiz , Janet Torres , Paulo Covarrubias , Javier Gimpel , Ingrid Araya
IPC: A61K38/16
CPC classification number: A61K38/16
Abstract: Therapeutic compositions and an associated method for improving a Toll-like receptor (TLR)-related condition, including determining a set of peptide sequences associated with a microorganism-related modulator of a TLR, determining a first set of binding parameters for the set of peptide sequences in relation to the TLR, selecting a target subset of peptide sequences from the set of peptide sequences based on the first set of binding parameters, reengineering the target subset of peptide sequences based on mutating amino acid residues of the target subset of peptide sequences, determining a second set of binding parameters for the reengineered target subset of peptide sequences in relation to the TLR, and identifying a first peptide for use in a therapeutic composition for improving the TLR-related condition, based on the second set of binding parameters for the reengineered target subset of peptide sequences.
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147.发明授权公开(公告)号：US10073952B2
公开(公告)日：2018-09-11
申请号：US15098027
申请日：2016-04-13
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Daniel Almonacid , Jessica Richman , Siavosh Rezvan Behbahani
CPC classification number: G16H50/20 , G06F19/00 , G06F19/3418 , G16B35/00 , G16B40/00 , G16B50/00 , G16C20/60 , G16H40/67 , Y02A90/26
Abstract: A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the autoimmune condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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148.发明申请公开(公告)号：US20180137930A1
公开(公告)日：2018-05-17
申请号：US15848779
申请日：2017-12-20
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Daniel Almonacid , Jessica Richman
CPC classification number: G16H10/40 , C12Q1/6883 , C12Q2600/112 , G01N2800/044 , G01N2800/32 , G06F19/3418 , G16B40/00 , G16B50/00 , G16H50/20 , H01L27/3211 , H01L27/322 , H01L27/3272 , H01L51/0097 , H01L51/5234 , H01L51/5265 , H01L51/5281 , H01L51/5284 , H01L2251/5338 , Y02A90/26
Abstract: A method for at least one of characterizing, diagnosing, and treating a cardiovascular disease condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cardiovascular disease condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cardiovascular disease condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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公开(公告)号：US20180122510A1
公开(公告)日：2018-05-03
申请号：US15844139
申请日：2017-12-15
Applicant: uBiome, Inc.
Inventor： Zachary Apte , Jessica Richman , Daniel Almonacid , Catalina Valdivia , Rodrigo Ortiz , Inti Pedroso , Victoria Dumas , Paz Tapia , Eduardo Morales
IPC: G06F19/28
Abstract: Embodiments of a method and/or system for characterizing a diet-related condition for a user can include one or more of: generating a microbiome dataset for each of an aggregate set of biological samples associated with a population of subjects, based on sample processing of the biological samples; processing a supplementary dataset associated with one or more diet-related conditions for the set of users; and performing a diet-related characterization process for the one or more diet-related conditions, based on the supplementary dataset and/or microbiome features extracted from the microbiome dataset.
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150.发明申请公开(公告)号：US20180070826A1
公开(公告)日：2018-03-15
申请号：US15815622
申请日：2017-11-16
Applicant: uBiome, Inc
Inventor： Zachary Apte , Daniel Almonacid , Jessica Richman
CPC classification number: A61B5/0022 , A61B5/4836 , C12Q1/689 , C12Q2600/112 , G06F19/3418 , G16B40/00 , G16B50/00 , G16H40/67 , G16H50/20 , G16H50/80 , Y02A90/24 , Y02A90/26
Abstract: A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome-derived functional features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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