公开(公告)号：US10775462B2

公开(公告)日：2020-09-15

申请号：US16027895

申请日：2018-07-05

申请人： The General Hospital Corporation

发明人： Phillip Zhe Sun ,  Iris Yuwen Zhou

IPC分类号： G01R33/483 ,  G01R33/56 ,  G01R33/485 ,  G01R33/50

摘要： A system and method is provided that includes acquiring chemical exchange saturation transfer (CEST) data with the MRI system and generating an acquired Z-spectrum (Z) from the CEST data. The system and method also includes computing an estimated direct water saturation (Z′) based using at least one of relaxation measurements derived from the CEST data or imaging parameters used to acquire the CEST data with the MRI system, computing a direct saturation corrected Z-spectrum (ΔZ) using the acquired Z-spectrum (Z) and the estimated direct water saturation (Z′), and generating a CEST image of the subject using the direct saturation corrected Z-spectrum (ΔZ).

公开(公告)号：US20200278406A1

公开(公告)日：2020-09-03

申请号：US16290574

申请日：2019-03-01

申请人： Canon Medical Systems Corporation

发明人： Samir Dev SHARMA

IPC分类号： G01R33/48 ,  G01R33/485 ,  G01R33/561 ,  G01R33/565

摘要： A method and apparatuses are provided to perform chemical species separation in magnetic resonance (MR) imaging (MRI). At least three MR images corresponding respectively to different echo times are obtained and represent signals from multiple chemical species including a first species and a second species in a tissue. A plurality of dual-echo pairs is selected from the at least three MR images. For each pair, a set of dual-echo separated images including a B0 field map, a first image for the first species, and a second image for the second species is estimated. An initial set of combined images including at least one of: an initial combined B0 field map, first, and second image is generated by combining at least one of: two or more of the B0 field maps, two or more of the first images, and two or more of the second images.

公开(公告)号：US10753892B2

公开(公告)日：2020-08-25

申请号：US14785486

申请日：2014-04-18

申请人： The Johns Hopkins University

发明人： Amnon Bar-Shir ,  Jeff W. M. Bulte ,  Michael T. McMahon

IPC分类号： G01N24/08 ,  A61B5/055 ,  A61K49/10 ,  G01R33/485 ,  G01R33/56 ,  C07C229/40 ,  G01R33/46 ,  G01R33/465 ,  G01R33/28

摘要： The invention features a novel non-invasive approach for imaging, detecting and/or sensing metal ions with improved sensitivity and specificity in a biological sample or tissue. In certain embodiments, the invention provides a MR contrast-based approach for imaging, detecting and/or sensing metal ions in the biological sample/tissue containing various background ions by using 19F-based chemical exchange saturation transfer (CEST) technique.

公开(公告)号：US10743791B2

公开(公告)日：2020-08-18

申请号：US14981710

申请日：2015-12-28

申请人： Wisconsin Alumni Research Foundation

发明人： Scott B. Reeder ,  Roberta M. Strigel

IPC分类号： G01R33/00 ,  A61B5/055 ,  A61B5/00 ,  G01R33/48 ,  G06T7/00 ,  G01R33/485 ,  G01R33/56

摘要： A system and method for assessing tissue properties of a subject within a region of interest (ROI) using a magnetic resonance imaging (MRI) system includes acquiring chemical-shift-encoded imaging data of the ROI. The method also includes determining, from imaging data a proton density water fraction (PDWF) map and quantifying, using the PDWF map, a property of tissue within the ROI. The method further includes generating, using the PDWF map, a report indicating the quantified property of the tissue. The tissue may include fibroglandular tissue (FGT).

公开(公告)号：US10739429B2

公开(公告)日：2020-08-11

申请号：US16095345

申请日：2017-04-20

申请人： Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.

发明人： David Porter ,  Marco Vicari

IPC分类号： G01R33/60 ,  G01R33/485 ,  G01N24/08 ,  G01R33/48 ,  G01R33/561

摘要： The invention relates to a system for performing echo-planar spectroscopic imaging. The system comprises an acquisition unit for acquiring magnetic resonance data, wherein the acquisition unit is adapted to use a first encoding gradient in a readout direction and a second encoding gradient in a phase-encoding direction, wherein the first encoding gradient and the second encoding gradient are stepped. The system further comprises a reconstruction unit for reconstructing a magnetic resonance image based on the acquired magnetic resonance data.

公开(公告)号：US10459052B2

公开(公告)日：2019-10-29

申请号：US16067204

申请日：2015-12-30

申请人： Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences

发明人： Hairong Zheng ,  Xin Liu ,  Chuanli Cheng ,  Chao Zou

IPC分类号： G01R33/56 ,  G01R33/48 ,  A61B5/055 ,  G01R33/44 ,  G01R33/46 ,  G01R33/485 ,  G01R33/565

摘要： Provided are a magnetic resonance chemical-shift-encoded imaging method, apparatus, and device, belonging to the technical field of magnetic resonance imaging. The method comprises: in a phasor-error plot established on the basis of a two-point magnetic resonance signal model, determining to be an initial seed point a pixel having a unique phasor and causing said plot to reach a minimal local value; according to the initial seed point, estimating the phasor value of a to-be-estimated pixel to obtain a field map; mapping and merging the field map at the highest resolution to obtain a reconstructed field map; determining a reconstructed seed point from the reconstructed field map, and estimating the reconstructed seed point to obtain the phasor value of the reconstructed to-be-estimated pixel; according to the reconstructed seed point and the phasor value of the reconstructed to-be-estimated pixel, obtaining two separate images having predetermined components. In the method, a region simultaneously containing two components is identified as a seed point, eliminating the deviation caused by phasor-value jump at high resolution and ensuring the correctness of the seed point ultimately selected.

