公开(公告)号：US10073444B2

公开(公告)日：2018-09-11

申请号：US14919720

申请日：2015-10-21

Applicant: Macau University of Science and Technology

Inventor： Naiqi Wu ,  Fajun Yang ,  Yan Qiao ,  Mengchu Zhou

IPC: G05B19/41 ,  G05B19/418

CPC classification number: G05B19/4187 ,  G05B2219/31429 ,  G05B2219/45032 ,  Y02P90/205 ,  Y10S901/02 ,  Y10S901/41

Abstract: Since single and dual-arm tools behave differently, it is difficult to coordinate their activities in a hybrid multi-cluster tool that is composed of both single- and dual-arm tools. Aiming at finding an optimal one-wafer cyclic schedule for a treelike hybrid multi-cluster tool whose bottleneck tool is process-bound, the present work extends a resource-oriented Petri net to model such system. By the developed Petri net model, to find a one-wafer cyclic schedule is to determine robot waiting times. By doing so, it is shown that, for any treelike hybrid multi-cluster tool whose bottleneck tool is process-bound, there is always a one-wafer cyclic schedule. Then, computationally efficient algorithms are developed to obtain the minimal cycle time and the optimal one-wafer cyclic schedule. Examples are given to illustrate the developed method.

公开(公告)号：US10062187B1

公开(公告)日：2018-08-28

申请号：US15635217

申请日：2017-06-28

Applicant: Macau University of Science and Technology

Inventor： Zhanchuan Cai ,  Ben Ye ,  Ting Lan ,  Youqing Xiao

IPC: G09G5/00 ,  G06T11/20 ,  G06F17/11 ,  G06T7/60 ,  G06T7/13 ,  G06T7/12 ,  G06T5/00

CPC classification number: G06T11/203 ,  G06F17/11 ,  G06T5/002 ,  G06T7/12 ,  G06T7/13 ,  G06T7/168 ,  G06T7/60 ,  G06T9/20 ,  G06T2207/10024 ,  G06T2207/20016 ,  G06T2207/20056 ,  G06T2207/20064 ,  G06T2207/30176

Abstract: Example embodiments include a method that reduces consumption of computer resources in a computer system to reconstruct a shape of a multi-object image using finite terms. The method includes computing an initial function by performing V-system of degree 0 and functions of curves by performing hierarchical V-system. Norms of the functions of curves are compared with a predetermined threshold. A reconstruction function of the shape of the multi-object image is generated by summing the initial function and the functions of curves.

公开(公告)号：US10001772B2

公开(公告)日：2018-06-19

申请号：US14918564

申请日：2015-10-21

Applicant: Macau University of Science and Technology

Inventor： Naiqi Wu ,  Qinghua Zhu ,  Mengchu Zhou ,  Yan Qiao

IPC: G05B19/418

CPC classification number: G05B19/41865 ,  G05B2219/34418 ,  G05B2219/45031 ,  G05B2219/50391 ,  Y10S901/02 ,  Y10S901/30

Abstract: Recent trends of larger wafer and smaller lot sizes bring cluster tools with frequent lot switches. Practitioners must deal with more transient processes during such switches, including start-up and close-down processes. To obtain higher yield, it is necessary to shorten the duration of transient processes. Much prior effort was poured into the modeling and scheduling for the steady state of cluster tools. In the existing literature, no attention has been turned to optimize the close-down process for single-arm cluster tools with wafer residency constraints. This invention intends to do so by 1) developing a Petri net model to analyze their scheduling properties and 2) proposing Petri net-based methods to solve their close-down optimal scheduling problems under different workloads among their process steps. Industrial examples are used to illustrate the effectiveness and application of the proposed methods.

公开(公告)号：US09962378B2

公开(公告)日：2018-05-08

申请号：US14927825

申请日：2015-10-30

Applicant: Macau University of Science and Technology

Inventor： Xiao Jun Yao ,  Lai Han Leung ,  Lian Xiang Luo ,  Liang Liu

IPC: A61K31/4743

CPC classification number: A61K31/4743

Abstract: The administration of a compound advantageously efficacious as ROS1 inhibitor and its effect on subjects with cancer includes administering a compound having certain structural components such as a quinoline moiety in the backbone and at least one tertiary amine containing moiety in a side chain as well as heteroatoms, in particular oxygen atoms, present in the backbone and the side chain for treating a subject suffering from a disease such as cancer. The presence of such structural components allows for an advantageous interaction with the ROS1 kinase domain, in particular with the hinge region. The administered compounds represent a highly promising opportunity in particular for patients bearing ROS1-dependent cancer. A method for targeting tumor cells harboring an abnormality in ROS1 gene includes contacting a cell with compounds of the present invention as well as pharmaceutical compositions comprising such compounds.

公开(公告)号：US09961002B2

公开(公告)日：2018-05-01

申请号：US14972062

申请日：2015-12-16

Applicant: Macau University of Science and Technology

Inventor： Li Feng ,  Liang Zhou ,  Zhijun Xu ,  Yujun Zhang

IPC: H04L12/803 ,  H04L12/707 ,  H04L12/851 ,  H04L29/06

CPC classification number: H04L47/125 ,  H04L45/24 ,  H04L47/2483 ,  H04L69/22

Abstract: Compute-intensive packet processing (CIPP) in a computer system comprising a programmable computing platform is accelerated by using a packet I/O engine, implemented on the platform, to perform packet I/O functions, where the packet I/O engine is configured to achieve direct access to a network interface card (NIC) from a user application. For a Linux-based computer system, standard I/O mechanisms of Linux are bypassed and only the packet I/O engine is used in performing the I/O functions. Furthermore, the computer system is configured to: process a batch of packets, instead of packet by packet, in every function call; and when moving a packet between a buffer of an individual user application and a queue of the packet I/O engine, copy a packet descriptor of the packet instead the entire packet. In addition, workflows across different working threads are balanced and parallelism is exploited to fully utilize resources of the platform.

