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    Devices and methods for detection of internal bleeding and hematoma
    4.
    发明授权
    Devices and methods for detection of internal bleeding and hematoma 有权

    公开(公告)号：US10292598B2

    公开(公告)日：2019-05-21

    申请号：US14569396

    申请日：2014-12-12

    Applicant: Hadasit Medical Research Services and Development Ltd.

    Inventor： Dean Nahman ,  Yaron Ilan ,  Ilan Ben Oren ,  Yaron Bar-Ilan ,  Shmuel Chen

    IPC: A61B5/02 ,  A61B5/00

    Abstract: A device for detection of internal bleeding in a patient's body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.

    Combination Therapy of Beta-Glycolipids and Antibodies for the Treatment of Immune-Related Disorders
    5.
    发明申请
    Combination Therapy of Beta-Glycolipids and Antibodies for the Treatment of Immune-Related Disorders 有权
    β-糖脂的组合疗法和抗体用于治疗免疫相关性疾病

    公开(公告)号：US20140255420A1

    公开(公告)日：2014-09-11

    申请号：US14183248

    申请日：2014-02-18

    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

    Inventor： Yaron Ilan ,  Howard L. Weiner

    IPC: A61K39/395 ,  A61K31/7028

    CPC classification number: A61K39/3955 ,  A61K31/7028 ,  A61K31/7032 ,  A61K45/06 ,  C07K16/2809 ,  A61K2300/00

    Abstract: The present invention relates to a combination therapy for the treatment of immune-related disorders. More particularly, the invention relates to oral or mucosal synergistic compositions combining beta-glycolipids, preferably, β-glycosphin-golipids with immunoglobulin molecules specific for at least one antigen derived from a component of the immune system, specifically an anti-CD3 antibody. The invention further provides methods kits and uses of the combined compositions of the invention for immune-modulation and thereby for the treatment of immune-related disorders. In a preferred embodiment, anti-CD3 antibody (OKT3) is orally administered in combination with β-glucosylceramide (also known as glycocerebroside) in an animal model of type 2 diabetes.

    Abstract translation: 本发明涉及用于治疗免疫相关疾病的组合疗法。 更具体地说，本发明涉及将β-糖脂，优选与β-糖蛋白 - 脂质与至少一种来自免疫系统组分的抗原，特别是抗CD3抗体特异的免疫球蛋白分子组合的口腔或粘膜协同组合物。 本发明还提供了本发明的组合组合物用于免疫调节并由此用于治疗免疫相关疾病的方法试剂盒和用途。 在优选的实施方案中，抗-CD3抗体（OKT3）与2型糖尿病动物模型中的β-葡糖基神经酰胺（也称为糖脑啡肽）组合口服施用。

    Devices And Methods For Detection Of Internal Bleeding And Hematoma
    7.
    发明申请
    Devices And Methods For Detection Of Internal Bleeding And Hematoma 审中-公开
    用于检测内部出血和血肿的装置和方法

    公开(公告)号：US20150099980A1

    公开(公告)日：2015-04-09

    申请号：US14569396

    申请日：2014-12-12

    Applicant: Hadasit Medical Research Services and Development Ltd.

    Inventor： Dean Nahman ,  Yaron Ilan ,  Ilan Ben Oren ,  Yaron Bar-Ilan ,  Shmuel Chen

    IPC: A61B5/02 ,  A61B5/00

    CPC classification number: A61B5/02042 ,  A61B5/0075 ,  A61B5/4875 ,  A61B5/6833 ,  A61B2505/05

    Abstract: A device for detection of internal bleeding in a patient's body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.

    Abstract translation: 提供了用于检测患者体内的内部出血的装置。 提供了用于将IR光透过患者皮肤区域并从皮肤区域收集IR光的光学接口。 在一些实施例中，光学接口包括一个或多个传送部件和一个或多个收集部件。 传送部件包括多个第一光通道，其被配置为将IR光穿过皮肤区域上的多个相应的第一子区域传输到身体的内部层。 收集组件包括多个第二光学通道，其被配置为从皮肤区域上的多个相应的第二子区域收集IR光。

    Compositions And Methods For Amelioration And Prevention Of Drug-Induced Toxicity
    8.
    发明申请
    Compositions And Methods For Amelioration And Prevention Of Drug-Induced Toxicity 有权
    用于改善和预防药物诱导毒性的组合物和方法

    公开(公告)号：US20150080348A1

    公开(公告)日：2015-03-19

    申请号：US14551724

    申请日：2014-11-24

    Applicant: Josef Mograbi ,  Hadasit Medical Research Services and Development Ltd.

    Inventor： Josef Mograbi ,  Yaron Ilan

    IPC: A61K31/661 ,  A61K45/06 ,  A61K31/10 ,  A61K31/198 ,  A61K31/357 ,  A61K31/197

    CPC classification number: A61K31/661 ,  A61K31/10 ,  A61K31/167 ,  A61K31/197 ,  A61K31/198 ,  A61K31/357 ,  A61K31/685 ,  A61K31/7056 ,  A61K31/7076 ,  A61K45/06 ,  A61K2300/00

    Abstract: Pharmaceutical compositions including combinations of protective agents selected from isosilybin B, methylsulfonylmethane (MSM), phosphatidylcholine, cysteine (Cys), seleno-cysteine (Se-Cys), ribose-cysteine (RibCys), N-acetylcysteine (NAC), N-acetylcysteine-amide (AD4), methionine (Met) and S-adenosylmethionine (SAM) for reducing and/or preventing drug-induced toxicity, such as acetaminophen-induced toxicity. The compositions may be formulated with or without acetaminophen, and accordingly may be used as safe formulations of acetaminophen with reduced risk of causing liver damage, or as an antidote for the treatment of acetaminophen overdose. Methods for treating acetaminophen intoxication.

    Abstract translation: 药物组合物，包括选自异水滑石B，甲磺酰甲烷（MSM），磷脂酰胆碱，半胱氨酸（Cys），硒半胱氨酸（Se-Cys），核糖半胱氨酸（RibCys），N-乙酰半胱氨酸（NAC），N-乙酰半胱氨酸 酰胺（AD4），甲硫氨酸（Met）和S-腺苷甲硫氨酸（SAM），用于降低和/或预防药物诱导的毒性，如对乙酰氨基酚诱导的毒性。 组合物可以配制有或没有对乙酰氨基酚，因此可以用作对乙酰氨基酚的安全配方，降低引起肝损伤的风险，或作为治疗对乙酰氨基酚过量的解毒剂。 对乙酰氨基酚中毒治疗方法。

    Alpha-1 anti-trypsin for treating liver diseases
    9.
    发明授权
    Alpha-1 anti-trypsin for treating liver diseases 有权

    公开(公告)号：US10980866B2

    公开(公告)日：2021-04-20

    申请号：US15507383

    申请日：2015-09-21

    Applicant: Hadasit Medical Research Services and Development Ltd.

    Inventor： Yaron Ilan

    IPC: A61K38/57 ,  A61P1/16

    Abstract: Methods of treating liver diseases are provided. Accordingly there is provided a method of treating a liver disease selected from the group consisting of fatty liver disease and chronic liver rejection in a subject in need thereof, wherein said liver disease is not associated with genetic alpha-1 anti-trypsin (AAT) deficiency, the method comprising administering to the subject a therapeutically effective amount of AAT.

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