公开(公告)号：US20190336539A1

公开(公告)日：2019-11-07

申请号：US15735817

申请日：2016-06-10

Applicant: HUDSON INSTITUTE OF MEDICAL RESEARCH ,  MONASH UNIVERSITY

Inventor： Euan Wallace ,  Rebecca Lim

IPC: A61K35/50 ,  A61P11/00 ,  A61P9/10

Abstract: The present disclosure relates generally to the methods of treatment of mammalian subjects by an enhanced cell-based therapeutic approach in order to facilitate tissue and neuronal repair, regeneration and/or reparation. Medicaments useful in the treatment of mammalian subjects and methods of production of the medicaments are also encompassed by the present disclosure.

公开(公告)号：US10458914B2

公开(公告)日：2019-10-29

申请号：US15988995

申请日：2018-05-24

Applicant: Monash University ,  University of Melbourne

Inventor： Bayden Robert Wood ,  Aazam Khoshmanesh ,  Matthew Dixon ,  Leann Tilley ,  Donald McNaughton

IPC: G01J5/00 ,  G01N21/552 ,  G01N21/3577 ,  G01N33/49 ,  G01N21/35

Abstract: The invention described herein relates to a method of detecting malaria comprising the steps of: (i) delivering an evanescent IR beam through said ATR substrate in contact with a patient blood sample; (ii) detecting IR radiation transmitted from the ATR substrate to produce a signal characteristic for one or more lipids in the sample, and (iii) processing said signal and a set of reference library spectra of lipids associated with malaria parasites in order to detect matches and quantify said one or more lipids in the sample. In contrast to the prior art, the present invention relies on detecting lipids instead of hemozoin.

公开(公告)号：US20190314770A1

公开(公告)日：2019-10-17

申请号：US16472139

申请日：2017-12-14

Applicant: MONASH UNIVERSITY

Inventor： Huanting WANG ,  Seungju KIM

IPC: B01D71/02 ,  B01D61/02 ,  B01D69/12 ,  B01D71/40 ,  B01D67/00 ,  C02F1/44

Abstract: The invention relates to a membrane, and method of manufacture of a membrane for reverse osmosis having a porous substrate, and a layer adjacent the porous substrate comprising a two dimensional nanosheet material and crosslinked polymer. The two dimensional nanosheet material is preferably chosen from the group comprising graphene oxide including reduced graphene oxide, holey graphene, holey graphene oxide, laminated graphene oxide and holey reduced graphene oxide.

公开(公告)号：US10328075B2

公开(公告)日：2019-06-25

申请号：US15548555

申请日：2016-02-04

Applicant: Baker Heart and Diabetes Institute ,  Monash University

Inventor： Rebecca Helen Ritchie ,  Cheng Xue Qin ,  Arthur Christopoulos ,  Patrick Michael Sexton ,  Jonathan Bayldon Baell

IPC: A61K31/501 ,  A61K31/50

Abstract: The present invention relates generally to a method of therapeutically or prophylactically treating ischaemia-induced myocardial tissue damage, in particular ischaemia-reperfusion-induced myocardial tissue damage. More particularly, the present invention relates to a method of reducing the extent of ischaemia-induced myocardial tissue damage in a mammal by selectively upregulating FPR1-mediated ERK signalling. The method of the present invention is useful, inter alia, in reducing the extent and/or severity of myocardial tissue damage associated with conditions characterized by myocardial ischaemia or myocardial ischaemia and reperfusion, such as acute myocardial infarction caused by atherosclerotic artery occlusion or blood clot-induced artery occlusion.

公开(公告)号：US20190187048A1

公开(公告)日：2019-06-20

申请号：US16326686

申请日：2017-08-19

Applicant: MONASH UNIVERSITY

Inventor： Bayden Robert Wood ,  Philip Robert Heraud ,  David Perez Guaita ,  Kamila Natalia Kochan

IPC: G01N21/35 ,  C12Q1/04 ,  G01N21/552 ,  G01N21/65

CPC classification number: G01N21/35 ,  C12Q1/04 ,  G01N21/3577 ,  G01N21/552 ,  G01N21/65 ,  G01N2021/3595 ,  G01N2800/26 ,  G16B5/00

Abstract: A system for detecting a disease agent in a sample derived from a patient biofluid may comprise a receiver coupled to a communication network and a controller coupled to the receiver. The controller may comprise a processor and a memory. The controller may be configured to generate an infrared spectrum of the sample. The sample spectrum may comprise one or more sample spectral components, the sample spectral components comprising a sample wavenumber and a sample absorbance value. A set of reference spectral models may comprise one or more reference spectral components. The reference spectral components may comprise a reference wavenumber and a reference absorbance value. The reference spectral components may comprise one or more pathogen characteristics associated with sepsis. The one or more sample spectral components may be classified as pathogenic using the reference spectral models. Pathogen data may be generated using the classified sample spectral components.

