公开(公告)号：US11628602B2

公开(公告)日：2023-04-18

申请号：US16489504

申请日：2018-02-27

Applicant: Consiglio Nazionale Delle Ricerche

Inventor： Monica Sandri ,  Anna Tampieri ,  Simone Sprio

IPC: B29C35/16 ,  A61M16/10 ,  C08J3/075

Abstract: Filter made entirely with natural and biodegradable materials, for the protection of the respiratory tract of patients in the medical-surgical field and process for making it. The filter has a porosity or 80-98% and pore diameters of 100-350 micrometers and the pores have a shape of channels open at the ends, which are parallel to each other. The filter is obtained by preparing an aqueous solution of chitosan and an aqueous solution of gelatin, mixing them, pouring it into a container, keeping the container closed until obtaining a hydrogel and freeze-drying. A cross-linking step takes place by (a) adding a chemical cross-linker to the mixture of the chitosan and gelatine solutions and cross-linking before freeze-drying, or (b) subjecting the freeze-drying product to a thermal dehydration treatment.

公开(公告)号：US11517860B2

公开(公告)日：2022-12-06

申请号：US16979030

申请日：2019-03-08

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  UNIVERSITÁ DI PISA ,  UNIVERSITÁ DELLA CALABRIA

Inventor： Alberto Figoli ,  Francesco Galiano ,  Giuseppe Barbieri ,  Adele Brunetti ,  Lidietta Giorno ,  Christian Silvio Pompelli ,  Cinzia Chiappe ,  Bartolo Gabriele ,  Raffaella Mancuso ,  Yujiro Itami

IPC: B01D53/22 ,  B01D71/40 ,  B01D67/00 ,  B01D69/12 ,  B01D71/82

Abstract: The invention relates to dense synthetic membranes made from polymerised phosphonium-based ionic liquids which were found to be particularly suitable for use in gas separation. The membranes are obtainable by copolymerization via UV-curing of a composition comprising a phosphonium-based ionic liquid monomer, a co-monomer, a cross-linker, a surfactant and a photo-initiator, the remainder of the polymerization mixture consisting of water.
The invention also relates to a process of manufacturing said membranes, resulting in solid, dense and mechanically stable membranes, and to the use of the membranes so produced in the separation of gas mixtures, particularly gas mixtures containing carbon dioxide.

公开(公告)号：US20220259075A1

公开(公告)日：2022-08-18

申请号：US17626227

申请日：2020-07-13

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  ALMA MATER STUDIORUM UNIVERSITA' DI BOLOGNA

Inventor： Sabrina Carola CARROCCIO ,  Francesca CUNSOLO ,  Tommaso MECCA ,  Vittorio PRIVITERA ,  Martina USSIA ,  Daniele CARETTI ,  Stefano SCURTI

IPC: C02F1/28 ,  B01J20/26 ,  B01J20/28

Abstract: The disclosure relates to N-alkyl-D-glucamine based macroporous polymeric cryogels with three-dimensional structure and with interconnected pores, which are used for sequestering and/or removing toxic contaminants, such as toxic metalloids and/or toxic heavy metals, for example from water and/or soil and the method for the preparation of said -alkyl-D-glucamine based macroporous polymeric cryogels.

公开(公告)号：US11415642B2

公开(公告)日：2022-08-16

申请号：US17231297

申请日：2021-04-15

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  UNIVERSITA' DEGLI STUDI “G. D'ANNUNZIO” CHIETI-PESCARA ,  QUANTIFIED AIR BV

Inventor： Luca Pellegrino ,  Nicola Manca ,  Daniele Marre′ ,  Federico Remaggi ,  Riccardo Bertacco ,  Federico Maspero ,  Warner Jurriën Venstra ,  Stefania Della Penna ,  Ingo Hilschenz ,  Alexei Kalaboukhov ,  Filomena Lombardi

IPC: G01R33/00 ,  G01R33/032

Abstract: A device for sensing a magnetic field, comprising a closed superconducting loop configured to collect a magnetic field to be sensed, hereinafter external magnetic field, the closed superconducting loop having a path width (wp) and being provided with a constriction having a width (wc) narrower than the path width, the constriction generating a non-uniform magnetic field, hereinafter internal magnetic field, in response to the external magnetic field, a vibrating mechanical oscillator coupled to, or formed by the constriction and responsive to the internal magnetic field, and a detector configured to detect deflection or vibration of the mechanical oscillator and providing a signal indicative of the deflection or vibration.

公开(公告)号：US20220129750A1

公开(公告)日：2022-04-28

申请号：US17507177

申请日：2021-10-21

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  DUE2LAB S.R.L.