公开(公告)号：US09913811B2

公开(公告)日：2018-03-13

申请号：US15186795

申请日：2016-06-20

Applicant: Macau University of Science and Technology

Inventor： Liang Liu ,  Lai Han Leung ,  Xia Li ,  Xing-Xing Fan

IPC: A61K31/122

CPC classification number: A61K31/122

Abstract: A compound suitable for treating EGFR-dependent non-small cell lung cancer exceptionally inhibits activity of the EGFR kinase, in particular in EGFR-dependent non-small cell lung cancer with intrinsic or acquired resistance against at least one EGFR inhibitor. Methods for inhibiting EGFR kinase activity in non-small cell lung cancer cells which harbor an abnormality in the EGFR gene and for targeting cancer cells harboring an abnormality in EGFR gene by contacting EGFR-dependent non-small cell lung cancer cells with said compound are also provided. The compounds allow for an advantageous inhibition of the EGFR kinase activity and induction of apoptosis of the non-small cell lung cancer cells with abnormality in the EGFR gene. Hence, said compounds represent a highly promising treatment option for patients harboring EGFR-dependent cancer.

公开(公告)号：US09907029B2

公开(公告)日：2018-02-27

申请号：US15219291

申请日：2016-07-26

Applicant: Macau University of Science and Technology

Inventor： Qinglin Zhao ,  Yuan Wu ,  Yanfei He ,  Jiachao Chen ,  Liping Qian

IPC: H04W52/24 ,  H04W52/52 ,  H04W52/26

CPC classification number: H04W52/243 ,  H04W52/267 ,  H04W52/52

Abstract: The present invention provides a method of power control for a plurality of secondary users (SUs), or unlicensed users, in a cognitive radio network having a plurality of primary users (PUs), or licensed users. The method comprises determining an optimal power level for each of the SUs such that a total throughput of all the SUs is maximized while satisfying an individual throughput requirement of each SU and an interference limit constraint of the PUs. In particular, a case having two SUs is considered.

公开(公告)号：US20180050045A1

公开(公告)日：2018-02-22

申请号：US15632738

申请日：2017-06-26

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Yuen Kwan Law ,  Man Chung Wong

IPC: A61K31/555

CPC classification number: A61K31/28 ,  A61K31/555 ,  A61K45/06

Abstract: A method for inhibiting the expression and/or functional activity of an ABC transporter protein in a subject suffering from a disorder associated with an overexpression of the ABC transporter protein includes administrating a cobalt-polypyridyl complex to the subject. A method for inhibiting the expression and/or functional activity of an ABC transporter in cells includes contacting the cells with an effective amount of the cobalt-polypyridyl complex.

公开(公告)号：US20180050044A1

公开(公告)日：2018-02-22

申请号：US15242883

申请日：2016-08-22

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Man Chung Wong

IPC: A61K31/555 ,  A61K45/06

CPC classification number: A61K31/555 ,  A61K31/28 ,  A61K45/06 ,  A61K2300/00

Abstract: A method for treating a subject suffering from a cancer, in particular a multidrug-resistant cancer includes administrating a cobalt-polypyridyl complex to the subject. A method for suppressing the growth of cancer cells, in particular inducing autophagy of the cancer cells, inducing cell cycle arrest of the cancer cells and/or inhibiting cell invasion of the cancer cells and for specifically targeting cancer cells with multidrug-resistance includes contacting said cancer cells with the cobalt-polypyridyl complex. A pharmaceutical composition and a kit are provided and include the cobalt-polypyridyl complex. Unexpectedly, the cobalt-polypyridyl complex is especially suitable to treat cancer, in particular multidrug-resistant cancer with an exceptionally increased cytotoxic activity towards multidrug-resistant cancer cells.

公开(公告)号：US20170360721A1

公开(公告)日：2017-12-21

申请号：US15186795

申请日：2016-06-20

Applicant: Macau University of Science and Technology

Inventor： Liang Liu ,  Lai Han Leung ,  Xia Li ,  Xing-Xing Fan

IPC: A61K31/122

CPC classification number: A61K31/122

Abstract: A compound suitable for treating EGFR-dependent non-small cell lung cancer exceptionally inhibits activity of the EGFR kinase, in particular in EGFR-dependent non-small cell lung cancer with intrinsic or acquired resistance against at least one EGFR inhibitor. Methods for inhibiting EGFR kinase activity in non-small cell lung cancer cells which harbor an abnormality in the EGFR gene and for targeting cancer cells harboring an abnormality in EGFR gene by contacting EGFR-dependent non-small cell lung cancer cells with said compound are also provided. The compounds allow for an advantageous inhibition of the EGFR kinase activity and induction of apoptosis of the non-small cell lung cancer cells with abnormality in the EGFR gene. Hence, said compounds represent a highly promising treatment option for patients harboring EGFR-dependent cancer.