公开(公告)号：US20200208201A1

公开(公告)日：2020-07-02

申请号：US16622445

申请日：2018-06-15

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Andrew ELLINGTON ,  Jimmy GOLLIHAR ,  Katy KAO ,  Elizabeth GARDNER

IPC: C12Q1/6811 ,  C12Q1/48

Abstract: Disclosed herein are methods and platforms using Receptor Compartmentalized Partnered Replication (CPR), in which the partner gene is a receptor, signal transduction pathway, or metabolic pathway that leads to the production of an effector molecule for the receptor or signal transduction pathway. The signal transduction pathway or receptor is coupled to the production of a thermostable polymerase. Emulsification of libraries of organisms with primers that can amplify the partner gene led to the selective amplification of those partner genes that were best able to produce the thermostable polymerase during thermal cycling of the emulsion.

公开(公告)号：US20200180219A1

公开(公告)日：2020-06-11

申请号：US16346923

申请日：2017-11-10

Applicant: TEXAS A&M UNIVERSITY SYSTEM

Inventor： Morgan G.B. Odom ,  Micah J. Green ,  Charles B. Sweeney

IPC: B29C64/165 ,  B29C64/209 ,  B29C64/264 ,  B29C64/227 ,  C01B32/158 ,  B82Y40/00

Abstract: The invention relates to additive manufacturing systems and methods using thermally cross-linkable materials. The thermally cross-linkable material includes at least one thermally cross-linkable polymeric material and an amount of at least one electromagnetic energy susceptor therein. A system with at least one print head and an electromagnetic energy generator is provided to produce electromagnetic energy in the area of the thermally cross-linkable material after being dispensed from the print head. This causes heating of the electromagnetic energy susceptor to cause curing of the thermally cross-linkable material.

公开(公告)号：US20200165324A1

公开(公告)日：2020-05-28

申请号：US16630768

申请日：2018-07-12

Applicant: International AIDS Vaccine Initiative ,  The Scripps Research Institute ,  The Texas A&M University System

Inventor： Devin SOK ,  Dennis R. BURTON ,  Vaughn V. SMIDER ,  Ian WILSON ,  Michael CRISCITIELLO ,  Waithaka MWANGI

IPC: C07K16/10 ,  C07K14/16

Abstract: The present disclosure relates to methods for generating broadly neutralizing bovine anti-HIV Env antibodies, compositions comprising the broadly neutralizing bovine antibodies, and methods of treatment or prevention of HIV using the broadly neutralizing bovine antibodies. In certain embodiments, a broadly neutralizing bovine antibody comprises a polyclonal F(ab) or F(ab′)2 fragment. In certain embodiments, a broadly neutralizing bovine antibody comprises a humanized bovine monoclonal antibody.

公开(公告)号：US20200071550A1

公开(公告)日：2020-03-05

申请号：US16493459

申请日：2018-03-13

Applicant: The Texas A&M University System

Inventor： Akhilesh K. GAHARWAR ,  David CHIMENE

IPC: C09D11/101 ,  B29C64/118 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  C09D11/03 ,  C09D11/04 ,  C09D11/107 ,  A61L26/00 ,  A61L27/02 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L27/22 ,  A61L27/16 ,  A61L27/26

Abstract: A biodegradable and biocompatible three dimensional construct comprising a combination of a nano silicate (e.g., laponite) and two different polymers, the two polymers each individually providing at least one covalently linked polymer chain and at least one ionically linked polymer chain, the polymeric chains forming a dual strengthening intertwined polymeric system. The constructs demonstrate improved mechanical and strength properties, while the bioinks provide a material having superior printability characteristics suitable for printing a three dimensional biodegradable construct having an aspect ratio of greater than 2.0. The bioink may also comprise cells or combinations of cells. Methods of using the constructs and bioinks for wound healing preparations and tissue regeneration are also provided.

公开(公告)号：US20200055302A1

公开(公告)日：2020-02-20

申请号：US16526697

申请日：2019-07-30

Applicant: The Texas A&M University System ,  The Board of Regents, The University of Texas System

Inventor： Venu G. Varanasi ,  Azhar Ilyas ,  Philip Roger Kramer ,  Taha Azimaie ,  Pranesh B. Aswath ,  Tugba Cebe

IPC: B33Y70/00 ,  B33Y10/00 ,  A61N5/06 ,  A61K33/00 ,  A61K31/722 ,  A61K38/39 ,  B29C64/106 ,  A61K41/00 ,  B33Y80/00

Abstract: Bio-Inks and methods of using compositions comprising the bio-Inks are disclosed. 3-D tissue repair and regeneration through precise and specific formation of biodegradable tissue scaffolds in a tissue site using the bio-inks are also provided. Specific methylacrylated gelatin hydrogels (MAC) and methacrylated chitosan (MACh) preparations formulated with sucrose, a silicate-containing component (such as laponite), and/or a cross-linking agent (such as a photo-initiator or chemical initiator), as well as powdered preparations of these, are also disclosed. Kits containing these preparations are provided for point-of-care tissue repair in vivo. Superior, more complete (up to 99.85% tissue regeneration within 4 weeks applied in situ), and rapid in situ tissue repair and bone formation are also demonstrated.