Inventor： Nicola SARZI AMADÈ ,  Manuele Bettelli ,  Andrea Zappettini ,  Nicola Zambelli

IPC: G06N3/08 ,  G06N3/063 ,  G06N3/04 ,  G06V10/32

Abstract: A method for identifying and quantifying radioisotopes in a gamma spectrum. and an algorithm based on convolutional neural networks (CNN) with a direct acyclic graph (DAG) structure are provided. The capacity to capture relevant attributes of CNNs combined with the possibility of carrying out several tasks of a DAG simultaneously allows performing precise, automatic identification and quantification in a single process. After appropriate training of the network, the only input needed is the raw spectrum measured by the device, without intervention of human operators and intermediate measurement processings.

公开(公告)号：US11273023B2

公开(公告)日：2022-03-15

申请号：US16955851

申请日：2018-12-18

Applicant: POLITECNICO DI MILANO ,  UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Manuela Teresa Raimondi ,  Giulio Cerullo ,  Claudio Conci ,  Tommaso Zandrini ,  Roberto Osellame ,  Giuseppe Chirico

IPC: A61F2/00 ,  A61B5/00

Abstract: An implantable medical device obtained by means of two-photon laser polymerisation of a resin to form a three-dimensional matrix, wherein: said three-dimensional matrix comprises a number of levels distributed in height; and said three-dimensional matrix comprises reference means designed to uniquely identify the height of each level from a pre-set reference, by means of a multi-photon fluorescence-excitation microscope; said implantable medical device being characterised in that said reference means comprise a solid having a cross section that varies with height.

公开(公告)号：US11180418B2

公开(公告)日：2021-11-23

申请号：US16072893

申请日：2017-01-26

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Diletta Sciti ,  Luca Zoli ,  Valentina Medri

IPC: C04B35/56 ,  C04B35/626 ,  C04B35/634 ,  C04B35/645 ,  C04B35/66 ,  C04B35/58 ,  C04B35/80 ,  F02K9/97 ,  F02K9/60 ,  C04B35/628 ,  C04B35/63

Abstract: The present invention relates to a process for the production of fiber-reinforced composite materials with an ultra-refractory, high tenacity, high ablation resistant matrix with self-healing properties, prepared from highly sinterable slurries. The composite material is produced using techniques of infiltration and drying at ambient pressure or under vacuum, and consolidated by sintering with or without the application of gas or mechanical pressure.

公开(公告)号：US11084854B2

公开(公告)日：2021-08-10

申请号：US16991517

申请日：2020-08-12

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Luigi Manni ,  Marzia Soligo

IPC: C07K14/475 ,  A61P25/28 ,  C07K16/22

Abstract: A protease-resistant neurotrophic peptide is provided. A pharmaceutical composition including the protease-resistant neurotrophic peptide in a pharmaceutically acceptable carrier, in combination with optional adjuvants, stabilizers and/or preservatives, is also provided.

公开(公告)号：US20210230255A1

公开(公告)日：2021-07-29

申请号：US17050947

申请日：2019-04-29

Applicant: FONDAZIONE EBRI RITA LEVI-MONTALCINI ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Giuseppina AMADORO ,  Pietro CALISSANO ,  Veronica CORSETTI

IPC: C07K16/18 ,  A61K39/395 ,  A61K45/06 ,  A61P25/28 ,  A61K39/00

Abstract: The present invention refers to an antibody or an antigen binding fragment thereof against a tau-derived neurotoxic peptide for use in the treatment and/or prevention of Alzheimer's disease (AD) or a non-AD tauopathy, as well as pharmaceutical compositions comprising the same.

公开(公告)号：US11027045B2

公开(公告)日：2021-06-08

申请号：US15755011

申请日：2016-08-31

Applicant: POLITECNICO DI MILANO ,  CONSIGLIO NAZIONALE DELLE RICERCHE ,  FONDAZIONE CARIPLO

Inventor： Manuela Teresa Raimondi ,  Giulio Cerullo ,  Roberto Osellame ,  Andrea Remuzzi

IPC: A61L27/38 ,  A61L27/56 ,  C12N5/00 ,  C12N5/0735 ,  C12N5/0775

Abstract: The present invention relates to a supermatrix of synthetic niches comprising at least two matrices of niches wherein each matrix comprises n×m niches and wherein the distance (d) between a matrix and the other is greater than zero and wherein in each matrix every synthetic niche has one or more walls in common with the others synthetic niches of the matrix.
A support for the culture of cells that includes at least one supermatrix and the use of said supermatrix or support for the in vitro culture of cells, in particular stem cells, or for the in vivo implant in a subject in order to promote tissue or organ regeneration through cell repopulation are also within the scope of the present invention.