公开(公告)号：US20190153301A1

公开(公告)日：2019-05-23

申请号：US16193248

申请日：2018-11-16

Applicant: MONASH UNIVERSITY

Inventor： Ranjith Pathegama Gamage ,  Radhika Shehan Vidanage De Silva

IPC: C09K8/66 ,  C09K8/68 ,  C09K8/74 ,  E21B43/263

Abstract: A soundless cracking demolition agent (SCDA) comprising quicklime, water, a viscosity enhancing agent (VEA), a high range water reducing admixture (HRWR) and an anhydrous accelerator component. A method for in-situ leaching and a method for the recovery of unconventional oil or gas utilising the SCDA of the present invention are also described.

公开(公告)号：US20190134395A1

公开(公告)日：2019-05-09

申请号：US16092989

申请日：2017-04-10

Applicant: MONASH UNIVERSITY

Inventor： Paul B FITZGERALD ,  Caley LIVAN ,  Richard H. THOMSON

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/0482

Abstract: Closed-loop transcranial stimulation and monitoring is disclosed that includes generating a stimulation signal having a set of first oscillation parameters; applying the stimulation signal transcranially to a patient; monitoring the stimulation signal as applied to the patient; receiving a brain activity signal from the patient; generating a feedback signal based on the monitored stimulation signal as applied to the patient; and generating a modified activity signal by subtracting the feedback signal from the brain activity signal; determining one or more second oscillation parameters of the modified activity signal; and adjusting the set of first oscillation parameters of the stimulation signal based on the one or more second oscillation parameters of the modified activity signal. Closed-loop transcranial stimulation and monitoring is also disclosed in which the patient is engaged in a cognitive task.

公开(公告)号：US20180333682A1

公开(公告)日：2018-11-22

申请号：US15773851

申请日：2016-11-02

Applicant: MONASH UNIVERSITY

Inventor： Huanting WANG ,  Xiaocheng LIN

IPC: B01D67/00 ,  B01D61/14 ,  B01D61/24 ,  B01D71/52 ,  B01D69/02 ,  C08J5/22

CPC classification number: B01D67/0093 ,  B01D61/145 ,  B01D61/243 ,  B01D69/02 ,  B01D71/52 ,  B01D2325/023 ,  B01D2325/14 ,  B01D2325/16 ,  B01D2325/42 ,  C08J5/2287

Abstract: The invention relates to a membrane and method for its manufacture, the method including the steps of (1) providing of an ultrafiltration membrane, and (2) modification of the resultant ultrafiltration membrane to provide an asymmetric porous ion exchange membrane. The modification of the ultrafiltration membrane is typically carried out by (i) exposing said ultrafiltration membrane to a first functional reagent to provide a cross-linked ultrafiltration membrane, and then (ii) exposing said cross-lined ultrafiltration membrane to a second functional reagent to introduce positive charged groups to produce an anion exchange membrane.

公开(公告)号：US20180266948A1

公开(公告)日：2018-09-20

申请号：US15988995

申请日：2018-05-24

Applicant: Monash University ,  University of Melbourne

Inventor： Bayden Robert WOOD ,  Aazam KHOSHMANESH ,  Matthew DIXON ,  Leann TILLEY ,  Donald MCNAUGHTON

IPC: G01N21/552 ,  G01N33/49 ,  G01N21/3577 ,  G01N21/35

Abstract: The invention described herein relates to a method of detecting malaria comprising the steps of: (i) delivering an evanescent IR beam through said ATR substrate in contact with a patient blood sample; (ii) detecting IR radiation transmitted from the ATR substrate to produce a signal characteristic for one or more lipids in the sample, and (iii) processing said signal and a set of reference library spectra of lipids associated with malaria parasites in order to detect matches and quantify said one or more lipids in the sample. In contrast to the prior art, the present invention relies on detecting lipids instead of hemozoin.

公开(公告)号：US10077301B2

公开(公告)日：2018-09-18

申请号：US14392256

申请日：2014-06-27

Applicant: Monash University

Inventor： Charles Reay Mackay ,  Di Yu

IPC: A61K39/395 ,  C07K16/24 ,  A61K45/06 ,  A61K39/00

Abstract: The present disclosure provides proteins comprising antigen binding sites of antibodies that bind to interleukin-21 (IL-21) and uses thereof, e.g., in therapy.