公开(公告)号：US20190389874A1

公开(公告)日：2019-12-26

申请号：US16304073

申请日：2017-05-23

Applicant: The Texas A&M University System

Inventor： Dai Lu ,  Chang-Jiang Qiao ,  Boqiao Fu ,  Anantha Lakshmi Duddupudi ,  Zhixing Wu

IPC: C07D491/052

Abstract: Functionalized pyrano[2,3-d]pyrimidin-7-one derivatives, methods for making the derivatives, and methods of using the derivatives as protein kinase inhibitors.

公开(公告)号：US20190382417A1

公开(公告)日：2019-12-19

申请号：US16555741

申请日：2019-08-29

Applicant: The Texas A&M University System

Inventor： Daniel Romo ,  Ken Hull ,  Mingzhao Zhu ,  Omar Robles

IPC: C07D513/08 ,  A61K47/68

Abstract: Pateamine A derivatives and pharmaceutical compositions that include the derivatives. The pateamine A derivatives are α-amino pateamine A derivatives that lack the C5-methyl group of pateamine A.

公开(公告)号：US20190323845A1

公开(公告)日：2019-10-24

申请号：US16342273

申请日：2017-11-09

Applicant: The Texas A&M University System

Inventor： Saurav Agarwal ,  Suman Chakravorty

IPC: G01C21/32 ,  G05D1/02

Abstract: Described herein are embodiments of a method and system that uses a vertical or upward facing imaging sensor to compute vehicle attitude, orientation, or heading and combines the computed vehicle attitude, orientation, or heading with range bearing measurements from an imaging sensor, LiDAR, sonar, etc., to features in the vicinity of the vehicle to compute accurate position and map estimates.

公开(公告)号：US20190314381A1

公开(公告)日：2019-10-17

申请号：US16422594

申请日：2019-05-24

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Manchi CM Reddy ,  James C. Sacchettini ,  Nian E. Zhou ,  Billy F. McCutchen

IPC: A61K31/5377 ,  A61K31/501 ,  A61K31/496 ,  A61K31/454 ,  A61K31/423 ,  A61K31/498 ,  A61K31/44 ,  A61K31/428 ,  A61K31/4439

Abstract: A composition comprising a drug selected from the group consisting of an arylphenoxypropionate derivative, an aryloxyphenoxyacetate derivative, an aryloxyphenylacetate derivative, a substituted quinol, or a salt, hydrate, or prodrugs thereof, or a combination thereof, in an amount and formulation sufficient to inhibit a mycobacterium is disclosed.

公开(公告)号：US10442182B2

公开(公告)日：2019-10-15

申请号：US15360788

申请日：2016-11-23

Applicant: The Texas A&M University System ,  The Board of Regents, The University of Texas System

Inventor： Venu G. Varanasi ,  Azhar Ilyas ,  Philip Roger Kramer ,  Taha Azimaie ,  Pranesh B. Aswath ,  Tugba Cebe

IPC: B33Y70/00 ,  A61K38/39 ,  A61K31/722 ,  A61K33/00 ,  A61N5/06 ,  B33Y10/00 ,  A61K41/00 ,  B33Y80/00 ,  B29C64/106 ,  B29K67/00

Abstract: Bio-Inks and methods of using compositions comprising the bio-Inks are disclosed. 3-D tissue repair and regeneration through precise and specific formation of biodegradable tissue scaffolds in a tissue site using the bio-inks are also provided. Specific methylacrylated gelatin hydrogels (MAC) and methacrylated chitosan (MACh) preparations formulated with sucrose, a silicate-containing component (such as laponite), and/or a cross-linking agent (such as a photo-initiator or chemical initiator), as well as powdered preparations of these, are also disclosed. Kits containing these preparations are provided for point-of-care tissue repair in vivo. Superior, more complete (up to 99.85% tissue regeneration within 4 weeks applied in situ), and rapid in situ tissue repair and bone formation are also demonstrated.