公开(公告)号：US20190195974A1

公开(公告)日：2019-06-27

申请号：US16331687

申请日：2017-06-23

申请人： UNIVERSITEIT GENT

发明人： Hacene SERRAI ,  Eric ACHTEN ,  Sourav BHADURI

IPC分类号： G01R33/485 ,  G01R33/56 ,  G01R33/565

CPC分类号： G01R33/485 ,  G01R33/483 ,  G01R33/5608 ,  G01R33/56509 ,  G01R33/56527

摘要： A method is provided for performing NMR spectroscopy. The method comprises positioning a sample in a homogeneous stationary magnetic field directed along an axis, preparing nuclei in at least a predetermined volume of the sample for resonant emission of an NMR signal and creating this NMR signal. This comprises irradiating the sample with at least one RF excitation pulse in accordance with an MRI sequence preparation and/or evolution module. The method also comprises sensing the NMR signal in the absence of frequency encoding magnetic field gradients such that analysis of the NMR signal yields a chemical shift spectrum from the nuclei. During this sensing, a plurality of intermittently blipped phase gradient pulses are applied to incrementally shift a position in k-space such that different time segments of the NMR signal, demarcated by the blipped phase gradient pulses, correspond to different predetermined locations in k-space.

公开(公告)号：US10203389B2

公开(公告)日：2019-02-12

申请号：US15304948

申请日：2015-04-22

申请人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Tao Jin ,  Seong-Gi Kim ,  Hunter S. Mehrens ,  Kristy S. Hendrich

IPC分类号： A61B5/055 ,  A61B5/00 ,  A61B5/145 ,  G01R33/50 ,  G01R33/56 ,  G01R33/485 ,  G01R33/563

摘要： A method of monitoring glucose transport and/or metabolism in a tissue or an organ of a subject using spin-locking magnetic resonance (MR) includes acquiring pre-glucose MR data by executing a pre-glucose chemical exchange spin-lock (CESL) pulse sequence a number of times each including applying pre-glucose chemical exchange spin-lock pulse sequence irradiation to the tissue or the organ, administering glucose to the subject, acquiring post-glucose MR data by executing a post-glucose chemical exchange spin-lock (CESL) pulse sequence a number of times each including applying post-glucose chemical exchange spin-lock (CESL) pulse sequence irradiation to the tissue or the organ, and using the pre-glucose MR data and the post-glucose MR data to generate a measure of glucose transport, glucose metabolism or both glucose transport and glucose metabolism in the tissue or the organ.

公开(公告)号：US09915714B2

公开(公告)日：2018-03-13

申请号：US15013584

申请日：2016-02-02

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Qiuhong He

IPC分类号： G01V3/00 ,  G01R33/46 ,  G01R33/56 ,  G01R33/12 ,  G01R33/34 ,  G01R33/48 ,  G01R33/485

CPC分类号： G01R33/4608 ,  G01R33/1284 ,  G01R33/34046 ,  G01R33/4828 ,  G01R33/485 ,  G01R33/5605 ,  G01R33/5607

摘要： Systems and methods employing spin editing techniques to improve magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging (MRSI) are discussed. Using these spin editing techniques, magnetic resonance signals of one or more unwanted chemicals (that is, chemicals whose signals are to be filtered out or suppressed) chemicals can be suppressed, so that the signal(s) of a first set of chemicals can be obtained without signals from the one or more unwanted chemicals. Information about and differences between the molecular topologies of the first set of chemicals and the one or more unwanted chemicals can be used to design a sequence that suppresses the one or more unwanted chemicals while allowing acquisition of signal(s) from the first set of chemicals.

公开(公告)号：US20170299677A1

公开(公告)日：2017-10-19

申请号：US15512998

申请日：2015-09-11

申请人： KONINKLIJKE PHILIPS N.V.

发明人： IVAN DIMITROV

IPC分类号： G01R33/465 ,  G01R33/485 ,  G01R33/483 ,  G01R33/56 ,  A61B5/055

摘要： A guide map is created for use in placing a spectroscopic single voxel in a region of interest in single voxel magnetic resonance spectroscopy. An anatomical planning image of the region of interest is obtained through MRI. A spectroscopy voxel is stepped across the region of interest, characteristics of the magnetic field used in the MRI are measured at each location of the imaging voxel, and a guide-FWHM map indicative of the homogeneity/inhomogeneity of the magnetic field over the region of interest is derived using the measurements. The guide map is created by overlaying the guide-FWHM map on the anatomical planning image. A spectroscopic single voxel of a size corresponding to that of the spectroscopy voxel is placed within the region of interest as per the guide map. Then spectral data is acquired from the region of interest confined to the single voxel.