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公开(公告)号：US11230696B2
公开(公告)日：2022-01-25
申请号：US15748541
申请日：2016-07-28
Inventor： Benjamin Eithan Reubinoff , Orna Singer
Abstract: A method of generating retinal pigment epithelial (RPE) cells is disclosed. The method comprises: (a) culturing human pluripotent stem cells in a human feeder cell-conditioned medium to obtain a cultured population of human pluripotent stem cells; (b) culturing said cultured population of human pluripotent stem cells in a medium comprising a differentiating agent to obtain differentiating cells; and (c) culturing said differentiating cells in a medium comprising one or more members of the TGFβ superfamily.
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152.发明申请公开(公告)号：US20220010009A1
公开(公告)日：2022-01-13
申请号：US17388218
申请日：2021-07-29
Inventor： Rifaat SAFADI
Abstract: Method for treating, attenuating and/or preventing progression of a liver disorder in a subject, the method including administering a therapeutically effective amount of an agent capable of interfering with, inhibiting and/or preventing neuroligin 4 (NLGn4)-Neurexin 1-beta (Nrx1b) protein-protein interaction; and compositions including the agent.
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公开(公告)号：US11122972B2
公开(公告)日：2021-09-21
申请号：US16304199
申请日：2017-06-15
Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Inventor： Jose Cohen , Vladimir Goldman , Yousef Nadim Farraj , Amnon Buxboim , Yoav Mintz , Elchanan Fried , Gahl Levy , Tsevi Beatus , Yoav Kan-Tor
Abstract: Devices and method for determining a pupil size of a subject having closed eyelids.
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154.发明授权公开(公告)号：US11098116B2
公开(公告)日：2021-08-24
申请号：US16407848
申请日：2019-05-09
Inventor： Rifaat Safadi
Abstract: Method for treating, attenuating and/or preventing progression of a liver disorder in a subject, the method including administering a therapeutically effective amount of an agent capable of interfering with, inhibiting and/or preventing neuroligin 4 (NLGn4)-Neurexin 1-beta (Nrx1b) protein-protein interaction; and compositions including the agent.
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公开(公告)号：US11091434B2
公开(公告)日：2021-08-17
申请号：US16553647
申请日：2019-08-28
Inventor： Bernard Lerer , Mugesh Govindasamy , Tzuri Lifschytz
IPC: A61K31/40 , C07D207/456 , C07D405/06 , C07D517/04 , A61P25/24 , A61P35/00 , A61K31/4015 , A61K31/4025 , A61K31/402
Abstract: The present invention relates to compounds that inhibit the activity of Type III deiodinase (DIO3). The present invention further relates to methods for treating or preventing depression, depression associated with other psychiatric or general medical diseases or conditions, condition amenable to treatment with known anti-depressants and cancer, particularly by using the compounds of the invention.
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Patent Agency Ranking
公开(公告)号：US11053231B2
公开(公告)日：2021-07-06
申请号：US16485577
申请日：2018-02-22
Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Or Kakhlon , Miguel Enrique Weil , Leonardo Javier Solmesky
IPC: C07D409/12 , A61P25/28 , C07D487/08
Abstract: Compounds represented by general Formulae I to IV as described herein are disclosed. Further disclosed are composition utilizing the herein disclosed compounds and using the same for the treatment of glycogen storage disorders.
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公开(公告)号：US20210146101A1
公开(公告)日：2021-05-20
申请号：US17156761
申请日：2021-01-25
Applicant: Ramot at Tel-Aviv University Ltd. , Tel HaShomer Medical Research Infrastructure and Services Ltd. , Hadasit Medical Research Services and Development Ltd.
Inventor： Ofer BARNEA , Omer DORON
Abstract: A method for influencing cerebral perfusion in a patient by modifying a volume of a volume adaptor introduced into a cerebral ventricle of the patient, the method comprising identifying a timing of a cerebral blood inflow and/or outflow in a cardiac activity of the patient, modifying a volume of the volume adaptor in synchronization to the identified timing of the cerebral blood flow, to an amount sufficient to modify an intracranial pressure in the cerebral ventricle, such that a flow of the cerebral blood flow is enhanced. In some exemplary embodiments of the invention, the inflation duration of the volume adapter is short relative to the cardiac cycle.
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公开(公告)号：US10980866B2
公开(公告)日：2021-04-20
申请号：US15507383
申请日：2015-09-21
Inventor： Yaron Ilan
Abstract: Methods of treating liver diseases are provided. Accordingly there is provided a method of treating a liver disease selected from the group consisting of fatty liver disease and chronic liver rejection in a subject in need thereof, wherein said liver disease is not associated with genetic alpha-1 anti-trypsin (AAT) deficiency, the method comprising administering to the subject a therapeutically effective amount of AAT.
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公开(公告)号：US10918677B2
公开(公告)日：2021-02-16
申请号：US15525094
申请日：2015-11-10
Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
Inventor： Ofer Mandelboim , Gilad Benjamin Bachrach , Chamutal Gur , Vladimir Yutkin
Abstract: The present invention provides attenuated or inactivated pathogenic bacteria having anti-cancer properties, compositions comprising the bacteria, and use thereof for treating cancers of the urogenital system.
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160.发明申请公开(公告)号：US20190282086A1
公开(公告)日：2019-09-19
申请号：US16304199
申请日：2017-06-15
Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Inventor： Jose COHEN , Vladimir GOLDMAN , Yousef Nadim FARRAJ , Amnon BUXBOIM , Yoav MINTZ , Elchanan FRIED , Gahl LEVY , Tsevi BEATUS , Yoav KAN-TOR
Abstract: Devices and method for determining a pupil size of a subject having closed eyelids.
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