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公开(公告)号：US12188047B2
公开(公告)日：2025-01-07
申请号：US15771046
申请日：2016-10-26
Inventor： Benjamin Eithan Reubinoff , Orna Singer , Osnat Bohana-Kashtan , Ofer Wiser
IPC: C12N5/079 , C12N5/00 , C12N5/0735 , G01N33/53
Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.
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公开(公告)号：US11746324B2
公开(公告)日：2023-09-05
申请号：US17547863
申请日：2021-12-10
Inventor： Benjamin Eithan Reubinoff , Orna Singer
CPC classification number: C12N5/0621 , A61K9/0051 , A61K35/30 , A61P27/02 , C12N2500/38 , C12N2501/115 , C12N2501/15 , C12N2502/13 , C12N2506/02 , C12N2533/52 , C12N2533/54
Abstract: A method of generating retinal pigment epithelial (RPE) cells is disclosed. The method comprises: (a) culturing human pluripotent stem cells in a human feeder cell-conditioned medium to obtain a cultured population of human pluripotent stem cells; (b) culturing said cultured population of human pluripotent stem cells in a medium comprising a differentiating agent to obtain differentiating cells; and (c) culturing said differentiating cells in a medium comprising one or more members of the TGFβ superfamily.
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公开(公告)号：US11230696B2
公开(公告)日：2022-01-25
申请号：US15748541
申请日：2016-07-28
Inventor： Benjamin Eithan Reubinoff , Orna Singer
Abstract: A method of generating retinal pigment epithelial (RPE) cells is disclosed. The method comprises: (a) culturing human pluripotent stem cells in a human feeder cell-conditioned medium to obtain a cultured population of human pluripotent stem cells; (b) culturing said cultured population of human pluripotent stem cells in a medium comprising a differentiating agent to obtain differentiating cells; and (c) culturing said differentiating cells in a medium comprising one or more members of the TGFβ superfamily.
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